MedComm,
Journal Year:
2023,
Volume and Issue:
4(6)
Published: Nov. 20, 2023
Immune
responses
induced
by
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
infection
play
a
critical
role
in
the
pathogenesis
and
outcome
of
disease
2019
(COVID-19).
However,
dynamic
profile
immune
postinfection
SARS-CoV-2
variants
concern
(VOC)
is
not
fully
understood.
In
this
study,
peripheral
blood
mononuclear
cells
single-cell
sequencing
was
performed
to
determine
profiles
response
Prototype,
Alpha,
Beta,
Delta
rhesus
monkey
model.
Overall,
all
strains
dramatic
changes
both
cellular
subpopulations
gene
expression
levels
at
1
day
(dpi),
which
associated
function
including
adaptive
response,
innate
immunity,
IFN
response.
COVID-19-related
genes
revealed
different
dpi
among
four
strains,
reported
COVID-19
patients
with
increased
risk
autoimmune
rheumatic
diseases.
Delta-infected
animal
showed
inhibition
translation
pathway.
B
cells,
T
monocytes
much
commonality
rather
than
specificity
strains.
Monocytes
were
major
responders
infection,
lasted
longer
Alpha
other
Thus,
study
reveals
early
Proto
or
its
nonhuman
primates,
important
information
for
controlling
rapidly
evolving
viruses.
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: July 31, 2023
Abstract
Cellular
mechanotransduction,
a
critical
regulator
of
numerous
biological
processes,
is
the
conversion
from
mechanical
signals
to
biochemical
regarding
cell
activities
and
metabolism.
Typical
cues
in
organisms
include
hydrostatic
pressure,
fluid
shear
stress,
tensile
force,
extracellular
matrix
stiffness
or
tissue
elasticity,
viscosity.
Mechanotransduction
has
been
expected
trigger
multiple
such
as
embryonic
development,
repair
regeneration.
However,
prolonged
excessive
stimulation
can
result
pathological
multi-organ
fibrosis,
tumorigenesis,
cancer
immunotherapy
resistance.
Although
associations
between
normal
homeostasis
diseases
have
identified,
regulatory
mechanisms
among
different
are
not
yet
comprehensively
illustrated,
no
effective
therapies
currently
available
targeting
cue-related
signaling.
This
review
systematically
summarizes
characteristics
typical
conditions
with
updated
evidence.
The
key
effectors
responding
stimulations
listed,
Piezo
channels,
integrins,
Yes-associated
protein
(YAP)
/transcriptional
coactivator
PDZ-binding
motif
(TAZ),
transient
receptor
potential
vanilloid
4
(TRPV4).
We
also
reviewed
signaling
pathways,
therapeutic
targets
cutting-edge
clinical
applications
related
cues.
The Innovation,
Journal Year:
2023,
Volume and Issue:
4(6), P. 100503 - 100503
Published: Aug. 29, 2023
•Insights
into
the
intricate
facets
of
immune
microenvironment
hold
key
to
pioneering
clinical
strategies
in
combatting
bacterial
infections.•The
design
principles
for
antimicrobial
biomaterials
vary
depending
on
at
different
stages
infection.•Immunomodulatory
display
robust
efficacy
and
vaccine
attributes
animals
trials,
promising
intractable
infections.
Bacterial
infectious
diseases
are
one
leading
causes
death
worldwide.
Even
with
use
multiple
antibiotic
treatment
strategies,
4.95
million
people
died
from
drug-resistant
infections
2019.
By
2050,
number
deaths
will
reach
10
annually.
The
increasing
mortality
may
be
partly
due
heterogeneity
infection
microenvironment,
such
as
bacteria,
biofilms,
persister
cells,
intracellular
small
colony
variants.
In
addition,
complexity
makes
direct
activity
unsatisfactory
long-term
chronic
attributed
failing
modulate
active
action
cells.
Therefore,
there
is
an
urgent
need
effective
alternatives
treat
Accordingly,
development
immunomodulatory
has
recently
received
considerable
interest;
however,
a
comprehensive
review
their
research
progress
lacking.
this
review,
we
focus
mainly
future
perspectives
used
infection.
First,
describe
characteristics
acute
phases
Then,
highlight
corresponding
advantages
disadvantages.
Moreover,
discuss
biomaterial-mediated
vaccines'
potential
applications
challenges
activating
innate
adaptive
memory.
This
serve
reference
studies
develop
next-generation
accelerate
translation
practice.
Journal of Nanobiotechnology,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: Oct. 8, 2022
Abstract
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
led
to
COVID-19
and
has
become
a
pandemic
worldwide
with
mortality
of
millions.
Nanotechnology
can
be
used
deliver
antiviral
medicines
or
other
types
viral
reproduction-inhibiting
medications.
At
various
steps
infection,
nanotechnology
could
suggest
practical
solutions
for
usage
in
the
fight
against
infection.
Nanotechnology-based
approaches
help
SARS-CoV-2
Nanoparticles
play
an
essential
role
progressing
treatment
vaccine
production
efficacy
safety.
Nanocarriers
have
increased
speed
development
efficiency
vaccines.
As
result,
investigation
into
nanoparticles
as
nano-delivery
systems
nanotherapeutics
new
effective
methods
are
inhibiting
In
this
article,
we
compare
attributes
several
evaluate
their
capability
create
novel
vaccines
different
diseases,
especially
disease.
Graphical
MedComm,
Journal Year:
2022,
Volume and Issue:
3(1)
Published: Feb. 17, 2022
Abstract
Since
the
rapid
onset
of
COVID‐19
or
SARS‐CoV‐2
pandemic
in
world
2019,
extensive
studies
have
been
conducted
to
unveil
behavior
and
emission
pattern
virus
order
determine
best
ways
diagnosis
thereof
formulate
effective
drugs
vaccines
combat
disease.
The
emergence
novel
diagnostic
therapeutic
techniques
considering
multiplicity
reports
from
one
side
contradictions
assessments
other
necessitates
instantaneous
updates
on
progress
clinical
investigations.
There
is
also
growing
public
anxiety
time
mutation
COVID‐19,
as
reflected
considerable
mortality
transmission,
respectively,
delta
Omicron
variants.
We
comprehensively
review
summarize
different
aspects
prevention,
diagnosis,
treatment
COVID‐19.
First,
biological
characteristics
were
explained
standpoint.
Thereafter,
preclinical
animal
models
discussed
frame
symptoms
effects
patient
with
strategies
in‐silico/computational
biology.
Finally,
opportunities
challenges
nanoscience/nanotechnology
identification,
discussed.
This
covers
almost
all
SARS‐CoV‐2‐related
topics
extensively
deepen
understanding
latest
achievements
(last
updated
January
11,
2022).
Chemical Biology & Drug Design,
Journal Year:
2022,
Volume and Issue:
100(5), P. 699 - 721
Published: Aug. 25, 2022
Application
of
materials
capable
energy
harvesting
to
increase
the
efficiency
and
environmental
adaptability
is
sometimes
reflected
in
ability
discovery
some
traces
an
environment-either
experimentally
or
computationally-to
enlarge
practical
application
window.
The
emergence
computational
methods,
particularly
computer-aided
drug
(CADD),
provides
ample
opportunities
for
rapid
development
unprecedented
drugs.
expensive
time-consuming
process
traditional
no
longer
feasible,
nowadays
identification
potential
candidates
much
easier
therapeutic
targets
through
elaborate
silico
approaches,
allowing
prediction
toxicity
drugs,
such
as
repositioning
(DR)
chemical
genomics
(chemogenomics).
Coronaviruses
(CoVs)
are
cross-species
viruses
that
able
spread
expeditiously
from
into
new
host
species,
which
turn
cause
epidemic
diseases.
In
this
sense,
review
furnishes
outline
strategies
their
applications
discovery.
A
special
focus
placed
on
chemogenomics
DR
unique
emerging
system-based
disciplines
CoV
target
model
protein
networks
against
a
library
compounds.
Furthermore,
demonstrate
advantages
CADD
methods
rapidly
finding
deadly
virus,
numerous
examples
recent
achievements
grounded
molecular
docking,
chemogenomics,
reported,
analyzed,
interpreted
detail.
It
believed
outcome
assists
developers
systems
detection
future
unexpected
kinds
CoVs
other
variants.
