Published: Nov. 15, 2024
Language: Английский
Talanta, Journal Year: 2023, Volume and Issue: 266, P. 125124 - 125124
Published: Aug. 26, 2023
Language: Английский
Citations
47
Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 164, P. 112409 - 112409
Published: April 12, 2024
Language: Английский
Citations
15
Cells, Journal Year: 2024, Volume and Issue: 13(8), P. 682 - 682
Published: April 15, 2024
The tumor microenvironment (TME) plays an important role in the process of tumorigenesis, regulating growth, metabolism, proliferation, and invasion cancer cells, as well contributing to resistance conventional chemoradiotherapies. Several types cells with relatively stable phenotypes have been identified within TME, including cancer-associated fibroblasts (CAFs), tumor-associated macrophages (TAMs), neutrophils, natural killer (NK) which shown modulate cell metastasis, interaction immune system, thus promoting heterogeneity. Growing evidence suggests that tumor-cell-derived extracellular vesicles (EVs), via transfer various molecules (e.g., RNA, proteins, peptides, lipids), play a pivotal transformation normal TME into their protumorigenic counterparts. This review article focuses on functions EVs modulation view how exosomes contribute importance for diagnosis therapy.
Language: Английский
Citations
9
Nano Letters, Journal Year: 2024, Volume and Issue: 24(28), P. 8732 - 8740
Published: July 3, 2024
Piwi-interacting RNAs (piRNAs) are small noncoding that repress transposable elements to maintain genome integrity. The canonical catalytic hairpin assembly (CHA) circuit relies on random collisions of free-diffused reactant probes, which substantially slow down reaction efficiency and kinetics. Herein, we demonstrate the construction a spatial-confined self-stacking for rapid sensitive imaging piRNA in living cells based intramolecular intermolecular hybridization-accelerated CHA. We rationally design 3WJ probe not only accelerates kinetics by increasing local concentration probes but also eliminates background signal leakage caused cross-entanglement preassembled probes. This strategy achieves high sensitivity good specificity with shortened assay time. It can quantify intracellular expression at single-cell level, discriminate tissues breast cancer patients healthy persons, situ image cells, offering new approach early diagnosis postoperative monitoring.
Language: Английский
Citations
9
TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 171, P. 117500 - 117500
Published: Dec. 22, 2023
Language: Английский
Citations
21
Genes, Journal Year: 2023, Volume and Issue: 14(7), P. 1429 - 1429
Published: July 11, 2023
Non-coding RNAs (ncRNAs) are, arguably, the enigma of RNA transcriptome. Even though there are more annotated ncRNAs (25,967) compared to mRNAs (19,827), we know far less about each genes that produce ncRNA, especially in terms their regulation, molecular functions, and interactions. Further, only beginning understand role differential regulation or function caused by genetic epigenetic perturbations, such as single nucleotide variants (SNV), deletions, insertions, histone/DNA modifications. The 22 papers this Special Issue describe emerging roles neurological, cardiovascular, immune, hepatic systems, name a few, well diseases cancer, Prader-Willi Syndrome, cardiac arrhythmias, diabetes. As begin class RNAs, strategies targeting could lead improved therapeutic interventions for some conditions.
Language: Английский
Citations
18
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 5, 2024
Abstract PIWI-interacting RNAs (piRNAs) have received a lot of attention for their functions in cancer research. This class short non-coding (ncRNA) has roles genomic stability, chromatin remodeling, messenger RNA (mRNA) integrity, and genome structure. We summarized the mechanisms underlying biogenesis regulatory molecular piRNAs. Among all piRNAs studied cancer, this review offers comprehensive analysis emerging piR-823 various types including colorectal, gastric, liver, breast, renal cancers, as well multiple myeloma. emerged crucial modulator hallmarks through regulating pathways. In current review, we analyzed several databases conducted an extensive literature search to explore influence carcinogenesis addition describing potential application prognostic diagnostic markers therapeutic toward ncRNA precision.
Language: Английский
Citations
8
Small Structures, Journal Year: 2023, Volume and Issue: 4(12)
Published: Aug. 11, 2023
Luminogens with aggregation‐induced emission properties (AIEgens), as a novel and attractive fluorescent molecule, have been used in various fields, such detection, imaging, disease treatment, which can overcome the traditional aggregation‐caused quenching of organic molecules. Nevertheless, AIEgens still problems water solubility fluorescence stability practical applications. Aiming for improving AIEgens’ performance promoting development diverse applications AIEgens, it is an available strategy to bind those inorganic materials abundant variety, easy synthesis, unique rigid pore structure. The constructed inorganic‐based AIE not only inherit luminescence characteristics but also retain biocompatibility degradability materials, endowing more versatility. Herein, up‐to‐date researches several representative are introduced, emphasis on their structure design, synthesis strategy, regulation AIE, application biological field. Finally, current situation, challenges, future potential discussed prospected.
Language: Английский
Citations
13
Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 10, 2025
Noncoding RNAs (ncRNAs) are identified as critical regulatory molecules in tumorigenesis and progression. Investigating the expression patterns of multiple ncRNAs living cells tissues may facilitate diagnosis cancers. Herein, we develop a programmable automatic cascade machinery for single-molecule profiling ncRNAs. This method involves two successive amplification events that can convert extremely low-abundance target into abundant FAM/Cy5 generation amplified fluorescence signals. The subsequent detection identify piR-36026 with FAM signal DSCAM-AS1 Cy5 signal. Due to high efficiency signal-to-noise ratio imaging, this achieve sensitive limit 44.67 aM 45.71 DSCAM-AS1, it measure endogenous at single-cell level. Moreover, healthy breast cancer demonstrates feasibility proposed diagnostics. By programming recognition sequences dumbbell probes, be extended other cancer-related ncRNAs, great prospects clinical applications.
Language: Английский
Citations
0
ACS Sensors, Journal Year: 2025, Volume and Issue: unknown
Published: March 6, 2025
Extracellular vesicles (EVs), as liquid biopsy markers for accurate tumor diagnosis, are considered to hold great promise. However, effectively isolating and sensitively detecting EVs with convenience still face challenges. Herein, we propose a highly sensitive specific platform EV detection by integrating metal-organic framework (MOF)-based DNA biobarcodes strategy rolling circle amplification (RCA)/G-quadruplex system. In this study, first, Zr-MOFs act signal converters comodification barcodes antibodies, converting amplifying the abundance of into barcodes. Second, released can trigger RCA, followed G-quadruplex formation further amplify signal. Consequently, approach significantly enhances sensitivity biomarker detection, achieving low limit 100 mL-1. Furthermore, offers high sensitivity, specificity, accuracy, simplicity, highlighting its potential clinical applications in noninvasive detection.
Language: Английский
Citations
0