Platelet signaling in immune landscape: comprehensive mechanism and clinical therapy DOI Creative Commons

Mengyao Yan,

Zhe Wang, Zhiwei Qiu

et al.

Biomarker Research, Journal Year: 2024, Volume and Issue: 12(1)

Published: Dec. 31, 2024

Platelets are essential for blood clotting and maintaining normal hemostasis. In pathological conditions, platelets increasingly recognized as crucial regulatory factors in various immune-mediated inflammatory diseases. Resting induced by such immune complexes through Fc receptors, platelet-targeting autoantibodies other platelet-activating stimuli. Platelet activation immunological processes involves the release of stimuli, antigen presentation interaction with cells. participate both innate system (neutrophils, monocytes/macrophages, dendritic cells (DCs) Natural Killer (NK) adaptive (T B cells). Clinical therapeutic strategies include targeting platelet activation, platelet-immune cell platelet-endothelial interaction, which display positive development prospects. Understanding mechanisms immunity is important, developing targeted modulations these will pave way promising strategies.

Language: Английский

Expanding applications of allogeneic platelets, platelet lysates, and platelet extracellular vesicles in cell therapy, regenerative medicine, and targeted drug delivery DOI Creative Commons
Thierry Burnouf, Ming‐Li Chou, David J. Lundy

et al.

Journal of Biomedical Science, Journal Year: 2023, Volume and Issue: 30(1)

Published: Sept. 14, 2023

Abstract Platelets are small anucleated blood cells primarily known for their vital hemostatic role. Allogeneic platelet concentrates (PCs) collected from healthy donors an essential cellular product transfused by hospitals to control or prevent bleeding in patients affected thrombocytopenia dysfunctions. fulfill additional functions innate and adaptive immunity inflammation, as well wound-healing tissue-repair mechanisms. contain mitochondria, lysosomes, dense granules, alpha-granules, which collectively a remarkable reservoir of multiple trophic factors, enzymes, signaling molecules. In addition, platelets prone release the circulation unique set extracellular vesicles (p-EVs), carry rich biomolecular cargo influential cell–cell communications. The exceptional functional roles played p-EVs explain recent interest exploring use allogeneic PCs source material develop new biotherapies that could address needs cell therapy, regenerative medicine, targeted drug delivery. Pooled human lysates (HPLs) can be produced have reached expiration date no longer suitable transfusion but remain valuable materials other applications. These HPLs substitute fetal bovine serum clinical grade xeno-free supplement growth media used vitro expansion transplantation purposes. expired has opened way small-pool large-pool HPL-derived biotherapy ocular surface disorders, wound care and, potentially, neurodegenerative diseases, osteoarthritis, others. Additionally, now seen readily available EVs exploited delivery vehicles. This article aims offer in-depth update on emerging translational applications while also highlighting advantages limitations modality medicine therapies.

Language: Английский

Citations

46
Blood-brain barrier biomarkers DOI

Juan F. Zapata-Acevedo,

Alejandra Mantilla-Galindo,

Karina Vargas-Sánchez

et al.

Advances in clinical chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 88

Published: Jan. 1, 2024

Language: Английский

Citations

9
Plasma brain-related biomarkers and potential therapeutic targets in pediatric ECMO DOI Creative Commons
Sue J. Hong,

Bradley J. De Souza,

Kristen K. Penberthy

et al.

Neurotherapeutics, Journal Year: 2025, Volume and Issue: 22(1), P. e00521 - e00521

Published: Jan. 1, 2025

Language: Английский

Citations

1
Neutrophil extracellular traps and their implications in airway inflammatory diseases DOI Creative Commons

Nanxia Xuan,

Jie Zhao,

Zhi-Ying Kang

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 10

Published: Jan. 12, 2024

Neutrophil extracellular traps (NETs) are essential for immune defense and have been increasingly recognized their role in infection inflammation. In the context of airway inflammatory diseases, there is growing evidence suggesting involvement significance NETs. This review aims to provide an overview formation mechanisms components NETs impact on various including acute lung injury/ARDS, asthma, chronic obstructive pulmonary disease (COPD) cystic fibrosis. By understanding inflammation, we can gain valuable insights into underlying pathogenesis these diseases identify potential targets future therapeutic strategies that either target or modulate harmful effects. Further research warranted elucidate complex interactions between inflammation develop targeted therapies effectively mitigate detrimental effects while preserving beneficial functions host defense.

Language: Английский

Citations

6
Serum high-sensitivity C-reactive protein and dementia in a community-dwelling Japanese older population (JPSC-AD) DOI Creative Commons
Ayumi Tachibana, Jun‐ichi Iga,

Tomoki Ozaki

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 28, 2024

Abstract In recent years, the association between neuroinflammatory markers and dementia, especially Alzheimer’s disease (AD), has attracted much attention. However, evidence for relationship serum-hs-CRP dementia including AD are inconsistent. Therefore, relationships of serum high-sensitivity CRP (hs-CRP) with regions interest brain MRI were investigated. A total 11,957 community residents aged 65 years or older recruited in eight sites Japan (JPSC-AD Study). After applying exclusion criteria, 10,085 participants who underwent blood tests health-related examinations analyzed. Then, hs-CRP levels classified according to clinical cutoff values, odds ratios presence all-cause its subtypes calculated each level. addition, volume was also examined using analysis covariance data from 8614 individuals same cohort MRI. multivariable adjustment, (ORs) 1.04 (95% confidence interval [CI] 0.76–1.43), 1.68 (95%CI 1.08–2.61), 1.51 1.08–2.11) 1.0–1.9 mg/L, 2.0–2.9 ≥ 3.0 respectively, compared < 1.0 those 0.72 0.48–1.08), 1.76 1.08–2.89), 1.61 1.11–2.35), mg/L. Multivariable-adjusted ORs prevalence increased significantly increasing ( p trend 0.001 = 0.001, respectively). multivariable-adjusted temporal cortex volume/estimated intracranial ratio decreased (< mg/L 4.28%, 4.27%, 4.29%, 4.21%; 0.004). This study’s results suggest that elevated associated greater risk AD, atrophy a community-dwelling Japanese population.

Language: Английский

Citations

6
Intermittent Metabolic Switching and Vascular Cognitive Impairment DOI Creative Commons

Vismitha Rajeev,

Nishat I. Tabassum,

David Y. Fann

et al.

Journal of Obesity & Metabolic Syndrome, Journal Year: 2024, Volume and Issue: 33(2), P. 92 - 107

Published: May 13, 2024

Intermittent fasting (IF), a dietary pattern alternating between eating and periods within 24-hour cycle, has garnered recognition for its potential to enhance both healthspan lifespan in animal models humans. It also shows promise alleviating age-related diseases, including neurodegeneration. Vascular cognitive impairment (VCI) spans severity range from mild deficits severe loss of function vascular dementia. Chronic cerebral hypoperfusion emerged as significant contributor VCI, instigating pathologies such microbleeds, blood-brain barrier dysfunction, neuronal loss, white matter lesions. Preclinical studies rodents strongly suggest that IF the attenuate pathological mechanisms, excitotoxicity, oxidative stress, inflammation, cell death pathways VCI models. Hence, this supports evaluating clinical trials existing at-risk patients. This review compiles data supporting IF's treating VCI-related pathologies, emphasizing mechanisms by which may mitigate these issues. Hence providing comprehensive overview available underlying make promising intervention VCI.

Language: Английский

Citations

4
Peripheral immunity is associated with cognitive impairment after acute minor ischemic stroke and transient ischemic attack DOI Creative Commons
Panpan Zhao, Guimei Zhang, Yongchun Wang

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 13, 2024

Abstract Immunoinflammation is associated with the development of post-stroke cognitive impairment (PSCI), however, peripheral immunity has not been fully explored. We aimed to investigate association between PSCI and immune indicators, including neutrophil, lymphocyte, mononuclear percentages counts; systemic inflammation index; platelet-to-lymphocyte ratio; neutrophil-to-lymphocyte ratio (NLR); lymphocyte-to-monocyte ratio. A total 224 patients acute minor ischemic stroke or transient attack 6–12 months follow-up were included. was defined as a Montreal Cognitive Assessment score < 22 during period. performed logistic regression, subgroup analyses based on age sex, further established predictive models. found that increased innate indicators (neutrophils, neutrophil percentage) risk PSCI, whereas adaptive indicator (lymphocytes) protective against especially in aged 50–65 years. Neutrophil percentage NLR improved efficacy models included demographic, clinical, imaging information, area under curve from 0.765 0.804 0.803 ( P = 0.042 0.049, respectively). conducted comprehensive analysis providing novel perspective early detection, etiology, treatment PSCI.

Language: Английский

Citations

4
Human platelet lysate: a potential therapeutic for intracerebral hemorrhage DOI Creative Commons

Dachang Qiu,

Lin Wang, Lanlan Wang

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 18

Published: Jan. 15, 2025

Intracerebral hemorrhage (ICH) is a major public health challenge worldwide, and associated with elevated rates of mortality, disability, morbidity, especially in low- middle-income nations. However, our knowledge the detailed molecular processes involved ICH remains insufficient, particularly those secondary injury stage, resulting lack effective treatments for ICH. Human platelet lysates (HPL) are abundant bioactive factors, numerous studies have demonstrated their beneficial effects on neurological diseases, including anti-neuroinflammatory ability, anti-oxidant effects, maintenance blood-brain barrier integrity, promotion neurogenesis. In this review, we thoroughly explore potential HPL treating from three critical perspectives: rationale selecting as treatment ICH, mechanisms through which contributes to management, additional measures necessary We elucidate role platelets pathophysiology highlight limitations current options advancements preclinical research application disorders. Furthermore, historical developments preparation methods field biomedicine discussed. Additionally, summarize molecules present therapeutic Finally, outline issues that must be addressed regarding utilizing modality

Language: Английский

Citations

0
Neutrophils: a new target for postoperative cognitive dysfunction. DOI
Jianxin Cheng, Jin Gao, Jianjun Li

et al.

PubMed, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Language: Английский

Citations

0
Biomarker Profile in Peripheral Blood Cells Related to Alzheimer’s Disease DOI Creative Commons

Mirko Lomi,

Filippo Geraci,

Cristina Del Seppia

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Abstract In a healthy brain, neuroinflammation, controlled by the main intermediary for immune response microglia and astrocytes, contributes to maintain physiological functions such as secretion of neurotrophic factors, removal cell tau amyloid-β (Aβ) debris, local homeostasis. When becomes chronic, it can become pathological fuel causing glial cells malfunction not perform their function clearing resulting in further damage neurons. Multiple studies highlight that an intense crosstalk is activated between peripheral blood white (PBWCs) central nervous system (CNS). Nevertheless, how PBWC be carriers biomarkers CNS neuropathological states still far completely known. this work, we aimed observe content could related moderate-severity DAT order have early signals from neurodegeneration brain initiate. Protein analysis been performed Mild Cognitive Impairment (MCI) patients respect those controls differently expressed proteins investigated. Our data showed deregulation pathways involved since MCI level deregulated considered markers onset progression.

Language: Английский

Citations

0