The adverse role of endocrine disrupting chemicals in the reproductive system

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 17, 2024

Reproductive system diseases pose prominent threats to human physical and mental well-being. Besides being influenced by genetic material regulation changes in lifestyle, the occurrence of these is closely connected exposure harmful substances environment. Endocrine disrupting chemicals (EDCs), characterized hormone-like effects, have a wide range influences on reproductive system. EDCs are ubiquitous natural environment present industrial everyday products. Currently, thousands been reported exhibit endocrine this number likely increase as testing for potential has not consistently required, obtaining data limited, partly due long latency many diseases. The ability avoid EDCs, especially those artificially synthesized origin, increasingly challenging. While can be divided into persistent non-persistent depending their degree degradation, recent uptick research studies area, we chosen focus pertaining detrimental effects health several that widely encountered daily life over past six years, specifically bisphenol A (BPA), phthalates (PAEs), polychlorinated biphenyls (PCBs), parabens, pesticides, heavy metals, so on. By focusing impact hypothalamic-pituitary-gonadal (HPG) axis, which leads development diseases, review aims provide new insights molecular mechanisms EDCs’ damage encourage further in-depth clarify potentially EDC through various other mechanisms. Ultimately, it offers scientific basis enhance risk management, an endeavor significant societal importance safeguarding health.

Language: Английский

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Endometriosis: Update of Pathophysiology, (Epi) Genetic and Environmental Involvement

Biomedicines, Journal Year: 2023, Volume and Issue: 11(3), P. 978 - 978

Published: March 22, 2023

Endometriosis is a chronic disease caused by ectopic endometrial tissue. Endometriotic implants induce inflammation, leading to pain and impaired fertility. Characterized their dependence on estradiol (via estrogen receptor β (ESRβ)) resistance progesterone, endometriotic produce own source of through active aromatase. Steroidogenic factor-1 (SF1) key transcription factor that promotes aromatase synthesis. The expression SF1 ESRβ enhanced the demethylation promoter in progenitor cells female reproductive system. High local concentrations are involved inflammatory environment favoring implantation development implants. Similar conditions can promote, directly indirectly, appearance genital cancer. Recently, certain components microbiota have been identified as potentially promoting high level blood. Many environmental factors also suspected increasing concentration, especially prenatal exposure estrogen-like endocrine disruptors such DES bisphenol A. Phthalates endometriosis but throughmeans other than binding receptors. impact dioxin or tobacco seems be more controversial.

Language: Английский

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An update for endometriosis management: a position statement

Journal of Endometriosis and Uterine Disorders, Journal Year: 2024, Volume and Issue: 6, P. 100062 - 100062

Published: Jan. 22, 2024

Endometriosis is a complex disease and still many areas of uncertainty exist on the clinical management, from diagnosis to treatment. The modern diagnostic workup should include family history (including genetic epigenetic factors), presentation, an accurate gynecological examination imaging evaluation (transvaginal ultrasound and/or magnetic resonance) performed by expert practitioners. Laparoscopy must no longer be with sole purpose diagnosing endometriosis. Furthermore, endometriosis already suspected among adolescents young women severe dysmenorrhea, interfering daily activities not responding analgesic drugs. For patients without immediate desire pregnancy, hormonal drugs are first line choices for treating endometriosis-related pain, aiming reduce menstruation frequency even abolishing any bleeding. Progestins or continuous combined oral contraceptives used long term treatments prescribed as first-line In case failure intolerance, GnRH analogs more recently antagonists may proposed (with add-back therapy). Surgery remains important treatment option, but it at right time, single operation, preferentially in referral centers dedicated multidisciplinary teams order avoid recurrences repetitive surgery. Assisted reproductive technology (ART) option infertility either approach, after surgical approach. Fertility preservation can discussed moment before performing surgery when indicated.

Language: Английский

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Advances in polychlorinated biphenyls-induced female reproductive toxicity

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 918, P. 170543 - 170543

Published: Feb. 1, 2024

Language: Английский

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IGF2BP2 and IGFBP3 Genotypes, Haplotypes, and Genetic Models Studies in Polycystic Ovary Syndrome

Journal of Clinical Laboratory Analysis, Journal Year: 2024, Volume and Issue: 38(5)

Published: March 1, 2024

ABSTRACT Background Insulin resistance has been correlated with the genetic diversity within insulin‐like binding proteins genes. Moreover, insulin is one of key characteristics widespread reproductive endocrine condition known as polycystic ovarian syndrome (PCOS). Hence, this study aimed to determine association between IGFBP3 and IGF2BP2 gene variants PCOS risk. Methods A total 300 subjects (150 cases diagnosed based on Rotterdam ESHRE/ASRM consensus criteria 150 healthy subjects) were recruited in case–control cross‐sectional study. Tetra‐primer amplification refractory mutation system polymerase chain reaction (ARMS‐PCR) was used for genotyping rs11705701, whereas rs1470579 rs2854744 done employing PCR‐restriction fragment length polymorphism (PCR‐RFLP) technique. Results The CC AA+AC genotypes conferred an increased risk our population. Regarding rs2854744, observed under codominant homozygous (TT vs. GG) model by 2.54 fold. C allele T enhanced 1.97 1.46 folds, respectively. Haplotype analysis showed that rs11705701 haplotype a decreased (odds ratio = 0.53, 95% confidence interval 0.34–0.83, p 0.006). AC/GG/GT, AA/GA/GT, AC/GA/GG, AC/GA/GT genotype combinations rs1470579/rs11705701/rs2854744 associated disease. Conclusions susceptibility Southeastern Iranian Further investigation involving larger cohorts representing diverse ethnic backgrounds needed confirm current findings.

Language: Английский

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Invisible Hand behind Female Reproductive Disorders: Bisphenols, Recent Evidence and Future Perspectives

Toxics, Journal Year: 2023, Volume and Issue: 11(12), P. 1000 - 1000

Published: Dec. 7, 2023

Reproductive disorders are considered a global health problem influenced by physiological, genetic, environmental, and lifestyle factors. The increased exposure to bisphenols, chemical used in large quantities for the production of polycarbonate plastics, has raised concerns regarding risks humans, particularly their endocrine-disrupting effects on female reproductive health. To provide basis future research environmental interference health, we reviewed relevant studies patterns levels bisphenols matrices humans (including susceptible populations such as pregnant women children). In addition, focused

Language: Английский

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Multiclass Determination of Endocrine-Disrupting Chemicals in Meconium: First Evidence of Perfluoroalkyl Substances in This Biological Compartment

Toxics, Journal Year: 2024, Volume and Issue: 12(1), P. 75 - 75

Published: Jan. 15, 2024

Major concerns have been raised about human exposure to endocrine-disrupting chemicals (EDCs) during pregnancy. Effective methodologies for the assessment of this are needed support implementation preventive measures and prediction negative health effects. Meconium has proven a valuable non-invasive matrix evaluating cumulative xenobiotics last two trimesters The study objective was develop novel method determine presence in meconium perfluoroalkyl substances (PFASs), bisphenols, parabens, benzophenones, EDCs that widely used manufacture numerous consumer goods personal care products, including cosmetics. Ten PFASs, four benzophenones were measured samples prepared by using combination Captiva Enhanced Matrix Removal (EMR) lipid cartridges with salt-assisted liquid–liquid extraction (SALLE) dispersive microextraction (DLLME) before application liquid chromatography–tandem mass spectrometry (LC–MS/MS). Experimental parameters optimized applying different chemometric techniques. Limits detection ranged from 0.05 0.1 ng g−1, between-day variabilities (relative standard deviations) 6.5% 14.5%. validated matrix-matched calibration followed recovery assay spiked samples, obtaining percentage recoveries 89.9% 114.8%. then employed measure compounds not previously studied 20 samples. proposed analytical procedure yields information on utero selected EDCs.

Language: Английский

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Serum Phthalate Biomarkers, Adipose Tissue Metabolites and 20-Years Incidence of Elevated LDL Levels: A Metabolome-Wide Association Study in the&nbsp;<span>GraMo&nbsp;</span>Cohort

Published: Jan. 1, 2025

Language: Английский

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Unraveling ER dimerization dynamics in endocrine disruption based on a BRET-focused approach

Animal Cells and Systems, Journal Year: 2025, Volume and Issue: 29(1), P. 282 - 295

Published: April 28, 2025

Endocrine-disrupting chemicals (EDCs) are exogenous compounds that interact with the estrogen receptor (ER), thereby disrupting estrogen-mediated signaling. In a previous study, we employed bioluminescence resonance energy transfer (BRET) system to assess ER dimerization for detecting EDCs. To further determine whether BRET assay could be used independently identify EDCs, investigated ER-EDC interactions before and after dimerization. Results from isothermal titration calorimetry (ITC) dynamic light scattering (DLS) revealed can mediated by Consequently, proved effective in clarifying its relevance EDC-induced signaling disruption. Additionally, examine transcriptional changes, performed chromatin immunoprecipitation sequencing (ChIP-seq), followed gene ontology (GO) analysis. These analyses demonstrated EDCs affect various pathways, including those involved antibody-dependent cytotoxicity, bone morphogenetic protein (BMP) cardiac induction, hepatocyte growth factor Overall, this study elucidates molecular mechanisms which influence findings highlight utility of BRET-based EDC detection contribute deeper understanding systemic effects on endocrine

Language: Английский

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Plastic-related endocrine disrupting chemicals significantly related to the increased risk of estrogen-dependent diseases in women

Environmental Research, Journal Year: 2024, Volume and Issue: 252, P. 118966 - 118966

Published: April 18, 2024

To evaluate the association between exposure to plastic-related endocrine-disrupting chemicals (EDCs), specifically Bisphenol A (BPA), Phthalates, Cadmium, and Lead, risk of estrogen-dependent diseases (EDDs) such as polycystic ovary syndrome (PCOS), endometriosis, or endometrial cancer by conducting a meta-analysis relevant studies. PubMed, Web Science, Cochrane Library databases were used for literature retrieval articles published until 21st April, 2023. Literature that evaluated BPA, phthalates, cadmium, and/or lead PCOS, development exacerbation included in our analysis. STATA/MP 17.0 was all statistical analyses. Overall, 22 with total 83,641 subjects whom females aged 18 83 years old. The overall effect size each study follows: endometriosis relation BPA ES 1.82 (95% CI; 1.50, 2.20). PCOS 1.61 1.39, 1.85). Phthalate metabolites risk; MBP 1.07 0.86, 1.33), MEP 1.05 0.87, 1.28), MEHP 1.15 0.67, 1.98), MBzP 0.97 0.63, 1.49), MEOHP 1.87 1.21, 2.87), MEHHP 1.98 1.32, 2.98). Cadmium 1.14 0.92, 1.41). 2.54 1.71, 3.77). Lead 1.74 1.13, 2.69). Increased serum, urinary, dietary concentration women is significantly associated risk. cadmium

Language: Английский

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