Microfluidic Devices for Precision Nanoparticle Production

Micro, Journal Year: 2023, Volume and Issue: 3(4), P. 822 - 866

Published: Oct. 31, 2023

In recent years, the field of drug delivery has seen a significant shift towards exploration and utilization nanoparticles (NPs) as versatile carriers for therapeutic agents. With its ability to provide exact control over NPs’ characteristics, microfluidics emerged potent platform efficient controlled synthesis NPs. Microfluidic devices designed precise fluid manipulation at micro-scale offer unique tailoring NP properties, enabling enhanced properties such size, morphology, size distribution while ensuring high batch-to-batch reproducibility. Microfluidics can be used produce liposomes, solid lipid nanoparticles, polymer-based NPs, lipid-polymer hybrid well variety inorganic NPs silica, metal, metal oxide, quantum dots, carbon-based offering composition surface properties. Its precision in holds great promise advancing NP-based systems both clinical industrial settings. Although challenges with large-scale production still remain, offers transformative approach synthesis. this review, starting from historical development microfluidic systems, materials create microfabrication methods, system components will discussed order reader an overview systems. following, studies on fabrication polymeric are included.

Language: Английский

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Prospects of Microfluidic Technology in Nucleic Acid Detection Approaches

Biosensors, Journal Year: 2023, Volume and Issue: 13(6), P. 584 - 584

Published: May 27, 2023

Conventional diagnostic techniques are based on the utilization of analyte sampling, sensing and signaling separate platforms for detection purposes, which must be integrated to a single step procedure in point care (POC) testing devices. Due expeditious nature microfluidic platforms, trend has been shifted toward implementation these systems analytes biochemical, clinical food technology. Microfluidic molded with substances such as polymers or glass offer specific sensitive infectious noninfectious diseases by providing innumerable benefits, including less cost, good biological affinity, strong capillary action simple process fabrication. In case nanosensors nucleic acid detection, some challenges need addressed, cellular lysis, isolation amplification before its detection. To avoid laborious steps executing processes, advances have deployed this perspective on-chip sample preparation, introduction an emerging field modular microfluidics that multiple advantages over microfluidics. This review emphasizes significance technology non-infectious diseases. The isothermal conjunction lateral flow assay greatly increases binding efficiency nanoparticles biomolecules improves limit sensitivity. Most importantly, deployment paper-based material made cellulose reduces overall cost. discussed explicating applications different fields. Next-generation methods can improved using CRISPR/Cas systems. concludes comparison future prospects various systems, plasma separation used

Language: Английский

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Open and closed microfluidics for biosensing

Materials Today Bio, Journal Year: 2024, Volume and Issue: 26, P. 101048 - 101048

Published: April 4, 2024

Biosensing is vital for many areas like disease diagnosis, infectious prevention, and point-of-care monitoring. Microfluidics has been evidenced to be a powerful tool biosensing via integrating biological detection processes into palm-size chip. Based on the chip structure, microfluidics two subdivision types: open closed microfluidics, whose operation methods would diverse. In this review, we summarize fundamentals, liquid control methods, applications of separately, point out bottlenecks, propose potential directions microfluidics-based biosensing.

Language: Английский

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Data‐Driven Theoretical Modeling of Centrifugal Step Emulsification and Its Application in Comprehensive Multiscale Analysis

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Tailored droplet generation is crucial for microfluidics that involve samples of varying sizes. However, the absence precise predictive models forces platforms to rely on empiricism derived from extensive experiments, underscoring need comprehensive modeling analysis. To address this, a novel customized assembled centrifugal step emulsifier (CASE) presented by incorporating "jigsaw puzzles" design efficiently acquire large-scale experimental data. Numerical simulations are utilized analyze fluid configurations during emulsification, identifying key connection tube determines size. By training and verifying with simulation datasets, theoretical model established allows preliminary size frequency an average error rate 4.8%, successfully filling critical gap in existing field. This empowers CASE achieve all-in-one functionality, including pre-design, generation, manipulation, on-site detection. As proof concept, multiscale sample analysis ranging nanoscale nucleic acids microscale bacteria 3D cell spheroids realized CASE. In summary, this platform offers valuable guidance emulsifiers promotes adoption biochemical assays.

Language: Английский

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Size-Tunable Elasto-Inertial Sorting of Haematococcus pluvialis in the Ultrastretchable Microchannel

Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(35), P. 13338 - 13345

Published: Aug. 16, 2023

Haematococcus pluvialis is a good source of astaxanthin, which reduces oxidation in the human body, treats inflammation, and slows growth breast skin cancer cells. Since size H. often closely related to astaxanthin yield, size-based microalgal separation has far-reaching significance for high-value algae extraction algal directed evolution. In this work, we report novel size-tunable elasto-inertial sorting Ecoflex ultrastretchable microfluidic devices. chips can deform be flexible, bringing flexibility stretchability microchannels as well new possibilities large-scale modulation channel geometry. Here, effects velocity, elongation, particle on migration particles are systematically studied. We found that elongation strong regulating effect focusing. addition, verified continuous regulation threshold cells by stretching channel, providing technical support evolution high-yield microalgae.

Language: Английский

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Self-Adhesive, Biocompatible, Wearable Microfluidics with Erasable Liquid Metal Plasmonic Hotspots for Glucose Detection in Sweat

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 30, 2023

Sweat is a noninvasive metabolite that can provide clinically meaningful information about physical conditions without harming the body. Glucose, vital component in sweat, closely related to blood glucose levels, and changes its concentration reflect health status of diabetics. We introduce self-adhesive, wearable microfluidic chip with erasable liquid metal plasmonic hotspots for precise detection sweat. The made from modified polydimethylsiloxane (PDMS) enhanced stickiness, enabling conformal contact skin, collect, deliver, store are located inside channel, generated by synthesizing silver nanostructures on metal, be removed alkaline solution. It indicates reproducible nature hotspots. method based surface-enhanced Raman spectroscopy (SERS), which allows accurate concentration. To enhance sensitive glucose, SERS substrate 4-mercaptophenylboronic acid achieve limit 1 ng/L much lower than physiological (7.2–25.2 μg/L). developed soft, stretchable, nontoxic, bringing new possibilities sweat-sensing devices.

Language: Английский

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Phase Change Materials Meet Microfluidic Encapsulation

Advanced Science, Journal Year: 2023, Volume and Issue: 11(37)

Published: Nov. 14, 2023

Improving the utilization of thermal energy is crucial in world nowadays due to high levels consumption. One way achieve this use phase change materials (PCMs) as storage media, which can be used regulate temperature or provide heating/cooling various applications. However, PCMs have limitations like low conductivity, leakage, and corrosion. To overcome these challenges, are encapsulated into microencapsulated (MEPCMs) capsules/fibers. This encapsulation prevents from leakage corrosion issues, microcapsules/fibers act conduits for heat transfer, enabling efficient exchange between PCM its surroundings. Microfluidics-based MEPCMs attracted intensive attention over past decade exquisite control flow conditions size microcapsules. review paper aims an overview state-of-art progress microfluidics-based PCMs. The principle method preparing MEPCM capsules/fibers using microfluidic technology elaborated, followed by analysis their microstructure characteristics. Meanwhile, applications fields building conservation, textiles, military aviation, solar utilization, bioengineering summarized. Finally, perspectives on discussed.

Language: Английский

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Advances in biomedical fluid–structure interaction: Methodologies and applications from an interfacing perspective

Physics of Fluids, Journal Year: 2024, Volume and Issue: 36(2)

Published: Feb. 1, 2024

Fluid–structure interaction (FSI) is a nonlinear multiphysics phenomenon that describes the interactions between incompressible fluid flows and immersed structures, making it invaluable to biomedical research. In this work, common FSI methodologies in research were systematically summarized classified into three groups based on interfaces: fluid–channel interfaces, fluid–particle multi-interface interactions. A discussion of role numerical methods was also made, outlining its indispensable advantage handling complex geometries, boundary conditions, thus interfaces. The applications these are discussed terms blood vessel-related applications, drug-delivering micropumps, particle dynamics/cell sorting, deformation rapture. development progress, current advances, prospects FSI's future application illustrated. It concluded with advances computation technologies, rapidly developing can achieve state-of-the-art level details, helping improve our understanding various biomedical-related problems use techniques likely continue grow.

Language: Английский

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Low-cost inertial microfluidic device for microparticle separation: A laser-Ablated PMMA lab-on-a-chip approach without a cleanroom

HardwareX, Journal Year: 2023, Volume and Issue: 16, P. e00493 - e00493

Published: Nov. 12, 2023

Although microparticles are frequently used in chemistry and biology, their effectiveness largely depends on the homogeneity of particle size distribution. Microfluidic devices to separate purify particles based have been developed, but many require expensive cleanroom manufacturing processes. A cost-effective, passive microfluidic separator is presented, capable efficiently sorting purifying spanning range 15 µm 40 µm. Fabricated from Polymethyl Methacrylate (PMMA) substrates using laser ablation, this device circumvents need for facilities. Prior fabrication, rigorous optimization device's design was carried out through computational simulations conducted COMSOL Multiphysics. To gauge its performance, chitosan were employed as a test case. The results notably promising, achieving precision 96.14 %. This quantitative metric underscores size-based separation. low-cost accessible offers pragmatic solution laboratories researchers seeking precise control over sizes, without constraints environments. innovation not only mitigates limitations tied traditional cleanroom-based fabrication also widens horizons various applications within realms biology.

Language: Английский

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Periodic Flows in Microfluidics

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 9, 2024

Abstract Microfluidics, the science and technology of manipulating fluids in microscale channels, offers numerous advantages, such as low energy consumption, compact device size, precise control, fast reaction, enhanced portability. These benefits have led to applications biomedical assays, disease diagnostics, drug discovery, neuroscience, so on. Fluid flow within microfluidic channels is typically laminar region, which characterized by Reynolds numbers but brings challenge efficient mixing fluids. Periodic flows are time‐dependent fluid flows, featuring repetitive patterns that can significantly improve extend effective length microchannels for submicron nanoparticle manipulation. Besides, periodic crucial organ‐on‐a‐chip (OoC) accurately modeling physiological processes, advancing understanding, development, personalized medicine. Various techniques generating been reported, including syringe pumps, peristalsis, actuation based on electric, magnetic, acoustic, mechanical, pneumatic, fluidic forces, yet comprehensive reviews this topic remain limited. This paper aims provide a review microfluidics, from fundamental mechanisms generation applications. The challenges future perspectives also discussed exploit potential microfluidics.

Language: Английский

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