Insight into the Regulation Mechanism of Iron Oxide Nanoparticles in Anammox Consortia: Autophagy-Dependent Ferroptosis

ACS ES&T Water, Journal Year: 2024, Volume and Issue: 4(4), P. 1751 - 1762

Published: Feb. 9, 2024

Iron oxide nanoparticles (IONPs) have been widely used and pose a high risk to human animal health. In this study, the fate regulation mechanism of γ-Fe2O3 NPs in an anaerobic ammonium oxidation (anammox) system were studied from perspective morphology, biotransformation, microbial interaction. The lowest nitrogen removal efficiency (NRE) anammox process was 63.8% under NP stress. Fe(II) Fe(III) concentrations increased with bioaccumulation NPs, which caused high-level reactive oxygen species (ROS) ferroptosis consortia. They inhibited synthesis pathways ATP heme c, further reduced detoxification ability microbiota. Moreover, could be oxidized form Fe(III)-O, formed biocrusts on cell surface limited substrate utilization. Microbial community analysis showed that low-concentration abundance functional bacteria related transformation, while 50 mg L–1 significantly their activity metabolism. These findings deepen our understanding Fe–N network provide guidance for practical application operation process, especially treating wastewater containing iron nanomaterials.

Language: Английский

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Ferrostatin‑1 alleviates liver injury via decreasing ferroptosis following ricin toxin poisoning in rat

Toxicology, Journal Year: 2024, Volume and Issue: 503, P. 153767 - 153767

Published: March 1, 2024

Ricin is a highly toxic plant toxin that can cause multi-organ failure, especially liver dysfunction, and potential bioterrorism agent. Despite the serious public health challenge posed by ricin, effective therapeutic for ricin-induced poisoning currently unavailable. Therefore, it important to explore mechanism of ricin develop appropriate treatment protocols accordingly. Previous studies have shown lipid peroxidation iron accumulation are associated with poisoning. Ferroptosis an iron-dependent form cell death caused excessive peroxide. The role ferroptosis in unclear require further study. We investigated effect on injury elucidated mechanism. results showed occurred ricin-intoxicated rats, Ferrostatin‑1 could ameliorate hepatic thus injury. induced decreasing reduced glutathione protein level peroxidase 4 Solute Carrier Family 7 Member 11, increasing iron, malondialdehyde reactive oxygen species, mitochondrial damage, whereas pretreatment increased decreased malondialdehyde, ameliorated thereby alleviated These suggested exacerbated after inhibition may be novel strategy

Language: Английский

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α‐Lipoic Acid Ameliorates Arsenic‐Induced Lipid Disorders by Promoting Peroxisomal β‐Oxidation and Reducing Lipophagy in Chicken Hepatocyte

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Abstract Liver disease poses a significant threat to global public health, with arsenic (As) recognized as major environmental toxin contributing liver injury. However, the specific mechanisms and protective effects of α‐lipoic acid (LA) remain unclear. Therefore, this study employs network toxicology pharmacology comprehensively analyze hepatotoxic mechanism As hepatoprotective LA, further verifies peroxisomal β‐oxidation lipophagy in process. The analysis results show that induces damage mainly through autophagy, apoptosis, lipid metabolism, oxidative stress, whereas LA exerts its properties by regulating metabolism. Further verifications find inhibits SIRT1 expression, activates P53 Notch pathways, damages mitochondria, β‐oxidation, increases accumulation, enhances liver, while intervention alleviates As‐induced accumulation targeting SIRT1, ameliorating mitochondrial damage, enhancing thereby alleviating damage. This clarifies hepatotoxicity provides theoretical basis for potential agent.

Language: Английский

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Ferritinophagy: multifaceted roles and potential therapeutic strategies in liver diseases

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 25, 2025

Ferritinophagy, the selective autophagic degradation of ferritin to release iron, is emerging as a critical regulator iron homeostasis and key player in pathogenesis various liver diseases. This review comprehensively examines mechanisms, regulation, multifaceted roles ferritinophagy health disease. Ferritinophagy intricately regulated by several factors, including Nuclear Receptor Coactivator 4 (NCOA4), Iron regulatory proteins signaling pathways such mTOR AMPK. These mechanisms ensure proper utilization prevent overload, which can induce oxidative stress ferroptosis. In diseases, exhibits dual roles. fibrosis, promoting hepatic stellate cells (HSCs) cell senescence reduce fibrosis progression. However, non-alcoholic fatty disease (NAFLD), chronic may exacerbate injury through overload stress. hepatocellular carcinoma (HCC), be harnessed novel therapeutic strategy inducing ferroptosis cancer cells. Additionally, implicated drug-induced sepsis-associated damage, highlighting its broad impact on pathology. also explores crosstalk between other autophagy pathways, mitophagy lipophagy, collectively influence cellular Understanding these interactions essential for developing comprehensive strategies targeting multiple pathways. summary, complex dynamic process with significant implications provides an in-depth analysis ferritinophagy's potential target, emphasizing need further research elucidate role

Language: Английский

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Lycopene, a natural plant extract, alleviates atrazine-induced ferroptosis in hepatocytes by activating cytochrome P450 oxidoreductase

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142311 - 142311

Published: March 1, 2025

Language: Английский

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A novel mechanism of FBXW7 in combating intervertebral disc degeneration: Mitigating ferroptosis in nucleus pulposus cells through the regulation of mitophagy

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 155, P. 114668 - 114668

Published: April 15, 2025

Language: Английский

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Oxidative stress and iron homeostasis imbalance mediate AlCl3-induced liver damage in mice

Journal of Environmental Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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miR-15b-5p promotes HgCl2-induced chicken embryo kidney cells ferroptosis by targeting β-TrCP-mediated ATF4 ubiquitin degradation

Toxicology, Journal Year: 2024, Volume and Issue: 503, P. 153742 - 153742

Published: Feb. 6, 2024

Language: Английский

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Follicular fluid-derived exosomal HMOX1 promotes granulosa cell ferroptosis involved in follicular atresia in geese (Anser cygnoides)

Poultry Science, Journal Year: 2024, Volume and Issue: 103(8), P. 103912 - 103912

Published: May 29, 2024

The proliferation and death of granulosa cells (GCs) in poultry play a decisive role follicular fate egg production. fluid (FF) contains variety nutrients genetic substances to ensure the communication between cells. Exosomes, as new intercellular communication, could carry transport proteins, RNA, lipids react on GCs, which had been found FF various domestic animals. Whether exosomes similar is unclear. In this study, geese, with low production, were chosen, effect GCs was investigated. Firstly, there not only large number healthy small yellow follicles (HSYFs) but also some atresia (ASYFs) egg-laying stage. Also, GC layers ASYFs became loose interconnections, inward detachment, diminished survival rate than that HSYFs. Besides, compared HSYFs, contents E2, P4, mRNA expression levels ferroptosis-related genes GPX4, FPN1, FTH1 significantly decreased, while COX2, NCOA4, VDAC3 increased, structure mitochondrial cristae disappeared outer membrane broke ASYFs. Moreover, ROS, MDA, oxidation higher those All these hinted ferroptosis might result involvement follicle atresia. Secondly, isolated from HSYFs ASYFs, respectively, identified by TEM, NTA, detection exosome marker proteins. we phagocytic tracking CM‐Dil. addition ASYF-FF elevated MDA content, Fe2+ levels, potential thus inhibiting restored inhibitor ferrostatin-1. Thirdly, proteomic sequencing performed FF-derived We obtained 1615 differentially expressed mainly enriched protein pathways. Among them, HMOX1 pathway based differential protein-protein interaction network analysis. Finally, regulating further explored. highly observed HSYF-FF. Overexpression increased ATG5, LC3II, NCOA4 reduced FTH1, PCBP2, FPN1 pathway, promoted intracellular accumulation surge, drove GCs. effects be blocked its Znpp. Taken together, important FF, delivered via exosomes, triggering determining follicles.

Language: Английский

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Copper exposure promotes ferroptosis of chicken (Gallus gallus) kidney cells and causes kidney injury

Journal of Trace Elements in Medicine and Biology, Journal Year: 2024, Volume and Issue: 86, P. 127501 - 127501

Published: July 23, 2024

Language: Английский

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