Frontiers in Cell and Developmental Biology,
Journal Year:
2022,
Volume and Issue:
10
Published: Nov. 21, 2022
Medicine
today
faces
the
combined
challenge
of
an
increasing
number
untreatable
diseases
and
fewer
drugs
reaching
clinic.
While
pharmaceutical
companies
have
increased
in
early
development
entering
phase
I
clinical
trials,
actually
successfully
pass
III
launch
into
market.
In
fact,
only
1
out
every
9
will
launch.
Organs-on-chips
(OoCs)
are
systems
containing
engineered
or
natural
miniature
tissues
grown
inside
microfluidic
chips.
To
better
mimic
human
physiology,
the
chips
designed
to
control
cell
microenvironments
and
maintain
tissue-specific
functions.
Combining
advances
in
tissue
engineering
microfabrication,
OoCs
have
gained
interest
as
a
next-generation
experimental
platform
investigate
pathophysiology
effect
of
therapeutics
body.
There
many
examples
there
applications,
making
it
difficult
for
new
researchers
understand
what
makes
one
OoC
more
suited
an
application
than
another.
This
Primer
is
intended
give
introduction
aspects
that
need
be
considered
when
developing
application-specific
OoC.
The
covers
guiding
principles
considerations
design,
fabricate
operate
OoC,
well
subsequent
assaying
techniques
extract
biological
information
from
devices.
Alongside
this
discussion
current
future
applications
technology,
inform
design
operational
decisions
during
implementation
systems.
with
aim
mimicking
physiology
range
biomedical
therapeutic
applications.
Leung,
de
Haan
et
al.
report
practical
tips
organ-on-a-chip
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
121(13), P. 7468 - 7529
Published: May 22, 2021
Drug
development
is
a
long
process
whose
main
content
includes
drug
synthesis,
delivery,
and
evaluation.
Compared
with
conventional
procedures,
microfluidics
has
emerged
as
revolutionary
technology
in
that
it
offers
miniaturized
highly
controllable
environment
for
bio(chemical)
reactions
to
take
place.
It
also
compatible
analytical
strategies
implement
integrated
high-throughput
screening
evaluations.
In
this
review,
we
provide
comprehensive
summary
of
the
entire
microfluidics-based
system,
from
synthesis
The
challenges
current
status
prospects
future
are
discussed.
We
believe
review
will
promote
communications
throughout
diversified
scientific
engineering
communities
continue
contributing
burgeoning
field.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(7), P. 9994 - 10041
Published: June 22, 2022
Worldwide
nanotechnology
development
and
application
have
fueled
many
scientific
advances,
but
technophilic
expectations
technophobic
demands
must
be
counterbalanced
in
parallel.
Some
of
the
burning
issues
today
are
following:
(1)
Where
is
nano
today?
(2)
How
good
communication
investment
networks
between
academia/research
governments?
(3)
Is
there
any
spotlight
for
nanotechnology?
Nanomedicine
a
particular
arm
within
healthcare
landscape,
focused
on
diagnosis,
treatment,
monitoring
emerging
(such
as
coronavirus
disease
2019,
COVID-19)
contemporary
(including
diabetes,
cardiovascular
diseases,
neurodegenerative
disorders,
cancer)
diseases.
However,
it
may
only
represent
bright
side
coin.
In
fact,
recent
past,
concept
nanotoxicology
has
emerged
to
address
dark
shadows
nanomedicine.
The
nanomedicine
field
requires
more
nanotoxicological
studies
identify
undesirable
effects
guarantee
safety.
Here,
we
provide
an
overall
perspective
central
pieces
giant
puzzle
nanotechnology.
First,
impact
education
research
highlighted,
followed
by
market
trends
output
tendencies.
next
section,
dilemma
addressed
through
interplay
silico,
vitro,
vivo
models
with
support
omics
microfluidic
approaches.
Lastly,
reflection
regulatory
clinical
trials
provided.
Finally,
some
conclusions
future
perspectives
proposed
clearer
safer
translation
nanomedicines
from
bench
bedside.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: July 1, 2024
The
applications
of
hydrogels
have
expanded
significantly
due
to
their
versatile,
highly
tunable
properties
and
breakthroughs
in
biomaterial
technologies.
In
this
review,
we
cover
the
major
achievements
potential
therapeutic
applications,
focusing
primarily
on
two
areas:
emerging
cell-based
therapies
promising
non-cell
modalities.
Within
context
cell
therapy,
discuss
capacity
overcome
existing
translational
challenges
faced
by
mainstream
therapy
paradigms,
provide
a
detailed
discussion
advantages
principal
design
considerations
for
boosting
efficacy
as
well
list
specific
examples
different
disease
scenarios.
We
then
explore
drug
delivery,
physical
intervention
therapies,
other
areas
(e.g.,
bioadhesives,
artificial
tissues,
biosensors),
emphasizing
utility
beyond
mere
delivery
vehicles.
Additionally,
complement
our
latest
progress
clinical
application
outline
future
research
directions,
particularly
terms
integration
with
advanced
biomanufacturing
This
review
aims
present
comprehensive
view
critical
insights
into
selection
both
tailored
meet
requirements
diverse
diseases
situations.
Biomaterials,
Journal Year:
2022,
Volume and Issue:
285, P. 121531 - 121531
Published: April 21, 2022
Recent
advances
in
biomaterials,
microfabrication,
microfluidics,
and
cell
biology
have
led
to
the
development
of
organ-on-a-chip
devices
that
can
reproduce
key
functions
various
organs.
Such
platforms
promise
provide
novel
insights
into
physiological
events,
including
mechanisms
disease,
evaluate
effects
external
interventions,
such
as
drug
administration.
The
neuroscience
field
is
expected
benefit
greatly
from
these
innovative
tools.
Conventional
ex
vivo
studies
nervous
system
been
limited
by
inability
culture
adequately
mimic
physiology.
While
animal
models
be
used,
their
relevance
human
physiology
uncertain
use
laborious
associated
with
ethical
issues.
To
date,
systems
developed
model
different
tissue
components
brain,
brain
regions
specific
blood
barrier,
both
normal
pathophysiological
conditions.
still
its
infancy,
it
major
impact
on
neurophysiology,
pathology
neuropharmacology
future.
Here,
we
review
made
limitations
faced
an
effort
stimulate
next
generation
brain-on-a-chip
devices.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(26)
Published: Jan. 12, 2023
Abstract
Cartilage
degeneration
is
among
the
fundamental
reasons
behind
disability
and
pain
across
globe.
Numerous
approaches
have
been
employed
to
treat
cartilage
diseases.
Nevertheless,
none
shown
acceptable
outcomes
in
long
run.
In
this
regard,
convergence
of
tissue
engineering
microfabrication
principles
can
allow
developing
more
advanced
microfluidic
technologies,
thus
offering
attractive
alternatives
current
treatments
traditional
constructs
used
applications.
Herein,
developments
involving
hydrogel‐based
scaffolds,
promising
structures
for
regeneration,
ranging
from
hydrogels
with
channels
prepared
by
devices,
that
enable
therapeutic
delivery
cells,
drugs,
growth
factors,
as
well
cartilage‐related
organ‐on‐chips
are
reviewed.
Thereafter,
anatomy
types
damages,
present
treatment
options
briefly
overviewed.
Various
introduced,
advantages
scaffolds
over
thoroughly
discussed.
Furthermore,
available
technologies
fabricating
chips
presented.
The
preclinical
clinical
applications
regeneration
development
time
further
explained.
developments,
recent
key
challenges,
prospects
should
be
considered
so
develop
systems
repair
highlighted.
Acta Pharmaceutica Sinica B,
Journal Year:
2023,
Volume and Issue:
13(6), P. 2483 - 2509
Published: Feb. 15, 2023
New
drug
discovery
is
under
growing
pressure
to
satisfy
the
demand
from
a
wide
range
of
domains,
especially
pharmaceutical
industry
and
healthcare
services.
Assessment
efficacy
safety
prior
human
clinical
trials
crucial
part
development,
which
deserves
greater
emphasis
reduce
cost
time
in
discovery.
Recent
advances
microfabrication
tissue
engineering
have
given
rise
organ-on-a-chip,
an
Theranostics,
Journal Year:
2023,
Volume and Issue:
13(13), P. 4526 - 4558
Published: Jan. 1, 2023
Drug
evaluation
has
always
been
an
important
area
of
research
in
the
pharmaceutical
industry.
However,
animal
welfare
protection
and
other
shortcomings
traditional
drug
development
models
pose
obstacles
challenges
to
evaluation.
Organ-on-a-chip
(OoC)
technology,
which
simulates
human
organs
on
a
chip
physiological
environment
functionality,
with
high
fidelity
reproduction
organ-level
physiology
or
pathophysiology,
exhibits
great
promise
for
innovating
pipeline.
Meanwhile,
advancement
artificial
intelligence
(AI)
provides
more
improvements
design
data
processing
OoCs.
Here,
we
review
current
progress
that
made
generate
OoC
platforms,
how
single
multi-OoCs
have
used
applications,
including
testing,
disease
modeling,
personalized
medicine.
Moreover,
discuss
issues
facing
field,
such
as
large
reproducibility,
point
integration
OoCs
AI
analysis
automation,
is
benefit
future
Finally,
look
forward
opportunities
faced
by
coupling
AI.
In
summary,
advancements
development,
combinations
AI,
will
eventually
break
state
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: March 11, 2023
The
advancement
of
microfluidics
has
enabled
numerous
discoveries
and
technologies
in
life
sciences.
However,
due
to
the
lack
industry
standards
configurability,
design
fabrication
microfluidic
devices
require
highly
skilled
technicians.
diversity
discourages
biologists
chemists
from
applying
this
technique
their
laboratories.
Modular
microfluidics,
which
integrates
standardized
modules
into
a
whole,
complex
platform,
brings
capability
configurability
conventional
microfluidics.
exciting
features,
including
portability,
on-site
deployability,
high
customization
motivate
us
review
state-of-the-art
modular
discuss
future
perspectives.
In
review,
we
first
introduce
working
mechanisms
basic
evaluate
feasibility
as
components.
Next,
explain
connection
approaches
among
these
modules,
summarize
advantages
over
integrated
biological
applications.
Finally,
challenge
perspectives