Alleviation of bovine serum albumin on the neurotoxicity of silver nanoparticles in zebrafish (Danio rerio) larvae DOI Creative Commons
Zhenhua Yan, Yufang Chen,

Yang Yu-qiong

et al.

Frontiers in Marine Science, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 19, 2024

Silver nanoparticles (AgNPs) are ubiquitous in the aquatic environment and have attracted extensive attention to their toxic effects on species. However, responses of nervous system AgNPs little known, especially co-existing with natural organic matter (NOM), which is critical for ability act Here, this study investigated neurotoxicology environmentally relevant or without bovine serum albumin (BSA; a classical NOM) zebrafish ( Danio rerio ) using visualized transgenic zebrafish. Exposure reduced locomotor behavior by 28%–45%, including swimming distance velocity, exhibiting obvious behavioral inhibition. The treated showed developmental retardation early development heart, central nervous, motor nerve, as well related neurodevelopment genes, may be responsible lowered behavior. In addition, can specifically interfere cholinergic affect neuronal signaling, ultimately leading abnormalities. BSA alleviated neurotoxicity zebrafish, partially attributed increased size electronegativity caused BSA, thus reducing direct interaction cells. between released Ag + from also alleviation dysfunction These findings provide valuable insights into toxicity risks environments.

Language: Английский

Neurotoxicity of polystyrene nanoplastics with different particle sizes at environment-related concentrations on early zebrafish embryos DOI
Ranran Zhou,

Dao Zhou,

Shixin Yang

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 872, P. 162096 - 162096

Published: Feb. 13, 2023

Language: Английский

Citations

55
Exploring Cr(VI)-induced blood-brain barrier injury and neurotoxicity in zebrafish and snakehead fish, and inhibiting toxic effects of astaxanthin DOI
Muyang Li,

Yan-Chao Shi,

Wan-Xin Xu

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 355, P. 124280 - 124280

Published: May 28, 2024

Language: Английский

Citations

25
Safety of benzophenone-type UV filters: A mini review focusing on carcinogenicity, reproductive and developmental toxicity DOI
Junchao Ma, Zeming Wang, Chao Qin

et al.

Chemosphere, Journal Year: 2023, Volume and Issue: 326, P. 138455 - 138455

Published: March 20, 2023

Language: Английский

Citations

28
Long-term exposure of zebrafish (Danio rerio) to Cr(VI): Reproductive toxicity and neurotoxicity DOI
Lei Zhao,

Hengxuan Duan,

Yihan Liu

et al.

Regional Studies in Marine Science, Journal Year: 2024, Volume and Issue: 74, P. 103559 - 103559

Published: April 30, 2024

Language: Английский

Citations

11
Fosab, but not fosaa, plays important role in learning and memory in fish—insights from zebrafish gene knockout study DOI Creative Commons
Qiuling Wang, Lixin Zhang, Chenyuan Zhu

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 27, 2025

Introduction: Learning and memory allow individuals to adapt their environmental needs survive. Fish have the ability solve complex learning tasks, associative learning, flexible spatial memory. The proto-oncogene fos ( c-fos ) has been reported be involved in brain development, mammals. However, whether plays a vital role fish is unclear. Methods: Almost all two paralogues of named fosaa fosab . We used CRISPR/Cas9 technology generate knockout zebrafish models. Results: In this study, we discovered weight marked reduction −/− compared with wild-type (WT) (AB strain) zebrafish. T-maze behavioral assay, took significantly more than average time complete assigned trial as increase days WT zebrafish, while did not show notable variance. was higher relative mRNA expression level c- jun that no discernible trend. Additionally, phylogenetic multiple amino acid alignment results indicated identity mammals Fos. Discussion: By integrating above results, found , but fosaa, may possess function fish. For first time, illustrated via fish, which can provide new insights into adaptation.

Language: Английский

Citations

1
Phenyl salicylate induces neurotoxicity and early Alzheimer's disease-like symptoms through ndrg1-regulated myelin damage, increasing bace1 in zebrafish DOI

Siyu Liu,

Xiao‐Mei Li, Shuping Jiao

et al.

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 965, P. 178664 - 178664

Published: Feb. 1, 2025

Language: Английский

Citations

1
Revealing the relationship between molecular weight of lignin and its color, UV-protecting property DOI
Yarong Li, Siyu Zhao, Yihan Li

et al.

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 223, P. 1287 - 1296

Published: Nov. 14, 2022

Language: Английский

Citations

29
Hydroxylase-like Biomimetic Nanozyme Synthesized via a Urea-Mediated MOF Pyrolytic Reconstruction Strategy for Non-“o-Phenol hydroxyl”-Dependent Dopamine Electrochemical Sensing DOI
Yifei Xing, Xinyu Chen, Huimin Zhao

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(15), P. 6037 - 6044

Published: April 1, 2024

Dopamine (DA), an essential neurotransmitter, is closely associated with various neurological disorders, whose real-time dynamic monitoring significant for evaluating the physiological activities of neurons. Electrochemical sensing methods are commonly used to determine DA, but they mostly rely on redox reaction its o-phenolic hydroxyl group, which makes it difficult distinguish from substances this group. Here, we design a biomimetic nanozyme inspired by coordination structure copper-based active site dopamine β-hydroxylase, was successfully synthesized via urea-mediated MOF pyrolysis reconstruction strategy. Experimental studies and theoretical calculations revealed that Cu–N3 could hydroxylate carbon atom DA β-site at suitable potential sites have lowest binding energy β-site. With property, new oxidation peak achieves specific detection rather than traditional electrochemical signal o-phenol redox, would effectively differentiate neurotransmitters, such as norepinephrine epinephrine. The sensor exhibited good capability in concentrations 0.05 16.7 μM, limit 0.03 μM. Finally, enables released living cells can be quantitatively analyze effect polystyrene microplastics amount released. research provides method highly technical support initial screening neurocytotoxicity pollutants.

Language: Английский

Citations

8
3-Bromocarbazole-Induced Developmental Neurotoxicity and Effect Mechanisms in Zebrafish DOI Creative Commons
Mingyue Dong, Jieyu Wang, Yingying Liu

et al.

ACS ES&T Water, Journal Year: 2023, Volume and Issue: 3(8), P. 2471 - 2480

Published: May 31, 2023

Polyhalogenated carbazoles (PHCZs) are dioxin-like emerging contaminants, but limited information exists on their neurotoxicity and mechanisms. This study employed zebrafish embryos to investigate the adverse effects of 3-bromocarbazole (3-BCZ), a typical PHCZ, exposure in early life stages found that 120 h post fertilization (hpf)-median lethal concentration (LC50) value 3-BCZ larvae was 2.88 mg/L. The results revealed inhibited tail coiling at ≥0.06 mg/L, decreased hatchability ≥2.88 increased mortality malformation rates ≥1.44 induced aryl hydrocarbon receptor reduced body length ≥0.58 behavior activities Further mechanism investigations showed exposures repressed motor neuron axon via downregulating mRNA transcription levels α1-tubulin, Gap43, Syn2a, shha, central nervous system neurogenesis elavl3, nrd, mbp, gfap. Overall, induces developmental 0.06 mg/L (1/50 LC50). Tail activity 24 hpf swimming total distance could be ideal indicators health risks zebrafish. These findings provide valuable insights for ecological risk assessments other PHCZs.

Language: Английский

Citations

16
Zebrafish: A Pharmacological Model for Learning and Memory Research DOI Creative Commons
Jen Kit Tan,

Faris Hazwan Nazar,

Suzana Makpol

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(21), P. 7374 - 7374

Published: Oct. 30, 2022

Learning and memory are essential to organism survival conserved across various species, especially vertebrates. Cognitive studies involving learning require using appropriate model organisms translate relevant findings humans. Zebrafish becoming increasingly popular as one of the animal models for neurodegenerative diseases due their low maintenance cost, prolific nature amenability genetic manipulation. More importantly, zebrafish exhibit a repertoire neurobehaviors comparable In this review, we discuss forms abilities in tests used evaluate species. addition, pharmacological that screen effects neuroprotective neurotoxic compounds on cognitive performance will be summarized here. Lastly, challenges perspectives establishing robust research memory. an indispensable screening agents against impairment.

Language: Английский

Citations

22