Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

Nature Reviews Molecular Cell Biology, Journal Year: 2020, Volume and Issue: 21(7), P. 363 - 383

Published: March 30, 2020

Language: Английский

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Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology

Nature Reviews Molecular Cell Biology, Journal Year: 2022, Volume and Issue: 23(7), P. 499 - 515

Published: Feb. 21, 2022

Language: Английский

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Selective neuronal vulnerability in Parkinson disease

Nature reviews. Neuroscience, Journal Year: 2017, Volume and Issue: 18(2), P. 101 - 113

Published: Jan. 20, 2017

Language: Английский

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Mitochondria dysfunction in the pathogenesis of Alzheimer’s disease: recent advances

Molecular Neurodegeneration, Journal Year: 2020, Volume and Issue: 15(1)

Published: May 29, 2020

Abstract Alzheimer’s disease (AD) is one of the most prevalent neurodegenerative diseases, characterized by impaired cognitive function due to progressive loss neurons in brain. Under microscope, neuronal accumulation abnormal tau proteins and amyloid plaques are two pathological hallmarks affected brain regions. Although detailed mechanism pathogenesis AD still elusive, a large body evidence suggests that damaged mitochondria likely play fundamental roles AD. It believed healthy pool not only supports activity providing enough energy supply other related mitochondrial functions neurons, but also guards minimizing oxidative damage. In this regard, exploration multitude mechanisms altered constitutes novel promising therapeutic targets for disease. review, we will summarize recent progress underscores essential role dysfunction discuss underlying with focus on structural functional integrity including biogenesis dynamics, axonal transport, ER-mitochondria interaction, mitophagy proteostasis.

Language: Английский

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Redox metabolism: ROS as specific molecular regulators of cell signaling and function

Molecular Cell, Journal Year: 2021, Volume and Issue: 81(18), P. 3691 - 3707

Published: Sept. 1, 2021

Language: Английский

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The functional universe of membrane contact sites

Nature Reviews Molecular Cell Biology, Journal Year: 2019, Volume and Issue: 21(1), P. 7 - 24

Published: Nov. 15, 2019

Language: Английский

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Mitochondrial dynamics in adaptive and maladaptive cellular stress responses

Nature Cell Biology, Journal Year: 2018, Volume and Issue: 20(7), P. 755 - 765

Published: June 22, 2018

Language: Английский

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Microglia monitor and protect neuronal function through specialized somatic purinergic junctions

Science, Journal Year: 2019, Volume and Issue: 367(6477), P. 528 - 537

Published: Dec. 13, 2019

Microglia are the main immune cells in brain and have roles homeostasis neurological diseases. Mechanisms underlying microglia-neuron communication remain elusive. Here, we identified an interaction site between neuronal cell bodies microglial processes mouse human brain. Somatic junctions a specialized nanoarchitecture optimized for purinergic signaling. Activity of mitochondria was linked with junction formation, which induced rapidly response to activation blocked by inhibition P2Y12 receptors. Brain injury-induced changes at somatic triggered receptor-dependent neuroprotection, regulating calcium load functional connectivity. Thus, these could potentially monitor protect functions.

Language: Английский

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Calcium signalling in T cells

Nature reviews. Immunology, Journal Year: 2019, Volume and Issue: 19(3), P. 154 - 169

Published: Jan. 8, 2019

Language: Английский

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Amyloid β-based therapy for Alzheimer’s disease: challenges, successes and future

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: June 30, 2023

Abstract Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer’s disease (AD), and its accumulation has been considered as molecular driver pathogenesis progression. Aβ prime target for development AD therapy. However, repeated failures Aβ-targeted clinical trials have cast considerable doubt on amyloid cascade hypothesis whether drug followed correct course. recent successes targeted assuaged those doubts. In this review, we discussed evolution over last 30 years summarized application diagnosis modification. particular, extensively pitfalls, promises important unanswered questions regarding current anti-Aβ therapy, well strategies further study more feasible approaches optimization prevention treatment.

Language: Английский

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