The potential toxicity of microplastics on human health

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 912, P. 168946 - 168946

Published: Dec. 2, 2023

Language: Английский

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Polystyrene microplastics promote liver inflammation by inducing the formation of macrophages extracellular traps

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 452, P. 131236 - 131236

Published: March 21, 2023

Language: Английский

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4-tert-butylphenol triggers common carp hepatocytes ferroptosis via oxidative stress, iron overload, SLC7A11/GSH/GPX4 axis, and ATF4/HSPA5/GPX4 axis

Ecotoxicology and Environmental Safety, Journal Year: 2022, Volume and Issue: 242, P. 113944 - 113944

Published: Aug. 1, 2022

4-tert-butylphenol (4-tBP) is a toxic environmental pollutant with moderate bioaccumulation, persistence, and long-term toxicity. Its toxicity to aquatic organisms has become an issue of concern. However, the molecular mechanism 4-tBP remained unclear. Liver target organ for pollutants. Here, we established 4-tBP-exposed model in vivo primary hepatocyte vitro common carp (Cyprinus carpio L.). We found increased hepatic-somatic index (HSI) abnormal serum biochemical indexes (ALT, AST, LDH) after exposure, indicating liver damage. further revealed that damaged structural integrity livers typical features ferroptosis. Based on toxicogenomics analysis, ferroptosis likely be involved 4-tBP-induced Moreover, our experiment provided evidences 4-tBP-exposure led excess oxidative stress, iron overload, decreased MMP, expression ferroptosis-related factors. Interestingly, ferrostatin-1 (Fer-1, inhibitor) pretreatment alleviated above changes. In summary, demonstrated triggered hepatocytes via SLC7A11/GSH/GPX4 axis, ATF4/HSPA5/GPX4 axis. For first time, discovered Fer-1 can ameliorate 4-tBP, which needs more investigations. Our results scientific basis fish poisoning.

Language: Английский

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Dose-effect of polystyrene microplastics on digestive toxicity in chickens (Gallus gallus): Multi-omics reveals critical role of gut-liver axis

Journal of Advanced Research, Journal Year: 2022, Volume and Issue: 52, P. 3 - 18

Published: Nov. 10, 2022

Microplastic pollution seriously threatens the health and safety of humans wildlife. Avian is one main species endangered by microplastics. However, damage mechanism microplastics to digestive system avian not clear. The gut-liver axis a bidirectional channel that regulates exchange information between gut liver also key target for tissue caused pollutants. This study aimed elucidate toxicity in role it. We constructed an exposure model environmental concentrations toxicological chickens reveal polystyrene (PS-MPs) 16S rRNA, transcriptomics metabolomics. PS-MPs changed death mode from apoptosis necrosis pyroptosis upregulating Caspase 8, disrupting intestinal vascular barrier, disturbing flora promoting accumulation lipopolysaccharide. Harmful metabolites were translocated through liver-gut axis, eliciting hepatic immune responses lipid metabolism disorders apoptosis. Liver injury involves multiple molecular effects mitochondrial dynamics disturbance, oxidative stress, endoplasmic reticulum cell cycle disturbance. Furthermore, metabolomics suggested caffeine melanin may be potential natural resistance substances Taken together, our data demonstrate avian, revealing critical will provide reference protecting populations.

Language: Английский

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Atrazine exposure induces necroptosis through the P450/ROS pathway and causes inflammation in the gill of common carp (Cyprinus carpio L.)

Fish & Shellfish Immunology, Journal Year: 2022, Volume and Issue: 131, P. 809 - 816

Published: Oct. 17, 2022

Language: Английский

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Microplastics induce neurotoxicity in aquatic animals at environmentally realistic concentrations: A meta-analysis

Environmental Pollution, Journal Year: 2022, Volume and Issue: 318, P. 120939 - 120939

Published: Dec. 26, 2022

Language: Английский

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Human Microplastics Exposure and Potential Health Risks to Target Organs by Different Routes: A Review

Current Pollution Reports, Journal Year: 2023, Volume and Issue: 9(3), P. 468 - 485

Published: Aug. 17, 2023

Language: Английский

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International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis

Autophagy, Journal Year: 2024, Volume and Issue: 20(6), P. 1213 - 1246

Published: March 6, 2024

Macroautophagy/autophagy is a complex degradation process with dual role in cell death that influenced by the types are involved and stressors they exposed to. Ferroptosis an iron-dependent oxidative form of characterized unrestricted lipid peroxidation context heterogeneous plastic mechanisms. Recent studies have shed light on involvement specific autophagy (e.g. ferritinophagy, lipophagy, clockophagy) initiating or executing ferroptotic through selective anti-injury proteins organelles. Conversely, other forms reticulophagy lysophagy) enhance cellular defense against damage. Dysregulated autophagy-dependent ferroptosis has implications for diverse range pathological conditions. This review aims to present updated definition ferroptosis, discuss influential substrates receptors, outline experimental methods, propose guidelines interpreting results.

Language: Английский

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Microplastics induced inflammation and apoptosis via ferroptosis and the NF-κB pathway in carp

Aquatic Toxicology, Journal Year: 2023, Volume and Issue: 262, P. 106659 - 106659

Published: Aug. 14, 2023

Language: Английский

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A comprehensive review on the source, ingestion route, attachment and toxicity of microplastics/nanoplastics in human systems

Journal of Environmental Management, Journal Year: 2024, Volume and Issue: 352, P. 120039 - 120039

Published: Jan. 13, 2024

Language: Английский

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