Foods,
Journal Year:
2024,
Volume and Issue:
13(20), P. 3268 - 3268
Published: Oct. 15, 2024
Myofibrillar
proteins
primarily
consist
of
myosin,
actin,
myogenin,
and
actomyosin.
These
form
complex
networks
within
muscle
fibers
are
crucial
to
the
physical
chemical
properties
meat.
Additionally,
myofibrillar
serve
as
significant
substrates
for
adsorption
volatile
flavor
compounds,
including
aldehydes,
alcohols,
ketones,
sulfur
nitrogen
which
contribute
overall
profile
meat
products.
A
series
reactions
occur
during
processing,
storage,
transportation
Oxidation
is
one
most
reactions.
Oxidative
modification
can
alter
proteins,
ultimately
impacting
sensory
quality
products,
flavor,
taste,
color.
In
recent
years,
considerable
attention
has
been
focused
on
effects
protein
oxidation
its
regulation.
This
study
investigates
impact
attributes
products
by
analyzing
processes
factors
that
initiate
oxidation.
it
explores
control
implications
providing
theoretical
insights
relevant
processing
methods
procedures.
Oxygen,
Journal Year:
2022,
Volume and Issue:
2(4), P. 437 - 478
Published: Oct. 10, 2022
Oxidative
stress
(OS)
has
greatly
interested
the
research
community
in
understanding
damaging
processes
occurring
cells.
OS
is
triggered
by
an
imbalance
between
reactive
oxygen
species
(ROS)
production
and
their
elimination
antioxidant
system;
however,
ROS
function
as
second
messengers
under
physiological
conditions.
are
produced
from
endogenous
exogenous
sources.
Endogenous
sources
involve
mitochondria,
nicotinamide
adenine
dinucleotide
phosphate
hydrogen
(NADPH),
oxidases
(NOXs),
endoplasmic
reticulum
(ER),
xanthine
(XO),
endothelial
nitric
oxide
synthase
(eNOs),
others.
In
contrast,
might
be
generated
through
ultraviolet
(UV)
light,
ionizing
radiation
(IR),
contaminants,
heavy
metals,
among
It
can
damage
DNA,
lipids,
proteins
if
not
controlled.
To
avoid
oxidative
damage,
systems
activated.
present
review,
we
focus
on
basic
concepts
of
OS,
highlighting
nitrogen
(RONS)
derived
internal
external
last
elimination.
Moreover,
include
cellular
system
regulation
ability
to
decrease
OS.
External
antioxidants
also
proposed
alternatives
ameliorate
Finally,
review
diseases
involving
mechanisms.
Molecules,
Journal Year:
2022,
Volume and Issue:
27(23), P. 8124 - 8124
Published: Nov. 22, 2022
Crosslinking
of
proteins
has
gained
immense
significance
in
the
fabrication
biomaterials
for
various
health
care
applications.
Various
novel
chemical-based
strategies
are
being
continuously
developed
intra-/inter-molecular
crosslinking
to
create
a
network/matrix
with
desired
mechanical/functional
properties
without
imparting
toxicity
host
system.
Many
materials
that
used
biomedical
and
food
packaging
industries
prepared
by
chemical
means
proteins,
besides
physical
or
enzymatic
crosslinking.
Such
methods
utilize
compounds
crosslinkers
available
from
natural
sources
synthetically
generated
ability
form
covalent/non-covalent
bonds
proteins.
linkages
possible
chemicals
like
carbodiimides/epoxides,
while
photo-induced
also
available.
In
this
review,
we
have
discussed
different
protein
under
methods,
along
corresponding
reactions/conditions,
material
significant
Free Radical Biology and Medicine,
Journal Year:
2023,
Volume and Issue:
196, P. 81 - 92
Published: Jan. 16, 2023
Biological
milieus
are
highly
crowded
and
heterogeneous
systems
where
organization
of
macromolecules
within
nanodomains
(e.g.
membraneless
compartments)
is
vital
to
the
regulation
metabolic
processes.
There
an
increasing
interest
in
understanding
effects
that
such
packed
environments
have
on
different
biochemical
biological
In
this
context,
redox
biochemistry
signaling
fields
moving
towards
investigating
oxidative
processes
under
conditions
exhibit
these
key
features
order
solve
existing
paradigms
including
those
related
generation
transmission
specific
signals
between
cells
both
normal
physiology
stress.
This
review
outlines
crowding,
nanodomain
formation
altered
local
viscosities
can
involving
proteins,
then
discusses
some
reactions
pathways
proteins
oxidants
may,
or
known
to,
be
modulated
by
factors.
We
postulate
knowledge
protein
modification
kinetics,
product
formation)
mimic
milieus,
will
provide
a
better
response
endogenous
exogenous
stressors,
their
role
ageing,
signaling,
health
disease.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(11), P. 6099 - 6099
Published: June 1, 2024
Michael
acceptors
represent
a
class
of
compounds
with
potential
anti-cancer
properties.
They
act
by
binding
to
nucleophilic
sites
in
biological
molecules,
thereby
disrupting
cancer
cell
function
and
inducing
death.
This
mode
action,
as
well
their
ability
be
modified
targeted,
makes
them
promising
avenue
for
advancing
therapy.
We
are
investigating
the
molecular
mechanisms
underlying
interactions
cells,
particular
interfere
cellular
processes
induce
apoptosis.
The
properties
not
accidental
but
due
chemical
structure
reactivity.
electrophilic
nature
these
allows
selectively
target
residues
on
disease-associated
proteins,
resulting
significant
therapeutic
benefits
minimal
toxicity
various
diseases.
opens
up
new
perspectives
development
more
effective
precise
drugs.
Nevertheless,
further
studies
essential
fully
understand
impact
our
discoveries
translate
into
clinical
practice.
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: April 12, 2023
Collagen
is
a
force-bearing,
hierarchical
structural
protein
important
to
all
connective
tissue.
In
tendon
collagen,
high
load
even
below
macroscopic
failure
level
creates
mechanoradicals
by
homolytic
bond
scission,
similar
polymers.
The
location
and
type
of
initial
rupture
sites
critically
decide
on
both
the
mechanical
chemical
impact
these
micro-ruptures
tissue,
but
are
yet
be
explored.
We
here
use
scale-bridging
simulations
supported
gel
electrophoresis
mass
spectrometry
determine
breakage
points
in
collagen.
find
collagen
crosslinks,
as
opposed
backbone,
harbor
weakest
bonds,
with
one
particular
trivalent
crosslinks
most
dominant
site.
identify
this
sacrificial,
rupturing
prior
other
bonds
while
maintaining
material's
integrity.
Also,
collagen's
weak
funnel
ruptures
such
that
potentially
harmful
readily
stabilized.
Our
results
suggest
unique
mode
tailored
towards
combatting
an
early
onset
material
ageing.
Physical Chemistry Chemical Physics,
Journal Year:
2024,
Volume and Issue:
26(10), P. 8528 - 8538
Published: Jan. 1, 2024
Oxidative
stress,
generated
by
reactive
oxygen
species
(ROS),
is
responsible
for
the
loss
of
structure
and
functionality
proteins
associated
with
several
aging-related
diseases.
Cells,
Journal Year:
2024,
Volume and Issue:
13(5), P. 438 - 438
Published: March 2, 2024
The
extracellular
matrix
(ECM)
provides
structural
support
for
tissues
and
regulatory
signals
resident
cells.
ECM
requires
a
careful
balance
between
protein
accumulation
degradation
homeostasis.
Disruption
of
this
can
lead
to
pathological
processes
such
as
fibrosis
in
organs
across
the
body.
Post-translational
crosslinking
modifications
proteins
collagens
alter
structure
function.
Dysregulation
enzymes
well
changes
composition
are
prevalent
fibrosis.
Because
crucial
roles
these
pathways
play
disease,
that
govern
events
being
explored
therapeutic
targets
Here,
we
review
depth
molecular
mechanisms
underlying
crosslinking,
how
contributes
fibrosis,
strategies
target
restore
normal
tissue
FEBS Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 7, 2024
Aging
is
characterized
by
a
progressive
decline
in
physiological
function
and
underlies
several
disabilities,
including
the
increased
sensitivity
of
cells
tissues
to
undergo
pathological
oxidative
stress.
In
recent
years,
efforts
have
been
made
better
understand
relationship
between
age
stress
further
develop
therapeutic
strategies
minimize
impact
both
events
on
age-related
diseases.
this
work,
we
review
oxidant
antioxidant
systems
during
aging
disease
development
discuss
crosstalk
other
processes,
with
focus
studies
conducted
elderly
populations.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(13), P. 10985 - 10985
Published: July 1, 2023
Collagen,
the
most
abundant
structural
protein
found
in
mammals,
plays
a
vital
role
as
constituent
of
extracellular
matrix
(ECM)
that
surrounds
cells.
Collagen
fibrils
are
strengthened
through
formation
covalent
cross-links,
which
involve
complex
enzymatic
and
non-enzymatic
reactions.
Lysyl
oxidase
(LOX)
is
responsible
for
catalyzing
oxidative
deamination
lysine
hydroxylysine
residues,
resulting
production
aldehydes,
allysine,
hydroxyallysine.
These
intermediates
undergo
spontaneous
condensation
reactions,
leading
to
immature
initial
step
development
mature
cross-links.
Additionally,
glycation
contributes
abnormal
cross-linking
collagen
fibrils.
During
glycation,
specific
arginine
residues
modified
by
reducing
sugars,
creation
Advanced
Glycation
End-products
(AGEs).
AGEs
have
been
associated
with
changes
mechanical
properties
fibers.
Interestingly,
various
studies
reported
plant
polyphenols
possess
amine
oxidase-like
activity
can
act
potent
inhibitors
glycation.
This
review
article
focuses
on
compiling
literature
describing
antiglycation
properties.
Specifically,
we
explore
molecular
mechanisms
flavonoids
impact
or
protect
normal
process.
Furthermore,
discuss
how
these
dual
activities
be
harnessed
generate
properly
cross-linked
molecules,
thereby
promoting
stabilization
highly
organized
