Diverse Roles of Mitochondria in Immune Responses: Novel Insights Into Immuno-Metabolism

Frontiers in Immunology, Journal Year: 2018, Volume and Issue: 9

Published: July 12, 2018

Lack of immune system cells or impairment in differentiation is the basis for many chronic diseases. Metabolic changes could be root cause this cell impairment. These a result altered transcription, cytokine production from surrounding cells, and metabolic pathways. Immunity mitochondria are interlinked with each other. An important feature it can regulate activation, differentiation, survival cells. In addition, also release signals such as mitochondrial DNA (mtDNA) ROS (mtROS) to transcription From current literature, we found that immunity different ways. First, alterations pathways (TCA cycle, oxidative phosphorylation, FAO) induced transcriptional lead entirely outcomes For example, M1 macrophages exhibit broken TCA cycle have pro-inflammatory role. By contrast, M2 undergo β-oxidation produce anti-inflammatory responses. amino acid metabolism, especially arginine, glutamine, serine, glycine, tryptophan, critical T macrophage polarization. Second, activate inflammatory response. instance, antiviral signaling NLRP3 activated by mitochondria. Third, mass mobility influenced fission fusion. Fission fusion influence functions. Finally, placed near endoplasmic reticulum (ER) Therefore, ER junction metabolism. Mitochondrial machinery pathways, antioxidant systems, dynamics, mtDNA, mitophagy, mtROS crucial Here, demonstrated how coordinate alter responses contribute A better understanding molecular components necessary. This help development safe effective therapy prevention review, presented an updated prospective drives various

Language: Английский

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Oxidative Stress and Hypertension

Circulation Research, Journal Year: 2021, Volume and Issue: 128(7), P. 993 - 1020

Published: April 1, 2021

A link between oxidative stress and hypertension has been firmly established in multiple animal models of but remains elusive humans. While initial studies focused on inactivation nitric oxide by superoxide, our understanding relevant reactive oxygen species (superoxide, hydrogen peroxide, peroxynitrite) how they modify complex signaling pathways to promote expanded significantly. In this review, we summarize recent advances delineating the primary secondary sources (nicotinamide adenine dinucleotide phosphate oxidases, uncoupled endothelial synthase, endoplasmic reticulum, mitochondria), posttranslational modifications induce protein targets important for redox signaling, their interplay with endogenous antioxidant systems, role inflammasome activation reticular development hypertension. We highlight different organ systems contributes hypertension, describe new that have clarified importance specific proteins, discuss clinical shed light these processes are altered human Finally, focus promise proteomics biology help us fully understand relationship ROS potential designing evaluating novel antihypertensive therapies.

Language: Английский

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p53 in ferroptosis regulation: the new weapon for the old guardian

Cell Death and Differentiation, Journal Year: 2022, Volume and Issue: 29(5), P. 895 - 910

Published: Jan. 27, 2022

Language: Английский

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ROS Signaling in the Pathogenesis of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS)

Advances in experimental medicine and biology, Journal Year: 2017, Volume and Issue: unknown, P. 105 - 137

Published: Jan. 1, 2017

Language: Английский

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The Reactive Species Interactome: Evolutionary Emergence, Biological Significance, and Opportunities for Redox Metabolomics and Personalized Medicine

Antioxidants and Redox Signaling, Journal Year: 2017, Volume and Issue: 27(10), P. 684 - 712

Published: April 11, 2017

Significance: Oxidative stress is thought to account for aberrant redox homeostasis and contribute aging disease. However, more often than not, administration of antioxidants ineffective, suggesting that our current understanding the underlying regulatory processes incomplete. Recent Advances: Similar reactive oxygen species nitrogen species, sulfur are now emerging as important signaling molecules, targeting cysteine switches in proteins, affecting gene regulation, ion transport, intermediary metabolism, mitochondrial function. To rationalize complexity chemical interactions with themselves their targets help define role systemic metabolic control, we here introduce a novel integrative concept defined interactome (RSI). The RSI primeval multilevel system whose architecture, together physicochemical characteristics its constituents, allows efficient sensing rapid adaptation environmental changes various other stressors enhance fitness resilience at local whole-organism level. Critical Issues: better characterize RSI-related determine fluxes through specific pathways enable integration, it necessary disentangle biology activity (including precursors reaction products), targets, communication systems, effects on cellular, organ, bioenergetics using system-level/network analyses. Future Directions: Understanding mechanisms which operates will appreciation possibilities modulate entire biological system; moreover, unveiling molecular signatures challenges or forms provide new prevention/intervention opportunities personalized medicine. Antioxid. Redox Signal. 00, 000–000.

Language: Английский

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Role of resveratrol in regulation of cellular defense systems against oxidative stress

BioFactors, Journal Year: 2017, Volume and Issue: 44(1), P. 36 - 49

Published: Nov. 28, 2017

Abstract Resveratrol, a natural polyphenolic compound, is found in various kinds of fruits, plants, and their commercial products such as red wine. It has been demonstrated to exhibit variety health‐promoting effects including prevention and/or treatment cardiovascular diseases, inflammation, diabetes, neurodegeneration, aging, cancer. Cellular defensive properties resveratrol can be explained through its ability either directly neutralizing reactive oxygen species/reactive nitrogen species (ROS/RNS) or indirectly upregulating the expression cellular genes. As direct antioxidant agent, scavenges diverse ROS/RNS well secondary organic radicals with mechanisms hydrogen atom transfer sequential proton loss electron transfer, thereby protecting biomolecules from oxidative damage. Resveratrol also enhances enzymes heme oxygenase 1, catalase, glutathione peroxidase, superoxide dismutase induction level responsible for maintaining redox balance. Such defenses could achieved by regulating signaling pathways sirtuin nuclear factor‐erythroid 2‐related factor 2 κB. This review provides current understanding information on role defense system against stress. © 2017 BioFactors, 44(1):36–49, 2018

Language: Английский

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European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

Redox Biology, Journal Year: 2017, Volume and Issue: 13, P. 94 - 162

Published: May 18, 2017

The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated providing new insights tools for better understanding redox biology medicine and, the long run, finding therapeutic strategies target dysregulated processes various diseases. This report highlights major achievements EU-ROS as well updates perspectives arising its members. comprised more than 140 active members worked together four years on topics briefly described below. formation reactive oxygen nitrogen species (RONS) is established hallmark our aerobic environment metabolism but RONS also act messengers via regulation essential cellular processes. fact that many diseases have been found be associated with oxidative stress theory trigger can corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical still generate controversial results, due complex pathophysiology humans. For future improvement therapy redox-associated disease progression detailed knowledge sources targets discrimination their detrimental or beneficial roles required. In order advance important area medicine, highly synergistic approaches combining variety diverse contrasting needed.

Language: Английский

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Reactive Oxygen Species: Involvement in T Cell Signaling and Metabolism

Trends in Immunology, Journal Year: 2018, Volume and Issue: 39(6), P. 489 - 502

Published: Feb. 13, 2018

Language: Английский

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The Role of Oxidative Stress in Physiopathology and Pharmacological Treatment with Pro- and Antioxidant Properties in Chronic Diseases

Oxidative Medicine and Cellular Longevity, Journal Year: 2020, Volume and Issue: 2020, P. 1 - 16

Published: July 24, 2020

Oxidative stress (OS) has the ability to damage different molecules and cellular structures, altering correct function of organs systems. OS accumulates in body by endogenous exogenous mechanisms. Increasing evidence points involvement physiopathology various chronic diseases that require prolonged periods pharmacological treatment. Long-term treatments may contribute changes systemic OS. In this review, we discuss pathological mechanisms some diseases, pro- or antioxidant effects their treatments, possible adjuvant alternatives. Diseases such as high blood pressure, arteriosclerosis, diabetes mellitus increased risk cardiovascular disease. Antihypertensive, lipid-lowering, hypoglycemic help reduce with an additional benefit. Treatment methotrexate autoimmune inflammatory rheumatoid arthritis, a dual role stimulating production producing mitochondrial dysfunction. However, it can also indirectly decrease induced inflammation. Medicaments used treat neurodegenerative tend related reactive oxygen species (ROS) balance On other hand, immunosuppressive cancer human immunodeficiency virus infection increase ROS, causing significant oxidative systems without widely documented administration

Language: Английский

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Oxidative Stress, Inflammation, and Disease

Elsevier eBooks, Journal Year: 2016, Volume and Issue: unknown, P. 35 - 58

Published: Jan. 1, 2016

Language: Английский

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