Toxic effects of triclosan in aquatic organisms: A review focusing on single and combined exposure of environmental conditions and pollutants

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 920, P. 170902 - 170902

Published: Feb. 12, 2024

Language: Английский

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Gender-specific effects of polystyrene nanoplastic exposure on triclosan-induced reproductive toxicity in zebrafish (Danio rerio)

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 932, P. 172876 - 172876

Published: April 29, 2024

Language: Английский

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Effective removal of personal care product residues from aqueous media using hydrophobic deep eutectic solvents: Experimental and computational approach

Microchemical Journal, Journal Year: 2024, Volume and Issue: 197, P. 109891 - 109891

Published: Jan. 2, 2024

Language: Английский

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Associations of urinary non-persistent endocrine disrupting chemical biomarkers with early-to-mid pregnancy plasma sex-steroid and thyroid hormones

Environment International, Journal Year: 2024, Volume and Issue: 183, P. 108433 - 108433

Published: Jan. 1, 2024

Pregnant women are exposed to numerous endocrine disrupting chemicals (EDCs) that can affect hormonal pathways regulating pregnancy outcomes and fetal development. Thus, we evaluated overall sex-specific associations of phthalate/replacement, paraben, phenol biomarkers with sex-steroid thyroid hormones. Illinois (n=302) provided plasma for progesterone, estradiol, testosterone, free T4 (FT4), total (TT4), stimulating hormone (TSH) at median 17 weeks gestation. Women also up-to-five first-morning urine samples monthly across (8-40 weeks), which pooled measure 19 phthalate/replacement metabolites (reflecting ten parent compounds), three parabens, six phenols. We used linear regression evaluate hormones, as well weighted quantile sum Bayesian kernel machine (BKMR) assess cumulative associations, non-linearities, chemical interactions. In relatively high socioeconomic status, several EDC were associated select without or non-linear FT4, TT4. The biomarker mixture was negatively estradiol (only higher concentrations using BKMR), TSH, where each 10% increase -5.65% (95%C.I.: -9.79, -1.28) lower testosterone -0.09 μIU/mL (95%CI: -0.20, 0.00) TSH. Associations FT4 did not differ by sex. However, in carrying females, identified an inverted u-shaped relationship the estradiol. Additionally, 1.50% -0.15, 3.18) TT4, whereas males, -1.77% -4.08, 0.58) TT4 -0.18 -0.33, -0.03) Some early-to-mid There some associations. Future studies could consider how these findings relate pregnancy/birth outcomes.

Language: Английский

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Co-exposure to polystyrene nanoplastics and triclosan induces synergistic cytotoxicity in human KGN granulosa cells by promoting reactive oxygen species accumulation

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 273, P. 116121 - 116121

Published: Feb. 24, 2024

In recent years, nanoplastics (NPs) and triclosan (TCS, a pharmaceutical personal care product) have emerged as environmental pollution issues, their combined presence has raised widespread concern regarding potential risks to organisms. However, the toxicity mechanisms of NPs TCS remain unclear. this study, we investigated toxic effects polystyrene on KGN cells, human ovarian granulosa cell line. We exposed cells (150 μg/mL) (15 μM) alone or together for 24 hours. Co-exposure significantly reduced viability. Compared with exposure alone, co-exposure increased reactive oxygen species (ROS) production. Interestingly, produced synergistic effects. examined activity superoxide dismutase (SOD) catalase (CAT), two antioxidant enzymes; it was decreased after co-exposure. also noted an increase in lipid oxidation product malondialdehyde (MDA) Furthermore, had more detrimental effect mitochondrial function than individual treatments. activated NRF2–KEAP1–HO-1 stress pathway. Surprisingly, expression SESTRIN2, protein, inhibited by autophagy-related proteins LC3B-II LC3B-Ⅰ P62. Moreover, enhanced CASPASE-3 BCL-2/BAX ratio. summary, our study revealed vitro exposure. Our findings provide insight into associated inducing oxidative stress, activations NRF2-KEAP1-HO-1 pathway, autophagy, apoptosis.

Language: Английский

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Reproductive endocrine disruption effect and mechanism in male zebrafish after life cycle exposure to environmental relevant triclosan

Aquatic Toxicology, Journal Year: 2024, Volume and Issue: 270, P. 106899 - 106899

Published: March 13, 2024

Language: Английский

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Toxic effects of triclosan on hepatic and intestinal lipid accumulation in zebrafish via regulation of m6A-RNA methylation

Aquatic Toxicology, Journal Year: 2024, Volume and Issue: 269, P. 106884 - 106884

Published: March 2, 2024

Language: Английский

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GESTATIONAL TRICLOSAN EXPOSURE AND ITS EFFECTS ON CHILDNEURODEVELOPMENT - A SYSTEMATIC REVIEW

Reproductive Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 108849 - 108849

Published: Jan. 1, 2025

Language: Английский

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Unveiling the effect of urinary xenoestrogens on chronic kidney disease in adults: A machine learning model

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 292, P. 117945 - 117945

Published: Feb. 22, 2025

Language: Английский

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Bioremediation of Synthetic Wastewater with Contaminants of Emerging Concern by Nannochloropsis sp. and Lipid Production: A Circular Approach

Bioengineering, Journal Year: 2025, Volume and Issue: 12(3), P. 246 - 246

Published: Feb. 28, 2025

Contaminants of emerging concern (CECs) pose a potential risk to human and environmental health. Microalgae bioremediation is promising approach for transforming or removing contaminants from the environment, while contributing circular economy. In this study, Nannochloropsis sp. was effectively used simultaneous removal six CECs: paracetamol, ibuprofen, imidacloprid, methylparaben bisphenol A at 10 µg mL−1 triclosan 0.5 synthetic wastewater, which were able survive under such concentrations, higher than those commonly found in environment (up 2.82 methylparaben). High efficiencies reached (100%) (93 ± 2%), paracetamol 30 1%, 64 2% 49 5% removed, respectively. Subsequently, lipids extracted, FAME profile characterised using GS-MS. The main fatty acids identified after hexadecadienoic acid isomers (C16:2), palmitic (C16), linoleic (C18:2) γ-linolenic (C18:3). absence oleic stearic noticed, suggesting an alteration lipidic due contaminant exposure. By exploring quantification future work, applications extracted can be explored, further demonstrating feasibility process.

Language: Английский

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