Viruses,
Journal Year:
2022,
Volume and Issue:
14(7), P. 1419 - 1419
Published: June 28, 2022
Porcine
circoviruses
(PCVs),
including
PCV1
to
PCV4,
are
non-enveloped
DNA
viruses
with
a
diameter
of
about
20
nm,
belonging
the
genus
Circovirus
in
family
Circoviridae.
PCV2
is
an
important
causative
agent
porcine
circovirus
disease
or
circovirus-associated
(PCVD/PCVAD),
which
highly
prevalent
pigs
and
seriously
affects
swine
industry
globally.
Furthermore,
mainly
causes
subclinical
symptoms
immunosuppression,
PCV3
PCV4
were
detected
healthy
pigs,
sick
other
animals.
Although
pathogenicity
field
still
controversial,
infection
rates
increasing.
Moreover,
rescued
from
infected
clones
pathogenic
vivo.
It
worth
noting
that
interaction
between
virus
host
crucial
virus.
This
review
discusses
latest
research
progress
on
molecular
mechanism
PCVs–host
interaction,
may
provide
scientific
basis
for
prevention
control.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(19), P. 14876 - 14876
Published: Oct. 4, 2023
SARS-CoV-2
infection,
discovered
and
isolated
in
Wuhan
City,
Hubei
Province,
China,
causes
acute
atypical
respiratory
symptoms
has
led
to
profound
changes
our
lives.
COVID-19
is
characterized
by
a
wide
range
of
complications,
which
include
pulmonary
embolism,
thromboembolism
arterial
clot
formation,
arrhythmias,
cardiomyopathy,
multiorgan
failure,
more.
The
disease
caused
worldwide
pandemic,
despite
various
measures
such
as
social
distancing,
preventive
strategies,
therapeutic
approaches,
the
creation
vaccines,
novel
coronavirus
infection
(COVID-19)
still
hides
many
mysteries
for
scientific
community.
Oxidative
stress
been
suggested
play
an
essential
role
pathogenesis
COVID-19,
determining
free
radical
levels
patients
with
may
provide
insight
into
severity.
generation
abnormal
oxidants
under
COVID-19-induced
cytokine
storm
irreversible
oxidation
macromolecules
subsequent
damage
cells,
tissues,
organs.
Clinical
studies
have
shown
that
oxidative
initiates
endothelial
damage,
increases
risk
complications
post-COVID-19
or
long-COVID-19
cases.
This
review
describes
radicals
mediation
mitochondrial
dysfunction.
Viruses,
Journal Year:
2022,
Volume and Issue:
14(3), P. 602 - 602
Published: March 14, 2022
Metabolic
reprogramming
is
a
hallmark
of
cancer
and
has
proven
to
be
critical
in
viral
infections.
provides
the
cell
with
energy
biomass
for
large-scale
biosynthesis.
Based
on
studies
cellular
changes
that
contribute
metabolic
reprogramming,
seven
main
hallmarks
can
identified:
(1)
increased
glycolysis
lactic
acid,
(2)
glutaminolysis,
(3)
pentose
phosphate
pathway,
(4)
mitochondrial
changes,
(5)
lipid
metabolism,
(6)
amino
acid
(7)
other
biosynthetic
bioenergetic
pathways.
Viruses
depend
increase
fuel
genome
replication
production
new
virions.
take
advantage
non-metabolic
effects
creating
an
anti-apoptotic
environment
evading
immune
system.
Other
negatively
affect
function.
Understanding
role
plays
pathogenesis
may
provide
better
therapeutic
targets
antivirals.
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: May 12, 2023
Background:
The
incidence
of
glycolipid
metabolic
diseases
is
extremely
high
worldwide,
which
greatly
hinders
people’s
life
expectancy
and
patients’
quality
life.
Oxidative
stress
(OS)
aggravates
the
development
in
metabolism.
Radical
oxygen
species
(ROS)
a
key
factor
signal
transduction
OS,
can
regulate
cell
apoptosis
contribute
to
inflammation.
Currently,
chemotherapies
are
main
method
treat
disorders
metabolism,
but
this
lead
drug
resistance
damage
normal
organs.
Botanical
drugs
an
important
source
new
drugs.
They
widely
found
nature
with
availability,
practicality,
low
cost.
There
increasing
evidence
that
herbal
medicine
has
definite
therapeutic
effects
on
diseases.
Objective:
This
study
aims
provide
valuable
for
treatment
botanical
from
perspective
ROS
regulation
by
further
promote
effective
clinical
Methods:
Using
herb*,
plant
medicine,
Chinese
phytochemicals,
natural
phytomedicine,
extract,
drug,
ROS,
free
radicals,
radical,
oxidizing
agent,
glucose
lipid
saccharometabolism,
glycometabolism,
blood
glucose,
lipoprotein,
triglyceride,
fatty
liver,
atherosclerosis,
obesity,
diabetes,
dysglycemia,
NAFLD,
DM
as
keywords
or
subject
terms,
relevant
literature
was
retrieved
Web
Science
PubMed
databases
2013
2022
summarized.
Results:
regulating
mitochondrial
function,
endoplasmic
reticulum,
phosphatidylinositol
3
kinase
(PI3K)/protein
B
(AKT),
erythroid
2-related
2
(Nrf-2),
nuclear
κB
(NF-κB),
other
signaling
pathways
improve
OS
glucolipid
Conclusion:
multi-mechanism
multifaceted.
Both
studies
animal
experiments
have
demonstrated
effectiveness
ROS.
However,
safety
need
be
improved,
more
needed
support
application
Food Chemistry Advances,
Journal Year:
2023,
Volume and Issue:
3, P. 100539 - 100539
Published: Nov. 21, 2023
Oxidative
stress
has
a
significant
impact
on
the
occurrence
of
many
chronic
diseases.
Antioxidants
have
ability
to
prevent,
postpone
or
treat
effects
free
radicals.
Resveratrol
is
polyphenol
from
class
stilbenes.
The
importance
this
compound
determined
by
its
numerous
biological
properties.
strong
antioxidant
potential
special
significance,
because
way
it
acts
in
prevention
and
treatment
action
direct,
inhibiting
production
reactive
species,
indirect,
influencing
activity
enzymes.
In
case
analyzing
known
methods,
was
observed
that
RSV
had
higher
capacity
than
standard
used.
Also,
vitro
vivo
studies
demonstrate
neurodegenerative,
cardiovascular
renal
addition,
active
preeclampsia
infertility.
An
important
aspect
fact
reduce
counteract
adverse
some
anticancer
agents.
