Oridonin loaded peptide nanovesicles alleviate nonalcoholic fatty liver disease in mice DOI
Lifen Zhang, Yu Yao, Qi Wang

et al.

Pharmaceutical Development and Technology, Journal Year: 2024, Volume and Issue: 29(2), P. 123 - 130

Published: Feb. 7, 2024

This study was to construct a nanovesicle delivery system improve the loading efficiency and stability of ORI for treatment nonalcoholic fatty liver disease (NAFLD). nanovesicles (NVs) exerted narrow size distribution (195.6 ± 11.49 nm) high entrapment (84.46 1.34%). In vitro cell studies demonstrated that NVs enhanced cellular uptake reduced lipid over-accumulation total cholesterol levels in NAFLD model. At same time, vivo proved that, compared with normal group, model group mice showed decrease body weight, significant increase index (6.71 0.62, p < 0.01), symptoms accumulation, vesicles, tissue fibrosis. Compared after high-dose intervention, gained decreased (4.69 0.55, hepatic droplet vacuoles, accumulation (reduced oil red area, 0.001), alleviated degree fibrosis blue collagen 0.001). conclusion, ORI/HP-β-CD/H9-HePC specific improved therapeutic effects, nano drug provides promising strategy encapsulation effectively alleviate process NAFLD.

Language: Английский

A review of environmental metabolism disrupting chemicals and effect biomarkers associating disease risks: Where exposomics meets metabolomics DOI Creative Commons
Jiachen Sun, Runcheng Fang, Hua Wang

et al.

Environment International, Journal Year: 2021, Volume and Issue: 158, P. 106941 - 106941

Published: Oct. 22, 2021

Humans are exposed to an ever-increasing number of environmental toxicants, some which have gradually been elucidated be important risk factors for metabolic diseases, such as diabetes and obesity. These metabolism-sensitive diseases typically occur when key signaling pathways were disrupted, can influenced by the exposure contaminants endocrine disrupting chemicals (EDCs), along with genetic lifestyle factors. This promotes concept research on metabolism (MDCs). In addition, identifying endogenous biochemical markers effect linked disease states is becoming tool screen biological targets following contaminant exposure, well provide overview toxicity assessment. As such, current review aims contribute further understanding exposome human health characterizing biomarkers. We summarized MDC-associated biomarkers in laboratory animal cohort studies using high throughput targeted nontargeted metabolomics techniques. Contaminants including heavy metals organohalogen compounds, especially EDCs, repetitively associated disorders, whereas emerging perfluoroalkyl substances microplastics also found disrupt metabolism. we major limitations effective identification studies, toxicological mixed has insufficient compared single chemicals. Thus, it timely call efforts dedicated study combined alterations better assessment exposomic toxicology risks. Moreover, advanced computational prediction tools, validation biomarkers, systematic integrative investigations needed order reliably identify novel elucidate mechanisms, utilize metabolome profiling public safety management.

Language: Английский

Citations

124
Antidiabetic activity of Solanum torvum fruit extract in streptozotocin-induced diabetic rats DOI Creative Commons

N Satyanarayana,

Suresh V. Chinni, Gobinath Ramachawolran

et al.

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Oct. 28, 2022

Background Solanum torvum Swartz, a medicinal plant belonging to the family Solanaceae, is an important widely distributed throughout world and used as medicine treat diabetes, hypertension, tooth decay, reproductive problems in traditional systems of around including Malaysia. The objective this study was investigate hypoglycemic, antilipidemic, hepatoprotective activities, histopathology pancreas, specific glucose regulating gene expression ethanolic extract S. fruit streptozotocin-induced diabetic Sprague–Dawley rats. Materials methods Acute toxicity done according OECD-423 guidelines. Diabetes induced by intraperitoneal (i.p.) injection streptozotocin (55 mg/kg) male Experimental rats were divided into six different groups; normal, control, glibenclamide at 6 mg/kg body weight, other three groups animals treated with oral administration 120, 160, 200 for 28 days. effect on blood glucose, lipid profile, liver enzymes, transporter 2 (slc2a2), phosphoenolpyruvate carboxykinase (PCK1) determined RT-PCR. Results studies showed LD 50 be dose 1600 weight. Blood total cholesterol, triglycerides, low-density lipoproteins, very serum alanine aminotransferase, aspartate aminotransferase significantly reduced, whereas high-density lipoproteins increased (200 mg/kg)-treated Histopathological pancreas increase number, size, regeneration β-cell islets Langerhans. Gene revealed lower slc2a2 PCK1 when compared control. Conclusion Ethanolic fruits hypolipidemic, activity streptozocin-induced β cells indicated indicating that prefer gluconeogenesis pathway.

Language: Английский

Citations

19
Untargeted Lipidomics Revealed the Protective Effects of Cyanidin-3-O-glucoside on Bisphenol A-Induced Liver Lipid Metabolism Disorder in Rats DOI
Ruijing Liu, Yulong Jin, Bo Liu

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(2), P. 1077 - 1090

Published: Jan. 3, 2023

Bisphenol A (BPA) is an estrogenic endocrine disruptor that induces metabolic disorders. Cyanidin-3-O-glucoside (C3G) has multiple functional activities and the most abundant anthocyanin belonging to flavonoid subgroup. This study aimed investigate protective effect of C3G on BPA-induced liver lipid metabolism disorder explore its mechanism via lipidomics analysis. The results showed supplementation significantly ameliorated serum levels low-density lipoprotein cholesterol, high-density total triacylglycerols (TG), alanine aspartate aminotransferase (ALT AST). Furthermore, indicated effectively facilitated recovery differential metabolites, including TGs, phosphatidylethanolamines, phosphatidylcholines, lysophosphatidylcholines, phosphatidylinositol, cholesteryl esters, phosphatidylserine, reversed hepatic synthesis-related genes. Our suggest effective regulatory disorders metabolism.

Language: Английский

Citations

11
Deciphering the molecular mechanism of NLRP3 in BPA-mediated toxicity: Implications for targeted therapies DOI Creative Commons

D. Charles,

Evan Prince Sabina

Heliyon, Journal Year: 2024, Volume and Issue: 10(7), P. e28917 - e28917

Published: March 30, 2024

Bisphenol-A (BPA), a pervasive industrial chemical used in polymer synthesis, is found numerous consumer products including food packaging, medical devices, and resins. Detectable majority of the global population, BPA exposure occurs via ingestion, inhalation, dermal routes. Extensive research has demonstrated adverse health effects BPA, particularly its disruption immune endocrine systems, along with genotoxic potential. This review focuses on complex relationship between NOD-like receptor protein 3 (NLRP3) inflammasome, multiprotein central to inflammatory disease processes. We examine how induces oxidative stress through generation intracellular free radicals, subsequently activating NLRP3 signaling. The mechanistic details this process are explored, involvement signaling cascades such as PI3K/AKT, JAK/STAT, AMPK/mTOR, ERK/MAPK, which implicated inflammasome activation. A key focus wide-ranging organ toxicities associated exposure, hepatic, renal, gastrointestinal, cardiovascular dysfunction. investigate immunopathogenesis molecular pathways driving these injuries, highlighting interplay among stress, inflammasome. Finally, explores emerging concept targeting potential therapeutic strategy mitigate stemming from exposure. work integrates current knowledge, emphasizes mechanisms, promotes further into NLRP3-targeted interventions.

Language: Английский

Citations

4
The protection of bisphenol A-modulated miRNAs and targets by natural products DOI Creative Commons

Ya-Ting Chuang,

Ching-Yu Yen, Wangta Liu

et al.

Environment International, Journal Year: 2025, Volume and Issue: unknown, P. 109299 - 109299

Published: Jan. 1, 2025

Bisphenol A (BPA) is a ubiquitous environmental pollutant with endocrine-disrupting functions. Identifying protective drugs and exploring the mechanisms against BPA are crucial in healthcare. Natural products exhibiting antioxidant properties considered to be able protect toxicity. Although BPA-modulated targets miRNAs have been individually reported, their connections natural were rarely organized. With help of protein-protein interaction database (STRING), relationship between individual was interconnected provide systemic view. In this review, BPA-downregulated -upregulated classified, interactive network innovatively analyzed using bioinformatic (STRING). also retrieved ingeniously connected targets. Moreover, novel connection BPA-countering integrated into All these targets-associated and/or incorporated STRING network, providing relationships. Overall, target-miRNA-protecting product axis constructed, straightforward direction for effects products.

Language: Английский

Citations

0
Epidemiological perspectives on emerging contaminants and gout or hyperuricemia DOI Creative Commons

Weiwen Fu,

Yangyi Guang,

Zixing Zhang

et al.

Emerging contaminants, Journal Year: 2025, Volume and Issue: unknown, P. 100485 - 100485

Published: Feb. 1, 2025

Language: Английский

Citations

0
Urate-lowering effect of delphinidin-3-glucoside in red kidney beans via binding to the FAD site of the XO enzyme DOI Creative Commons
Yanling Chen,

Yingtong Jiang,

Lei Huang

et al.

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
1, 8-Cineole Ameliorated Staphylococcus aureus-Induced Pneumonia through Modulation of TRP-KYN and Arginine-NO Reprogramming DOI

Qianwen Cao,

Luyao Liu,

Xiaoge Ma

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

1, 8-Cineole (Cin), a cyclic monoterpenoid derived from tea trees and eucalyptus species, exhibits diverse pharmacological properties. Yet, its therapeutic impact underlying mechanism against Staphylococcus aureus (S. aureus) pneumonia remain to be elucidated. In this study, metabolomics based on UPLC-MS/MS was integrated with network pharmacology, molecular biology, docking investigate the effects of Cin. The findings demonstrated that Cin markedly reduced mortality lung bacterial load, lessened pulmonary damage while suppressing levels proinflammatory factors, including tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) in bronchoalveolar lavage fluid (BALF) infected mice. Additionally, 19 metabolites, primarily involved tryptophan metabolism arginine biosynthesis, were notably modified by via enzymatic activity indoleamine 2, 3-dioxygenase 1 (IDO1) inducible nitric oxide synthase (iNOS), thereby attenuating inflammatory response. Notably, knockdown IDO1 or iNOS significantly diminished anti-inflammation effect conclusion, our study validates potential S. downregulating iNOS. Our results provide theoretical basis natural substances applied treatment.

Language: Английский

Citations

0
Glutamine metabolism: from proliferating cells to cardiomyocytes DOI
Yimin Shen, Yuhao Zhang,

Wudi Li

et al.

Metabolism, Journal Year: 2021, Volume and Issue: 121, P. 154778 - 154778

Published: April 24, 2021

Language: Английский

Citations

26
Reprogramming of arachidonic acid metabolism using α-terpineol to alleviate asthma: insights from metabolomics DOI
Ying Rong, Fanglin Liu, Hui Zhou

et al.

Food & Function, Journal Year: 2024, Volume and Issue: 15(8), P. 4292 - 4309

Published: Jan. 1, 2024

α-Terpineol and Hp-β-CD were prepared for Ter-Hp-β-CD inclusion complex nebulized inhalation treatment in asthmatic mice. Biochemical indices differential metabolite assays mice showed that is a potential drug to prevent asthma by reprogramming arachidonic acid metabolism.

Language: Английский

Citations

3