ROS signaling in innate immunity via oxidative protein modifications

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 7, 2024

The innate immune response represents the first-line of defense against invading pathogens. Reactive oxygen species (ROS) and reactive nitrogen (RNS) have been implicated in various aspects function, which involves respiratory bursts inflammasome activation. These widely distributed within cellular environment are short-lived intermediates that play a vital role signaling proliferation likely to depend on their subcellular site formation. NADPH oxidase complex phagocytes is known generate superoxide anion radical (O 2 •− ) functions as precursor for antimicrobial hydrogen peroxide (H O production, H utilized by myeloperoxidase (MPO) hypochlorous acid (HOCl) mediates pathogen killing. modulates expression redox-responsive transcriptional factors, namely NF-kB, NRF2, HIF-1, thereby mediating redox-based epigenetic modification. Survival function cells under redox control intracellular extracellular levels ROS/RNS. current review focuses factors involved activation ROS oxidative modification proteins macrophage polarization neutrophil function.

Language: Английский

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The emerging role of oxidative stress in inflammatory bowel disease

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: July 15, 2024

Inflammatory bowel disease (IBD) is a chronic immune-mediated condition that affects the digestive system and includes Crohn’s (CD) ulcerative colitis (UC). Although exact etiology of IBD remains uncertain, dysfunctional immunoregulation gut believed to be main culprit. Amongst immunoregulatory factors, reactive oxygen species (ROS) nitrogen (RNS), components oxidative stress event, are produced at abnormally high levels in IBD. Their destructive effects may contribute disease’s initiation propagation, as they damage lining activate inflammatory signaling pathways, further exacerbating inflammation. Oxidative markers, such malondialdehyde (MDA), 8-hydroxy-2’-deoxyguanosine (8-OHdG), serum-free thiols (R-SH), can measured blood stool patients with These markers elevated IBD, their correlate severity disease. Thus, used not only diagnosis but also monitoring response treatment. It targeted treatment through use antioxidants, including vitamin C, E, glutathione, N-acetylcysteine. In this review, we summarize role pathophysiology its diagnostic targets, potential application antioxidant therapies manage treat

Language: Английский

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Protein carbonylation in food and nutrition: a concise update

Amino Acids, Journal Year: 2021, Volume and Issue: 54(4), P. 559 - 573

Published: Oct. 20, 2021

Protein oxidation is a topic of indisputable scientific interest given the impact oxidized proteins on food quality and safety. Carbonylation regarded as one most notable post-translational modifications in yet, this reaction its consequences are poorly understood. From mechanistic perspective, primary protein carbonyls (i.e. α-aminoadipic γ-glutamic semialdehydes) have been linked to radical-mediated oxidative stress, but recent studies emphasize role alternative carbonylation pathways Maillard reaction. Secondary introduced via covalent linkage lipid protein-bound malondialdehyde). The high reactivity foods other biological systems indicates intricate chemistry these species urges further research provide insight into molecular mechanisms pathways. In particular, involved formation aberrant dysfunctional aggregates, undergo yield carboxylic acids relevance establish interactions with biomolecules such oxidizing lipids phytochemicals. methodological routine dinitrophenylhydrazine (DNPH) method criticized not only for lack accuracy consistency also authors typically perform poor interpretation DNPH results, which leads misleading conclusions. practical field science nutrition still debate. Though implication impaired functionality digestibility generally recognized, underlying mechanism connections requires clarification. medical highlighted markers oxidation, stress disease. Yet, specific onset particular impairments needs investigations. Recent that regardless origin (in vivo or dietary) may act signalling molecules activate endogenous antioxidant defences implicate immune system. present paper concisely reviews advances identify, when applicable, potential fields future studies.

Language: Английский

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Oxidative Crosslinking of Peptides and Proteins: Mechanisms of Formation, Detection, Characterization and Quantification

Molecules, Journal Year: 2021, Volume and Issue: 27(1), P. 15 - 15

Published: Dec. 21, 2021

Covalent crosslinks within or between proteins play a key role in determining the structure and function of proteins. Some these are formed intentionally by either enzymatic molecular reactions critical to normal physiological function. Others generated as consequence exposure oxidants (radicals, excited states two-electron species) other endogenous external stimuli, result actions number enzymes (e.g., oxidases peroxidases). Increasing evidence indicates that accumulation unwanted crosslinks, is seen ageing multiple pathologies, has adverse effects on biological In this article, we review spectrum both reducible non-reducible, currently known be proteins; mechanisms their formation; experimental approaches detection, identification characterization species.

Language: Английский

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Health position paper and redox perspectives - Disease burden by transportation noise

Redox Biology, Journal Year: 2023, Volume and Issue: 69, P. 102995 - 102995

Published: Dec. 19, 2023

Transportation noise is a ubiquitous urban exposure. In 2018, the World Health Organization concluded that chronic exposure to road traffic risk factor for ischemic heart disease. contrast, they quality of evidence link other diseases was very low moderate. Since then, several studies on impact various have been published. Also, investigating mechanistic pathways underlying noise-induced health effects are emerging. We review current regarding and related disease-mechanisms. Several high-quality cohort consistently found be associated with higher disease, failure, diabetes, all-cause mortality. Furthermore, recent indicated railway may increase not commonly investigated in an environmental context, including breast cancer, dementia, tinnitus. The harmful activation physiological stress response nighttime sleep disturbance. Oxidative inflammation downstream hormone signaling dysregulated circadian rhythms identified as major disease-relevant pathomechanistic drivers. discuss role reactive oxygen species present results from antioxidant interventions. Lastly, we provide overview oxidative markers adverse redox processes reported noise-exposed animals humans. This position paper summarizes all available epidemiological, clinical, preclinical transportation important public discusses its implications population level.

Language: Английский

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Recent advances in analytical methods of oxidative stress biomarkers induced by environmental pollutant exposure

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 160, P. 116978 - 116978

Published: Feb. 9, 2023

Language: Английский

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Application of lipids and their potential replacers in plant-based meat analogs

Trends in Food Science & Technology, Journal Year: 2023, Volume and Issue: 138, P. 645 - 654

Published: July 13, 2023

Language: Английский

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Effect of transglutaminase and laccase on pea protein gel properties compared to that of soybean

Food Hydrocolloids, Journal Year: 2024, Volume and Issue: 156, P. 110314 - 110314

Published: June 14, 2024

Language: Английский

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Diabetic Retinopathy: New Treatment Approaches Targeting Redox and Immune Mechanisms

Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 594 - 594

Published: May 12, 2024

Diabetic retinopathy (DR) represents a severe complication of diabetes mellitus, characterized by irreversible visual impairment resulting from microvascular abnormalities. Since the global prevalence continues to escalate, DR has emerged as prominent area research interest. The development and progression encompass complex interplay pathological physiological mechanisms, such high glucose-induced oxidative stress, immune responses, vascular endothelial dysfunction, well damage retinal neurons. Recent years have unveiled involvement genomic epigenetic factors in formation mechanisms. At present, extensive explores potential biomarkers cytokines, molecular cell therapies, antioxidant interventions, gene therapy for treatment. Notably, certain drugs, anti-VEGF agents, antioxidants, inhibitors inflammatory protein kinase C (PKC)-β inhibitors, demonstrated promising outcomes clinical trials. Within this context, review article aims introduce recent on highlight current progress field, with particular focus emerging experimental treatment strategies targeting redox signaling pathways.

Language: Английский

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Peroxisomal hydrogen peroxide signaling: A new chapter in intracellular communication research

Current Opinion in Chemical Biology, Journal Year: 2024, Volume and Issue: 78, P. 102426 - 102426

Published: Jan. 21, 2024

Language: Английский

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