Molecular Cancer,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: Nov. 28, 2023
The
advent
of
iPSCs
has
brought
about
a
significant
transformation
in
stem
cell
research,
opening
up
promising
avenues
for
advancing
cancer
treatment.
formation
is
multifaceted
process
influenced
by
genetic,
epigenetic,
and
environmental
factors.
offer
distinctive
platform
investigating
the
origin
cancer,
paving
way
novel
approaches
to
treatment,
drug
testing,
tailored
medical
interventions.
This
review
article
will
provide
an
overview
science
behind
iPSCs,
current
limitations
challenges
iPSC-based
therapy,
ethical
social
implications,
comparative
analysis
with
other
types
also
discuss
applications
tumorigenesis,
future
tumorigenesis
highlight
successful
case
studies
utilizing
research.
conclusion
summarize
advancements
made
research
importance
continued
investment
iPSC
unlock
full
potential
these
cells.
Materials,
Journal Year:
2024,
Volume and Issue:
17(2), P. 456 - 456
Published: Jan. 18, 2024
Biomaterials
embody
a
groundbreaking
paradigm
shift
in
the
field
of
drug
delivery
and
human
applications.
Their
versatility
adaptability
have
not
only
enriched
therapeutic
outcomes
but
also
significantly
reduced
burden
adverse
effects.
This
work
serves
as
comprehensive
overview
biomaterials,
with
particular
emphasis
on
their
pivotal
role
delivery,
classifying
them
terms
biobased,
biodegradable,
biocompatible
nature,
highlighting
characteristics
advantages.
The
examination
delves
into
extensive
array
applications
for
biomaterials
encompassing
diverse
medical
fields
such
cancer
therapy,
cardiovascular
diseases,
neurological
disorders,
vaccination.
explores
actual
challenges
within
this
domain,
including
potential
toxicity
complexity
manufacturing
processes.
These
emphasize
necessity
thorough
research
continuous
development
regulatory
frameworks.
second
aim
review
is
to
navigate
through
compelling
terrain
recent
advances
prospects
envisioning
healthcare
landscape
where
they
empower
precise,
targeted,
personalized
delivery.
transform
staggering,
promise
treatments
tailored
individual
patient
needs,
offering
hope
improved
efficacy,
fewer
side
effects,
brighter
future
practice.
Cells,
Journal Year:
2024,
Volume and Issue:
13(6), P. 511 - 511
Published: March 14, 2024
Neuroinflammatory
and
neurodegenerative
disorders
including
Alzheimer’s
disease
(AD),
Parkinson’s
(PD),
traumatic
brain
injury
(TBI)
Amyotrophic
lateral
sclerosis
(ALS)
are
chronic
major
health
disorders.
The
exact
mechanism
of
the
neuroimmune
dysfunctions
these
pathogeneses
is
currently
not
clearly
understood.
These
show
dysregulated
inflammatory
responses,
activation
neurons,
glial
cells,
neurovascular
unit
damage
associated
with
excessive
release
proinflammatory
cytokines,
chemokines,
neurotoxic
mediators,
infiltration
peripheral
immune
cells
into
brain,
as
well
entry
mediators
through
damaged
endothelial
blood–brain
barrier
tight
junction
proteins.
Activation
leads
to
many
molecules
that
cause
neuroinflammation
neurodegeneration.
Gulf
War
Illness
(GWI)
myalgic
encephalomyelitis/chronic
fatigue
syndrome
(ME/CFS)
also
dysfunctions.
Currently,
there
no
effective
disease-modifying
therapeutic
options
available
for
diseases.
Human
induced
pluripotent
stem
cell
(iPSC)-derived
astrocytes,
microglia,
pericytes
used
models
drug
discovery.
This
review
highlights
certain
recent
trends
in
neuroinflammatory
responses
iPSC-derived
applications
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(3), P. e25400 - e25400
Published: Feb. 1, 2024
Articular
cartilage
injury
is
a
prevalent
clinical
condition
resulting
from
trauma,
tumors,
infection,
osteoarthritis,
and
other
factors.
The
intrinsic
lack
of
blood
vessels,
nerves,
lymphatic
vessels
within
tissue
severely
limits
its
self-regenerative
capacity
after
injury.
Current
treatment
options,
such
as
conservative
drug
therapy
joint
replacement,
have
inherent
limitations.
Achieving
perfect
regeneration
repair
articular
remains
an
ongoing
challenge
in
the
field
regenerative
medicine.
Tissue
engineering
has
emerged
key
focus
research,
aiming
to
utilize
cultured
expanded
cells
combined
with
suitable
scaffold
materials
create
viable,
functional
tissues.
This
review
article
encompasses
latest
advancements
seed
cells,
scaffolds,
cytokines.
Additionally,
role
stimulatory
factors
including
cytokines
growth
factors,
genetic
techniques,
biophysical
stimulation,
bioreactor
systems,
well
scaffolding
natural
synthetic
nanostructured
scaffolds
tissues
are
discussed.
Finally,
we
also
outline
signaling
pathways
involved
regeneration.
Our
provides
valuable
insights
for
scholars
address
complex
problem
repair.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
167, P. 115416 - 115416
Published: Sept. 6, 2023
Hydrogels
are
three-dimensional
polymer
networks
with
hydrophilic
properties.
The
modifiable
properties
of
hydrogels
and
the
structure
resembling
living
tissue
allow
their
versatile
application.
Therefore,
increasing
attention
is
focused
on
use
as
bioinks
for
(3D)
printing
in
engineering.
Bioprinting
involves
fabrication
complex
structures
from
several
types
materials,
cells,
bioactive
compounds.
Stem
cells
(SC),
such
mesenchymal
stromal
(MSCs)
frequently
employed
3D
constructs.
SCs
have
desirable
biological
ability
to
differentiate
into
various
high
proliferative
capacity.
Encapsulating
hydrogel
constructs
enhances
reparative
abilities
improves
likelihood
reaching
target
tissues.
In
addition,
created
can
simulate
environment
mimic
signals.
Importantly,
immunogenicity
scaffolds
minimized
through
patient-specific
biocompatibility
biodegradability
biopolymers.
Regenerative
medicine
taking
advantage
aforementioned
capabilities
regenerating
tissues-
muscle,
bones,
nerves,
heart,
skin,
cartilage.
Stem Cell Reviews and Reports,
Journal Year:
2024,
Volume and Issue:
20(6), P. 1375 - 1386
Published: April 19, 2024
Various
groups
including
animal
protection
organizations,
medical
research
centers,
and
even
federal
agencies
such
as
the
U.S.
Food
Drug
Administration,
are
working
to
minimize
use
in
scientific
experiments.
This
movement
primarily
stems
from
welfare
ethical
concerns.
However,
recent
advances
technology
new
studies
medicine
have
contributed
an
increase
experiments
throughout
years.
With
rapid
testing,
concerns
arise
issues,
high
cost,
complex
procedures,
potential
inaccuracies.Alternative
solutions
recently
been
investigated
address
problems
of
testing.
Some
these
technologies
related
stem
cell
technologies,
organ-on-a-chip,
organoids,
induced
pluripotent
models.
The
aim
review
is
focus
on
methodologies,
that
can
serve
alternative
testing
discuss
its
advantages
limitations,
alongside
regulatory
considerations.Although
methodologies
has
shortcomings,
it
replace
Achieving
this
requires
further
cells,
with
societal
technological
benefits.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(4), P. 2392 - 2392
Published: Feb. 18, 2024
Induced
pluripotent
stem
cells
(iPSCs)
are
derived
from
reprogrammed
adult
somatic
cells.
These
manipulated
in
vitro
to
express
genes
and
factors
essential
for
acquiring
maintaining
embryonic
cell
(ESC)
properties.
This
technology
is
widely
applied
many
fields,
much
attention
has
been
given
developing
iPSC-based
disease
models
validate
drug
discovery
platforms
study
the
pathophysiological
molecular
processes
underlying
onset.
Especially
neurological
diseases,
there
a
great
need
technological
research,
as
these
can
be
obtained
each
patient
carry
individual’s
bulk
of
genetic
mutations
unique
Moreover,
iPSCs
differentiate
into
multiple
types.
characteristics,
since
diseases
affected
by
limited
access
injury
sites,
composed
various
types,
complexity
reproducing
brain’s
anatomy,
challenges
postmortem
culture,
ethical
issues.
Neurodegenerative
strongly
impact
global
health
due
their
high
incidence,
symptom
severity,
lack
effective
therapies.
Recently,
analyses
using
specific,
confirmed
efficacy
testing
drugs.
review
summarizes
advances
iPSC
used
modelling
testing,
with
primary
focus
on
neurodegenerative
including
Parkinson’s
Alzheimer’s
diseases.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: March 7, 2024
The
failure
of
endogenous
repair
is
the
main
feature
neurological
diseases
that
cannot
recover
damaged
tissue
and
resulting
dysfunction.
Currently,
range
treatment
options
for
limited,
approved
drugs
are
used
to
treat
diseases,
but
therapeutic
effect
still
not
ideal.
In
recent
years,
different
studies
have
revealed
neural
stem
cells
(NSCs)
made
exciting
achievements
in
diseases.
NSCs
potential
self-renewal
differentiation,
which
shows
great
foreground
as
replacement
therapy
broadens
a
new
way
cell
therapy.
biological
functions
nerve
injury
include
neuroprotection,
promoting
axonal
regeneration
remyelination,
secretion
neurotrophic
factors,
immune
regulation,
improve
inflammatory
microenvironment
injury.
All
these
reveal
play
an
important
role
improving
progression
Therefore,
it
significance
better
understand
functional
view
this,
we
comprehensively
discussed
application
value
well
existing
problems
challenges.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(16), P. e35836 - e35836
Published: Aug. 1, 2024
Stem
cell
transplantation
has
emerged
as
a
promising
avenue
in
regenerative
medicine,
potentially
facilitating
tissue
repair
degenerative
diseases
and
injuries.
This
review
comprehensively
examines
recent
developments
challenges
stem
transplantation.
It
explores
the
identification
isolation
of
various
types,
including
embryonic,
induced
pluripotent,
adult
cells
derived
from
multiple
sources.
Additionally,
highlights
tissue-specific
applications
these
cells,
focusing
on
bone
cartilage
regeneration,
treatment
neurological
disorders,
management
hematological
conditions.
Future
advancements
effective
resolution
current
will
be
crucial
fully
realizing
potential
medicine.
With
responsible
ethical
practices,
field
can
transform
disease
injury
treatment,
ultimately
improving
quality
life
for
countless
individuals.
