Cell Biology and Toxicology, Journal Year: 2024, Volume and Issue: 40(1)
Published: Sept. 18, 2024
The N
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)
Published: Feb. 17, 2023
Abstract Having a hypoxic microenvironment is common and salient feature of most solid tumors. Hypoxia has profound effect on the biological behavior malignant phenotype cancer cells, mediates effects chemotherapy, radiotherapy, immunotherapy through complex mechanisms, closely associated with poor prognosis in various patients. Accumulating studies have demonstrated that normalization tumor vasculature, nanoparticle carriers biocarriers can effectively increase oxygen concentration microenvironment, improve drug delivery efficacy radiotherapy. They also infiltration innate adaptive anti-tumor immune cells to enhance immunotherapy. Furthermore, drugs targeting key genes hypoxia, including hypoxia tracers, hypoxia-activated prodrugs, hypoxia-inducible factors downstream targets, be used for visualization quantitative analysis antitumor activity. However, relationship between an area research requires further exploration. Here, we investigated potential development cancer, changes signaling pathways occur adapt environments, mechanisms hypoxia-induced tolerance, chemotherapeutic enhanced radiation as well insights applications therapy.
Language: Английский
Citations
521
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2606 - 2606
Published: Jan. 30, 2023
Cancer cells undergo metabolic reprogramming and switch to a ‘glycolysis-dominant’ profile promote their survival meet requirements for energy macromolecules. This phenomenon, also known as the ‘Warburg effect,’ provides advantage cancer make tumor environment more pro-cancerous. Additionally, increased glycolytic dependence promotes chemo/radio resistance. A similar is shown by immune in microenvironment, inducing competition between tumor-infiltrating over nutrients. Several recent studies have that targeting enhanced glycolysis promising strategy them susceptible treatment with other conventional modalities, including chemotherapy, radiotherapy, hormonal therapy, immunotherapy, photodynamic therapy. Although several strategies been developed of are different stages pre-clinical clinical evaluation, there still lack effective specifically target cell improve efficacy. Herein, we reviewed our current understanding role how this phenomenon could be potential efficacy
Language: Английский
Citations
164
Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(15), P. 9081 - 9112
Published: June 20, 2024
Nanomaterial-microorganism hybrid systems (NMHSs), integrating semiconductor nanomaterials with microorganisms, present a promising platform for broadband solar energy harvesting, high-efficiency carbon reduction, and sustainable chemical production. While studies underscore its potential in diverse solar-to-chemical conversions, prevailing NMHSs grapple suboptimal conversion efficiency. Such limitations stem predominantly from an insufficient systematic exploration of the mechanisms dictating flow. This review provides overview notable advancements this nascent field, particular focus on discussion three pivotal steps flow: capture, cross-membrane transport, into chemicals. key challenges faced each stage are independently identified discussed, viable solutions correspondingly postulated. In view interplay affecting overall efficiency conversion, subsequent discussions thus take integrative viewpoint to comprehend, analyze improve flow current different configurations, highlighting contemporary techniques that can be employed investigate various aspects within NMHSs. Finally, concluding section summarizes opportunities future research, providing roadmap continued development optimization
Language: Английский
Citations
21
Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)
Published: Feb. 11, 2025
Abstract Accumulated evidence has implicated the diverse and substantial influence of lactate on cellular differentiation fate regulation in physiological pathological settings, particularly intricate conditions such as cancer. Specifically, been demonstrated to be pivotal molding tumor microenvironment (TME) through its effects different cell populations. Within cells, impacts signaling pathways, augments shuttle process, boosts resistance oxidative stress, contributes lactylation. In various populations, interplay between immune cells governs processes differentiation, response, surveillance, treatment effectiveness. Furthermore, communication stromal/endothelial supports basal membrane (BM) remodeling, epithelial-mesenchymal transitions (EMT), metabolic reprogramming, angiogenesis, drug resistance. Focusing production transport, specifically dehydrogenase (LDH) monocarboxylate transporters (MCT), shown promise Inhibitors targeting LDH MCT act both suppressors enhancers immunotherapy, leading a synergistic therapeutic effect when combined with immunotherapy. The review underscores importance progression provides valuable perspectives potential approaches that target vulnerability metabolism, highlighting Heel Achilles for cancer treatment.
Language: Английский
Citations
9
Journal of Cancer, Journal Year: 2023, Volume and Issue: 14(13), P. 2574 - 2584
Published: Jan. 1, 2023
Background and aim:As non-coding RNAs, circular RNAs (circRNAs) contribute to the progression of malignancies by regulating various biological processes.In prostate cancer, however, there is still a lack understanding regarding potential molecular pathways roles circRNAs.Methods: Loss-off function experiments were performed investigate circRNA in cancer.Western blot, qRT-PCR, IHC assay used examine expression level different genes or circRNAs.Further biology conducted uncover mechanism underlying cancer using dual luciferase reporter RNA immunoprecipitation (RIP) assays.Results: A novel (hsa_circ_0124696, named circROBO1) was identified as significantly upregulated both cells tissues.Suppression circROBO1 attenuated proliferation cells.In addition, we found that knockdown remarkably increased sensitivity enzalutamide treatment.A deceleration glycolysis rate observed after inhibition circROBO1, which could suppress growth overcome resistance enzalutamide.Our results revealed promotes via accelerating glycolysis. Conclusion:Our study role circROBO1-miR-556-5p-PGK1 axis therapeutic target cancer.
Language: Английский
Citations
39
Cancers, Journal Year: 2023, Volume and Issue: 15(3), P. 726 - 726
Published: Jan. 24, 2023
Adipocytes are the main components in breast tissue, and cancer-associated adipocytes (CAAs) one of most important tumor microenvironment cancer (BC). Bidirectional regulation was found between CAAs BC cells. facilitates dedifferentiation adjacent to form with morphological biological changes. increase secretion multiple cytokines adipokines promote tumorigenesis, progression, metastasis by remodeling extracellular matrix, changing aromatase expression, metabolic reprogramming, shaping immune microenvironment. also associated therapeutic response provide potential targets therapy. The present review provides a comprehensive description crosstalk discusses strategies target overcome treatment resistance.
Language: Английский
Citations
29
Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 481, P. 215050 - 215050
Published: Feb. 2, 2023
Language: Английский
Citations
27
Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0
Published: Jan. 1, 2024
Metabolic reprogramming is a defining hallmark of cancer metastasis, warranting thorough exploration. The tumor-promoting function the "Warburg Effect", marked by escalated glycolysis and restrained mitochondrial activity, widely acknowledged. Yet, functional significance mitochondria-mediated oxidative phosphorylation (OXPHOS) during metastasis remains controversial. Circulating tumor cells (CTCs) are considered metastatic precursors that detach from primary or secondary sites harbor potential to seed distant metastases through hematogenous dissemination. A comprehensive metabolic characterization CTCs faces formidable obstacles, including isolation these rare billions blood cells, coupled with complexities ex vivo-culturing CTC lines establishment CTC-derived xenograft models (CDX). This review summarized role Effect" in both tumorigenesis CTC-mediated metastasis. Intriguingly, bioinformatic analysis single-CTC transcriptomic studies unveils OXPHOS dominance over Glycolysis signature genes across several important types. From observations, we postulate "Anti-Warburg (AWE) CTCs—a shift bridging tumors metastases. observed AWE could be clinically as they significantly correlated therapeutic response melanoma prostate patients. Thus, unraveling dynamic regulations within populations might reveal an additional layer regulatory providing avenue for innovative anti-metastasis therapies.
Language: Английский
Citations
14
Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217458 - 217458
Published: Jan. 1, 2025
Language: Английский
Citations
1
Frontiers in Cell and Developmental Biology, Journal Year: 2022, Volume and Issue: 10
Published: Sept. 19, 2022
Cancer cells and immune all undergo remarkably metabolic reprogramming during the oncogenesis tumor immunogenic killing processes. The increased dependency on glycolysis is most typical trait, profoundly involved in microenvironment cancer immunity regulation. However, how to best utilize glycolytic targets boost anti-tumor improve immunotherapies are not fully illustrated. In this review, we describe remodeling of various within (TME) deleterious effects limited nutrients acidification derived from enhanced immunological capacity. Moreover, elucidate underlying regulatory mechanisms reprogramming, including crosstalk between pathways checkpoint signaling. Importantly, summarize potential glycolysis-related that expected immunotherapy benefits. Our understanding will be instrumental for future therapeutic regimen development.
Language: Английский
Citations
32