Immunological Investigations,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 25
Published: April 21, 2025
Antibodies
have
long
served
as
fundamental
tools
in
disease
diagnosis
and
surveillance.
Their
utility
biomarkers
has
expanded
beyond
infectious
diseases
to
encompass
a
wide
range
of
health
conditions.
This
review
aims
explore
recent
advancements
antibody
biomarker
discovery
their
applications
diagnosing
monitoring
diverse
It
also
examines
the
role
surveillance
public
epidemiological
studies.
A
comprehensive
analysis
literature
was
conducted,
focusing
on
studies
that
identify
characterize
disease-specific
antibodies.
Particular
attention
given
relevance
autoimmune
diseases,
infections,
cancers,
neurological
disorders.
The
highlights
clinical
significance.
discusses
challenges
antibody-based
assessing
prevalence,
tracking
immunity
trends,
supporting
One
Health
strategies.
Recent
demonstrate
significant
potential
improving
early
diagnosis,
personalized
treatment,
population-level
management.
Antibody
continues
play
pivotal
guiding
responses
understanding
dynamics.
ACS Sensors,
Journal Year:
2024,
Volume and Issue:
9(9), P. 4469 - 4494
Published: Sept. 9, 2024
Lung
cancer
remains
a
global
health
concern,
demanding
the
development
of
noninvasive,
prompt,
selective,
and
point-of-care
diagnostic
tools.
Correspondingly,
breath
analysis
using
nanobiosensors
has
emerged
as
promising
noninvasive
nose-on-chip
technique
for
early
detection
lung
through
monitoring
diversified
biomarkers
such
volatile
organic
compounds/gases
in
exhaled
breath.
This
comprehensive
review
summarizes
state-of-the-art
breath-based
diagnosis
employing
chemiresistive-module
supported
by
theoretical
findings.
It
unveils
fundamental
mechanisms
biological
basis
biomarker
generation
associated
with
cancer,
technological
advancements,
clinical
implementation
nanobiosensor-based
analysis.
explores
merits,
challenges,
potential
alternate
solutions
implementing
these
settings,
including
standardization,
biocompatibility/toxicity
analysis,
green
sustainable
technologies,
life-cycle
assessment,
scheming
regulatory
modalities.
highlights
nanobiosensors'
role
facilitating
precise,
real-time,
on-site
leading
to
improved
patient
outcomes,
enhanced
management,
remote
personalized
monitoring.
Additionally,
integrating
biosensors
artificial
intelligence,
machine
learning,
Internet-of-things,
bioinformatics,
omics
technologies
is
discussed,
providing
insights
into
prospects
intelligent
sniffing
nanobiosensors.
Overall,
this
consolidates
knowledge
on
breathomic
biosensor-based
screening,
shedding
light
its
significance
applications
advancing
medical
diagnostics
reduce
burden
hospitals
save
human
lives.
World Journal of Advanced Research and Reviews,
Journal Year:
2024,
Volume and Issue:
21(1), P. 2740 - 2752
Published: Jan. 30, 2024
As
healthcare
systems
strive
to
meet
the
evolving
demands
of
an
ever-changing
landscape,
biotechnology
emerges
as
a
pivotal
force
driving
transformative
advancements.
This
comprehensive
review
explores
multifaceted
role
in
healthcare,
examining
global
trends
that
underscore
its
profound
impact
on
diagnostics,
treatment
modalities,
and
overall
landscape
delivery.
The
study
begins
by
elucidating
fundamental
principles
diverse
applications
healthcare.
From
genomics
personalized
medicine,
biotechnological
innovations
are
reshaping
understanding
diseases,
enabling
tailored
interventions
based
individual
genetic
profiles.
delves
into
burgeoning
field
precision
where
tools
empower
clinicians
deliver
targeted
therapies,
optimize
outcomes,
minimize
adverse
effects.
integration
platforms
including
advanced
imaging
techniques
liquid
biopsies,
is
transforming
early
detection
monitoring
ushering
era
proactive
Moreover,
characterized
collaborative
research
initiatives
cross-disciplinary
partnerships.
interconnectedness
with
artificial
intelligence
data
analytics
explored,
highlighting
synergistic
potential
unlocking
intricate
patterns
within
vast
datasets
inform
more
precise
effective
strategies.
accelerates
development
novel
therapeutics,
gene
cell
addresses
ethical
considerations,
regulatory
frameworks,
accessibility
challenges.
It
critically
analyzes
disparities
adoption
advancements
across
systems,
emphasizing
need
for
equitable
access
ensure
benefits
reach
populations
worldwide.
In
conclusion,
elucidates
extends
beyond
scientific
breakthroughs
encompass
paradigm
shift.
By
continents,
it
underscores
power
fostering
new
precision,
innovation,
unwavering
commitment
improving
patient
outcomes
scale.
Frontiers in Cell and Developmental Biology,
Journal Year:
2025,
Volume and Issue:
13
Published: Jan. 22, 2025
Oral
squamous
cell
carcinoma
(OSCC)
is
the
most
common
malignant
tumour
in
oral
and
maxillofacial
region.
Early
diagnosis
can
significantly
improve
5-year
survival
rate
of
patients
with
OSCC.
Therefore,
it
extremely
important
to
differentiate
OSCC
early,
easily
quickly.
Human
saliva
contains
a
variety
components
that
be
used
as
biomarkers
for
prognosis
Studies
have
shown
salivary
microRNAs
(miRNAs)
cytokines
are
closely
associated
progression
The
aim
this
review
summarize
research
progress
(miRNAs
cytokines)
past
3
years,
explore
possibility
using
miRNAs
Journal of the Oman Medical Association,
Journal Year:
2025,
Volume and Issue:
2(1), P. 4 - 4
Published: Feb. 27, 2025
Human
papillomavirus
(HPV)
infection
poses
significant
public
health
issues
for
both
men
and
women.
Recent
studies
have
brought
attention
to
the
substantial
impact
of
HPV-linked
cancers
in
despite
historically
focusing
more
on
its
effects
It
was
revealed
that
2019,
HPV
root
cause
approximately
70,000
cancer
cases
men.
Modes
transmission
include
sexual
contact,
encompassing
various
practices
such
as
vaginal,
anal,
oral
intercourse,
well
use
devices.
Moreover,
HPV-associated
are
becoming
increasingly
common
men,
with
penile,
being
most
prevalent.
Although
human
body
can
clear
about
90%
cases,
it’s
crucial
take
preventive
measures
lower
risk
developing
cancer.
Using
condoms,
quitting
smoking,
male
circumcision
identified
essential
factors
preventing
among
heterosexual
couples.
However,
promising
measure
is
vaccination.
There
ongoing
discussions
regarding
protective
efficacy
cost-effectiveness;
vaccinating
boys
before
their
debut
presents
a
compelling
rationale.
The
existing
literature
primarily
focuses
women
lacks
comprehensive
review
development
prevention
methods
specifically
related
HPV-related
This
strives
bridge
this
gap
by
offering
detailed
overview
males,
particularly
head
&
neck
will
cover
important
aspects
treatment
strategies
provide
valuable
information
initiatives
clinical
practice.
Expert Review of Proteomics,
Journal Year:
2024,
Volume and Issue:
21(4), P. 149 - 168
Published: April 2, 2024
Introduction
Saliva
has
gained
increasing
attention
in
the
quest
for
disease
biomarkers.
Because
it
is
a
biological
fluid
that
can
be
collected
an
easy,
painless,
and
safe
way,
been
increasingly
studied
identification
of
oral
cancer
This
particularly
important
because
often
diagnosed
at
late
stages
with
poor
prognosis.
Current Oncology,
Journal Year:
2023,
Volume and Issue:
31(1), P. 168 - 182
Published: Dec. 28, 2023
Microorganisms
in
the
oral
cavity
are
abundant
human
body.
At
present,
more
than
700
species
of
microorganisms
have
been
identified.
Recently,
a
lot
literature
has
indicated
that
microbiota
plays
an
important
role
occurrence,
development,
and
prognosis
squamous
cell
carcinoma
(OSCC)
through
various
mechanisms.
And
researchers
now
trying
to
utilize
cancer
diagnosis
treatment.
However,
few
articles
systematically
summarize
effects
microbes
diagnosis,
treatment,
disease
outcomes
cancer.
Herein,
we
made
summary
microbial
changes
at
cancerous
sites
placed
emphasis
on
mechanisms
by
which
microbiome
promotes
cancerization.
Moreover,
aimed
find
out
clinical
value
OSCC.
Expert Review of Molecular Diagnostics,
Journal Year:
2024,
Volume and Issue:
24(4), P. 311 - 331
Published: April 2, 2024
Introduction
Oral
Squamous
Cell
Carcinoma
(OSCC),
the
sixth
most
widespread
malignancy
in
world,
accounts
for
90%
of
all
cases
oral
cancer.
The
primary
risk
factors
are
tobacco
chewing,
alcohol
consumption,
viral
infection,
and
genetic
modifications.
OSCC
has
a
high
morbidity
rate
due
to
lack
early
diagnostic
methods.
Nowadays,
liquid
biopsy
plays
vital
role
initial
diagnosis
ctNAs
extracted
from
saliva
serum/plasma
offer
meaningful
insights
into
tumor
genetics
dynamics.
interplay
these
elements
showcases
their
significance
advancing
noninvasive,
effective
detection
monitoring.
Journal of Medical Virology,
Journal Year:
2024,
Volume and Issue:
96(6)
Published: June 1, 2024
Abstract
Head
and
neck
cancers
(HNCs),
primarily
head
squamous
cell
carcinoma
(HNSCC),
are
associated
with
high‐risk
human
papillomavirus
(HR
HPV),
notably
HPV16
HPV18.
HPV
status
guides
treatment
predicts
outcomes,
distinct
molecular
pathways
in
HPV‐driven
HNSCC
influencing
survival
rates.
HNC
incidence
is
rising
globally,
regional
variations
reflecting
diverse
risk
factors,
including
tobacco,
alcohol,
infection.
Oropharyngeal
attributed
to
have
significantly
increased,
particularly
regions
like
the
United
States.
The
genome,
characterized
by
oncoproteins
E6
E7,
disrupts
crucial
cycle
regulators,
tumor
protein
p53
(TP53)
retinoblastoma
(Rb),
contributing
pathogenesis.
P16
immunohistochemistry
(IHC)
a
reliable
surrogate
marker
for
positivity,
while
situ
hybridization
polymerase
chain
reaction
(PCR)
techniques,
reverse
transcription‐quantitative
PCR
(RT‐qPCR),
offer
sensitive
detection.
Liquid‐based
RT‐qPCR,
especially
saliva,
shows
promise
noninvasive
detection,
offering
simplicity,
cost‐effectiveness,
patient
compliance.
These
advancements
enhance
diagnostic
accuracy,
guide
decisions,
improve
outcomes
management.
In
conclusion,
advances
detection
understanding
significant
clinical
management
implications.
Integrating
these
into
routine
practice
could
ultimately
outcomes.
