The cerebellum and fear extinction: evidence from rodent and human studies DOI Creative Commons
Alice Doubliez, Enzo Nio,

Fernando Senovilla-Sanz

et al.

Frontiers in Systems Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: April 21, 2023

The role of the cerebellum in emotional control has gained increasing interest, with studies showing it is involved fear learning and memory both humans rodents. This review will focus on contributions to extinction learned responses. Extinction fearful memories critical for adaptive behaviour, clinically relevant anxiety disorders such as post-traumatic stress disorder, which deficits processes are thought occur. We present evidence that supports cerebellar involvement extinction, from rodent investigate molecular mechanisms functional connectivity other brain regions known network, fMRI humans. considered relation theoretical framework formation updating internal models inner outer world by detecting errors between predicted actual outcomes. In case conditioning, these predict occurrence an aversive unconditioned stimulus (US), when US unexpectedly omitted during uses prediction update model. Differences human highlighted help inform future work.

Language: Английский

Behavioral and neural processes in counterconditioning: Past and future directions DOI Creative Commons
Nicole E. Keller, Augustin C. Hennings, Joseph E. Dunsmoor

et al.

Behaviour Research and Therapy, Journal Year: 2019, Volume and Issue: 125, P. 103532 - 103532

Published: Dec. 12, 2019

Language: Английский

Citations

88
Functional architecture of dopamine neurons driving fear extinction learning DOI Creative Commons

Ximena I. Salinas-Hernández,

Daphne Zafiri,

Torfi Sigurdsson

et al.

Neuron, Journal Year: 2023, Volume and Issue: 111(23), P. 3854 - 3870.e5

Published: Sept. 22, 2023

The ability to extinguish fear responses stimuli that no longer predict danger is critical for adaptive behavior and increases the likelihood of survival. During extinction, dopamine (DA) neurons signal absence expected aversive outcome, this extinction prediction error (EPE) crucial initiating driving learning. However, neural circuits underlying EPE have remained elusive. Here, we investigate input-output circuitry EPE-encoding DA in male mice. By employing projection-specific fiber photometry optogenetics, demonstrate these project a restricted subregion nucleus accumbens. Comprehensive anatomical analyses, as well chemogenetic manipulations combined with recordings biosensors, further uncover dorsal raphe one key input structure generating signal. Together, our results reveal first time functional architecture

Language: Английский

Citations

28
From neural circuits to communities: an integrative multidisciplinary roadmap for global mental health DOI Open Access
Michelle G. Craske, Mohammad M. Herzallah, Robin Nusslock

et al.

Nature Mental Health, Journal Year: 2023, Volume and Issue: 1(1), P. 12 - 24

Published: Jan. 17, 2023

Language: Английский

Citations

25
Pavlovian safety learning: An integrative theoretical review DOI
Patrick A.F. Laing,

Bram Vervliet,

Joseph E. Dunsmoor

et al.

Psychonomic Bulletin & Review, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 21, 2024

Language: Английский

Citations

9
Dopamine induces fear extinction by activating the reward-responding amygdala neurons DOI Creative Commons
Xiangyu Zhang,

Katelyn Flick,

Marianna Rizzo

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(18)

Published: April 28, 2025

The extinction of conditioned fear responses is crucial for adaptive behavior, and its impairment a hallmark anxiety disorders such as posttraumatic stress disorder. Fear takes place when animals form new memory that suppresses the original memory. In case context-dependent memory, formed within reward-responding posterior subset basolateral amygdala (BLA) genetically marked by Ppp1r1b + neurons. These engram cells suppress activity fear-responding Rspo2 present in anterior BLA, hence extinction. However, neurological nature teaching signal instructs formation neurons unknown. Here, we demonstrate ventral tegmental area (VTA) dopaminergic signaling drives distinct BLA neuronal populations. We show populations receive topographically divergent inputs from VTA via differentially expressed dopamine receptors. Fiber photometry recordings reveal (DA) time-locked to freezing cessation neurons, but not Furthermore, this correlates with learning. Finally, using projection-specific optogenetic manipulation, find activation DA projections reward accelerated or impaired extinction, respectively. Together, work demonstrates bidirectionally controls patterns at

Language: Английский

Citations

1
Dopamine: from prediction error to psychotherapy DOI Creative Commons
Silvia Papalini, Tom Beckers,

Bram Vervliet

et al.

Translational Psychiatry, Journal Year: 2020, Volume and Issue: 10(1)

Published: May 25, 2020

Abstract Dopamine, one of the main neurotransmitters in mammalian brain, has been implicated coding prediction errors that govern reward learning as well fear extinction learning. Psychotherapy too can be viewed a form error-based learning, because it challenges erroneous beliefs and behavioral patterns order to induce long-term changes emotions, cognitions, behaviors. Exposure therapy, for example, relies part on principles violate expectancies danger novel safety inhibits therefore reduces long term. As most forms psychotherapy, however, exposure therapy suffers from non-response, dropout, relapse. This narrative review focuses role midbrain prefrontal dopamine investigates possible pathways through which dopamine-based interventions could used an adjunct improve both response effects therapy. Convincing evidence exists involvement system acquisition new, safe memories. Additionally, is emerging key ingredient consolidation extinction. We propose applying error perspective psychotherapy inspire pharmacological non-pharmacological studies aimed at discovering innovative ways enhance we call further empirical investigations dopamine-oriented drugs might able maximize successful its retention after also include with putative dopaminergic effects, like working memory training.

Language: Английский

Citations

61
Dopamine, endocannabinoids and their interaction in fear extinction and negative affect in PTSD DOI
Luke J. Ney, Jane Akhurst, Raimondo Bruno

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2020, Volume and Issue: 105, P. 110118 - 110118

Published: Sept. 28, 2020

Language: Английский

Citations

52
The cerebellum contributes to context-effects during fear extinction learning: A 7T fMRI study DOI Creative Commons
Giorgi Batsikadze, Nicolas Diekmann, Thomas Ernst

et al.

NeuroImage, Journal Year: 2022, Volume and Issue: 253, P. 119080 - 119080

Published: March 9, 2022

The cerebellum is involved in the acquisition and consolidation of learned fear responses. Knowledge about its contribution to extinction learning, however, sparse. Extinction processes likely involve erasure memories, but there ample evidence that at least part original memory remains. We asked question whether persists within following training. renewal effect, reoccurrence extinguished during recall a context different from context, constitutes one phenomena indicating responses not fully erased performed differential AB-A/B conditioning paradigm 7-Tesla (7T) MRI system 31 young healthy men. On day 1, training was A B. 2, tested contexts As expected, participants predict CS+ followed by an aversive electric shock Skin conductance (SCRs) were significantly higher compared CS- end acquisition. Differences SCRs vanished reoccurred renewal. Fitting SCR data, deep neural network model trained correct value for given stimulus context. Event-related fMRI analysis with model-derived prediction values as parametric modulations showed significant effects on activation posterolateral (lobules VI Crus I) recall. Since differ based (CS+ CS-) recall, data provide support context-related associations. Likewise, mean β highest lobules I bilaterally related early similar pattern seen vermis, only trend level. Thus, remains found cerebellar activations which reflect associative non-associative aspects task. Cerebellar activations, CS-. never shock, may contribute learning CS, example safety cue.

Language: Английский

Citations

34
Fear extinction relies on ventral hippocampal safety codes shaped by the amygdala DOI Creative Commons
Robin Nguyen,

Konstantinos Koukoutselos,

Thomas Forro

et al.

Science Advances, Journal Year: 2023, Volume and Issue: 9(22)

Published: May 31, 2023

Extinction memory retrieval is influenced by spatial contextual information that determines responding to conditioned stimuli (CS). However, it poorly understood whether representations are imbued with emotional values support selection. Here, we performed activity-dependent engram tagging and in vivo single-unit electrophysiological recordings from the ventral hippocampus (vH) while optogenetically manipulating basolateral amygdala (BLA) inputs during formation of cued fear extinction memory. During when CS acquire safety properties, found CS-related activity vH reactivated sleep consolidation was strengthened upon retrieval. Moreover, facilitated context exhibited precise coding its affective zones. Last, these patterns along were dependent on glutamatergic transmission BLA learning. Thus, relies stimulus instructed BLA.

Language: Английский

Citations

23
A ventral striatal prediction error signal in human fear extinction learning DOI Creative Commons
Martina Thiele, Kenneth S.L. Yuen,

A.V.M. Gerlicher

et al.

NeuroImage, Journal Year: 2021, Volume and Issue: 229, P. 117709 - 117709

Published: Jan. 15, 2021

Animal studies have shown that the prediction error (PE) signal drives fear extinction learning is encoded by phasic activity of midbrain dopamine (DA) neurons. Thus, PE resembles appetitive reward learning. In humans, less well understood. Using computational neuroimaging, a previous study from our group reported hemodynamic in left ventral putamen, subregion striatum (VS), to correlate with function derived formal associative model. The was modulated genetic variation DA-related gene. To conceptually replicate and extend this finding, we here asked whether an (EPE) putamen can also be observed when genotype information not taken into account. optimized experimental design for model estimation, again EPE-related same striatal region, indicating activation region feature human We further significant EPE signals across wider parts VS as frontal cortical areas. These results may suggest errors during are available larger brain, has been neuroimaging signaling. Conclusive evidence DAergic nature still outstanding.

Language: Английский

Citations

39