The High Risk of Bivalve Farming in Coastal Areas With Heavy Metal Pollution and Antibiotic-Resistant Bacteria: A Chilean Perspective DOI Creative Commons
Alequis Pavón, Diego Riquelme,

Víctor Jaña

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2022, Volume and Issue: 12

Published: April 7, 2022

Anthropogenic pollution has a huge impact on the water quality of marine ecosystems. Heavy metals and antibiotics are anthropogenic stressors that have major effect health organisms. Although heavy also associate with volcanic eruptions, wind erosion or evaporation, most them come from industrial urban waste. Such contamination, coupled to use subsequent misuse antimicrobials in aquatic environments, is an important stress factor capable affecting communities ecosystem. Bivalves ecological components oceanic environments can bioaccumulate pollutants during their feeding through filtration, acting as environmental sentinels. However, affect several physiologic immunological processes, including microbiome. In fact, potential select resistance genes bacteria, those part microbiota bivalves, such Vibrio spp. Worryingly, antibiotic-resistant phenotypes been shown be more tolerant metals, vice versa, which probably occurs co- cross-resistance pathways. this regard, crucial role metal spread mobile element-mediated antibiotic suggested. Thus, it might expected associated bivalves would higher contaminated environments. review, we focused co-occurrence addition, explore Chilean situation respect contaminants described above, focusing main bivalves-producing region for human consumption, considering vehicles humans ingestion seafood.

Language: Английский

Kaempferol: Antimicrobial Properties, Sources, Clinical, and Traditional Applications DOI Open Access
Argyrios Periferakis, Konstantinos Periferakis, Ioana Anca Bădărău

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(23), P. 15054 - 15054

Published: Nov. 30, 2022

Flavonoids are a category of plant-derived compounds which exhibit large number health-related effects. One the most well-known and studied flavonoids is kaempferol, can be found in wide variety herbs plant families. Apart from their anticarcinogenic anti-inflammatory effects, kaempferol its associated also antibacterial, antifungal, antiprotozoal activities. The development drugs treatment schemes based on these becoming increasingly important face emerging resistance numerous pathogens as well complex molecular interactions between various drug therapies. In addition, many kaempferol-containing plants used traditional systems all over world for centuries to treat conditions. Due sources compounds, some mechanisms antimicrobial activity known while others still under analysis. This paper thoroughly documents vegetal food recent significant studies regarding applications.

Language: Английский

Citations

172
Review on Multiple Facets of Drug Resistance: A Rising Challenge in the 21st Century DOI Creative Commons
Mousumi Saha, Agniswar Sarkar

Journal of Xenobiotics, Journal Year: 2021, Volume and Issue: 11(4), P. 197 - 214

Published: Dec. 13, 2021

With the advancements of science, antibiotics have emerged as an amazing gift to human and animal healthcare sectors for treatment bacterial infections other diseases. However, evolution new strains, along with excessive use reckless consumption led unfolding antibiotic resistances level. Multidrug resistance is a potential threat worldwide, escalating at extremely high rate. Information related drug resistance, its regulation control are still very little. To interpret onset resistances, investigation on molecular analysis genes, their distribution mechanisms urgently required. Fine-tuned research profile regarding ESKAPE pathogen also necessary multidrug resistant bacteria. In present scenario, interaction SARS-CoV-2 crucial. Tracking in-silico various or gene/s crucial overcoming problem, thus, maintenance relevant databases wise should be promoted. Creating awareness this critical situation among individuals every level important strengthen fight against fast-growing calamity. The review aimed provide detailed information regulatory responsible information. article, we tried focus correlation between antimicrobial COVID-19 pandemic. This study will help in developing interventions, approaches, strategies handle complexity prevent incidences life-threatening infections.

Language: Английский

Citations

145
Vibrio spp.: Life Strategies, Ecology, and Risks in a Changing Environment DOI Creative Commons
Ana Sampaio, Vanessa Silva, Patrícia Poeta

et al.

Diversity, Journal Year: 2022, Volume and Issue: 14(2), P. 97 - 97

Published: Jan. 29, 2022

Vibrios are ubiquitous bacteria in aquatic systems, especially marine ones, and belong to the Gammaproteobacteria class, most diverse class of Gram-negative bacteria. The main objective this review is update information regarding ecology Vibrio species, contribute discussion their potential risk a changing environment. As heterotrophic organisms, spp. live freely environments, from depths surface water column, frequently may be associated with micro- macroalgae, invertebrates, vertebrates such as fish, or symbiosis. Some pathogenic humans animals, there evidence that infections caused by vibrios increasing world. This rise related global changes human behavior (increases tourism, maritime traffic, consumption seafood, aquaculture production, demand, pollution), temperature. Most likely future, seafood will monitored order safeguard animal health. Regulators microbiological quality (marine freshwater) food for consumption, professionals involved freshwater production chains, consumers users resources, health challenged anticipate mitigate new risks.

Language: Английский

Citations

96
Usage of antibiotics in aquaculture and the impact on coastal waters DOI
Adenike Adenaya,

Martine Berger,

Thorsten Brinkhoff

et al.

Marine Pollution Bulletin, Journal Year: 2023, Volume and Issue: 188, P. 114645 - 114645

Published: Jan. 30, 2023

Language: Английский

Citations

58
In hot water: effects of climate change on Vibrio–human interactions DOI Open Access
Brett Froelich, Dayle A. Daines

Environmental Microbiology, Journal Year: 2020, Volume and Issue: 22(10), P. 4101 - 4111

Published: March 2, 2020

Sea level rise and the anthropogenic warming of world's oceans is not only an environmental tragedy, but these changes also result in a significant threat to public health. Along with coastal flooding encroachment saltwater farther inland comes increased risk human interaction pathogenic Vibrio species, such as cholerae, V. vulnificus parahaemolyticus. This minireview examines current literature for updates on climatic practices that impact location duration presence spp., well infection routes, trends virulence factors highly successful pathogens. Finally, overview treatments methods mitigation both oral cutaneous exposures are presented.

Language: Английский

Citations

94
Foodborne Pathogenic Vibrios: Antimicrobial Resistance DOI Creative Commons
Dipanjan Dutta, Anupam Kaushik, Dhirendra Kumar

et al.

Frontiers in Microbiology, Journal Year: 2021, Volume and Issue: 12

Published: June 30, 2021

Foodborne illness caused by pathogenic Vibrios is generally associated with the consumption of raw or undercooked seafood. Fish and other seafood can be contaminated Vibrio species, natural inhabitants marine, estuarine, freshwater environment. Pathogenic major public health concerns are

Language: Английский

Citations

93
Bacterial toxin-antitoxin modules: classification, functions, and association with persistence DOI Creative Commons
Garima Singh, Mohit Yadav, Chaitali Ghosh

et al.

Current Research in Microbial Sciences, Journal Year: 2021, Volume and Issue: 2, P. 100047 - 100047

Published: July 7, 2021

Toxin-antitoxin (TA) modules are ubiquitous gene loci among bacteria and comprised of a toxin part its cognate antitoxin part. Under normal physiological conditions, counteracts the toxicity whereas, during stress TA play crucial role in bacterial physiology through involvement post-segregational killing, abortive infection, biofilms, persister cell formation. Most toxins proteinaceous that affect translation or DNA replication, although some other intracellular molecular targets have also been described. While antitoxins may be protein RNA, generally neutralizes by direct interaction with help signaling elements thus helps module regulation. In this review, we discussed current state multifaceted (type I-VIII) highlighting their classification specific targets. We presence various pathogens antibiotic persistence development as well biofilm formation, influencing different cellular processes. end, assembling knowledge about systems from pathogenic facilitated us to propose multiple novel antibacterial strategies involving artificial activation modules.

Language: Английский

Citations

73
Diagnosis, Management, and Future Control of Cholera DOI
Fahima Chowdhury, Allen G. Ross, Md Taufiqul Islam

et al.

Clinical Microbiology Reviews, Journal Year: 2022, Volume and Issue: 35(3)

Published: June 21, 2022

Cholera, caused by Vibrio cholerae , persists in developing countries due to inadequate access safe water, sanitation, and hygiene. There are approximately 4 million cases 143,000 deaths each year cholera.

Language: Английский

Citations

59
Combination Strategies of Different Antimicrobials: An Efficient and Alternative Tool for Pathogen Inactivation DOI Creative Commons
Nagaraj Basavegowda, Kwang-Hyun Baek

Biomedicines, Journal Year: 2022, Volume and Issue: 10(9), P. 2219 - 2219

Published: Sept. 7, 2022

Despite the discovery and development of an array antimicrobial agents, multidrug resistance poses a major threat to public health progressively increases mortality. Recently, several studies have focused on developing promising solutions overcome these problems. This has led effective alternative methods controlling antibiotic-resistant pathogens. The use agents in combination can produce synergistic effects if each drug invades different target or signaling pathway with mechanism action. Therefore, combinations achieve higher probability selectivity therapeutic responses than single drugs. In this systematic review, we discuss combined such as plant extracts, essential oils, nanomaterials. Furthermore, review their interactions activities action, toxicity, future directions combination. Upon at optimum ratio, two more drugs significantly enhanced effect lower concentrations. Hence, using could be new, simple, solve problem antibiotic reduce susceptibility.

Language: Английский

Citations

51
An overview of novel antimicrobial carbonic anhydrase inhibitors DOI
Claudiu T. Supuran

Expert Opinion on Therapeutic Targets, Journal Year: 2023, Volume and Issue: 27(10), P. 897 - 910

Published: Sept. 25, 2023

Four different genetic families of the enzyme carbonic anhydrase (CA, EC 4.2.1.1) are present in bacteria, α-, β-, γ- and ι-CAs. They play relevant functions related to CO2, HCO3-/H+ ions homeostasis, being involved metabolic biosynthetic pathways, pH regulation, represent virulence survival factors for bacteria various niches. Bacterial CAs started be considered druggable targets last decade, as their inhibition impairs survival, growth, these pathogens.Significant advances were registered years designing effective inhibitors sulfonamide type Helicobacter pylori α-CA, Neisseria gonorrhoeae vacomycin-resistant enterococci (VRE) α- γ-CAs, which vivo validation has also been achieved. MIC-s range 0.25-4.0 µg/mL wild drug resistant N. strains, 0.007-2.0 VRE observed some 1,3,4-thiadiazole-2-sulfonamides, acetazolamide was gut decolonization from VRE.Targeting bacterial other pathogens, among Vibrio cholerae, Mycobacterium tuberculosis, Brucella suis, Salmonella enterica serovar Typhimurium, Legionella pneumophila, Porphyromonas gingivalis, Clostridium perfringens, Streptococcus mutans, Burkholderia pseudomallei, Francisella tularensis, Escherichia coli, Mammaliicoccus (Staphylococcus) sciuri, Pseudomonas aeruginosa, may lead novel antibacterials devoid resistance problems.

Language: Английский

Citations

31