Environmentally Relevant Concentrations of S-6PPD-Quinone Caused More Serious Hepatotoxicity Than R-Enantiomer and Racemate in Oncorhynchus mykiss DOI
Shanshan Di,

Haigui Xu,

Yundong Yu

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(40), P. 17617 - 17628

Published: Sept. 23, 2024

6PPD-quinone (6PPD-Q) is frequently detected in various environmental media, and the environmentally relevant concentrations can be fatal to

Language: Английский

Tire-rubber related pollutant 6-PPD quinone: A review of its transformation, environmental distribution, bioavailability, and toxicity DOI
Xin Hua, Dayong Wang

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 459, P. 132265 - 132265

Published: Aug. 15, 2023

Language: Английский

Citations

82
Widespread occurrence of two typical N, N’-substituted p-phenylenediamines and their quinones in humans: Association with oxidative stress and liver damage DOI
Shiming Song, Yanxia Gao,

Shuai Feng

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 468, P. 133835 - 133835

Published: Feb. 19, 2024

Language: Английский

Citations

37
Polyethylene nanoparticles at environmentally relevant concentrations enhances neurotoxicity and accumulation of 6-PPD quinone in Caenorhabditis elegans DOI

Xin Hua,

Dayong Wang

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 918, P. 170760 - 170760

Published: Feb. 6, 2024

Language: Английский

Citations

28
Evaluation of 6-PPD quinone toxicity on lung of male BALB/c mice by quantitative proteomics DOI
Wenmiao He,

Chao Jie,

Aihua Gu

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 922, P. 171220 - 171220

Published: Feb. 25, 2024

Language: Английский

Citations

26
Comparison of intestinal toxicity in enhancing intestinal permeability and in causing ROS production of six PPD quinones in Caenorhabditis elegans DOI
Yuxing Wang, Geyu Liang, Jie Chao

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 927, P. 172306 - 172306

Published: April 7, 2024

Language: Английский

Citations

25
Exposure to 6-PPD quinone causes ferroptosis activation associated with induction of reproductive toxicity in Caenorhabditis elegans DOI

Zhengying Liu,

Qian Bian, Dayong Wang

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 471, P. 134356 - 134356

Published: April 19, 2024

Language: Английский

Citations

25
Environmentally realistic dose of tire-derived metabolite 6PPD-Q exposure causes intestinal jejunum and ileum damage in mice via cannabinoid receptor-activated inflammation DOI
Yang Yan,

Nan Sun,

Jia Lv

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 918, P. 170679 - 170679

Published: Feb. 5, 2024

Language: Английский

Citations

23
Chronic exposure to tire rubber-derived contaminant 6PPD-quinone impairs sperm quality and induces the damage of reproductive capacity in male mice DOI
Kezhen Yao,

Quanmin Kang,

Wenbo Liu

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 470, P. 134165 - 134165

Published: March 28, 2024

Language: Английский

Citations

21
Environmental profiles, hazard identification, and toxicological hallmarks of emerging tire rubber-related contaminants 6PPD and 6PPD-quinone DOI Creative Commons

Yang Jiang,

Chunzhi Wang,

Ling Ma

et al.

Environment International, Journal Year: 2024, Volume and Issue: 187, P. 108677 - 108677

Published: April 21, 2024

N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) is commonly used in rubber compounds as antioxidants to protect against degradation from heat, oxygen, and ozone exposure. This practice extends the lifespan of products, including tires, by preventing cracking, aging, deterioration. However, environmental consequences waste generated during product use, particularly formation 6PPD-quinone (6PPD-Q) through reaction 6PPD with ozone, have raised significant concerns due their detrimental effects on ecosystems. Extensive research has revealed widespread occurrence its derivate 6PPD-Q various compartments, air, water, soil. The emerging substance been shown pose acute mortality long-term hazards aquatic terrestrial organisms at concentrations below environmentally relevant levels. Studies demonstrated toxic a range organisms, zebrafish, nematodes, mammals. These include neurobehavioral changes, reproductive dysfunction, digestive damage exposure pathways. Mechanistic insights suggest that mitochondrial stress, DNA adduct formation, disruption lipid metabolism contribute toxicity induced 6PPD-Q. Recent findings human samples, such blood, urine, cerebrospinal fluid, underscore importance further public health toxicological implications these compounds. distribution, fate, biological effects, underlying mechanisms environment highlight urgent need for additional understand address impacts

Language: Английский

Citations

21
Exposure to 6-PPD quinone causes damage on mitochondrial complex I/II associated with lifespan reduction in Caenorhabditis elegans DOI

Xin Hua,

Geyu Liang, Jie Chao

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 472, P. 134598 - 134598

Published: May 13, 2024

Language: Английский

Citations

20