Genetic Evidence for Estrogenic Effects of Benzophenone-2 on Zebrafish Neurodevelopment and Its Signaling Mechanism DOI
Zhipeng Qi,

Yue Zhai,

Yi Han

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 23, 2024

Estrogens play a crucial role in regulating various biological responses during the early stages of neurodevelopment. Benzophenone-2 (BP2), widely used organic ultraviolet (UV) filter, has been proven as an estrogenic compound, whereas effects BP2 on neurodevelopment remain largely unknown. Here, we investigated neurodevelopmental toxicity by exposing zebrafish embryos from 2 to 120 h postfertilization (hpf) at environmentally relevant concentrations. We demonstrated that life exposure induced multiple concentration-dependent impairments nervous system, including hypoactivity, abnormal brain morphology, impaired neurocyte proliferation, shortened axon, and increased apoptosis. Moreover, metabolomic profiling revealed decrease dopamine (DA) its metabolites BP2-treated larvae. Using E2 treatment morpholino knockdown assays, provided strong genetic evidence BP2-induced behavioral disorders were associated with estrogen-dependent signaling, especially estrogen receptors 2a 2b (esr2). Subsequently, transcriptomic indicated activation esr2 further inhibited expression LIM homeobox transcription factor 1 β (lmx1ba), which is vital for normal Consistently, overexpression lmx1ba inhibition obviously alleviated BP2-caused neurotoxicity, uncovering seminal toxicity. Our findings provide first fish can induce deficits dysfunction offer novel insights into mechanisms well other emerging benzophenones.

Language: Английский

Therapeutic potential of hydrogen-rich water in zebrafish model of Alzheimer’s disease: targeting oxidative stress, inflammation, and the gut-brain axis DOI Creative Commons
Jiaxuan He,

Peiye Xu,

Ting Xu

et al.

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 7, 2025

Alzheimer's disease (AD) is a complex neurodegenerative disorder, with amyloid-beta (Aβ) aggregation playing key role in its pathogenesis. Aβ-induced oxidative stress leads to neuronal damage, mitochondrial dysfunction, and apoptosis, making antioxidative strategies promising for AD treatment. This study investigates the effects of hydrogen-rich water (HRW) zebrafish model. Zebrafish were exposed aluminum chloride induce AD-like pathology then treated HRW using nanobubble device. Behavioral assays, ELISA, Hematoxylin-eosin (H&E) staining, reactive oxygen species (ROS) neutrophil fluorescence labeling employed assess HRW's impact. Additionally, 16S rRNA sequencing analyzed effect on gut microbiota. can significantly improve cognitive impairment depression-like behavior model, reduce Aβ deposition (p < 0.0001), regulate liver Soluble epoxide hydrolase (sEH) levels 0.05), neuroinflammation, stress. Furthermore, reduced number harmful bacteria linked by restoring balance microbiota gut. These findings suggest that has potential as therapeutic strategy targeting stress, inflammation, gut-brain axis modulation.

Language: Английский

Citations

1
Embryotoxic Effects of Pesticides in Zebrafish (Danio rerio): Diflubenzuron, Pyriproxyfen, and Its Mixtures DOI Creative Commons

Júlia Robert de Sousa Teixeira,

Augusto Monteiro de Souza,

João Vitor de Macedo-Sampaio

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(2), P. 160 - 160

Published: Feb. 18, 2024

Diflubenzuron (DFB) and pyriproxyfen (PPF) are larvicides used in crops to control insect plagues. However, these pesticides known impact non-target organisms like fish mammals. Here, we aimed at assessing the embryotoxicity of purified DFB, PPF, their mixtures a organism—zebrafish. Zebrafish embryos were exposed different concentrations for 120 h: 0.025, 0.125, 0.25, 1.25, 2.5, 10 mg/L PPF while 0.025 + DFB (Mix A), 0.125 B), 0.25 C) DFB. We observed mortality, teratogenicity, cardiotoxicity. For neurotoxicity tests evaluation reactive oxygen species (ROS) levels brain, h 0.379 0.754 established LC50 as 3.79 mg/L, was not determinable. Survival hatching affected by above 1.25 lower pesticide mixtures. exposure induced types malformations, higher number malformations mixtures, suggesting potentiating effect. Pesticides diminished avoidance responses increased ROS across all concentrations, indicating neurotoxicity. Our findings underscore detrimental exposure, spanning from biochemistry morphology. There is critical need reconsider global use transition more ecologically friendly forms pest control, raising an alarm regarding repercussions on human animal health well-being.

Language: Английский

Citations

8
Toxicity comparison of benzophenone-3 and its metabolite benzophenone-8 in different tissues of zebrafish DOI
Yonghua Wang,

Yujia Shang,

Xiaodan Liu

et al.

Aquatic Toxicology, Journal Year: 2024, Volume and Issue: 268, P. 106852 - 106852

Published: Jan. 29, 2024

Language: Английский

Citations

6
Neurotoxic and cardiotoxic effects of pyrogallol on catfish (Clarias gariepinus) DOI
Mohamed Hamed, Christopher J. Martyniuk, Hamdy A.M. Soliman

et al.

Environmental Toxicology and Pharmacology, Journal Year: 2024, Volume and Issue: 109, P. 104481 - 104481

Published: June 9, 2024

Language: Английский

Citations

6
Exposure Profiles, Determinants, and Health Risks of Chemicals in Personal Care Products Among Healthy Older Adults from the China BAPE Study DOI

Xiaojie Guo,

Jiankun Qian,

Huimin Ren

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 488, P. 137365 - 137365

Published: Jan. 25, 2025

Language: Английский

Citations

0
Environmentally relevant concentrations lithium exposure induces neurotoxicity in yellowstripe goby (Mugilogobius chulae): Responses of BDNF/AKT/FoxOs in regulating glutamate excitotoxicity and mitochondrial function DOI

Weibo Gong,

Yufei Zhao,

Huiyu Zhang

et al.

Aquatic Toxicology, Journal Year: 2025, Volume and Issue: 281, P. 107294 - 107294

Published: Feb. 20, 2025

Language: Английский

Citations

0
Optimization and Validation of a Multi-residue Method for Analyzing Organic UV Absorbers in Human Urine by UHPLC-MS/MS DOI
Lin Xiao,

Dejun Bao,

Qi Sun

et al.

Talanta, Journal Year: 2025, Volume and Issue: unknown, P. 128031 - 128031

Published: March 1, 2025

Language: Английский

Citations

0
Molecular response of earthworm, Eisenia fetida to Oxybenzone (Benzophenone-3) exposure DOI
Krishna Gautam,

S. Mangijao Singh,

Beena Vamadevan

et al.

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 975, P. 179265 - 179265

Published: March 31, 2025

Language: Английский

Citations

0
Use of Cosmetics in Pregnancy and Neurotoxicity: Can It Increase the Risk of Congenital Enteric Neuropathies? DOI Creative Commons

Kendra Jones,

Lucas M. Wessel, Karl‐Herbert Schäfer

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 984 - 984

Published: Aug. 10, 2024

Pregnancy is a particularly vulnerable period for the growing fetus, when exposure to toxic agents, especially in early phases, can decisively harm embryo development and compromise future health of newborn. The inclusion various chemical substances personal care products (PCPs) cosmetic formulations be associated with disruption damage nervous system. Microplastics, benzophenones, parabens, phthalates metals are among most common found cosmetics that have been shown induce neurotoxic mechanisms. Although neurotoxin believed minimal, different scenarios suggest these neurotoxins remain threat. Special attention should paid first weeks gestation, critical processes, like migration proliferation neural crest derived cells, start form ENS. Importantly, cross placental barrier affect embryo, but they also secreted breast milk, so babies exposed longer periods, even after birth. In this review, we explore how contained PCPs may role pathogenesis neurodevelopmental disorders neurodegenerative diseases and, therefore, congenital enteric aganglionosis as well postnatal motility disorders. Understanding mechanisms chemicals used their neurotoxicity crucial determining safety use during pregnancy.

Language: Английский

Citations

2
Use of Cosmetics in Pregnancy and Neurotoxicity: Increased Risk of Congenital Enteric Neuropathies DOI Open Access

Kendra Jones,

Lucas M. Wessel, Karl‐Herbert Schäfer

et al.

Published: July 4, 2024

The inclusion of various chemical substances in personal care products (PCPs) and cosmetic formulations can be associated with disruption damage to the nervous system. Microplastics, benzophenones, parabens, phthalates metals are among most common found cosmetics that have been shown induce neurotoxic mechanisms. Although neurotoxin exposure is believed minimal, different scenarios suggest these neurotoxins remain a threat. Special attention should paid early first gestation weeks, when critical processes, like migration proliferation neural crest derived cells start form ENS. Importantly, cosmetic&rsquo;s cross placenta barrier so affect future embryo, but also secreted breast milk, babies exposed for longer periods, even after birth. In this review we explore how contained PCPs may role pathogenesis neurodevelopment disorders neurodegenerative diseases, therefore congenital enteric aganglionosis as well postnatal motility disorders. Understanding mechanisms chemicals used their neurotoxicity crucial determining safety use during pregnancy.

Language: Английский

Citations

1