Social Determinants of Health and Suicide-Related Outcomes

JAMA Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Importance Preventing suicide is one of the top priorities in public health policy. Identifying key social determinants (SDOH) risk critical for informing clinical practices, future research, and policy solutions to prevent suicide. Objective To examine associations SDOH with suicide-related outcomes. Data Sources Studies published before July 2023 were searched through PubMed, PsycINFO, Embase, Web Science. The date search was August 4, 2023. Study Selection We included most up-to-date meta-analyses reporting between Extraction Synthesis Three independent reviewers extracted data conducted quality assessment using Joanna Briggs Institute Checklist Systematic Reviews Research Syntheses. Main Outcomes Measures main outcomes interest mortality, attempt, suicidal ideation. Results A total 46 met inclusion criteria. For justice system–involved individuals community, exposure others’ parental suicide, firearm accessibility, divorce, experience foster care, release from incarceration, midlife (age 35-65 years) unemployment consistently strong effects. Individuals released incarceration demonstrated a high prevalence mortality (114.5 per 100 000 persons). With regard childhood abuse maltreatment sexual assault, gender minority status, strongest factors. attempt among homeless (28.9%; 95% CI, 21.7%-37.2%) incarcerated female youths (27%; 20%-34%) adults (12.2%; 7.1%-17.2%) high. ideation, identification as bisexual intimate partner violence women lifetime ideation 41.6% (95% 28.6%-56.0%). Protective factors associated reduced religious affiliation being married. School connectedness showed protective against Conclusions Relevance Tailoring interventions research identified priority subpopulations, such implementing measures addressing that attempts, gun licensing requirements, are counteracting environmental forces increase risk.

Language: Английский

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Omega-3 Polyunsaturated Fatty Acids in Depression

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8675 - 8675

Published: Aug. 8, 2024

Omega-3 polyunsaturated fatty acids have received considerable attention in the field of mental health, particular regarding treatment depression. This review presents an overview current research on role omega-3 prevention and depressive disorders. The existing body evidence demonstrates that acids, eicosapentaenoic acid (EPA) docosahexaenoic (DHA), antidepressant effects can be attributed to their modulation neuroinflammation, neurotransmitter function, neuroplasticity. Nevertheless, clinical trials supplementation yielded inconsistent results. Some studies demonstrated significant reductions symptoms following treatment, whereas others shown minimal no beneficial impact. A range factors, encompassing dosage, ratio EPA DHA, baseline nutritional status, been identified as having a potential impact noted Furthermore, it has suggested may act adjunctive for those undergoing treatment. Notwithstanding these encouraging findings, discrepancies study designs variability individual responses underscore necessity further order establish uniform, standardized guidelines use management

Language: Английский

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Modelling the impact of environmental and social determinants on mental health using generative agents

npj Digital Medicine, Journal Year: 2025, Volume and Issue: 8(1)

Published: Jan. 17, 2025

Abstract Mental health is shaped by socio-environmental determinants, yet traditional research approaches struggle to capture their complex interactions. This review explores the potential of generative agents, powered large language models, simulate human-like behaviour in virtual environments for mental research. We outline applications including modelling adverse life events, urbanicity, climate change, discuss challenges and describe how agents could transform

Language: Английский

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Emerging strategies and clinical recommendations for the management of novel depression subtypes

Expert Review of Neurotherapeutics, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 21

Published: Feb. 27, 2025

Introduction The phenomenology of depression is characterized by a wide array emotional, cognitive, and physical symptoms that significantly disrupt an individual's life. Societal changes, driven technological advancements, economic pressures, environmental concerns including climate change, shifting cultural norms, have influenced how manifests understood. These developments led to the identification new subtypes, highlighting need for personalized treatment approaches based on individual underlying causes.

Language: Английский

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Positive global mental health: an overview

Published: March 6, 2025

At present, most healthcare systems are reactive, focusing on symptom control. They over-emphasize impairments, disorders, disabilities, and risk factors, without sufficient attention to individuals’ communities’ strengths, positive psychosocial characteristics, protective preventive the promotion of well-being. This disorder-oriented approach may contribute a broadening gap between service needs rapidly increasing urbanized world population supply adequately qualified providers. It is critical assess enhance personal such as resilience, wisdom, optimism, compassion, spirituality, purpose in life, along with social connections support. Strong evidence supports value determinants health, which reduce mental illnesses, improve long-term course, promote recovery persons serious illnesses physical maladies. The primary prevention can be operationalized. Appropriate strategies should culturally sensitive, applying interventions that appropriate local community. Interventions informed by biological similarities etiopathology across globe, but also diverse expressions varied people from communities. Recent reports global behavioral pandemic loneliness, isolation, suicides, drug abuse point an urgent need for developing therapeutic at both individual societal levels well-being general population, including illnesses. There potentially exciting examples age-friendly communities, intergenerational activities, digital support well health. important medicine psychiatry their focus diseases factors health factors.

Language: Английский

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Addressing social determinants of health in individuals with mental disorders in clinical practice: review and recommendations

Translational Psychiatry, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 3, 2025

Language: Английский

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Pervasive neurovascular dysfunction in the ventromedial prefrontal cortex of female depressed suicides with a history of childhood abuse

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 30, 2024

Abstract Exposure to early life adversity (ELA) poses a significant global public health concern, with profound pathophysiological implications for affected individuals. Studies suggest that ELA contributes endothelial dysfunction, bringing into question the functional integrity of neurovascular unit in brain regions vulnerable chronic stress. Despite importance neurovasculature maintaining normal physiology, human cells remain poorly characterized, particularly regard their contributory role ELA-associated pathophysiologies. In this study, we present first comprehensive transcriptomic analysis intact microvessels isolated from postmortem ventromedial prefrontal cortex samples adult healthy controls (CTRL) and matched depressed suicides histories ELA. Our findings point substantive differences between men women, latter exhibiting widespread gene expression changes at unit, including key vascular nodal regulators KLF2 KLF4 , alongside broad downregulation immune-related pathways. These results plays larger neurobiological consequences females.

Language: Английский

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Serum proteomic changes related to residual impairment in remittent depression are associated with immune and inflammatory processes

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 18, 2024

Abstract In patients with major depressive disorder, various functional areas are impaired, negatively impacting the quality of life. Remission can restore pre-depression functions; however, some may still have residual impairments. Distinguishing between near-normal recovery and impairment helps identify those at a high risk relapse tailor treatment. Accordingly, we aimed to discover validate biomarkers that distinguish in remission states through serum proteome analysis. Pooled individual samples from three groups (depression status, status impairment, normal recovery) were analyzed using liquid chromatography-tandem mass spectrometry. The combination four proteins—antithrombin-III, amyloid A4 protein, C1q subcomponent subunit B, P-component—was selected as candidate biomarker. trend protein changes suggests complement B P-component potential for distinguishing impairment. Changes suggest system inflammation-related immune mechanisms associated remittent disorder.

Language: Английский

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The Impact of Undermining Coparenting on the Mental and Physical Health Outcomes of Black Fathers: The Role of Depression and Restrictive Emotionality

Social Work in Public Health, Journal Year: 2024, Volume and Issue: 39(7), P. 568 - 585

Published: July 31, 2024

The parenting literature has established the coparenting relationship as central to behaviors and outcomes of men. construct encompasses supportive efforts among individuals that facilitate rearing children unsupportive actions can undermine (Merrifield & Gamble, 2013). Few studies have examined undermining an experience shapes Black men's health outcomes. In this study, we apply social determinants framework examine impact fathers' perceptions on their self-reported ratings mental physical health. Using a nationally representative sample men (

Language: Английский

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From diagnosis to dialogue – reconsidering the DSM as a conversation piece in mental health care: a hypothesis and theory

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 6, 2024

The Diagnostic and Statistical Manual of Mental Disorders, abbreviated as the DSM, is one mental health care's most commonly used classification systems. While DSM has been successful in establishing a shared language for researching communicating about distress, it its limitations an empirical compass. In transformation care towards system that centered around decision-making, person-centered care, personal recovery, problematic promotes disengagement people with distress primarily tool developed professionals to communicate

Language: Английский

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