Advances in Crosstalk between Porcine Circoviruses and Host DOI Creative Commons

Guyu Niu,

Si Chen, Xue Li

et al.

Viruses, Journal Year: 2022, Volume and Issue: 14(7), P. 1419 - 1419

Published: June 28, 2022

Porcine circoviruses (PCVs), including PCV1 to PCV4, are non-enveloped DNA viruses with a diameter of about 20 nm, belonging the genus Circovirus in family Circoviridae. PCV2 is an important causative agent porcine circovirus disease or circovirus-associated (PCVD/PCVAD), which highly prevalent pigs and seriously affects swine industry globally. Furthermore, mainly causes subclinical symptoms immunosuppression, PCV3 PCV4 were detected healthy pigs, sick other animals. Although pathogenicity field still controversial, infection rates increasing. Moreover, rescued from infected clones pathogenic vivo. It worth noting that interaction between virus host crucial virus. This review discusses latest research progress on molecular mechanism PCVs–host interaction, may provide scientific basis for prevention control.

Language: Английский

Reductive stress in cancer: coming out of the shadows DOI
Maolin Ge, Thales Papagiannakopoulos, Liron Bar‐Peled

et al.

Trends in cancer, Journal Year: 2023, Volume and Issue: 10(2), P. 103 - 112

Published: Nov. 2, 2023

Language: Английский

Citations

23
Complex II ambiguities—FADH2 in the electron transfer system DOI Creative Commons
Erich Gnaiger

Journal of Biological Chemistry, Journal Year: 2023, Volume and Issue: 300(1), P. 105470 - 105470

Published: Nov. 22, 2023

The prevailing notion that reduced cofactors NADH and FADH

Language: Английский

Citations

23
HCV-induced autophagy and innate immunity DOI Creative Commons
Ji‐Young Lee,

J H Ou

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 2, 2024

The interplay between autophagy and host innate immunity has been of great interest. Hepatitis C virus (HCV) impedes signaling pathways initiated by pattern-recognition receptors (PRRs) that recognize pathogens-associated molecular patterns (PAMPs). Autophagy, a cellular catabolic process, delivers damaged organelles protein aggregates to lysosomes for degradation recycling. Autophagy is also an immune response cells trap pathogens in membrane vesicles removal. However, HCV controls the autophagic pathway uses membranes enhance its replication. Mitophagy, selective targeting mitochondria, alters dynamics metabolism which play important roles antiviral responses. mitochondrial promotes mitophagy prevent premature cell death attenuate interferon (IFN) response. In addition, dysregulation inflammasomal leads IFN resistance tolerance. These evasion properties allow successfully replicate persist cells. this article, we discuss HCV-induced autophagy/mitophagy associated immunological responses provide review our current understanding how these processes are regulated HCV-infected

Language: Английский

Citations

12
The cGAS-STING pathway in viral infections: a promising link between inflammation, oxidative stress and autophagy DOI Creative Commons
Kunli Zhang,

Qiuyan Huang,

Xinming Li

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 15, 2024

The host defence responses play vital roles in viral infection and are regulated by complex interactive networks. immune system recognizes pathogens through the interaction of pattern-recognition receptors (PRRs) with pathogen-associated molecular patterns (PAMPs). As a PRR mainly cytoplasm, cyclic GMP-AMP synthase (cGAS) senses binds virus DNA subsequently activates stimulator interferon genes (STING) to trigger series intracellular signalling cascades defend against invading pathogenic microorganisms. Integrated omic functional analyses identify cGAS-STING pathway regulating various cellular controlling infections. Aside from its most common function inflammation type I interferon, growing body evidence suggests that axis is closely associated responses, such as oxidative stress, autophagy, endoplasmic reticulum which have major impacts on physiological homeostasis. Interestingly, these dual regulation clearance viruses. Here, we outline recent insights into inflammation, autophagy stress discuss their interactions A detailed understanding cGAS-STING-mediated potential antiviral effects contributes revealing pathogenesis certain viruses sheds light effective solutions for therapy.

Language: Английский

Citations

10
Varicella zoster virus glycoprotein E facilitates PINK1/Parkin-mediated mitophagy to evade STING and MAVS-mediated antiviral innate immunity DOI Creative Commons
Soo Jin Oh, Je‐Wook Yu, Jin‐Hyun Ahn

et al.

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 6, 2024

Viruses have evolved to control mitochondrial quality and content facilitate viral replication. Mitophagy is a selective autophagy, in which the damaged or unnecessary mitochondria are removed, thus considered an essential mechanism for control. Although mitophagy manipulation by several RNA viruses has recently been reported, effect of regulation varicella zoster virus (VZV) remains be fully determined. In this study, we showed that dynamin-related protein-1 (DRP1)-mediated fission subsequent PINK1/Parkin-dependent were triggered during VZV infection, facilitating addition, glycoprotein E (gE) promoted PINK1/Parkin-mediated interacting with LC3 upregulating reactive oxygen species. Importantly, gE inhibited MAVS oligomerization STING translocation disrupt MAVS- STING-mediated interferon (IFN) responses, was required gE-mediated inhibition IFN production. Similarly, carbonyl cyanide m-chlorophenyl hydrazone (CCCP)-mediated induction led increased replication but attenuated production three-dimensional human skin organ culture model. Our results provide new insights into immune evasion via mitophagy.

Language: Английский

Citations

9
A mitochondria targeted hydrogen peroxide fluorescent probe for monitoring oxidative stress during influenza virus infection DOI
Hao Chang, Jianing Wang, Yang Yang

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: 334, P. 125929 - 125929

Published: Feb. 22, 2025

Language: Английский

Citations

1
Zika virus modulates mitochondrial dynamics, mitophagy, and mitochondria-derived vesicles to facilitate viral replication in trophoblast cells DOI Creative Commons
Jae Kwan Lee, Ok Sarah Shin

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 14, 2023

Zika virus (ZIKV) remains a global public health threat with the potential risk of future outbreak. Since viral infections are known to exploit mitochondria-mediated cellular processes, we investigated effects ZIKV infection in trophoblast cells terms different mitochondrial quality control pathways that govern integrity and function. Here demonstrate (PRVABC59) JEG-3 manipulates dynamics, mitophagy, formation mitochondria-derived vesicles (MDVs). Specifically, nonstructural protein 4A (NS4A) translocates mitochondria, triggers fission suppresses associated antiviral (MAVS)-mediated type I interferon (IFN) response. Furthermore, proteomics profiling small extracellular (sEVs) revealed an enrichment proteins sEVs secreted by ZIKV-infected cells, suggesting MDV may also be another mechanism manipulated during placental infection. Altogether, our findings highlight mechanisms as host immune evasion utilized at placenta suppress response facilitate

Language: Английский

Citations

20
SARS-CoV-2 ORF3c impairs mitochondrial respiratory metabolism, oxidative stress, and autophagic flux DOI Creative Commons
Alessandra Mozzi,

Monica Oldani,

Matilde Forcella

et al.

iScience, Journal Year: 2023, Volume and Issue: 26(7), P. 107118 - 107118

Published: June 16, 2023

Coronaviruses encode a variable number of accessory proteins that are involved in host-virus interaction, suppression immune responses, or evasion. SARS-CoV-2 encodes at least twelve proteins, whose roles during infection have been studied. Nevertheless, the role ORF3c protein, an alternative open reading frame ORF3a, has remained elusive. Herein, we show protein mitochondrial localization and alters metabolism, inducing shift from glucose to fatty acids oxidation enhanced oxidative phosphorylation. These effects result increased ROS production block autophagic flux. In particular, affects lysosomal acidification, blocking normal degradation process leading autolysosome accumulation. We also observed different effect on autophagy for batCoV RaTG13 proteins; 36R 40K sites necessary sufficient determine these effects.

Language: Английский

Citations

19
The Role of Glutathione in Selected Viral Diseases DOI Creative Commons
Joanna Wróblewska, Marcin Wróblewski, Iga Hołyńska-Iwan

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(7), P. 1325 - 1325

Published: June 22, 2023

During inflammatory processes, immunocompetent cells are exposed to substantial amounts of free radicals and toxic compounds. Glutathione is a cysteine-containing tripeptide that an important ubiquitous antioxidant molecule produced in human organs. The intracellular content GSH regulates the detoxifying capacity cells, as well immune response. particularly liver, where it serves major non-protein thiol involved cellular defense. There numerous causes hepatitis. inflammation liver can be caused by variety infectious viruses. relationship between oxidative stress hepatitis A virus (HAV), B (HBV), C (HCV), E (HEV) infection not fully known. aim this study was examine hepatotropic viruses glutathione status, including reduced (GSH) oxidized (GSSG), enzymes, e.g., peroxidase (GPx), reductase (GR) glutathione-S-transferase (GST) diseases.

Language: Английский

Citations

19
Molecular Mechanisms of Oxidative Stress in Acute Kidney Injury: Targeting the Loci by Resveratrol DOI Open Access
Hina Rashid, Abdulmajeed M. Jali, Mohammad Suhail Akhter

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 25(1), P. 3 - 3

Published: Dec. 19, 2023

Reactive oxygen species are a group of cellular molecules that stand as double-edged swords, their good and bad being discriminated by precise balance. Several metabolic reactions in the biological system generate these interact with atoms to regulate functions ranging from cell homeostasis death. A prooxidative state concomitant decreased clearance such leads oxidative stress, which contributes prime pathophysiological mechanism various diseases including renal disorders, acute kidney injury. However, targeting generation stress disorders an antioxidant, resveratrol, is gaining considerable therapeutic importance known improve condition preclinical studies. This review aims discuss molecular mechanisms injury its amelioration resveratrol. The major sources data were PubMed Google Scholar, studies last five years primarily included, significant earlier also considered. Mitochondrial dysfunction, enzymatic reactions, protein misfolding reactive injury, interrupting loci or intersection other components resveratrol can mitigate severity condition.

Language: Английский

Citations

19