BMEMat,
Journal Year:
2023,
Volume and Issue:
1(3)
Published: July 19, 2023
Abstract
Cell
therapy
has
revolutionized
the
treatment
of
various
diseases,
such
as
cancers,
genetic
disorders,
and
autoimmune
diseases.
Currently,
most
cell
products
rely
on
ex
vivo
engineering,
which
requires
sophisticated
manufacturing
processes
poses
safety
concerns.
The
implementation
in
situ
holds
potential
to
overcome
current
limitations
provides
a
broad
range
applications
clinical
feasibility
future.
A
variety
biomaterials
have
been
developed
improve
function
target
delivery
specific
types
due
their
excellent
biocompatibility,
tunable
properties,
other
functionalities,
provide
reliable
method
achieve
modulation
reprogramming.
In
this
article,
we
summarize
recent
advances
for
including
T
cells,
macrophages,
dendritic
stem
cells
reprogramming
leveraging
lipid
nanoparticles,
polymers,
inorganic
materials,
biomaterials.
Finally,
discuss
challenges
future
perspectives
therapy.
Med,
Journal Year:
2022,
Volume and Issue:
4(1), P. 51 - 66.e10
Published: Nov. 16, 2022
BackgroundHuman
induced
pluripotent
stem
cells
(iPSCs)
are
expected
to
be
useful
for
regenerative
medicine
many
diseases.
Many
researchers
have
focused
on
and
enabled
the
generation
of
differentiated
or
tissue-like
structures,
including
organoids,
which
help
ameliorate
target
To
promote
such
cell
therapies,
we
established
a
clinically
applicable
iPSC
haplobank
matching
as
people
possible
in
Japan.MethodsThrough
cooperation
with
several
organizations,
recruited
donors
whose
human
leukocyte
antigens
(HLAs)
involved
immunorejection
were
homozygous.
The
peripheral
umbilical
cord
blood
collected
from
was
used
production
by
electroporation
episomal
vectors.
These
lines
then
subjected
testing,
genome
analyses
sterility,
maximize
safety.FindingsWe
constructed
clinical-grade
27
7
according
good
manufacturing
practice
regulations.
However,
reasons
avoid
using
include
presence
residual
vectors
genetic
mutations
cancer-related
genes.ConclusionsThis
provides
HLA-matched
approximately
40%
Japanese
population.
Since
haplobank's
release
2015,
these
been
more
than
10
clinical
trials.
establishment
this
is
an
important
step
toward
application
iPSCs
therapies.FundingThis
study
supported
research
center
network
realization
Japan
Agency
Medical
Research
Development
(AMED)
under
grant
number
JP20bm0104001h0108.
Technological Forecasting and Social Change,
Journal Year:
2023,
Volume and Issue:
193, P. 122588 - 122588
Published: May 4, 2023
The
recent
devastating
pandemic
has
drastically
reminded
humanity
of
the
importance
constant
scientific
and
technological
progress.
A
strong
interdisciplinary
dialogue
between
academic
industrial
scientists
various
specialties,
entrepreneurs,
managers
public
is
paramount
in
triggering
new
breakthrough
ideas
which
often
emerge
at
interface
disciplines.
following
sections,
compiled
by
a
highly
diverse
group
authors,
are
summarizing
recently
achieved
game-changing
leaps
science
technology.
game-changers
range
from
paradigm
shifts
theories
to
make
impact
over
several
decades
that
have
potential
change
our
everyday
lives
tomorrow.
paper
an
relevance
for
thinkers,
large
corporations'
strategic
planners,
top
executives
alike;
it
provides
glimpse
into
what
further
breakthroughs
future
may
hold
thereby
intends
spark
with
its
readers.
Regenerative Therapy,
Journal Year:
2022,
Volume and Issue:
21, P. 527 - 539
Published: Oct. 31, 2022
Hair
loss,
or
alopecia,
is
associated
with
several
psychosocial
and
medical
comorbidities,
it
remains
an
economic
burden
to
individuals
the
society.
Alopecia
attributable
varied
mechanisms
features
a
multifactorial
predisposition,
available
conventional
interventions
have
limitations.
Thus,
therapeutic
strategies
for
alopecia
in
regenerative
medicine
are
currently
being
explored,
increasing
evidence
suggesting
that
mesenchymal
stem
cell
(MSC)
implantation,
MSC-derived
secretome
treatment,
blood-derived
platelet-rich
plasma
therapies
potential
treatment
options.
In
this
review,
we
searched
Cochrane
Library,
MEDLINE
(PubMed),
EMBASE,
Scopus
using
various
combinations
of
terms,
such
as
“stem
cell,”
“alopecia,”
“hair
loss,”
“Androgenetic
alopecia,”
“male-pattern
hair
“female-pattern
“regenerative
growth,”
“cell
therapy,”
“mesenchymal
cells,”
“MSC-derived
extracellular
vesicles,”
exosomes,”
“platelet-rich
plasma”
summarized
most
promising
treatments
alopecia.
Moreover,
further
opportunities
improving
efficacy
innovative
promoting
clinical
application
were
discussed.
Nature Biotechnology,
Journal Year:
2023,
Volume and Issue:
42(3), P. 413 - 423
Published: May 8, 2023
Abstract
Genetic
engineering
of
allogeneic
cell
therapeutics
that
fully
prevents
rejection
by
a
recipient’s
immune
system
would
abolish
the
requirement
for
immunosuppressive
drugs
or
encapsulation
and
support
large-scale
manufacturing
off-the-shelf
products.
Previously,
we
generated
mouse
human
hypoimmune
pluripotent
(HIP)
stem
cells
depleting
HLA
class
I
II
molecules
overexpressing
CD47
(
B2M
−/−
CIITA
+
).
To
determine
whether
this
strategy
is
successful
in
non-human
primates,
engineered
rhesus
macaque
HIP
transplanted
them
intramuscularly
into
four
macaques.
The
survived
unrestricted
16
weeks
immunocompetent
recipients
differentiated
several
lineages,
whereas
wild-type
were
vigorously
rejected.
We
also
endocrinologically
active
pancreatic
islet
showed
they
immunocompetent,
diabetic
humanized
mice
4
ameliorated
diabetes.
HIP-edited
primary
islets
40
an
recipient
without
immunosuppression,
unedited
quickly
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: April 26, 2024
The
induced
pluripotent
stem
cell
(iPSC)
technology
has
transformed
in
vitro
research
and
holds
great
promise
to
advance
regenerative
medicine.
iPSCs
have
the
capacity
for
an
almost
unlimited
expansion,
are
amenable
genetic
engineering,
can
be
differentiated
into
most
somatic
types.
been
widely
applied
model
human
development
diseases,
perform
drug
screening,
develop
therapies.
In
this
review,
we
outline
key
developments
iPSC
field
highlight
immense
versatility
of
modeling
therapeutic
applications.
We
begin
by
discussing
pivotal
discoveries
that
revealed
potential
a
nucleus
reprogramming
led
successful
generation
iPSCs.
consider
molecular
mechanisms
dynamics
as
well
numerous
methods
available
induce
pluripotency.
Subsequently,
discuss
various
iPSC-based
cellular
models,
from
mono-cultures
single
type
complex
three-dimensional
organoids,
how
these
models
elucidate
diseases.
use
examples
neurological
disorders,
coronavirus
disease
2019
(COVID-19),
cancer
diversity
disease-specific
phenotypes
modeled
using
iPSC-derived
cells.
also
used
high-throughput
screening
toxicity
studies.
Finally,
process
developing
autologous
allogeneic
therapies
their
alleviate
Physiological Reviews,
Journal Year:
2023,
Volume and Issue:
103(4), P. 2623 - 2677
Published: May 12, 2023
Mammalian
eggs
(oocytes)
are
formed
during
fetal
life
and
establish
associations
with
somatic
cells
to
form
primordial
follicles
that
create
a
store
of
germ
(the
pool).
The
size
this
pool
is
influenced
by
key
events
the
formation
factors
influence
subsequent
activation
follicle
growth.
These
regulatory
pathways
must
ensure
reserve
oocytes
within
in
humans
lasts
for
up
50
years,
yet
only
approximately
0.1%
will
ever
be
ovulated
rest
undergoing
degeneration.
This
review
outlines
mechanisms
govern
processes
oocyte
later
growth,
ovarian
stroma,
through
ovulation
particular
reference
human
oocytes/follicles.
In
addition,
effects
aging
on
female
reproductive
capacity
changes
number
quality
emphasized,
both
cellular
clinical
implications
discussed.
Finally,
details
current
developments
culture
systems
support
all
stages
growth
generate
mature
vitro
emerging
prospects
making
new
from
stem
outlined.
MedComm,
Journal Year:
2023,
Volume and Issue:
4(4)
Published: June 17, 2023
Abstract
Regeneration
is
a
complex
process
affected
by
many
elements
independent
or
combined,
including
inflammation,
proliferation,
and
tissue
remodeling.
Stem
cells
class
of
primitive
with
the
potentiality
differentiation,
regenerate
self‐replication,
multidirectional
immunomodulatory
functions.
their
cytokines
not
only
inextricably
linked
to
regeneration
ectodermal
skin
tissues,
but
also
can
be
used
for
treatment
variety
chronic
wounds.
produce
exosomes
in
paracrine
manner.
cell
play
an
important
role
regeneration,
repair,
accelerated
wound
healing,
biological
properties
which
are
similar
stem
cells,
while
safer
more
effective.
Skin
bone
tissues
critical
organs
body,
essential
sustaining
life
activities.
The
weak
repairing
ability
leads
pronounced
impact
on
quality
patients,
could
alleviated
treatment.
However,
there
obstacles
that
trough
improved
bioavailability.
This
paper
summarizes
applications
mechanisms
healing.
We
propose
new
ways
utilizing
through
different
nanoformulations,
liposomes
nanoliposomes,
polymer
micelles,
microspheres,
hydrogels,
scaffold
microneedles,
improve
use
healing
regeneration.
