Food Science & Nutrition,
Journal Year:
2024,
Volume and Issue:
12(9), P. 6673 - 6689
Published: July 1, 2024
Abstract
Cyanidin‐3‐O‐glucoside
(C3G),
as
a
typical
anthocyanin,
exhibits
excellent
antioxidant
effects.
This
study
aimed
to
demonstrate
the
role
and
mechanism
of
C3G
in
regulating
3‐hydroxy‐3‐methylglutaryl‐coenzyme
A
reductase
(HMGCR)‐mediated
cholesterol
anabolism
on
H
2
O
‐induced
oxidative
stress
HEK‐293T
cells.
Firstly,
inhibitory
effect
was
confirmed
by
CCK‐8,
ROS,
mitochondrial
membrane
potential
(MMP)
experiments.
Then,
proteomics
used
investigate
screen
differentially
expressed
proteins
inhibiting
cellular
C3G.
HMGCR
screened
key
protein
proteomic
analysis.
The
results
verified
that
could
reduce
levels
sterol
regulatory
element‐binding
(SREBP2)/HMGCR
pathway,
increasing
ATP,
reducing
acetyl‐CoA.
Finally,
had
been
shown
positively
increase
ROS
accumulation
decrease
MMP,
which
were
reversed
intervention
through
series
knockdown
overexpression
In
conclusion,
demonstrated
inhibit
disorder
synthesis
cells
ROS/SREBP2/HMGCR
pathway.
Journal of Agricultural and Food Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 5, 2025
Nonalcoholic
fatty
liver
disease
(NAFLD)
has
become
one
of
the
most
concerning
health
problems
in
world.
Dietary
intervention
is
an
effective
way
to
prevent
and
improve
NAFLD.
As
main
metabolites
anthocyanins,
protocatechuic
acid
(PCA)
exhibited
strong
activity
NAFLD,
but
specific
mechanism
remains
unclear.
Currently,
proteomics
been
used
identify
that
PCA
treatment
could
significantly
influence
expression
224
proteins,
including
89
downregulated
proteins
135
upregulated
proteins.
KEGG
analysis
showed
obviously
inhibited
peroxisome
proliferator-activated
receptor
(PPAR)
signaling
pathway.
Immunofluorescence
Western
blot
analyses
further
confirmed
repressed
protein
PPARγ
subsequently
free
(FFA)
uptake
(CD36
FABP2)
FFA
synthesis
(ACC
FASN),
respectively.
These
effects
contributed
inhibitory
excessive
lipid
accumulation
liver.
Our
results
highlighted
effectively
alleviate
high-fat
diet-induced
(HFD)
NAFLD
by
inhibiting
absorption
through
Food & Function,
Journal Year:
2023,
Volume and Issue:
14(4), P. 2200 - 2211
Published: Jan. 1, 2023
Testicular
hyperthermia
induced
by
unhealthy
living
habits
and
pathological
or
occupational
factors
can
cause
spermatogenic
dysfunction
with
an
outcome
of
sub-fertility
even
infertility.
Cyanidin-3-O-glucoside
(C3G)
is
the
most
typical
anthocyanin
in
foods
that
has
been
recognized
as
antioxidant
promising
protection
for
male
reproduction.
However,
its
specific
effect
against
testicular
mechanisms
involving
primary
gastrointestinal
metabolite
protocatechuic
acid
(PCA)
are
still
unexplored.
In
present
study,
mice
was
established
employing
a
single
hot
water
bath
at
43
°C
30
min.
C3G
PCA
were
intragastrically
given
to
investigate
their
prevention
ability
heat
stress-induced
damage.
It
found
restored
external
diameter
thickness,
alleviated
atrophy
vacuolation
seminiferous
tubules.
Simultaneously,
enhanced
stress
tolerance
through
reducing
superfluous
eIF2α
phosphorylation
granule
formation.
effectively
improved
system
regulated
IRE1α-XBP1
pathway,
contributing
mitigatory
spermatogenesis
This
finding
revealed
anthocyanins
novel
compounds
alleviating
damage,
provided
reliable
theoretical
basis
improving
fertility
disturbed
stress.
Comprehensive Reviews in Food Science and Food Safety,
Journal Year:
2023,
Volume and Issue:
23(1)
Published: Dec. 13, 2023
Abstract
Foodborne
contaminants
refer
to
substances
that
are
present
in
food
and
threaten
safety.
Due
the
progress
detection
technology
rising
concerns
regarding
public
health,
there
has
been
a
surge
research
focusing
on
dangers
posed
by
foodborne
contaminants.
These
studies
aim
explore
implement
strategies
both
safe
efficient
mitigating
associated
risks.
Anthocyanins,
class
of
flavonoids,
abundantly
various
plant
species,
such
as
blueberries,
grapes,
purple
sweet
potatoes,
cherries,
mulberries,
others.
Numerous
epidemiological
nutritional
intervention
have
provided
evidence
indicating
consumption
anthocyanins
through
dietary
intake
offers
range
protective
effects
against
detrimental
impact
The
study
aims
differentiate
between
two
distinct
subclasses
contaminants:
those
generated
during
processing
originate
from
surrounding
environment.
Furthermore,
was
also
summarized
based
review
articles
published
within
last
10
years.
However,
further
investigation
is
warranted
mechanism
which
target
contaminants,
well
potential
individual
variations
response.
Additionally,
it
important
note
currently
dearth
clinical
examining
efficacy
an
for
pollutants.
Thus,
exploring
detoxification
effect
pollutants,
this
thereby
provides
evidence,
supporting
utilization
anthocyanin‐rich
diets
means
mitigate
Small Methods,
Journal Year:
2024,
Volume and Issue:
8(9)
Published: Jan. 8, 2024
Abstract
Given
the
inevitable
human
exposure
owing
to
its
increasing
production
and
utilization,
comprehensive
safety
evaluation
of
silica
nanoparticles
(SiNPs)
has
sparked
concerns.
Substantial
evidence
indicated
liver
damage
by
inhaled
SiNPs.
Notwithstanding,
few
reports
focused
on
persistence
or
reversibility
hepatic
injuries,
intricate
molecular
mechanisms
involved
remain
limited.
Here,
rats
are
intratracheally
instilled
with
SiNPs
in
two
regimens
(a
3‐month
a
subsequent
6‐week
recovery
after
terminating
administration)
assess
effects.
Nontargeted
lipidomics
revealed
alterations
lipid
metabolites
as
contributor
response
effects
In
line
functional
analysis
differential
metabolites,
activated
oxidative
stress,
induced
peroxidation
deposition
liver,
evidenced
elevated
levels
ROS,
MDA,
TC,
TG.
Of
note,
these
indicators
showed
great
improvements
recovery,
even
returning
control
levels.
According
correlation,
ROC
curve,
SEM
analysis,
11
lipids
identified
potential
regulatory
molecules
for
ameliorating
injury
Collectively,
work
first
SiNP‐elicited
hepatotoxicity
from
perspective
offered
valuable
laboratory
therapeutic
strategy
facilitate
nanosafety.
ACS ES&T Water,
Journal Year:
2024,
Volume and Issue:
4(5), P. 2192 - 2203
Published: April 12, 2024
Propofol
is
increasingly
perceived
as
an
emerging
threat
to
aquatic
ecosystems,
although
the
ecotoxicity
and
underlying
mechanisms
of
propofol
on
life
have
not
yet
been
clearly
established.
In
this
study,
zebrafish
(Danio
rerio)
was
exposed
different
concentrations
(0.008,
0.04,
0.2
mg·L–1)
probe
effect
functional
metabolism
ecological
response
mechanism
in
organisms.
induced
severe
hepatic
damage,
including
increased
interstitial
spaces
nuclear
malformations
at
tissue
level.
Reactive
oxygen
species
(ROS)
production
lipid
peroxidation
were
after
28
days
exposure,
while
activities
aspartate
aminotransferase
(AST)
alanine
(ALT)
substantially
increased,
suggesting
that
may
influence
injury
through
exacerbating
oxidative
damage.
Exacerbated
levels
triglyceride
(TG)
high-density
lipoprotein
cholesterol
(HDL-C)
indicative
dysregulated
metabolism.
Comprehensive
transcriptomics
metabolomics
analyses
showed
mainly
changed
glycerophospholipid
metabolism,
citric
acid
cycle,
purine
disorders
these
pathways
can
aggravate
accumulation
Overall,
study
revealed
hepatotoxicity
metabolic
dysfunction
zebrafish,
providing
constructive
insights
for
a
comprehensive
assessment
toxicity
risk
posed
by
environmental
health.
