Nanomaterial-based therapeutics for antibiotic-resistant bacterial infections

Nature Reviews Microbiology, Journal Year: 2020, Volume and Issue: 19(1), P. 23 - 36

Published: Aug. 19, 2020

Language: Английский

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Antibacterial Mechanism of Curcumin: A Review

Chemistry & Biodiversity, Journal Year: 2020, Volume and Issue: 17(8)

Published: June 13, 2020

Curcumin is a plant-derived polyphenolic active substance with broad-spectrum antibacterial properties. blocks bacterial growth owing to its structural characteristics and the generation of antioxidation products. can inhibit virulence factors, biofilm formation prevent adhesion host receptors through quorum sensing regulation system. As photosensitizer, curcumin acts under blue light irradiation induce phototoxicity growth. Moreover, it exert synergistic effect other substances. In this review, we summarize research progress on mechanism based five targeting structures two modes action. Our discussion provides theoretical basis technical foundation for development application natural agents.

Language: Английский

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Biofilms: hot spots of horizontal gene transfer (HGT) in aquatic environments, with a focus on a new HGT mechanism

FEMS Microbiology Ecology, Journal Year: 2020, Volume and Issue: 96(5)

Published: Feb. 27, 2020

Biofilms in water environments are thought to be hot spots for horizontal gene transfer (HGT) of antibiotic resistance genes (ARGs). ARGs can spread via HGT, though mechanisms known and have been shown depend on the environment, bacterial communities mobile genetic elements. Classically, HGT include conjugation, transformation transduction; more recently, membrane vesicles (MVs) reported as DNA reservoirs implicated interspecies HGT. Here, we review current knowledge with a focus role MVs methodological innovations research.

Language: Английский

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Innovative Strategies Toward the Disassembly of the EPS Matrix in Bacterial Biofilms

Frontiers in Microbiology, Journal Year: 2020, Volume and Issue: 11

Published: May 26, 2020

Bacterial biofilms represent a major concern at worldwide level due to the high demand for implantable medical devices and rising numbers of bacterial resistance. The complex structure extracellular polymeric substances (EPS) matrix plays role in this phenomenon, since it protects bacteria from antibiotics, avoiding drug penetration bactericidal concentrations. Besides, promotes cells adopt dormant lifestyle, becoming less susceptible antibacterial agents. Currently, available treatment biofilm-related infections consists administration conventional antibiotics doses long-term period. However, lacks efficiency against mature implant-associated may be necessary remove device. Thus, an economical burden healthcare systems. New strategies focusing on are being highlighted as alternative therapies eradicate biofilms. Here, we outline reported disruptive agents, nanocarriers, technologies, such application magnetic fields, photodynamic therapy, ultrasounds, that have been under investigation disrupt EPS clinically relevant In ideal synergistic effect between explored innovated is aimed completely avoid antimicrobial resistance phenomena.

Language: Английский

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Biofilms: Formation, drug resistance and alternatives to conventional approaches

AIMS Microbiology, Journal Year: 2022, Volume and Issue: 8(3), P. 239 - 277

Published: Jan. 1, 2022

<abstract> <p>Biofilms are aggregates of bacteria, in most cases, which resistant usually to broad-spectrum antibiotics their typical concentrations or even higher doses. A trend increasing multi-drug resistance biofilms, responsible for emerging life-threatening nosocomial infections, is becoming a serious problem. Biofilms, however, at various sensitivity levels environmental factors and versatile infectivity depending on virulence factors. This review presents the fundamental information about biofilms: formation, antibiotic resistance, impacts public health alternatives conventional approaches. Novel developments micro-biosystems that help reveal new treatment tools by sensing characterization biofilms will also be discussed. Understanding structure, physiology properties better helps eliminate them usage appropriate control novel therapy approaches, such as anti-biofilm molecules, effective gene editing, drug-delivery systems probiotics.</p> </abstract>

Language: Английский

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Nanotechnology as a Promising Approach to Combat Multidrug Resistant Bacteria: A Comprehensive Review and Future Perspectives

Biomedicines, Journal Year: 2023, Volume and Issue: 11(2), P. 413 - 413

Published: Jan. 31, 2023

The wide spread of antibiotic resistance has been alarming in recent years and poses a serious global hazard to public health as it leads millions deaths all over the world. sharing genes between different types bacteria led emergence multidrug resistant (MDR) microorganisms. This problem is exacerbated when microorganisms create biofilms, which can boost bacterial by up 1000-fold increase MDR infections. absence novel potent antimicrobial compounds linked rise resistance. sparked international efforts develop new improved agents well innovative efficient techniques for administration targeting. There an evolution nanotechnology treatment prevention biofilm formation infection. development nanomaterial-based therapeutics, could overcome current pathways acquired drug resistance, hopeful strategy treating difficult-to-treat Additionally, nanoparticles’ distinct size physical characteristics enable them target biofilms treat pathogens. review highlights advances combat In addition, provides insight on mechanisms XDR infection, nanoparticles their antibacterial activity. Moreover, this considers difference free antibiotics nanoantibiotics, synergistic effect nanoantibiotics planktonic bacteria, intracellular biofilm. Finally, we will discuss strength limitations application against infection future perspectives.

Language: Английский

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Antimicrobial Properties of the Ag, Cu Nanoparticle System

Biology, Journal Year: 2021, Volume and Issue: 10(2), P. 137 - 137

Published: Feb. 10, 2021

Microbes, including bacteria and fungi, easily form stable biofilms on many surfaces. Such have high resistance to antibiotics, cause nosocomial postoperative infections. The antimicrobial antiviral behaviors of Ag Cu nanoparticles (NPs) are well known, possible mechanisms for their actions, such as released ions, reactive oxygen species (ROS), contact killing, the immunostimulatory effect, others been proposed. NPs, derivative different capacities cytotoxicities. Factors, size, shape surface treatment, influence activities. biomedical application NPs involves coating onto substrates, textiles, polymers, ceramics, metals. Because immiscible, synthetic AgCu nanoalloys microstructures, which impact effects. When mixed, combination act synergistically, offering substantially enhanced behavior. However, when alloyed in Ag-Cu behavior is even more enhanced. reason this enhancement unclear. Here, we discuss these results that underlie them.

Language: Английский

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Biofilm microenvironment-responsive nanoparticles for the treatment of bacterial infection

Nano Today, Journal Year: 2022, Volume and Issue: 46, P. 101602 - 101602

Published: Sept. 1, 2022

Language: Английский

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Photodynamic therapy: Innovative approaches for antibacterial and anticancer treatments

Medicinal Research Reviews, Journal Year: 2023, Volume and Issue: 43(4), P. 717 - 774

Published: Feb. 9, 2023

Abstract Photodynamic therapy is an alternative treatment mainly for cancer but also bacterial infections. This dates back to 1900 when a German medical school graduate Oscar Raab found photodynamic effect while doing research his doctoral dissertation with Professor Hermann von Tappeiner. Unexpectedly, revealed that the toxicity of acridine on paramecium depends intensity light in laboratory. therefore based administration photosensitizer subsequent irradiation within absorption maxima this substance followed by reactive oxygen species formation and finally cell death. Although not novelty, there endeavor various modifications therapy. For example, selectivity efficiency photosensitizer, as well types sources are still being modified improve final results The main aim review summarize anticancer antibacterial modifications, namely compounds, approaches, techniques, enhance effectiveness

Language: Английский

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Antibacterial coatings on orthopedic implants

Materials Today Bio, Journal Year: 2023, Volume and Issue: 19, P. 100586 - 100586

Published: Feb. 15, 2023

With the aging of population and rapid improvement public health medical level in recent years, people have had an increasing demand for orthopedic implants. However, premature implant failure postoperative complications frequently occur due to implant-related infections, which not only increase social economic burden, but also greatly affect patient's quality life, finally restraining clinical use Antibacterial coatings, as effective strategy solve above problems, been extensively studied motivated development novel strategies optimize implant. In this paper, a variety antibacterial coatings recently developed implants were briefly reviewed, with focus on synergistic multi-mechanism multi-functional smart that are more potential use, thereby providing theoretical references further fabrication high-performance satisfying complex needs.

Language: Английский

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