Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(10), P. 1410 - 1410
Published: Oct. 4, 2023
Metal
nanoparticles
(NPs)
have
garnered
considerable
attention,
due
to
their
unique
physicochemical
properties,
that
render
them
promising
candidates
for
various
applications
in
medicine
and
industry.
This
article
offers
a
comprehensive
overview
of
the
most
recent
advancements
manufacturing,
characterization,
biomedical
utilization
metal
NPs,
with
primary
focus
on
silver
gold
NPs.
Their
potential
as
effective
anticancer,
anti-inflammatory,
antimicrobial
agents,
drug
delivery
systems,
imaging
agents
diagnosis
treatment
variety
disorders
is
reviewed.
Moreover,
translation
therapeutic
settings,
issue
inclusion
clinical
trials,
are
assessed
light
over
30
investigations
concentrate
administering
either
or
NPs
conditions
ranging
from
nosocomial
infections
different
types
cancers.
paper
aims
not
only
examine
biocompatibility
nanomaterials
but
also
emphasize
challenges
may
limit
safe
integration
into
healthcare
practices.
More
than
100
nanomedicines
currently
market,
which
justifies
ongoing
study
use
medicine.
Overall,
present
review
highlight
innovative
therapeutics
field
biomedicine,
citing
some
relevant
current
applications.
Scientific Reports,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: Nov. 1, 2023
Abstract
The
green
methodologies
of
nanoparticles
with
plant
extracts
have
received
an
increase
interest.
Copper
oxide
(CuO
NPs)
been
utilized
in
a
many
applications
the
last
few
decades.
current
study
presents
synthesis
CuO
NPs
aqueous
extract
Morinda
citrifolia
as
stabilizing
agent.
leaf
was
mixed
solution
copper
sulphate
(CuSO
4
·5H
2
O)
and
sodium
hydroxide
catalyst.
UV–visible
spectroscopy,
FTIR,
XRD,
SEM,
TEM,
EDAX
analysis
were
performed
to
synthesized
NPs.
Particle
size
distribution
measured
dynamic
light
scattering.
highly
stable,
sphere-like,
particles
from
20
50
nm.
Furthermore,
as-formed
shown
strong
antibacterial
activity
against
Gram-positive
bacteria
(
Bacillus
subtilis,
Staphylococcus
aureus
),
Gram-negative
Escherichia
coli
).
revealed
similar
trend
analysed
for
antifungal
activity.
zone
inhibition
fungi
evaluated
Aspergillus
flavus
(13.0
±
1.1),
niger
(14.3
0.7),
Penicillium
frequentans
(16.8
1.4).
According
results
this
investigation,
may
be
used
biomedicine
replacement
agent
biological
applications.
ACS Sensors,
Journal Year:
2024,
Volume and Issue:
9(9), P. 4469 - 4494
Published: Sept. 9, 2024
Lung
cancer
remains
a
global
health
concern,
demanding
the
development
of
noninvasive,
prompt,
selective,
and
point-of-care
diagnostic
tools.
Correspondingly,
breath
analysis
using
nanobiosensors
has
emerged
as
promising
noninvasive
nose-on-chip
technique
for
early
detection
lung
through
monitoring
diversified
biomarkers
such
volatile
organic
compounds/gases
in
exhaled
breath.
This
comprehensive
review
summarizes
state-of-the-art
breath-based
diagnosis
employing
chemiresistive-module
supported
by
theoretical
findings.
It
unveils
fundamental
mechanisms
biological
basis
biomarker
generation
associated
with
cancer,
technological
advancements,
clinical
implementation
nanobiosensor-based
analysis.
explores
merits,
challenges,
potential
alternate
solutions
implementing
these
settings,
including
standardization,
biocompatibility/toxicity
analysis,
green
sustainable
technologies,
life-cycle
assessment,
scheming
regulatory
modalities.
highlights
nanobiosensors'
role
facilitating
precise,
real-time,
on-site
leading
to
improved
patient
outcomes,
enhanced
management,
remote
personalized
monitoring.
Additionally,
integrating
biosensors
artificial
intelligence,
machine
learning,
Internet-of-things,
bioinformatics,
omics
technologies
is
discussed,
providing
insights
into
prospects
intelligent
sniffing
nanobiosensors.
Overall,
this
consolidates
knowledge
on
breathomic
biosensor-based
screening,
shedding
light
its
significance
applications
advancing
medical
diagnostics
reduce
burden
hospitals
save
human
lives.
ACS Sustainable Chemistry & Engineering,
Journal Year:
2024,
Volume and Issue:
12(28), P. 10296 - 10312
Published: July 1, 2024
Climate
change
is
a
profound
crisis
that
affects
every
aspect
of
life,
including
public
health.
Changes
in
environmental
conditions
can
promote
the
spread
pathogens
and
development
new
mutants
strains.
Early
detection
essential
managing
controlling
this
improving
overall
health
outcomes.
This
perspective
article
introduces
basic
biosensing
concepts
various
biosensors,
electrochemical,
optical,
mass-based,
nano
single-molecule
as
important
sustainability
preventive
tools.
The
discussion
also
includes
how
biosensor
crucial
to
minimizing
impacts
ensuring
long-term
availability
vital
technologies
resources
for
healthcare,
monitoring,
beyond.
One
promising
avenue
pathogen
screening
could
be
electrical
biomolecules
at
level,
some
recent
developments
based
on
bioelectronics
using
Scanning
Tunneling
Microscopy-assisted
break
junctions
(STM-BJ)
technique
are
shown
here.
Using
technique,
detected
with
high
sensitivity,
eliminating
need
amplification
cell
culture
steps,
thereby
enhancing
speed
efficiency.
Furthermore,
STM-BJ
demonstrates
exceptional
specificity,
accurately
detects
single-base
mismatches,
exhibits
limit
essentially
level
individual
biomolecules.
Finally,
case
made
here
sustainable
they
help,
paradigm
shift
needed
achieve
them,
potential
applications.
ECS Sensors Plus,
Journal Year:
2022,
Volume and Issue:
1(4), P. 042401 - 042401
Published: Oct. 4, 2022
Neurodegenerative
diseases
(NDD)
are
progressive
degenerative
disorders
of
the
neurological
system
with
significant
social
impact
worldwide.
Their
detection
at
initial
stage
is
necessary
to
provide
proper
therapeutic
interventions.
Biosensors
have
emerged
as
one
next-generation
tools
for
detecting
and
monitoring
physiochemical
changes
associated
disorders.
This
article
discusses
current
status
challenges
different
state-of-the-art
sensors
which
can
detect
NDD
biomarkers.
A
brief
overview
developing
advanced
biosensors
help
nanotechnology
integration,
mainly
polymer-based
functional
nanomaterials,
has
been
mentioned
prospect
these
management.
