Ferroptosis in ulcerative colitis: Potential mechanisms and promising therapeutic targets

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116722 - 116722

Published: May 9, 2024

Ulcerative colitis (UC) is a complex immune-mediated chronic inflammatory bowel disease. It mainly characterized by diffuse inflammation of the colonic and rectal mucosa with barrier function impairment. Identifying new biomarkers for development more effective UC therapies remains pressing task current research. Ferroptosis newly identified form regulated cell death iron-dependent lipid peroxidation. As research deepens, ferroptosis has been demonstrated to be involved in pathological processes numerous diseases. A growing body evidence suggests that pathogenesis associated ferroptosis, regulation provides opportunities treatment. However, specific mechanisms which participates remain fully thoroughly investigated. Therefore, this review, we focus on advances mechanism recent years describe potential role UC. In addition, explore underlying crosslinked pathway between other such as macrophages, neutrophils, autophagy, endoplasmic reticulum stress, gut microbiota Finally, also summarize compounds may act inhibitors future.

Language: Английский

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The influence of microbiota on ferroptosis in intestinal diseases

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(2)

Published: Oct. 5, 2023

Ferroptosis is a distinctive form of iron-dependent necrotic cell death, characterized by excessive lipid peroxidation on cellular membranes and compromised antioxidant defenses. Multiple metabolic pathways, including iron metabolism, as well systems, contribute to the execution ferroptosis. The gut microbiota exerts regulatory effects ferroptosis through its microbial composition, biological functions, metabolites. Notably, most pathogenic bacteria tend promote ferroptosis, thereby inducing or exacerbating diseases, while probiotics have been shown protect against death. Given colonization in gut, an intimate association found between intestinal diseases microbiota. This review consolidates essential aspects ferroptotic processes, emphasizing key molecules delineating intricate interplay Moreover, this underscores potential utility modulation regulating for treatment diseases.

Language: Английский

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Inhibition of ferroptosis: A new direction in the treatment of ulcerative colitis by traditional Chinese medicine

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 324, P. 117787 - 117787

Published: Jan. 21, 2024

Ulcerative colitis (UC) is a chronic idiopathic intestinal disease of unknown cause and has been classified as one the modern intractable diseases by World Health Organization (WHO). Ferroptosis, an iron-ion-dependent mode programmed cell death, closely related to iron metabolism, lipid peroxidation, imbalance antioxidant system, plays important role in development UC. In this paper, we will review regulatory pathways ferroptosis, relationship between ferroptosis pathogenesis UC, treatment UC TCM from perspective inhibition, summarize mechanism action active ingredients compounds improve through look forward prospect application inhibition This paper aims elucidate combinations inhibiting ferroptosis. The have significant advantages multi-targets multi-pathways, current research hotspot prevention so key direction for future research. keywords "ferroptosis", "ulcerative colitis" "TCM" were searched Pubmed, CNKI, Wed Science databases. Papers clinical trials pharmacological up August 2023 screened inclusion. Combined with theory TCM, systematically summarized effects thus preventing A large number studies shown that inhibit inflammatory response oxidative stress course mainly interfering correcting metabolism peroxidative accumulation, regulating processes glutathione (GSH) peroxidase 4 (GPX4), colonic mucosal damage promote repair tissue. Since study still exploratory stage, many issues deserve attention future. reviews prevent treat future, should also further increase experimental explore whether more medicines can play therapeutic genes targeting seek therapies We believe use regulate treatment.

Language: Английский

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Gut microbiota in health and disease: advances and future prospects

MedComm, Journal Year: 2024, Volume and Issue: 5(12)

Published: Nov. 20, 2024

Abstract The gut microbiota plays a critical role in maintaining human health, influencing wide range of physiological processes, including immune regulation, metabolism, and neurological function. Recent studies have shown that imbalances composition can contribute to the onset progression various diseases, such as metabolic disorders (e.g., obesity diabetes) neurodegenerative conditions Alzheimer's Parkinson's). These are often accompanied by chronic inflammation dysregulated responses, which closely linked specific forms cell death, pyroptosis ferroptosis. Pathogenic bacteria trigger these death pathways through toxin release, while probiotics been found mitigate effects modulating responses. Despite insights, precise mechanisms influences diseases remain insufficiently understood. This review consolidates recent findings on impact immune‐mediated inflammation‐associated conditions. It also identifies gaps current research explores potential advanced technologies, organ‐on‐chip models microbiome–gut–organ axis, for deepening our understanding. Emerging tools, single‐bacterium omics spatial metabolomics, discussed their promise elucidating microbiota's disease development.

Language: Английский

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Polysaccharides of Floccularia luteovirens regulate intestinal immune response, and oxidative stress activity through MAPK/Nrf2/Keap1 signaling pathway in immunosuppressive mice

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 134140 - 134140

Published: July 27, 2024

Language: Английский

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Host–microbe interaction-mediated resistance to DSS-induced inflammatory enteritis in sheep

Microbiome, Journal Year: 2024, Volume and Issue: 12(1)

Published: Oct. 21, 2024

The disease resistance phenotype is closely related to immunomodulatory function and immune tolerance has far-reaching implications in animal husbandry human health. Microbes play an important role the initiation, prevention, treatment of diseases, but mechanisms host-microbiota interactions disease-resistant phenotypes are poorly understood. In this study, we hope uncover explain microbes intestinal diseases their action identify new potential treatments.

Language: Английский

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Ferroptosis: a potential bridge linking gut microbiota and chronic kidney disease

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: May 15, 2024

Abstract Ferroptosis is a novel form of lipid peroxidation-driven, iron-dependent programmed cell death. Various metabolic pathways, including those involved in and iron metabolism, contribute to ferroptosis regulation. The gut microbiota not only supplies nutrients energy the host, but also plays crucial role immune modulation balance. In this review, we explore pathways associated with impact on host metabolism. We subsequently summarize recent studies influence regulation by discuss potential mechanisms through which affects ferroptosis. Additionally, conduct bibliometric analysis relationship between context chronic kidney disease. This can provide new insights into current research status future microbiota.

Language: Английский

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Regulation of gut microbiota on immune cell ferroptosis: A novel insight for immunotherapy against tumor

Cancer Letters, Journal Year: 2024, Volume and Issue: 598, P. 217115 - 217115

Published: July 17, 2024

Language: Английский

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Pulmonary Flora‐Derived Lipopolysaccharide Mediates Lung‐Brain Axis through Activating Microglia Involved in Polystyrene Microplastic‐Induced Cognitive Dysfunction

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 5, 2024

Abstract Microplastics (MPs) have been detected in the atmospheric and human respiratory system, indicating that tract is a significant exposure route for MPs. However, effect of inhaled MPs on cognitive function has not adequately studied. Here, C57BL/6 J mouse model inhalation to polystyrene (PS‐MPs, 5 µm, 60 d) established by intratracheal instillation. Interestingly, vivo fluorescence imaging transmission electron microscopy reveal PS‐MPs do accumulate brain. behavioral experiments shows mice impaired, accompanied histopathological damage lung brain tissue. Transcriptomic studies hippocampal tissue demonstrated key neuroplasticity factors as well deficits linked injury, respectively. Mechanistically, lung‐brain axis plays central role PS‐MPs‐induced neurological damage, pulmonary flora transplantation, lipopolysaccharide (LPS) intervention, cell co‐culture experiments. Together, reduces altering composition produce more LPS promoting M1 polarization microglia, which provides new insights into mechanism nerve caused also sheds light prevention neurotoxicity environmental pollutants.

Language: Английский

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The Gut Microbiota Metabolite Butyrate Modulates Acute Stress-Induced Ferroptosis in the Prefrontal Cortex via the Gut–Brain Axis

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1698 - 1698

Published: Feb. 17, 2025

Stress has been implicated in the onset of mental disorders such as depression, with prefrontal cortex (PFC) playing a crucial role. However, underlying mechanisms remain to be fully elucidated. Metabolites secreted by intestinal flora can enter bloodstream and exert regulatory effects on body. Consequently, this study aims investigate molecular which gut influences ferroptosis PFC neurons, thereby affecting depression-like behavioral changes mice subjected acute stress. Initially, we established mouse model restraint stress (3-day duration) verified that stress-induced neurons contributed alterations mice, evidenced morphological, behavioral, biology assessments. Subsequently, through fecal microbiota transplantation (FMT) experiments, significant correlation between stress-exposed mice. 16S rDNA sequencing identified butyric acid-producing bacteria, specifically g_Butyricimonas its primary metabolite, acid, critical regulators acutely stressed Furthermore, intervention butyrate demonstrated potential ameliorate damage blood-brain barriers these This also mitigated behaviors induced alleviating systemic inflammatory responses. The findings indicate plays role Additionally, metabolite modulate gut-brain axis.

Language: Английский

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