Aspects of Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
4, P. 100048 - 100048
Published: June 7, 2024
Flavonoids
are
a
group
of
bioactive
compounds
widely
distributed
in
edible
plants.
They
have
gained
special
attention
given
strong
scientific
evidence
supporting
their
health
promoting
actions.
This
review
summarizes
current
knowledge
on
the
biosynthetic
pathways
flavonoids
plants,
regulation
those
pathways,
and
conservation
plant
road
to
becoming
food.
Additionally,
main
dietary
sources
flavonoid,
from
population
clinical
studies,
possible
mechanisms
involved
beneficial
effects
human
also
discussed.
Journal of Advanced Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Flavonoids
are
naturally
occurring
dietary
phytochemicals
with
significant
antioxidant
effects
aside
from
several
health
benefits.
People
often
consume
them
in
combination
other
food
components.
Compiling
data
establishes
a
link
between
bioactive
flavonoids
and
prevention
of
diseases
animal
models,
including
cardiovascular
diseases,
diabetes,
gut
dysbiosis,
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD).
However,
numerous
clinical
studies
have
demonstrated
the
ineffectiveness
contradicting
rodent
thereby
challenging
validity
using
as
supplements.
This
review
provides
perspective
to
emphasize
effective
roles
well
summarize
their
specific
mechanisms
animals
briefly.
First,
this
offers
an
in-depth
elucidation
processes
within
human,
encompassing
small,
large
intestine,
liver.
Furthermore,
comprehensive
overview
various
functions
gastrointestinal
tract,
hindering
breakdown
assimilation
macronutrients,
such
polysaccharides
lipids,
regulating
hormone
secretion
inhibition
mineral
iron
absorption.
In
unabsorbed
major
portion
interact
flora
leading
biotransformation.
Once
absorbed
circulated
bloodstream,
or
metabolites
exert
beneficial
systemic
effects.
Lastly,
we
examine
protective
disorders,
endothelial
dysfunction,
MASLD,
disease,
obesity,
hyperlipidemia,
insulin
resistance.
conclusion,
outlines
safety
future
prospects
field
health,
especially
syndrome
(MetS).
Molecules,
Journal Year:
2025,
Volume and Issue:
30(5), P. 1184 - 1184
Published: March 6, 2025
Flavonoids
represent
a
class
of
natural
plant
secondary
metabolites
with
multiple
activities
including
antioxidant,
antitumor,
anti-inflammatory,
and
antimicrobial
properties.
However,
due
to
their
structural
characteristics,
they
often
exhibit
low
bioavailability
in
vivo.
In
this
review,
we
focus
on
the
vivo
study
flavonoids,
particularly
effects
gut
microbiome
common
modifications
such
as
methylation,
acetylation,
dehydroxylation,
etc.
These
aim
change
characteristics
original
substances
enhance
absorption
bioavailability.
order
improve
discuss
two
feasible
methods,
namely
dosage
form
modification
chemical
modification,
hope
that
these
approaches
will
offer
new
insights
into
application
flavonoids
for
human
health.
article,
also
introduce
types,
sources,
efficacy
flavonoids.
conclusion,
is
comprehensive
review
how
ABSTRACT
Hydroxytyrosol
(HT)
consumption
is
associated
with
healthy
outcomes.
Specifically,
its
ability
to
modulate
microRNA
(miRNA)
expression
has
been
described.
However,
whether
HT
influences
the
secretion
of
extracellular
vesicles
(EVs)
and
their
transported
miRNAs
remains
unknown.
Here,
following
administration,
we
explored
potential
changes
in
EV
miRNA
cargo
during
postprandial
state
after
1
week
daily
intake.
Twelve
participants
received,
first,
a
single
25
mg
dose
(postprandial
study)
then
daily,
for
one
(sustained
study).
Plasma
circulating
plasma‐isolated
EVs
were
analyzed
derived
metabolites
using
UPLC‐qTOF‐MS
by
RNA‐seq.
induced
1‐h
post‐ingestion
1‐week
administration
increased
fasting
reduced
oxidized
LDL
levels.
RNA‐seq
analysis
identified
55
modulated
(30
upregulated
downregulated)
related
response
oxygen
level
gland
development,
supplementation.
This
pilot
study
sheds
light
on
effects
modulation
exosomal
humans,
which
scarcely
studied
date.
Further
research
warranted
elucidate
molecular
mechanisms
underlying
observed
effects.
Journal of the American Heart Association,
Journal Year:
2024,
Volume and Issue:
13(13)
Published: June 27, 2024
The
association
between
soy
isoflavones
intake
and
cardiometabolic
health
remains
inconclusive.
We
investigated
the
associations
of
urinary
biomarkers
including
daidzein,
glycitein,
genistein,
equol
(a
gut
microbial
metabolite
daidzein),
equol-predicting
species
with
risk
markers.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(22), P. 5351 - 5351
Published: Nov. 14, 2024
Flavonoids
and
other
phenolic
constituents
are
a
large
group
of
plant
metabolites
that
have
long
attracted
interest
from
researchers
worldwide
due
to
their
functions
in
physiology,
as
well
huge
number
benefits
for
human
health
well-being.
This
review
attempts
reveal
promising
view
the
major
physiological
roles
flavonoids
phytochemical
molecules,
e.g.,
protection
agents
against
UV
damage,
pathogen
defense
agents,
detoxifying
promoting
pollen
fertility
successful
pollination.
Besides,
value
both
phytochemicals
species
delimitation
was
also
emphasized
first
time
with
determination
roles.
Furthermore,
medical
mankind
were
highlighted
this
current
work.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(23), P. 13190 - 13190
Published: Dec. 8, 2024
Metabolomics
has
come
to
the
fore
as
an
efficient
tool
in
search
for
biomarkers
that
are
critical
precision
health
approaches
and
improved
diagnostics.
This
review
will
outline
recent
advances
biomarker
discovery
based
on
metabolomics,
focusing
metabolomics
reported
cancer,
neurodegenerative
disorders,
cardiovascular
diseases,
metabolic
health.
In
provides
evidence
unique
oncometabolites
important
early
disease
detection
monitoring
of
treatment
responses.
Metabolite
profiling
conditions
such
mental
disorders
can
offer
diagnosis
mechanisms
into
especially
Alzheimer's
Parkinson's
diseases.
addition
these,
lipid
other
metabolites
relating
promising
patient
stratification
personalized
treatment.
The
gut
microbiome
environmental
exposure
also
feature
among
influential
factors
because
they
sculpt
individual
profiles,
impacting
overall
Further,
we
discuss
technological
current
clinical
applications,
challenges
faced
by
validation
toward
medicine.
Finally,
this
discusses
future
opportunities
regarding
integration
routine
healthcare
enable
preventive
approaches.
Pharmaceuticals,
Journal Year:
2025,
Volume and Issue:
18(2), P. 138 - 138
Published: Jan. 22, 2025
Background:
Cellular
senescence
is
a
biological
process
with
dual
role
in
organismal
health.
While
transient
supports
tissue
repair
and
acts
as
tumor-suppressive
mechanism,
the
chronic
accumulation
of
senescent
cells
contributes
to
aging
progression
age-related
diseases.
Senotherapeutics,
including
senolytics,
which
selectively
eliminate
cells,
senomorphics,
modulate
senescence-associated
secretory
phenotype
(SASP),
have
emerged
promising
strategies
for
managing
pathologies.
Among
these,
polyphenols,
diverse
group
plant-derived
bioactive
compounds,
gained
attention
their
potential
cellular
senescence.
Methods:
This
review
synthesizes
evidence
from
vitro,
vivo,
clinical
studies
on
senolytic
senomorphic
activities
resveratrol,
kaempferol,
apigenin,
fisetin.
The
analysis
focuses
molecular
mechanisms
action
impact
fundamental
aging-related
pathways.
Results:
Polyphenols
exhibit
therapeutic
versatility
by
activating
SIRT1,
inhibiting
NF-κB,
modulating
autophagy.
These
compounds
demonstrate
role,
promoting
survival
healthy
while
inducing
apoptosis
cells.
Preclinical
indicates
capacity
reduce
SASP-associated
inflammation,
restore
homeostasis,
attenuate
various
models
aging.
Conclusions:
represent
class
senotherapeutics
mitigating
diseases
lifespan
extension.
Further
research
should
focus
validation
long-term
effects
these
paving
way
development
agents
geriatric
medicine.
