Effect of microplastics deposition on human lung airways: A review with computational benefits and challenges DOI Creative Commons
Suvash C. Saha, Goutam Saha

Heliyon, Journal Year: 2024, Volume and Issue: 10(2), P. e24355 - e24355

Published: Jan. 1, 2024

Microplastics have become omnipresent in the environment, including air we inhale, water consume, and food eat. Despite limited research, accumulation of microplastics within human respiratory system has garnered considerable interest because its potential implications for health. This review offers a comprehensive examination impacts stemming from on lung airways explores computational benefits challenges associated with studying this phenomenon. The existence can lead to range adverse effects. Research indicated that induce inflammation, oxidative stress, impaired function. Furthermore, small size allows them penetrate deep into lungs, reaching alveoli, where gas exchange takes place. raises concerns about long-term health consequences, such as development diseases translocation other organs. Computational approaches been instrumental understanding impact microplastic deposition airways. models simulations enable investigation particle dynamics, patterns, interaction mechanisms at various levels complexity. However, using methods presents several challenges. complex anatomy physiological processes require accurate representation models. Obtaining relevant data model validation parameterization remains significant hurdle. Additionally, diverse nature microplastics, variations size, shape, chemical composition, poses capturing their full behaviours toxicological

Language: Английский

The potential impacts of micro-and-nano plastics on various organ systems in humans DOI Creative Commons
Nurshad Ali,

Jenny Katsouli,

Emma L. Marczylo

et al.

EBioMedicine, Journal Year: 2023, Volume and Issue: 99, P. 104901 - 104901

Published: Dec. 6, 2023

Humans are exposed to micro-and-nano plastics (MNPs) through various routes, but the adverse health effects of MNPs on different organ systems not yet fully understood. This review aims provide an overview potential impacts and identify knowledge gaps in current research. The summarized results suggest that exposure can lead oxidative stress, inflammation, immune dysfunction, altered biochemical energy metabolism, impaired cell proliferation, disrupted microbial metabolic pathways, abnormal development, carcinogenicity. There is limited human data MNPs, despite evidence from animal cellular studies. Most published research has focused specific types assess their toxicity, while other plastic particles commonly found environment remain unstudied. Future studies should investigate by considering realistic concentrations, dose-dependent effects, individual susceptibility, confounding factors.

Language: Английский

Citations

134
Toxic Chemicals and Persistent Organic Pollutants Associated with Micro-and Nanoplastics Pollution DOI Creative Commons
Charles Obinwanne Okoye, Charles Izuma Addey, Olayinka Oderinde

et al.

Chemical Engineering Journal Advances, Journal Year: 2022, Volume and Issue: 11, P. 100310 - 100310

Published: April 29, 2022

The prevalence of micro and nanoplastics (MNPs) across the various environments their negative impact on ecosystems have become a serious global threat are currently subject many environmental concerns. Studies provided evidence that MNPs potential to leach toxic plastic chemical additives can adsorb variety persistent organic pollutants, thereby enhancing bioavailability, toxicity, dispersion. Moreover, these easily penetrate food chain might cause health problems when ingested by humans other organisms. Currently, there is complexity in understanding mechanisms which chemicals adsorb/desorb onto/from MNPs, physical biological impacts additives. To date, considerable lack knowledge major concern used industry, fate once dispose into environment, factors affect degradation, consequent human health. This review critically analyzes current concerning physical, chemical, pollutants associated with MNPs. Emphasis was laid types, occurrence, fate, distribution environment. different techniques identification, characterization, removal were also elucidated. Furthermore, harmful effects discussed spur more future studies fill gaps this area.

Language: Английский

Citations

124
Overview on the occurrence of microplastics in air and implications from the use of face masks during the COVID-19 pandemic DOI Creative Commons
Ana Torres, Angeliki Karanasiou, Teresa Moreno

et al.

The Science of The Total Environment, Journal Year: 2021, Volume and Issue: 800, P. 149555 - 149555

Published: Aug. 8, 2021

Environmental pollution from microplastics (MPs) in air is a matter of growing concern because human health implications. Airborne MPs can be directly and continuously inhaled environments. Especially high contributions found indoor due to the erosion breakage consumer, domestic construction products, although there little information available on their sources concentrations risks they might pose. This part fact that sampling analysis airborne complex multistep procedure where techniques used are not yet standardized. In this study, we provide an overview presence air, potential impacts, methods for detection implications use face masks during COVID-19 pandemic.

Language: Английский

Citations

115
Nanotoxicological effects and transcriptome mechanisms of wheat (Triticum aestivum L.) under stress of polystyrene nanoplastics DOI
Jiapan Lian, Weitao Liu, Yuebing Sun

et al.

Journal of Hazardous Materials, Journal Year: 2021, Volume and Issue: 423, P. 127241 - 127241

Published: Sept. 17, 2021

Language: Английский

Citations

115
Methods and challenges in the detection of microplastics and nanoplastics: a mini‐review DOI Creative Commons
Sangeet Adhikari,

Varun Kelkar,

Rahul Kumar

et al.

Polymer International, Journal Year: 2021, Volume and Issue: 71(5), P. 543 - 551

Published: Dec. 10, 2021

Abstract Microplastics (MPs) and nanoplastics (NPs) constitute a newly recognized class of contaminants emerging concern in air, soil, water food, causing unavoidable exposure to humans animals. Detection, identification quantification MPs NPs environmental matrices biota is challenging due the analytes' small size, random morphology, polymeric diversity, applied coatings vast surface areas which attract chemical microbial sorbates. This mini‐review explores strengths weaknesses analytical methods commonly used for MP NP quantification, including stereomicroscopy, SEM, Fourier transform infrared spectroscopy, Raman flow cytometry mass spectrometry techniques matrix‐assisted laser desorption/ionization time‐of‐flight, pyrolysis gas chromatography–mass liquid chromatography–tandem spectrometry. Analytical challenges involved precise MP/NP detection have been identified recommendations provided ensure data quality addressing common concerns, difficulty obtaining irrefutable proof that detected polymers originated from sample as opposed contamination during acquisition, processing analysis. © 2021 The Authors. Polymer International published by John Wiley & Sons Ltd on behalf Society Industrial Chemistry.

Language: Английский

Citations

105
Environmental risks of polymer materials from disposable face masks linked to the COVID-19 pandemic DOI
Hao Du,

Shushi Huang,

Jun Wang

et al.

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 815, P. 152980 - 152980

Published: Jan. 8, 2022

Language: Английский

Citations

95
Microplastics exposure affects neural development of human pluripotent stem cell-derived cortical spheroids DOI
Timothy Hua, Sonia Kiran, Yan Li

et al.

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 435, P. 128884 - 128884

Published: April 11, 2022

Language: Английский

Citations

90
A systematic review of the impacts of exposure to micro- and nano-plastics on human tissue accumulation and health DOI Creative Commons
Yudong Feng,

Chen Tu,

Ruijie Li

et al.

Eco-Environment & Health, Journal Year: 2023, Volume and Issue: 2(4), P. 195 - 207

Published: Aug. 21, 2023

Micro- and nano-plastics (MNPs) pollution has become a pressing global environmental issue, with growing concerns regarding its impact on human health. However, evidence the effects of MNPs health remains limited. This paper reviews three routes exposure to MNPs, which include ingestion, inhalation, dermal contact. It further discusses potential translocation in lungs, intestines, skin, analyses homeostasis organ systems, provides an outlook future research priorities for There is that are present tissues or fluids. Lab studies, including

Language: Английский

Citations

81
A Children’s Health Perspective on Nano- and Microplastics DOI Creative Commons
Kam Sripada, Aneta Wierzbicka, Khaled Abass

et al.

Environmental Health Perspectives, Journal Year: 2022, Volume and Issue: 130(1)

Published: Jan. 1, 2022

Pregnancy, infancy, and childhood are sensitive windows for environmental exposures. Yet the health effects of exposure to nano- microplastics (NMPs) remain largely uninvestigated or unknown. Although plastic chemicals a well-established research topic, impacts particles unexplored, especially with regard early life exposures.This commentary aims summarize knowns unknowns around child- pregnancy-relevant exposures NMPs via inhalation, placental transfer, ingestion breastmilk, dermal absorption.A comprehensive literature search map state science on found 37 primary articles relevance during revealed major knowledge gaps in field. We discuss opportunities challenges quantifying child-specific (e.g., breastmilk infant formula) effects, light global inequalities baby bottle use, consumption packaged foods, air pollution, hazardous disposal, regulatory safeguards. also needs linking child NMP address context public action.Few studies have addressed sources exposure, estimates currently rely generic assumptions rather than empirical measurements. Furthermore, toxicological has not specifically focused health, yet children's immature defense mechanisms make them particularly vulnerable. Apart from few investigating transfer NMPs, physicochemical properties polymer, size, shape, charge) driving absorption, biodistribution, elimination be benchmarked. Accordingly, evidence base regarding potential remains sparse. Based date, we provide recommendations fill gaps, stimulate policymakers industry safety point families reduce plastic. https://doi.org/10.1289/EHP9086.

Language: Английский

Citations

74
Polystyrene micro and nano-particles induce metabolic rewiring in normal human colon cells: A risk factor for human health DOI Creative Commons
Marcella Bonanomi,

Noemi Salmistraro,

Danilo Porro

et al.

Chemosphere, Journal Year: 2022, Volume and Issue: 303, P. 134947 - 134947

Published: May 14, 2022

Polystyrene is a thermoplastic polymer widely used in commercial products. Like all plastics, polystyrene can be degraded into microplastic and nanoplastic particles ingested via food chain contamination. Although the ecological impact due to plastic contamination well known, there are no studies indicating carcinogenic potential of microplastics (MPs) nanoplastics (NPs). Here, we evaluated effects MPs NPs on normal human intestinal CCD-18Co cells. Our results show that internalization induces metabolic changes under both acute chronic exposure by inducing oxidative stress, increasing glycolysis lactate sustain energy metabolism glutamine anabolic processes. We also this decoupling nutrients mirrors effect potent agent azoxymethane HCT15 colon cancer cells, carrying out typical strategy cells optimize utilization allowing adaptation environmental stress conditions. Taken together our data provide new evidence could act as risk factor for health.

Language: Английский

Citations

73