Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Feb. 26, 2025
As
a
well-known
cancer
risk
region,
the
8q24
locus
is
frequently
amplified
in
variety
of
solid
tumors.
Here
we
identify
pseudogene-derived
oncogenic
lncRNA,
ZNF252P,
which
upregulated
types
by
copy
number
gain
as
well
c-Myc-mediated
transcriptional
activation.
Mechanistically,
ZNF252P
binds
and
drives
"phase
separation"
HNRNPK
ILF3
protein
nucleus
cytoplasm,
respectively,
to
transcriptionally
posttranscriptionally
activate
c-Myc,
thus
forming
c-Myc/ZNF252P/c-Myc
positive
feedback
loop.
These
findings
expand
understanding
relationship
between
genomic
instability
region
tumorigenesis
clarify
regulatory
mechanism
involved
transcription
posttranscription
from
perspective
RNA-mediated
nuclear
cytoplasmic
phase
separation,
sheds
light
on
dialogue
with
driver
oncogene
c-Myc.
The
pivotal
axis
ZNF252P/c-Myc
has
potential
promising
biomarker
therapeutic
target
development.
most
human
cancers.
Here,
authors
discover
that
located
8q24,
promotes
regulating
loop
through
separation
ILF3.
Cell Death Discovery,
Journal Year:
2023,
Volume and Issue:
9(1)
Published: May 18, 2023
Cancer-testis
genes
are
involved
in
the
occurrence
and
development
of
cancer,
but
role
cancer-testis-associated
lncRNAs
(CT-lncRNAs)
hepatocellular
carcinoma
(HCC)
remains
to
be
explored.
Here,
we
discovered
a
novel
CT-lncRNA,
LINC01977,
based
on
Genotype-Tissue
Expression
(GTEx)
The
Cancer
Genome
Atlas
(TCGA)
databases.
LINC01977
was
exclusively
expressed
testes
highly
HCC.
High
levels
correlated
with
poorer
overall
survival
(OS)
individuals
Functional
assays
showed
that
promoted
HCC
growth
metastasis
vitro
vivo.
Mechanistically,
directly
bound
RBM39
promote
further
entry
Notch2
into
nucleus,
thereby
preventing
ubiquitination
degradation
Notch2.
Furthermore,
RNA
binding
protein
IGF2BP2,
one
m6A
modification
readers,
enhanced
stability
resulting
its
high
level
Therefore,
data
suggest
interacts
promotes
progression
by
inhibiting
degradation,
indicating
may
potential
biomarker
therapeutic
target
for
patients.
International Journal of Oncology,
Journal Year:
2023,
Volume and Issue:
63(3)
Published: Aug. 1, 2023
Due
to
concealment,
high
invasiveness
and
a
lack
of
indicators,
malignant
tumors
have
emerged
as
one
the
deadliest
diseases
worldwide
their
incidence
is
rising
yearly.
Research
has
revealed
that
chaperonin
family
member,
containing
TCP‑1
(CCT),
serves
crucial
role
in
tumors.
CCT
involved
growth
numerous
such
lung
cancer,
breast
hepatocellular
carcinoma
colorectal
cancer
assists
folding
number
proteins
linked
KRAS,
p53
STAT3.
According
clinical
data,
highly
expressed
range
tumor
cells
associated
with
poor
patient
prognosis.
In
addition,
through
controlling
cell
cycle
or
interacting
other
(including
YAP1,
HoXB2
SMAD2),
an
effect
on
proliferation,
invasion
migration
cells.
As
result,
it
possible
will
become
new
marker
therapeutic
target,
which
provide
some
guidance
for
early
screening
late
present
review,
molecular
properties
are
introduced,
alongside
summary
its
interactions
cancer‑related
discussion
function
common
It
expected
review
offer
fresh
approaches
treatment
cancer.
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer,
Journal Year:
2024,
Volume and Issue:
1879(3), P. 189099 - 189099
Published: April 4, 2024
Protein
ubiquitination,
one
of
the
most
significant
post-translational
modifications,
plays
an
important
role
in
controlling
proteins
activity
diverse
cellular
processes.
The
reversible
process
protein
known
as
deubiquitination,
has
emerged
a
critical
mechanism
for
maintaining
homeostasis.
deubiquitinases
(DUBs),
which
participate
deubiquitination
are
increasingly
recognized
potential
candidates
drug
discovery.
Among
these
DUBs,
ubiquitin-specific
protease
9×
(USP9X),
highly
conserved
member
USP
family,
exhibits
versatile
functions
various
processes,
including
regulation
cell
cycle,
endocytosis,
apoptosis,
polarity,
immunological
microenvironment,
and
stem
characteristics.
dysregulation
abnormal
activities
USP9X
influenced
by
intricate
signaling
pathway
crosstalk
upstream
non-coding
RNAs.
complex
expression
patterns
controversial
clinical
significance
cancers
suggest
its
prognostic
biomarker.
Furthermore,
inhibitors
shown
promising
antitumor
holds
to
overcome
therapeutic
resistance
preclinical
models.
However,
comprehensive
summary
molecular
cancer
progression
is
currently
lacking.
In
this
review,
we
provide
delineation
participation
numerous
complicated
pathways
within
tumor
translational
applications
combat
resistance.
By
systematically
summarizing
updated
mechanisms
biology,
review
aims
contribute
advancement
therapeutics
essential
insights
specialists
clinicians
development
improved
treatment
strategies.
Journal of Hepatocellular Carcinoma,
Journal Year:
2022,
Volume and Issue:
Volume 9, P. 1029 - 1040
Published: Sept. 1, 2022
Abstract:
Hepatocellular
carcinoma
(HCC)
is
currently
the
second
leading
cause
of
cancer-related
deaths
worldwide,
with
high
morbidity
and
mortality.
The
clinical
diagnosis
HCC
mainly
depends
on
imaging
technology,
such
as
ultrasound
computed
tomography,
serum
biomarkers,
alpha-fetoprotein
(AFP).
However,
still
hard
to
diagnose
at
an
early
stage
due
low
sensitivity
above
mentioned
traditional
methods.
Typically,
diagnosed
advanced
when
limited
treatment
options
are
available.
It
urgent
identify
effective
biomarkers
for
HCC.
Increasing
evidence
uncovered
ncRNAs,
including
microRNAs
(miRNAs),
long
non-coding
RNAs
(lncRNAs),
circular
(circRNAs),
could
be
used
in
diagnosis.
aim
this
review
summarize
our
understanding
circulating
miRNAs,
lncRNAs
circRNAs
fluid-based
non-invasive
aiming
providing
new
insights
into
Keywords:
hepatocellular
carcinoma,
microRNAs,
RNAs,
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(12), P. 10299 - 10299
Published: June 18, 2023
This
review
paper
provides
an
extensive
analysis
of
the
rapidly
evolving
convergence
deep
learning
and
long
non-coding
RNAs
(lncRNAs).
Considering
recent
advancements
in
increasing
recognition
lncRNAs
as
crucial
components
various
biological
processes,
this
aims
to
offer
a
comprehensive
examination
these
intertwined
research
areas.
The
remarkable
progress
necessitates
thoroughly
exploring
its
latest
applications
study
lncRNAs.
Therefore,
insights
into
growing
significance
incorporating
methodologies
unravel
intricate
roles
By
scrutinizing
most
spanning
from
2021
2023,
understanding
how
techniques
are
employed
investigating
lncRNAs,
thereby
contributing
valuable
field.
is
aimed
at
researchers
practitioners
looking
integrate
their
lncRNA
studies.
Translational Cancer Research,
Journal Year:
2024,
Volume and Issue:
13(1), P. 423 - 436
Published: Jan. 1, 2024
Background:
Hepatocellular
carcinoma
(HCC),
a
malignant
tumor
with
high
mortality
rate,
is
serious
problem
worldwide.
This
research
sought
to
examine
how
long
non-coding
RNA
(lncRNA)
expression
in
hepatocellular
(HEIH)
affects
the
development
and
progression
of
HCC.
Experimental & Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
56(9), P. 1909 - 1920
Published: Sept. 2, 2024
Functional
variations
in
coding
and
noncoding
RNAs
are
crucial
tumorigenesis,
with
cancer-specific
alterations
often
resulting
from
chemical
modifications
posttranscriptional
processes
mediated
by
enzymes.
These
RNA
have
been
linked
to
tumor
cell
proliferation,
growth,
metastasis,
drug
resistance
valuable
for
identifying
diagnostic
or
prognostic
cancer
biomarkers.
The
diversity
of
modifications,
such
as
splicing,
polyadenylation,
methylation,
editing,
is
particularly
significant
due
their
prevalence
impact
on
progression.
Additionally,
other
including
acetylation,
circularization,
miRNA
isomerization,
pseudouridination,
recognized
key
contributors
development.
Understanding
the
mechanisms
underlying
these
can
enhance
our
knowledge
biology
facilitate
development
innovative
therapeutic
strategies.
Targeting
regulatory
enzymes
may
pave
way
novel
RNA-based
therapies,
enabling
tailored
interventions
specific
subtypes.
This
review
provides
a
comprehensive
overview
roles
various
progression
highlights
recent
advancements
applications.
Molecular Carcinogenesis,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 13, 2025
ABSTRACT
Hepatocellular
carcinoma
(HCC)
is
a
major
global
health
concern
that
accounts
for
more
than
80%
of
all
primary
hepatic
carcinomas.
The
long
noncoding
RNA
FGD5
antisense
1
(FGD5‐AS1)
has
been
linked
to
HCC
cell
stemness
and
proliferation.
However,
the
exact
function
FGD5‐AS1
in
remains
unclear.
Cell
viability
proliferation
were
examined
using
CCK8
colony
formation
assays,
respectively.
was
sphere
assay.
To
investigate
relation
between
Musashi
2
(MSI2)
(or
protein
kinase
D1
[PKD1]),
immunoprecipitation
pull‐down
assays
used.
Furthermore,
xenograft
mouse
model
established
evaluate
vivo.
FGD5‐AS1,
MSI2,
PKD1
upregulated
tissues.
knockdown
significantly
inhibited
viability,
proliferation,
cells
decreased
expression
PKD1,
octamer‐binding
transcription
factor
4,
SOX2,
NANOG,
Prominin‐1
cells.
Mechanistically,
increased
mRNA
stability
by
upregulating
MSI2
expression.
Both
ameliorated
sh‐FGD5‐AS1's
inhibition
stemness.
silencing
tumor
growth
promotes
activating
MSI2/PKD1
axis.
Our
study
provides
new
theoretical
foundation
development
novel
treatments.
