Frontiers in Cell and Developmental Biology, Journal Year: 2022, Volume and Issue: 10
Published: Nov. 21, 2022
Medicine today faces the combined challenge of an increasing number untreatable diseases and fewer drugs reaching clinic. While pharmaceutical companies have increased in early development entering phase I clinical trials, actually successfully pass III launch into market. In fact, only 1 out every 9 will launch.
Language: Английский
Nature Reviews Methods Primers, Journal Year: 2022, Volume and Issue: 2(1)
Published: May 12, 2022
Organs-on-chips (OoCs) are systems containing engineered or natural miniature tissues grown inside microfluidic chips. To better mimic human physiology, the chips designed to control cell microenvironments and maintain tissue-specific functions. Combining advances in tissue engineering microfabrication, OoCs have gained interest as a next-generation experimental platform investigate pathophysiology effect of therapeutics body. There many examples there applications, making it difficult for new researchers understand what makes one OoC more suited an application than another. This Primer is intended give introduction aspects that need be considered when developing application-specific OoC. The covers guiding principles considerations design, fabricate operate OoC, well subsequent assaying techniques extract biological information from devices. Alongside this discussion current future applications technology, inform design operational decisions during implementation systems. with aim mimicking physiology range biomedical therapeutic applications. Leung, de Haan et al. report practical tips organ-on-a-chip
Language: Английский
Citations
616
Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(13), P. 7468 - 7529
Published: May 22, 2021
Drug development is a long process whose main content includes drug synthesis, delivery, and evaluation. Compared with conventional procedures, microfluidics has emerged as revolutionary technology in that it offers miniaturized highly controllable environment for bio(chemical) reactions to take place. It also compatible analytical strategies implement integrated high-throughput screening evaluations. In this review, we provide comprehensive summary of the entire microfluidics-based system, from synthesis The challenges current status prospects future are discussed. We believe review will promote communications throughout diversified scientific engineering communities continue contributing burgeoning field.
Language: Английский
Citations
143
ACS Nano, Journal Year: 2022, Volume and Issue: 16(7), P. 9994 - 10041
Published: June 22, 2022
Worldwide nanotechnology development and application have fueled many scientific advances, but technophilic expectations technophobic demands must be counterbalanced in parallel. Some of the burning issues today are following: (1) Where is nano today? (2) How good communication investment networks between academia/research governments? (3) Is there any spotlight for nanotechnology? Nanomedicine a particular arm within healthcare landscape, focused on diagnosis, treatment, monitoring emerging (such as coronavirus disease 2019, COVID-19) contemporary (including diabetes, cardiovascular diseases, neurodegenerative disorders, cancer) diseases. However, it may only represent bright side coin. In fact, recent past, concept nanotoxicology has emerged to address dark shadows nanomedicine. The nanomedicine field requires more nanotoxicological studies identify undesirable effects guarantee safety. Here, we provide an overall perspective central pieces giant puzzle nanotechnology. First, impact education research highlighted, followed by market trends output tendencies. next section, dilemma addressed through interplay silico, vitro, vivo models with support omics microfluidic approaches. Lastly, reflection regulatory clinical trials provided. Finally, some conclusions future perspectives proposed clearer safer translation nanomedicines from bench bedside.
Language: Английский
Citations
131
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: July 1, 2024
The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements potential therapeutic applications, focusing primarily on two areas: emerging cell-based therapies promising non-cell modalities. Within context cell therapy, discuss capacity overcome existing translational challenges faced by mainstream therapy paradigms, provide a detailed discussion advantages principal design considerations for boosting efficacy as well list specific examples different disease scenarios. We then explore drug delivery, physical intervention therapies, other areas (e.g., bioadhesives, artificial tissues, biosensors), emphasizing utility beyond mere delivery vehicles. Additionally, complement our latest progress clinical application outline future research directions, particularly terms integration with advanced biomanufacturing This review aims present comprehensive view critical insights into selection both tailored meet requirements diverse diseases situations.
Language: Английский
Citations
109
Biomaterials, Journal Year: 2022, Volume and Issue: 285, P. 121531 - 121531
Published: April 21, 2022
Recent advances in biomaterials, microfabrication, microfluidics, and cell biology have led to the development of organ-on-a-chip devices that can reproduce key functions various organs. Such platforms promise provide novel insights into physiological events, including mechanisms disease, evaluate effects external interventions, such as drug administration. The neuroscience field is expected benefit greatly from these innovative tools. Conventional ex vivo studies nervous system been limited by inability culture adequately mimic physiology. While animal models be used, their relevance human physiology uncertain use laborious associated with ethical issues. To date, systems developed model different tissue components brain, brain regions specific blood barrier, both normal pathophysiological conditions. still its infancy, it major impact on neurophysiology, pathology neuropharmacology future. Here, we review made limitations faced an effort stimulate next generation brain-on-a-chip devices.
Language: Английский
Citations
99
Advanced Materials, Journal Year: 2023, Volume and Issue: 35(26)
Published: Jan. 12, 2023
Abstract Cartilage degeneration is among the fundamental reasons behind disability and pain across globe. Numerous approaches have been employed to treat cartilage diseases. Nevertheless, none shown acceptable outcomes in long run. In this regard, convergence of tissue engineering microfabrication principles can allow developing more advanced microfluidic technologies, thus offering attractive alternatives current treatments traditional constructs used applications. Herein, developments involving hydrogel‐based scaffolds, promising structures for regeneration, ranging from hydrogels with channels prepared by devices, that enable therapeutic delivery cells, drugs, growth factors, as well cartilage‐related organ‐on‐chips are reviewed. Thereafter, anatomy types damages, present treatment options briefly overviewed. Various introduced, advantages scaffolds over thoroughly discussed. Furthermore, available technologies fabricating chips presented. The preclinical clinical applications regeneration development time further explained. developments, recent key challenges, prospects should be considered so develop systems repair highlighted.
Language: Английский
Citations
73
Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 13(6), P. 2483 - 2509
Published: Feb. 15, 2023
New drug discovery is under growing pressure to satisfy the demand from a wide range of domains, especially pharmaceutical industry and healthcare services. Assessment efficacy safety prior human clinical trials crucial part development, which deserves greater emphasis reduce cost time in discovery. Recent advances microfabrication tissue engineering have given rise organ-on-a-chip, an
Language: Английский
Citations
60
Theranostics, Journal Year: 2023, Volume and Issue: 13(13), P. 4526 - 4558
Published: Jan. 1, 2023
Drug evaluation has always been an important area of research in the pharmaceutical industry. However, animal welfare protection and other shortcomings traditional drug development models pose obstacles challenges to evaluation. Organ-on-a-chip (OoC) technology, which simulates human organs on a chip physiological environment functionality, with high fidelity reproduction organ-level physiology or pathophysiology, exhibits great promise for innovating pipeline. Meanwhile, advancement artificial intelligence (AI) provides more improvements design data processing OoCs. Here, we review current progress that made generate OoC platforms, how single multi-OoCs have used applications, including testing, disease modeling, personalized medicine. Moreover, discuss issues facing field, such as large reproducibility, point integration OoCs AI analysis automation, is benefit future Finally, look forward opportunities faced by coupling AI. In summary, advancements development, combinations AI, will eventually break state
Language: Английский
Citations
56
Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)
Published: March 11, 2023
The advancement of microfluidics has enabled numerous discoveries and technologies in life sciences. However, due to the lack industry standards configurability, design fabrication microfluidic devices require highly skilled technicians. diversity discourages biologists chemists from applying this technique their laboratories. Modular microfluidics, which integrates standardized modules into a whole, complex platform, brings capability configurability conventional microfluidics. exciting features, including portability, on-site deployability, high customization motivate us review state-of-the-art modular discuss future perspectives. In review, we first introduce working mechanisms basic evaluate feasibility as components. Next, explain connection approaches among these modules, summarize advantages over integrated biological applications. Finally, challenge perspectives
Language: Английский
Citations
49
Biomedical Engineering Letters, Journal Year: 2023, Volume and Issue: 13(2), P. 97 - 109
Published: Jan. 2, 2023
Language: Английский
Citations
44