Journal of Biosciences and Medicines,
Journal Year:
2023,
Volume and Issue:
11(09), P. 90 - 113
Published: Jan. 1, 2023
Long
COVID
has
been
studied
as
different
sequelae
that
some
individuals
can
develop
after
the
acute
phase
of
disease.
Persistent
symptoms
such
dry
cough,
fatigue,
and
dyspnea
remain
six
months
COVID-19
cure.
Others
lung
fibrosis,
kidney
injury,
thrombotic
risk
also
are
observed.
Here,
a
deep
review
each
human
organ
system
infected
by
virus
was
performed
aiming
to
show
how
molecules
expression
cell
signaling
induce
organism
cure
or
injuries
and,
subsequently
sequelae.
The
suggests
importance
public
health
surveillance
for
these
cases
including
more
comprehensive
analysis
molecular
biology
tools
clarify
assist
in
prognosis,
treatment,
preventive
methods
potentially
serious
disorders
post-COVID-19
patients.
Saudi Journal of Biological Sciences,
Journal Year:
2022,
Volume and Issue:
29(5), P. 3586 - 3599
Published: Feb. 10, 2022
Coronavirus
disease
is
caused
by
the
SARS-CoV-2
virus.
The
virus
first
appeared
in
Wuhan
(China)
December
2019
and
has
spread
globally.
Till
now,
it
affected
269
million
people
with
5.3
deaths
224
countries
territories.
With
emergence
of
variants
like
Omicron,
COVID-19
cases
grew
exponentially,
thousands
deaths.
general
symptoms
include
fever,
sore
throat,
cough,
lung
infections,
and,
severe
cases,
acute
respiratory
distress
syndrome,
sepsis,
death.
predominantly
affects
lung,
but
can
also
affect
other
organs
such
as
brain,
heart,
gastrointestinal
system.
It
observed
that
75
%
hospitalized
patients
have
at
least
one
associated
comorbidity.
most
common
reported
comorbidities
are
hypertension,
NDs,
diabetes,
cancer,
endothelial
dysfunction,
CVDs.
Moreover,
older
pre-existing
polypharmacy
worsened
complications.
results
hypercoagulability
issues
gangrene,
stroke,
pulmonary
embolism,
This
review
aims
to
provide
latest
information
on
impact
CVDs,
COPD,
will
help
us
understand
current
scenario
comorbidities;
thus,
play
an
important
role
management
decision-making
efforts
tackle
International Journal of Environmental Research and Public Health,
Journal Year:
2022,
Volume and Issue:
19(11), P. 6555 - 6555
Published: May 27, 2022
Coronavirus
disease—COVID-19
(coronavirus
disease
2019)
has
become
the
cause
of
global
pandemic
in
last
three
years.
Its
etiological
factor
is
SARS-CoV-2
(Severe
Acute
Respiratory
Syndrome
type
2).
Patients
with
diabetes
(DM—diabetes
mellitus),
contrast
to
healthy
people
not
suffering
from
chronic
diseases,
are
characterised
by
higher
morbidity
and
mortality
due
COVID-19.
who
test
positive
for
SARCoV-2
at
risk
developing
hyperglycaemia.
In
this
paper,
we
present,
analyse
summarize
data
on
possible
mechanisms
underlying
increased
susceptibility
patients
mellitus
case
infection.
However,
further
research
required
determine
optimal
therapeutic
management
Abstract
Pre‐existing
cardiovascular
disease
(CVD)
increases
the
morbidity
and
mortality
of
COVID‐19
is
strongly
associated
with
poor
outcomes.
However,
SARS‐CoV‐2
infection
can
also
trigger
de
novo
acute
chronic
disease.
Acute
cardiac
complications
include
arrhythmia,
myocarditis
heart
failure,
which
are
significantly
higher
in‐hospital
mortality.
The
possible
mechanisms
by
causes
this
direct
damage
caused
viral
invasion
cardiomyocytes
as
well
indirect
through
systemic
inflammation.
long‐term
incompletely
characterised
thought
to
hypertension,
coronary
atherosclerosis
failure.
Although
some
cardiac‐related
symptoms
last
over
6
months,
effect
these
on
patient
health
remains
unclear.
risk
factors
remain
poorly
defined.
Determining
patients
most
at‐risk
vital
so
that
targeted
follow‐up
care
be
provided.
aim
review
was
summarise
current
evidence
consequences
may
cause
Infection Genetics and Evolution,
Journal Year:
2022,
Volume and Issue:
99, P. 105254 - 105254
Published: Feb. 23, 2022
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2),
accountable
for
causing
the
diseases
2019
(COVID-19),
is
already
declared
as
a
pandemic
disease
globally.
Like
previously
reported
SARS-CoV
strain,
novel
SARS-CoV-2
also
initiates
viral
pathogenesis
via
docking
spike-protein
with
membranal
angiotensin-converting
enzyme
(ACE2)
-
receptor
on
variety
of
cells
in
human
body.
Therefore,
COVID-19
broadly
characterized
that
targets
multiple
organs,
particularly
complications
organ-specific
accompanied
by
destruction
ACE2
Infectious Disease Reports,
Journal Year:
2023,
Volume and Issue:
15(6), P. 806 - 830
Published: Dec. 15, 2023
The
coronavirus
disease
2019
(COVID-19),
instigated
by
the
zoonotic
Severe
Acute
Respiratory
Syndrome
Coronavirus
2
(SARS-CoV-2),
rapidly
transformed
from
an
outbreak
in
Wuhan,
China,
into
a
widespread
global
pandemic.
A
significant
post-infection
condition,
known
as
'long-
COVID-19'
(or
simply
COVID'),
emerges
substantial
subset
of
patients,
manifesting
with
constellation
over
200
reported
symptoms
that
span
multiple
organ
systems.
This
also
'post-acute
sequelae
SARS-CoV-2
infection'
(PASC),
presents
perplexing
clinical
picture
far-reaching
implications,
often
persisting
long
after
acute
phase.
While
initial
research
focused
on
immediate
pulmonary
impact
virus,
recognition
COVID-19
multiorgan
disruptor
has
unveiled
gamut
protracted
and
severe
health
issues.
review
summarizes
primary
effects
COVID
respiratory,
cardiovascular,
nervous
It
delves
mechanisms
underlying
these
impacts
underscores
critical
need
for
comprehensive
understanding
COVID's
pathogenesis.
Journal of Clinical Medicine,
Journal Year:
2022,
Volume and Issue:
11(4), P. 948 - 948
Published: Feb. 11, 2022
The
coronavirus
disease
2019
(COVID-19),
a
deadly
pandemic
that
has
affected
millions
of
people
worldwide,
is
associated
with
cardiovascular
complications,
including
venous
and
arterial
thromboembolic
events.
Viral
spike
proteins,
in
fact,
may
promote
the
release
prothrombotic
inflammatory
mediators.
Vaccines,
coding
for
protein,
are
primary
means
preventing
COVID-19.
However,
some
unexpected
thrombotic
events
at
unusual
sites,
most
frequently
located
cerebral
sinus
but
also
splanchnic,
thrombocytopenia,
have
emerged
subjects
who
received
adenovirus-based
vaccines,
especially
fertile
women.
This
clinical
entity
was
soon
recognized
as
new
syndrome,
named
vaccine-induced
immune
probably
caused
by
cross-reacting
anti-platelet
factor-4
antibodies
activating
platelets.
For
this
reason,
regulatory
agencies
various
countries
restricted
use
vaccines
to
age
groups.
prevailing
opinion
experts,
however,
risk
developing
COVID-19,
clearly
outweighs
potential
risk.
point-of-view
aims
providing
narrative
review
epidemiological
issues,
data,
pathogenetic
hypotheses
thrombosis
linked
both
COVID-19
its
helping
medical
practitioners
offer
up-to-date
evidence-based
counseling
their
often-alarmed
patients
acute
or
chronic
Immunology,
Journal Year:
2022,
Volume and Issue:
168(3), P. 403 - 419
Published: Sept. 15, 2022
The
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
is
known
to
present
with
pulmonary
and
extra-pulmonary
organ
complications.
In
comparison
the
2009
pandemic
(pH1N1),
SARS-CoV-2
infection
likely
lead
more
disease,
multi-organ
effects,
including
cardiovascular
disease.
has
been
associated
long-term
but
molecular
changes
that
govern
this
remain
unknown.
study,
we
investigated
host
transcriptome
landscape
of
cardiac
tissues
collected
at
rapid
autopsy
from
seven
SARS-CoV-2,
two
pH1N1,
six
control
patients
using
targeted
spatial
transcriptomics
approaches.
Although
was
not
detected
in
tissue,
showed
upregulation
genes
DNA
damage
repair,
heat
shock,
M1-like
macrophage
infiltration
COVID-19
patients.
patient
samples,
were
further
confirmed
by
γ-H2Ax
immunohistochemistry.
comparison,
pH1N1
interferon-stimulated
genes,
particular
interferon
complement
pathways,
when
compared
These
data
demonstrate
emergence
distinct
transcriptomic
profiles
influenza
supporting
need
for
a
greater
understanding
effects
on
organs,
system
patients,
delineate
immunopathobiology
infection,
long
term
impact
health.
