Cancer-related fatigue—mechanisms, risk factors, and treatments

Nature Reviews Clinical Oncology, Journal Year: 2014, Volume and Issue: 11(10), P. 597 - 609

Published: Aug. 12, 2014

Language: Английский

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Pretrauma risk factors for posttraumatic stress disorder: A systematic review of the literature

Clinical Psychology Review, Journal Year: 2013, Volume and Issue: 33(6), P. 728 - 744

Published: May 14, 2013

Language: Английский

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Etiology of depression comorbidity in combat-related PTSD: A review of the literature

Clinical Psychology Review, Journal Year: 2013, Volume and Issue: 34(2), P. 87 - 98

Published: Dec. 20, 2013

Language: Английский

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Proinflammatory milieu in combat-related PTSD is independent of depression and early life stress

Brain Behavior and Immunity, Journal Year: 2014, Volume and Issue: 42, P. 81 - 88

Published: June 11, 2014

Language: Английский

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In the search for integrative biomarker of resilience to psychological stress

Neuroscience & Biobehavioral Reviews, Journal Year: 2016, Volume and Issue: 74, P. 310 - 320

Published: May 11, 2016

Language: Английский

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To Predict, Prevent, and Manage Post-Traumatic Stress Disorder (PTSD): A Review of Pathophysiology, Treatment, and Biomarkers

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5238 - 5238

Published: March 9, 2023

Post-traumatic stress disorder (PTSD) can become a chronic and severely disabling condition resulting in reduced quality of life increased economic burden. The is directly related to exposure traumatic event, e.g., real or threatened injury, death, sexual assault. Extensive research has been done on the neurobiological alterations underlying its phenotypes, revealing brain circuit disruption, neurotransmitter dysregulation, hypothalamic–pituitary–adrenal (HPA) axis dysfunction. Psychotherapy remains first-line treatment option for PTSD given good efficacy, although pharmacotherapy also be used as stand-alone combination with psychotherapy. In order reduce prevalence burden disorder, multilevel models prevention have developed detect early possible morbidity those established diseases. Despite clinical grounds diagnosis, attention increasing discovery reliable biomarkers that predict susceptibility, aid monitor treatment. Several potential linked pathophysiological changes PTSD, encouraging further identify actionable targets. This review highlights current literature regarding pathophysiology, disease development models, modalities, preventive from public health perspective, discusses state biomarker research.

Language: Английский

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Gene networks specific for innate immunity define post-traumatic stress disorder

Molecular Psychiatry, Journal Year: 2015, Volume and Issue: 20(12), P. 1538 - 1545

Published: March 10, 2015

Language: Английский

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An integrative model linking traumatization, cortisol dysregulation and posttraumatic stress disorder: Insight from recent hair cortisol findings

Neuroscience & Biobehavioral Reviews, Journal Year: 2016, Volume and Issue: 69, P. 124 - 135

Published: July 19, 2016

Language: Английский

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Hypothalamic‐Pituitary‐Adrenocortical Axis: Neuropsychiatric Aspects

Comprehensive physiology, Journal Year: 2014, Volume and Issue: unknown, P. 715 - 738

Published: March 19, 2014

Evidence of aberrant hypothalamic-pituitary-adrenocortical (HPA) activity in many psychiatric disorders, although not universal, has sparked long-standing interest HPA hormones as biomarkers disease or treatment response. may be chronically elevated melancholic depression, panic disorder, obsessive-compulsive and schizophrenia. The axis more reactive to stress social anxiety disorder autism spectrum disorders. In contrast, is likely low PTSD atypical depression. Antidepressants are widely considered inhibit activity, inhibition unanimously reported the literature. There evidence, also uneven, that mood stabilizers lithium carbamazepine have potential augment measures, while benzodiazepines, antipsychotics, some extent, typical antipsychotics activity. Currently, most reliable use measures disorders predict likelihood relapse, changes been proposed play a role clinical benefits treatments. Greater attention patient heterogeneity consistent approaches assessing effects on function solidify value predicting response developing novel strategies manage disease.

Language: Английский

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Posttraumatic Stress Disorder Post Iraq and Afghanistan: Prevalence among Military Subgroups

The Canadian Journal of Psychiatry, Journal Year: 2014, Volume and Issue: 59(9), P. 468 - 479

Published: Sept. 1, 2014

A large body of research has been produced in recent years investigating posttraumatic stress disorder (PTSD) among military personnel following deployment to Iraq and Afghanistan, resulting apparent differences PTSD prevalence. We compare prevalence estimates for current between subgroups, providing insight into how groups may be differentially affected by deployment. Systematic literature searches using the terms PTSD, disorder, acute stress, combined with relating personnel, identified 49 relevant papers. Studies a sample size less than 100 studies based on data treatment seeking or injured populations were excluded. categorized according theatre (Iraq Afghanistan), combat noncombat deployed samples, sex, enlistment type (regular reserve [or] National Guard), service branch (for example, army, navy, air force). Meta-analysis was used assess across subgroups. There variability studies, but, regardless heterogeneity, rates higher Iraq-deployed (12.9%; 95% CI 11.3% 14.4%), compared Afghanistan (7.1%; 4.6% 9.6%), serving Canadian, US, UK army navy marines (12.4%; 10.9% 13.4%), other services (4.9%; 1.4% 8.4%). Contrary findings from within-study comparisons, we did not find difference regular active-duty Guard personnel. Categorizing location subgroups that provide further support factors underlying development PTSD.

Language: Английский

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