International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 258, P. 129051 - 129051
Published: Dec. 28, 2023
Language: Английский
Pharmaceutics, Journal Year: 2021, Volume and Issue: 13(11), P. 1759 - 1759
Published: Oct. 21, 2021
In 2019, the world suffered from emergence of COVID-19 infection, one most difficult pandemics in recent history. Millions confirmed deaths this pandemic have been reported worldwide. This disaster was caused by SARS-CoV-2, which is last discovered member family Coronaviridae. Various studies shown that natural compounds effective antiviral properties against coronaviruses inhibiting multiple viral targets, including spike proteins and enzymes. review presents classification a detailed explanation SARS-CoV-2 molecular characteristics structure–function relationships. We present all currently available crystal structures different emphasized on structure virus binding modes their ligands. also discusses various therapeutic approaches for treatment vaccinations. addition, we highlight compare existing data about extracted algae, fungi, plants, scorpion venom were used as agents infection. Moreover, discuss repurposing select approved other viruses.
Language: Английский
Citations
58
Talanta, Journal Year: 2022, Volume and Issue: 253, P. 123992 - 123992
Published: Oct. 8, 2022
Language: Английский
Citations
58
MedComm, Journal Year: 2022, Volume and Issue: 3(1)
Published: Feb. 17, 2022
Abstract Since the rapid onset of COVID‐19 or SARS‐CoV‐2 pandemic in world 2019, extensive studies have been conducted to unveil behavior and emission pattern virus order determine best ways diagnosis thereof formulate effective drugs vaccines combat disease. The emergence novel diagnostic therapeutic techniques considering multiplicity reports from one side contradictions assessments other necessitates instantaneous updates on progress clinical investigations. There is also growing public anxiety time mutation COVID‐19, as reflected considerable mortality transmission, respectively, delta Omicron variants. We comprehensively review summarize different aspects prevention, diagnosis, treatment COVID‐19. First, biological characteristics were explained standpoint. Thereafter, preclinical animal models discussed frame symptoms effects patient with strategies in‐silico/computational biology. Finally, opportunities challenges nanoscience/nanotechnology identification, discussed. This covers almost all SARS‐CoV‐2‐related topics extensively deepen understanding latest achievements (last updated January 11, 2022).
Language: Английский
Citations
44
Advances in Natural Sciences Nanoscience and Nanotechnology, Journal Year: 2023, Volume and Issue: 14(3), P. 033001 - 033001
Published: Aug. 17, 2023
Abstract A critical step in the process for preventing and identifying emergencies relating to health, safety, welfare is testing quick diagnosis of microbial pathogens. Due fast spread waterborne food borne infections society high costs associated with them, pathogen identification has emerged as one most difficult parts water sectors. Since turn century, pathogens have demonstrated enormous epidemiological pandemic potential. The emergence dissemination a novel virus potential endanger livelihoods well-being individuals worldwide. severe acute respiratory syndrome-coronavirus-2 (SARS-COV-2) coronavirus propagated almost every country on Earth had considerable negative influence economies communities. Despite improvements techniques viral diseases, all nations must now execute biosensing speedy, sensitive, focused, consistent manner order address pressing global issues. Hence, this review, we critically summarised recent advancement electrochemical well optical biosensors monitoring SARS-COV-2 various Then, began by providing technical overview cutting-edge strategies utilised combat diseases it, including utilisation point-of-care technology (POCT), artificial intelligence (AI), internet medical things (IoMT). This review article explores integration POC, IoMT, AI technologies context personal healthcare, focusing their expedite treatment conditions, ultimately leading improved patient outcomes. Subsequently, notion execution multiplex are presented enhance comprehension detecting multiple analytes. Finally, conclusions future directions been presented.
Language: Английский
Citations
40
Computers in Biology and Medicine, Journal Year: 2023, Volume and Issue: 163, P. 107191 - 107191
Published: June 20, 2023
Language: Английский
Citations
25
Chemosphere, Journal Year: 2024, Volume and Issue: 352, P. 141269 - 141269
Published: Jan. 31, 2024
Language: Английский
Citations
9
International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(23), P. 12638 - 12638
Published: Nov. 23, 2021
Several coronaviruses (CoVs) have been associated with serious health hazards in recent decades, resulting the deaths of thousands around globe. The coronavirus pandemic has emphasized importance discovering novel and effective antiviral medicines as quickly possible to prevent more loss human lives. Positive-sense RNA viruses group spikes protruding from their surfaces an abnormally large genome enclose CoVs. CoVs already related a range respiratory infectious diseases possibly fatal humans, such MERS, SARS, current COVID-19 outbreak. As result, prevention, treatment, medications against (HCoV) is urgently needed. In years, many natural substances discovered variety biological significance, including properties. Throughout this work, we reviewed wide that interrupt life cycles for MERS well potential application treatment COVID-19.
Language: Английский
Citations
51
ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(8), P. 9136 - 9146
Published: April 15, 2024
We report a silver nanoparticle (AgNP) sensor array to detect SARS-CoV-2 viral particles utilizing five peptide receptors produce colorimetric response. show that the interaction of virus with peptides interferes shift in plasmonic absorbance and hinders formation snowflake-like fractal assemblies between AgNPs bridging peptides. The limit detection water was 500,000 copies/mL. demonstrate capabilities distinguish (Beta, Delta, Omicron variants) from influenza at 99% confidence level through linear discriminant analysis. also able discriminate three out negative exhaled breath condensate samples positive EBC samples.
Language: Английский
Citations
8
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 939, P. 173333 - 173333
Published: May 17, 2024
Language: Английский
Citations
8
Sensors, Journal Year: 2021, Volume and Issue: 21(23), P. 7823 - 7823
Published: Nov. 24, 2021
Selective, sensitive and affordable techniques to detect disease underlying health issues have been developed recently. Biosensors as nanoanalytical tools taken a front seat in this context. Nanotechnology-enabled progress the sector has aided pandemic management at very early stage efficiently. This report reflects state-of-the-art of nanobiosensor-based virus detection technology terms their methods, targets, limits detection, range, sensitivity, assay time, etc. The article effectively summarizes challenges with traditional technologies newly emerging biosensors, including nanotechnology-based kit for COVID-19; optically enhanced technology; electrochemical, smart wearable enabled nanobiosensors. less explored but crucial piezoelectric nanobiosensor reverse transcription-loop mediated isothermal amplification (RT-LAMP)-based biosensor are also discussed here. could be significance researchers doctors dedicated developing potent, versatile biosensors rapid identification COVID-19. kind is needed selecting suitable treatments avert epidemics.
Language: Английский
Citations
38