Frontiers in Bioengineering and Biotechnology,
Journal Year:
2021,
Volume and Issue:
9
Published: Sept. 20, 2021
Wound
healing
is
a
common
physiological
process
which
consists
of
sequence
molecular
and
cellular
events
that
occur
following
the
onset
tissue
lesion
in
order
to
reconstitute
barrier
between
body
external
environment.
The
inherent
properties
hydrogels
allow
damaged
heal
by
supporting
hydrated
environment
has
long
been
explored
wound
management
aid
autolytic
debridement.
However,
chronic
non-healing
wounds
require
added
therapeutic
features
can
be
achieved
incorporation
biomolecules
cells
promote
faster
better
outcomes.
In
recent
decades,
numerous
have
developed
modified
match
time
scale
for
distinct
stages
healing.
This
review
will
discuss
effects
various
types
on
pathophysiology,
as
well
ideal
characteristics
healing,
crosslinking
mechanism,
fabrication
techniques
design
considerations
hydrogel
engineering.
Finally,
several
challenges
related
adopting
future
perspectives
are
discussed.
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(8), P. 12687 - 12722
Published: Aug. 10, 2021
Hydrogels,
due
to
their
excellent
biochemical
and
mechnical
property,
have
shown
attractive
advantages
in
the
field
of
wound
dressings.
However,
a
comprehensive
review
functional
hydrogel
as
dressing
is
still
lacking.
This
work
first
summarizes
skin
healing
process
relates
evaluation
parameters
then
reviews
advanced
functions
dressings
such
antimicrobial
adhesion
hemostasis,
anti-inflammatory
anti-oxidation,
substance
delivery,
self-healing,
stimulus
response,
conductivity,
recently
emerged
monitoring
feature,
strategies
adopted
achieve
these
are
all
classified
discussed.
Furthermore,
applications
for
treatment
different
types
wounds
incisional
excisional
summarized.
Chronic
also
mentioned,
focus
attention
on
infected
wounds,
burn
diabetic
Finally,
future
directions
further
proposed.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(2), P. 3194 - 3207
Published: Jan. 31, 2022
In
view
of
the
lack
a
specific
drug-sustained
release
system
that
is
responsive
to
chronic
wounds
type
II
diabetic
foot,
and
demands
for
frequent
movement
at
foot
wound,
pH/glucose
dual-responsive
metformin-released
adhesion-enhanced
self-healing
easy-removable
antibacterial
antioxidant
conductive
hemostasis
multifunctional
phenylboronic
acid
benzaldehyde
bifunctional
polyethylene
glycol-co-poly(glycerol
sebacic
acid)/dihydrocaffeic
l-arginine
cografted
chitosan
(PEGS-PBA-BA/CS-DA-LAG,
denoted
as
PC)
hydrogel
dressings
were
constructed
based
on
double
dynamic
bond
Schiff-base
phenylboronate
ester.
It
was
further
demonstrated
PC
promotes
wound
healing
by
reducing
inflammation
enhancing
angiogenesis
in
rat
model.
addition,
addition
metformin
(Met)
graphene
oxide
(GO),
well
their
synergy,
confirmed
better
promote
repair
vivo.
summary,
PC/GO/Met
hydrogels
with
stimuli-responsive
ability
easy
removability
have
shown
promoting
effect
athletic
provide
local-specific
drug
dual-response
strategy
treatment
feet.
Advanced Science,
Journal Year:
2021,
Volume and Issue:
8(8)
Published: March 5, 2021
Treatment
of
wounds
in
special
areas
is
challenging
due
to
inevitable
movements
and
difficult
fixation.
Common
cotton
gauze
suffers
from
incomplete
joint
surface
coverage,
confinement
movement,
lack
antibacterial
function,
frequent
replacements.
Hydrogels
have
been
considered
as
good
candidates
for
wound
dressing
because
their
flexibility
biocompatibility.
Nevertheless,
the
adhesive,
mechanical,
properties
conventional
hydrogels
are
not
satisfactory.
Herein,
cationic
polyelectrolyte
brushes
grafted
bacterial
cellulose
(BC)
nanofibers
introduced
into
polydopamine/polyacrylamide
hydrogels.
The
1D
polymer
rigid
BC
backbones
enhance
mechanical
property
hydrogels,
realizing
high
tensile
strength
(21-51
kPa),
large
strain
(899-1047%),
ideal
compressive
property.
Positively
charged
quaternary
ammonium
groups
tethered
provide
long-lasting
promote
crawling
proliferation
negatively
epidermis
cells.
Moreover,
rich
catechol
capable
adhering
various
surfaces,
meeting
adhesive
demand
movement
areas.
With
above
merits,
demonstrate
less
inflammatory
response
faster
healing
speed
vivo
on
rats.
Therefore,
multifunctional
show
stable
covering,
little
displacement,
antibacteria,
fast
healing,
demonstrating
promise
dressing.
Advanced Functional Materials,
Journal Year:
2021,
Volume and Issue:
31(18)
Published: Feb. 1, 2021
Abstract
Current
treatments
for
chronic
diabetic
wounds
remain
unsatisfactory
due
to
the
lack
of
ideal
wound
dressings
that
can
integrate
matching
mechanical
strength,
fast
self‐healability,
facile
dressing
change,
and
multiple
therapeutic
effects
into
one
system.
In
this
work,
benefiting
from
catechol
groups
effect
epigallocatechin‐3‐gallate
(EGCG,
green
tea
derivative),
a
smart
hydrogel
be
conveniently
obtained
through
copolymerization
complex
formed
by
EGCG
3‐acrylamido
phenylboronic
acid
(APBA)
(the
formation
boronate
ester
bond)
acrylamide.
The
resulting
features
adequate
properties,
self‐healing
capability,
tissue
adhesiveness.
Otherwise,
substantial
release
not
only
realize
anti‐oxidation,
antibacterial,
anti‐inflammatory
proangiogenic
effect,
modulation
macrophage
polarization
accelerate
healing,
but
also
facilitate
easy
change.
This
advanced
provides
effective
way
management
may
extended
therapy
other
complicated
healings.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(8), P. 13022 - 13036
Published: Aug. 3, 2022
Burns
are
a
common
health
problem
worldwide
and
highly
susceptible
to
bacterial
infections
that
difficult
handle
with
ordinary
wound
dressings.
Therefore,
burn
repair
is
extremely
challenging
in
clinical
practice.
Herein,
series
of
self-healing
hydrogels
(QCS/OD/TOB/PPY@PDA)
good
electrical
conductivity
antioxidant
activity
were
prepared
on
the
basis
quaternized
chitosan
(QCS),
oxidized
dextran
(OD),
tobramycin
(TOB),
polydopamine-coated
polypyrrole
nanowires
(PPY@PDA
NWs).
These
Schiff
base
cross-links
between
aminoglycoside
antibiotic
TOB
OD
enable
be
slowly
released
responsive
pH.
Interestingly,
acidic
substances
during
bacteria
growth
process
can
induce
on-demand
release
TOB,
avoiding
abuse
antibiotics.
The
antibacterial
results
showed
QCS/OD/TOB/PPY@PDA9
hydrogel
could
kill
high
concentrations
Pseudomonas
aeruginosa
(PA),
Staphylococcus
aureus,
Escherichia
coli
short
time
bactericidal
effect
for
up
11
days
an
agar
plate
diffusion
experiment,
while
showing
vivo
activity.
Excellent
long-lasting
properties
make
it
suitable
severely
infected
wounds.
Furthermore,
incorporation
PPY@PDA
endowed
near-infrared
(NIR)
irradiation
assisted
drug-resistant
bacteria,
conductivity,
Most
importantly,
PA-infected
model,
more
effectively
controlled
inflammation
levels
promoted
collagen
deposition,
vascular
generation,
earlier
closure
compared
Tegaderm
smart
delivery
advantageous
bacterial-infected
healing.
Advanced Functional Materials,
Journal Year:
2021,
Volume and Issue:
31(30)
Published: May 26, 2021
Abstract
Diabetic
wound
healing
still
faces
great
challenges
due
to
the
excessive
inflammation,
easy
infection,
and
impaired
angiogenesis
in
beds.
The
immunoregulation
of
macrophages
polarization
toward
M2
phenotype
that
facilitates
transition
from
inflammation
proliferation
phase
has
been
proved
be
an
effective
way
improve
diabetic
healing.
Herein,
phenotype‐enabled
anti‐inflammatory,
antioxidant,
antibacterial
conductive
hydrogel
scaffolds
(GDFE)
for
producing
rapid
repair
are
reported.
GDFE
fabricated
facilely
through
dynamic
crosslinking
between
polypeptide
polydopamine
graphene
oxide.
possess
thermosensitivity,
self‐healing
behavior,
injectability,
broad‐spectrum
activity,
antioxidant
anti‐inflammatory
ability,
electronic
conductivity.
effectively
activates
significantly
promotes
dermal
fibroblasts,
migration,
vitro
endothelial
cells
paracrine
mechanisms.
vivo
results
a
full‐thickness
model
demonstrate
can
rapidly
promote
skin
regeneration,
fast
anti‐inflammation
macrophage
polarization.
This
study
provides
highly
efficient
strategy
treating
designing
polarization‐enabled
bioactive
materials.
Biomacromolecules,
Journal Year:
2020,
Volume and Issue:
21(8), P. 2983 - 3006
Published: July 16, 2020
Wound
healing
is
usually
accompanied
by
bacterial
infection.
The
excessive
use
of
synthetic
antibiotics
leads
to
drug
resistance,
posing
a
significant
threat
human
health.
Hydrogel-based
wound
dressings
aimed
at
mitigating
infections
have
emerged
as
an
effective
treatment.
review
presented
herein
particularly
focuses
on
the
hydrogels
originating
from
natural
polymers.
To
further
enhance
performance
dressings,
various
strategies
and
approaches
been
developed
endow
with
excellent
broad-spectrum
antibacterial
activity.
Those
that
are
summarized
in
current
intrinsic
or
stimuli-triggered
bactericidal
properties
others
serve
vehicles
for
loading
agents
without
antibiotics.
Specific
attention
paid
antimicrobial
mechanisms
hydrogels.
Practical
applications
accelerate
employing
these
antibiotic-free
also
introduced
along
discussion
challenges
perspectives
leading
new
technologies.
Biomaterials Science,
Journal Year:
2020,
Volume and Issue:
9(5), P. 1530 - 1546
Published: Dec. 22, 2020
Currently,
the
treatment
and
care
of
diabetic
wounds,
which
generally
possess
characteristics
a
high
amputation
rate,
recurrence
rate
mortality,
has
developed
into
worldwide
challenge.
Wound
dressings
have
been
playing
an
important
role
in
wound
continuously
innovated
to
obtain
many
amazing
properties.
Among
them,
hydrogel
become
one
most
attractive
promising
because
their
considerable
moisture
retention,
biocompatibility
therapeutic
In
recent
years,
with
depth
understanding
pathogenesis
various
functionalized
reported
shown
encouraging
results,
brought
great
benefits
improvement
wounds.
this
work,
we
will
systematically
comprehensively
summarize
advances
aiming
provide
not
only
theoretical
support
for
dressing
devising
but
also
inspiration
treatment.
