Bioaccumulation and trophic transfer of pharmaceuticals in food webs from a large freshwater lake

Environmental Pollution, Journal Year: 2016, Volume and Issue: 222, P. 356 - 366

Published: Dec. 26, 2016

Language: Английский

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Pharmacology beyond the patient – The environmental risks of human drugs

Environment International, Journal Year: 2019, Volume and Issue: 129, P. 320 - 332

Published: May 28, 2019

The presence of pharmaceuticals in the environment is a growing global concern and although environmental risk assessment required for approval new drugs Europe USA, adequacy current triggers effects-based assessments has been questioned. To provide comprehensive analysis all regulatory compliant aquatic ecotoxicity data evaluate to facilitate development more efficient approaches toxicity testing. Publicly-available targeting human proteins was compiled together with pharmacological information including drug targets, Cmax lipophilicity. Possible links between these factors effects on, growth, mortality and/or reproduction, were evaluated. risks then assessed based on combined predicted concentrations European patient consumption data. For most (88%) 975 approved small molecule complete set public domain lacking, highlighting need both intelligent prioritize legacy tailored transparent database that captures We show presence/absence drug-target orthologues are predictive susceptible species potent drugs. Drugs target endocrine system represent highest potency greatest risk. However, (>80%) full data, quotients assuming worst-case exposure below one countries indicating low endpoints assessed. believe presented can guide improvements testing procedures, valuable prioritising (i.e. those registered before 2006) further where possible (e.g. behaviour) not captured tests, additional mechanistic may be confidence avoiding impacts.

Language: Английский

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Occurrence and spatial distribution of pharmaceuticals and personal care products (PPCPs) in the aquatic environment, their characteristics, and adopted legislations

Journal of Water Process Engineering, Journal Year: 2023, Volume and Issue: 52, P. 103490 - 103490

Published: Feb. 4, 2023

Language: Английский

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A review of the state-of-the-art wastewater quality characterization and measurement technologies. Is the shift to real-time monitoring nowadays feasible?

Journal of Water Process Engineering, Journal Year: 2024, Volume and Issue: 60, P. 105061 - 105061

Published: March 12, 2024

Efficient characterization of wastewater stream quality is vital to ensure the safe discharge or reuse treated (WW). There are numerous parameters employed characterize water quality, some required by directives (e.g. biological oxygen demand (BOD), total nitrogen (TN), phosphates (TP)), while others used for process controls flow, temperature, pH). Well-accepted methods assess these have traditionally been laboratory-based, taking place either off-line at-line, and presenting a significant delay between sampling result. Alternative can run in-line on-line, generally being more cost-effective. Unfortunately, often not accepted when providing information regulatory bodies. The current review aims describe available laboratory-based approaches compare them with innovative real-time (RT) solutions. Transitioning from RT measurements means obtaining valuable data, avoiding time delays, possibility optimize (WW) treatment management. A variety sensor categories examined illustrate general framework in which applications replace longer conventional processes, an eye toward potential drawbacks. enhancement be achieved through employment advanced soft-sensing techniques Internet Things (IoT), coupled machine learning (ML) artificial intelligence (AI).

Language: Английский

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Performance of a microalgal photobioreactor treating toilet wastewater: Pharmaceutically active compound removal and biomass harvesting

The Science of The Total Environment, Journal Year: 2017, Volume and Issue: 592, P. 1 - 11

Published: March 11, 2017

Language: Английский

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Biogenic platinum and palladium nanoparticles as new catalysts for the removal of pharmaceutical compounds

Water Research, Journal Year: 2016, Volume and Issue: 108, P. 160 - 168

Published: Oct. 28, 2016

Language: Английский

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A comparative assessment of intensive and extensive wastewater treatment technologies for removing emerging contaminants in small communities

Water Research, Journal Year: 2015, Volume and Issue: 88, P. 777 - 785

Published: Nov. 4, 2015

Language: Английский

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Fish on Prozac (and Zoloft): Ten years later

Aquatic Toxicology, Journal Year: 2014, Volume and Issue: 151, P. 61 - 67

Published: Jan. 19, 2014

Language: Английский

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Prioritising anticancer drugs for environmental monitoring and risk assessment purposes

The Science of The Total Environment, Journal Year: 2013, Volume and Issue: 473-474, P. 159 - 170

Published: Dec. 22, 2013

Language: Английский

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Bioaccumulation and trophic dilution of human pharmaceuticals across trophic positions of an effluent-dependent wadeable stream

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2014, Volume and Issue: 369(1656), P. 20140058 - 20140058

Published: Oct. 14, 2014

Though pharmaceuticals are increasingly observed in a variety of organisms from coastal and inland aquatic systems, trophic transfer food webs have not been reported. In this study, bioaccumulation select was investigated lower order effluent-dependent stream central Texas, USA, using isotope dilution liquid chromatography-tandem mass spectrometry (MS). A fish plasma model, initially developed laboratory studies, tested to examine versus predicted internal dose pharmaceuticals. Pharmaceuticals accumulated higher concentrations invertebrates relative fish; elevated the antidepressant sertraline its primary metabolite desmethylsertraline were Asian clam, Corbicula fluminea, two unionid mussel species. Trophic positions determined stable isotopes (δ(15)N δ(13)C) collected by ratio-MS; Bayesian mixing model then used estimate diet contributions towards top predators. Because diphenhydramine carbamazepine only target compounds detected all species examined, magnification factors (TMFs) derived evaluate potential both compounds. TMFs for (0.38) (1.17) indicated neither compound experienced magnification, which suggests that inhalational dietary exposure represented route uptake stream.

Language: Английский

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