Pathophysiological mechanisms implicated in postpartum depression

Frontiers in Neuroendocrinology, Journal Year: 2018, Volume and Issue: 52, P. 165 - 180

Published: Dec. 12, 2018

Language: Английский

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Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond

Neurobiology of Stress, Journal Year: 2019, Volume and Issue: 11, P. 100196 - 100196

Published: Sept. 27, 2019

The recent FDA approval of the neurosteroid, brexanolone (allopregnanolone), as a treatment for women with postpartum depression, and successful trials related neuroactive steroid, SGE-217, men major depressive disorder offer hope new era in treating mood anxiety disorders based on potential neurosteroids modulators brain function. This review considers mechanisms contributing to antidepressant anxiolytic effects allopregnanolone other GABAergic focusing their actions positive allosteric GABAA receptors. We also consider roles endogenous "stress" possible additional therapeutic effects. argue that further understanding molecular, cellular, network psychiatric offers advances disorders.

Language: Английский

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Postpartum psychiatric disorders

Nature Reviews Disease Primers, Journal Year: 2018, Volume and Issue: 4(1)

Published: April 26, 2018

Language: Английский

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Brain plasticity in pregnancy and the postpartum period: links to maternal caregiving and mental health

Archives of Women s Mental Health, Journal Year: 2018, Volume and Issue: 22(2), P. 289 - 299

Published: July 14, 2018

Pregnancy and the postpartum period involve numerous physiological adaptations that enable development survival of offspring. A distinct neural plasticity characterizes female brain during this period, dynamic structural functional changes take place accompany fundamental behavioral adaptations, stimulating to progress from an individual with self-directed needs being responsible for care another life. While many animal studies detail these modifications, emerging body research reveals existence reproduction-related in human mothers too. Additionally, associations aspects maternal caregiving point adaptive benefit a woman's transition motherhood. However, affect are not merely adaptive, they likely confer vulnerability mental disorders. Here, we review structure function woman undergoes peripartum outlining between alterations different care. We additionally discuss mood disorders psychosis, neuroimaging investigate bases conditions.

Language: Английский

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Neural circuitry for maternal oxytocin release induced by infant cries

Nature, Journal Year: 2023, Volume and Issue: 621(7980), P. 788 - 795

Published: Sept. 20, 2023

Language: Английский

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Neuroanatomical changes observed over the course of a human pregnancy

Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(11), P. 2253 - 2260

Published: Sept. 16, 2024

Abstract Pregnancy is a period of profound hormonal and physiological changes experienced by millions women annually, yet the neural unfolding in maternal brain throughout gestation are not well studied humans. Leveraging precision imaging, we mapped neuroanatomical an individual from preconception through 2 years postpartum. Pronounced decreases gray matter volume cortical thickness were evident across brain, standing contrast to increases white microstructural integrity, ventricle cerebrospinal fluid, with few regions untouched transition motherhood. This dataset serves as comprehensive map human gestation, providing open-access resource for imaging community further explore understand brain.

Language: Английский

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Education level and risk of postpartum depression: results from the Japan Environment and Children’s Study (JECS)

BMC Psychiatry, Journal Year: 2019, Volume and Issue: 19(1)

Published: Dec. 1, 2019

Abstract Background Lower socioeconomic status is often thought to be associated with an elevated risk of postpartum depression; however, this relationship exhibits noticeable heterogeneity between studies. The present study examined in Japan. Methods Data were obtained from 90,194 mothers ongoing birth cohort the Japan Environment and Children’s Study. Socioeconomic was assessed based on mothers’ highest education level during pregnancy. Postpartum depression identified at 1 6 months Edinburgh Postnatal Depression Scale score ≥9, analyses also performed sub-scores for anxiety, depression, anhedonia symptoms. Logistic generalized linear regression model used calculate odds ratios according group (≥16 years education) defined as reference group, while controlling covariates a stepwise fashion. Results Univariate analysis revealed that lower higher prevalence related Although these relationships weakened fully adjusted models, cases symptoms remained significant postpartum. Among three symptom dimensions, strongest weakest depressive anxiety symptoms, respectively. Conclusions A independent factor depression. In view low mobility level, finding suggests potential importance collecting information regarding levels earliest opportunity.

Language: Английский

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It Is Time for Routine Screening for Perinatal Mood and Anxiety Disorders in Obstetrics and Gynecology Settings

Obstetrical & Gynecological Survey, Journal Year: 2017, Volume and Issue: 72(9), P. 553 - 568

Published: Sept. 1, 2017

Importance Women are 2 to 3 times more likely than men experience depression in their lifetime, and the greatest risk occurs during reproductive years. As an obstetrics gynecology physician or provider, you will encounter women who at of development relapse a mental disorder this vulnerable time. Objective The aim review is examine theory research on mood anxiety disorders perinatal period with emphasis screening recommendations. Evidence Acquisition A PubMed PsycINFO search for English-language publications about was performed included studies subtopics. Results literature reviewed suggests that symptoms prevalent have significant consequences, best practices early detection through routine setting. This includes overcoming barriers care use liaison services potentially reduce risk. Conclusions Relevance High-quality prenatal systems should develop capacity assessment treatment. Providers routinely screen using validated tools, provide maternal health education, be aware various medical, psychological, complementary approaches treating disorders, guide refer patients. practice increase quality life pregnant may help likelihood adverse birth outcomes, postpartum problems, effects offspring. Target Audience Obstetricians gynecologists, family physicians. Learning Objectives After completing activity, learner better able name outcomes related anxiety; identify symptoms, prevalence, consequences pregnancy postpartum; contrast apply reliable, valid, widely used tools assess appropriate referral population.

Language: Английский

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The HPA Axis During the Perinatal Period: Implications for Perinatal Depression

Endocrinology, Journal Year: 2018, Volume and Issue: 159(11), P. 3737 - 3746

Published: Sept. 25, 2018

The transition to motherhood is characterized by some of the most pronounced endocrine changes a woman will experience in her lifetime. Unfortunately, matrescence also time woman's life when she susceptible mental illness such as perinatal depression. A growing body research has aimed determine how key systems, hypothalamic-pituitary-adrenal (HPA) axis, are involved dysregulation health. However, very little consistently linked HPA axis with maternal illness. Therefore, aims this mini review to: (i) clearly summarize normative that occur during pregnancy and postpartum period; (ii) what we know about depression, (iii) propose areas for future research. Understanding physiological biomarkers can predict which women at risk mood disorders lead better tools treating, ultimately preventing, these debilitating disorders, improving health mother, child, family.

Language: Английский

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Estrogen receptor α drives pro-resilient transcription in mouse models of depression

Nature Communications, Journal Year: 2018, Volume and Issue: 9(1)

Published: March 12, 2018

Abstract Most people exposed to stress do not develop depression. Animal models have shown that resilience is an active state requires broad transcriptional adaptations, but how this homeostatic process regulated remains poorly understood. In study, we analyze upstream regulators of genes differentially expressed after chronic social defeat stress. We identify estrogen receptor α (ERα) as the top regulator pro-resilient changes in nucleus accumbens (NAc), a key brain reward region implicated accordance with these findings, nuclear ERα protein levels are altered by male and female mice. Further, overexpression NAc promotes both sexes. Subsequent RNA-sequencing reveals reproduces signature male, female, These results indicate important changes, sex-specific downstream targets.

Language: Английский

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