European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2024, Volume and Issue: unknown
Published: Feb. 27, 2024
The growing interest in the rapid and sustained antidepressant effects of dissociative anesthetic ketamine classic psychedelics, such as psilocybin, is remarkable. However, both psychedelics are known to induce acute mystical experiences; can cause symptoms out-of-body experience, while typically bring about hallucinogenic experiences, like a profound sense unity with universe or nature. role these experiences enhancing outcomes for patients depression currently an area ongoing investigation debate. Clinical studies have shown that following administration (S)-ketamine (esketamine) not directly linked their properties. In contrast, potential (R)-ketamine (arketamine), thought lack side effects, has yet be conclusively proven large-scale clinical trials. Moreover, although activation serotonin 5-HT
Language: Английский
Citations
29Neuroinflammation through the vagus nerve-dependent gut–microbiota–brain axis in treatment-resistant depression
Progress in brain research, Journal Year: 2023, Volume and Issue: unknown, P. 61 - 77
Published: Jan. 1, 2023
Language: Английский
Citations
31Gut microbiome-derived ammonia modulates stress vulnerability in the host
Nature Metabolism, Journal Year: 2023, Volume and Issue: 5(11), P. 1986 - 2001
Published: Oct. 23, 2023
Language: Английский
Citations
28Depression-like phenotypes in mice following common bile duct ligation: Insights into the gut–liver–brain axis via the vagus nerve
Neurobiology of Disease, Journal Year: 2024, Volume and Issue: 192, P. 106433 - 106433
Published: Feb. 7, 2024
Depression frequently occurs in patients with liver cirrhosis, yet the reasons for this correlation are not fully understood. Dysbiosis of gut microbiota has been implicated depression through gut–brain axis via vagus nerve. This study explored potential role gut–liver–brain nerve depression-like phenotypes mice cirrhosis. These underwent common bile duct ligation (CBDL), a method used to stimulate To assess behaviors, behavioral tests were conducted 10 days following either sham or CBDL surgeries. The displayed symptoms such as splenomegaly, elevated plasma levels interleukin-6 and tumor necrosis factor-α, decreased synaptic proteins prefrontal cortex (PFC), disrupted balance, changes blood metabolites (or lipids). Additionally, there positive negative correlations between relative abundance microbiome data Significantly, these reversed by performing subdiaphragmatic vagotomy. Intriguingly, improved after single injection arketamine, new antidepressant. results suggest that CBDL-induced mediated nerve, arketamine might offer treatment approach cirrhosis patients.
Language: Английский
Citations
11The vagus nerve: An old but new player in brain–body communication
Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Citations
9Role of the gut–brain axis via the subdiaphragmatic vagus nerve in stress resilience of 3,4-methylenedioxymethamphetamine in mice exposed to chronic restrain stress
Neurobiology of Disease, Journal Year: 2023, Volume and Issue: 189, P. 106348 - 106348
Published: Nov. 11, 2023
3,4-Methylenedioxymethamphetamine (MDMA) is the most widely used illicit substance worldwide. Nevertheless, recent observational studies demonstrated that lifetime MDMA use among U.S. adults was associated with a lower risk of depression and suicide thoughts. We recently reported gut-brain axis may contribute to MDMA-induced stress resilience in mice. To further explore this, we investigated effects subdiaphragmatic vagotomy (SDV) modulating mice subjected chronic restrain (CRS). Pretreatment (10 mg/kg/day for 14 days) blocked anhedonia-like behavior reduced expression synaptic proteins brain-derived neurotrophic factor prefrontal cortex (PFC) CRS-exposed Interestingly, SDV beneficial on these alterations Analysis gut microbiome revealed four measures α-diversity between sham + CRS group group. Moreover, specific microbes differed vehicle group, differences microbial composition were observed all groups. Untargeted metabolomics analysis showed prevented increase plasma levels three compounds [lactic acid, 1-(2-hydroxyethyl)-2,2,6-tetramethyl-4-piperidinol, 8-acetyl-7-hydroxyvumaline] positive correlations found two abundance several across In conclusion, our data suggest via vagus nerve might MDMA.
Language: Английский
Citations
17Role of oxidative phosphorylation in the antidepressant effects of arketamine via the vagus nerve-dependent spleen-brain axis
Neurobiology of Disease, Journal Year: 2024, Volume and Issue: 199, P. 106573 - 106573
Published: June 18, 2024
Arketamine, the (R)-enantiomer of ketamine, exhibits antidepressant-like effects in mice, though precise molecular mechanisms remain elusive. It has been shown to reduce splenomegaly and depression-like behaviors chronic social defeat stress (CSDS) model depression. This study investigated whether spleen contributes arketamine CSDS model. We found that splenectomy significantly inhibited arketamine's CSDS-susceptible mice. RNA-sequencing analysis identified oxidative phosphorylation (OXPHOS) pathway prefrontal cortex (PFC) as a key mediator splenectomy's impact on effects. Furthermore, oligomycin A, an inhibitor OXPHOS pathway, reversed suppressive Specific genes within pathways, such COX11, UQCR11 ATP5e, may contribute these inhibitory Notably, transforming growth factor (TGF)-β1, along with appears modulate Additionally, SRI-01138, agonist TGF-β1 receptor, alleviated Subdiaphragmatic vagotomy also counteracted These findings suggest PFC play significant roles arketamine, mediated through spleen-brain axis via vagus nerve.
Language: Английский
Citations
7Beneficial effects of arketamine on the reduced bone mineral density in susceptible mice after chronic social defeat stress: Role of the gut–microbiota–bone–brain axis
Neuropharmacology, Journal Year: 2023, Volume and Issue: 228, P. 109466 - 109466
Published: Feb. 15, 2023
Language: Английский
Citations
14Influence of gut microbiota on resilience and its possible mechanisms
International Journal of Biological Sciences, Journal Year: 2023, Volume and Issue: 19(8), P. 2588 - 2598
Published: Jan. 1, 2023
Excessive stress leads to disruptions of the central nervous system.Individuals' responses and trauma differ from person person.Some may develop various neuropsychiatric disorders, such as post-traumatic disorder, major depression, anxiety while others successfully adapt same stressful events.These two neural phenotypes are called susceptibility resilience.Previous studies have suggested resilience/susceptibility a complex, non-specific systemic response involving peripheral systems.Emerging research mechanisms underlying resilience is mostly focussing on physiological adaptation specific brain circuits, neurovascular impairment blood-brain barrier, role innate adaptive factors immune system, dysbiosis gut microbiota.In accordance with microbiota-gut-brain axis hypothesis, microbiome directly influences interface between periphery affect neuronal function.This review explored several up-to-date microbiota implicated in events-related resilience/susceptibility. We mainly focus changes behavior neuroimaging characteristics, involved regions epigenetic modifications, which contribute stress-induced susceptibility.The perspective gut-brain could help understand discovery biomarkers lead new directions therapeutic interventions for disorders.
Language: Английский
Citations
14A role of gut–brain axis on prophylactic actions of arketamine in male mice exposed to chronic restrain stress
Pharmacology Biochemistry and Behavior, Journal Year: 2024, Volume and Issue: 238, P. 173736 - 173736
Published: Feb. 23, 2024
Language: Английский
Citations
5