The metabolic crosstalk of cancer-associated fibroblasts and tumor cells: Recent advances and future perspectives DOI
Bing Xia, Liqing Qiu, Jing Yue

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: unknown, P. 189190 - 189190

Published: Sept. 1, 2024

Language: Английский

Targeting the Warburg effect: A revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer DOI Creative Commons

Minru Liao,

Dahong Yao,

Lifeng Wu

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 14(3), P. 953 - 1008

Published: Dec. 16, 2023

Cancer reprogramming is an important facilitator of cancer development and survival, with tumor cells exhibiting a preference for aerobic glycolysis beyond oxidative phosphorylation, even under sufficient oxygen supply condition. This metabolic alteration, known as the Warburg effect, serves significant indicator malignant transformation. The effect primarily impacts occurrence by influencing pathway in cells. Key enzymes involved this process include glucose transporters (GLUTs), HKs, PFKs, LDHs, PKM2. Moreover, expression transcriptional regulatory factors proteins, such FOXM1, p53, NF-

Language: Английский

Citations

49
Lactate and lactylation: Behind the development of tumors DOI

Enci Dai,

Wei Wang, Yingying Li

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 591, P. 216896 - 216896

Published: April 17, 2024

Language: Английский

Citations

26
Cancer-Associated Fibroblasts in the Hypoxic Tumor Microenvironment DOI Open Access
Iljin Kim,

Sanga Choi,

Seongkyeong Yoo

et al.

Cancers, Journal Year: 2022, Volume and Issue: 14(14), P. 3321 - 3321

Published: July 7, 2022

Solid cancers are composed of malignant cells and their surrounding matrix components. Hypoxia plays a critical role in shaping the tumor microenvironment that contributes to cancer progression treatment failure. Cancer-associated fibroblasts (CAFs) one most prominent components microenvironment. CAFs highly sensitive hypoxia participates crosstalk with cells. Hypoxic modulate several mechanisms induce malignancy, such as extracellular (ECM) remodeling, immune evasion, metabolic reprogramming, angiogenesis, metastasis, drug resistance. Key signaling molecules regulating include transforming growth factor (TGF-β) hypoxia-inducible factors (HIFs). In this article, we summarize underlying hypoxic regulation how affect development progression. We also discuss potential therapeutic strategies focused on targeting

Language: Английский

Citations

45
Survival strategies: How tumor hypoxia microenvironment orchestrates angiogenesis DOI Open Access

Mengchao YANG,

Yufeng Mu,

Xiaoyun Yu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116783 - 116783

Published: May 25, 2024

During tumor development, the itself must continuously generate new blood vessels to meet their growth needs while also allowing for invasion and metastasis. One of most common features tumors is hypoxia, which drives process angiogenesis by regulating microenvironment, thus adversely affecting prognosis patients. In addition, overcome unsuitable environments growth, such as nutrient deficiency, hyperacidity, immunosuppression, microenvironment (TME) coordinates in several ways restore supply oxygen nutrients remove metabolic wastes. A growing body research suggests that hypoxia interact through a complex interplay crosstalk, inextricably linked TME. Here, we review TME's positive contribution from an angiogenesis-centric perspective considering objective impact hypoxic phenotypes status limitations current angiogenic therapies.

Language: Английский

Citations

10
Hypoxia-associated autophagy flux dysregulation in human cancers DOI
Jiding Fu,

Jie Lin,

Zili Dai

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 590, P. 216823 - 216823

Published: March 21, 2024

Language: Английский

Citations

8
PSMC2 promotes resistance against temozolomide in glioblastoma via suppressing JNK-mediated autophagic cell death DOI
Pritam Roy,

K Deepak,

Chandan Kanta Das

et al.

Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 116755 - 116755

Published: Jan. 1, 2025

Language: Английский

Citations

1
Hypoxia as a potential inducer of immune tolerance, tumor plasticity and a driver of tumor mutational burden: Impact on cancer immunotherapy DOI
Raefa Abou Khouzam, Bassam Janji, Jérôme Thiery

et al.

Seminars in Cancer Biology, Journal Year: 2023, Volume and Issue: 97, P. 104 - 123

Published: Nov. 28, 2023

Language: Английский

Citations

18
Clinical applications of fibroblast activation protein inhibitor positron emission tomography (FAPI-PET) DOI Creative Commons
Yuriko Mori, Emil Novruzov, Dominik Schmitt

et al.

npj Imaging, Journal Year: 2024, Volume and Issue: 2(1)

Published: Nov. 13, 2024

Abstract The discovery of fibroblast activation protein inhibitor positron emission tomography (FAPI-PET) has paved the way for a new class PET tracers that target tumor microenvironment (TME) rather than itself. Although 18 F-fluorodeoxyglucose (FDG) is most common tracer used in clinical imaging cancer, multiple studies have now shown family FAP ligands commonly outperform FDG detecting cancers, especially those known to lower uptake on FDG-PET. Moreover, FAPI-PET will applications benign fibrotic or inflammatory conditions. Thus, even while are development and yet enter guidelines, significant body literature emerged FAPI-PET, suggesting it important roles. This article summarizes current state as well potential uses theranostic agent.

Language: Английский

Citations

8
Crosstalk between autophagy and metabolism: implications for cell survival in acute myeloid leukemia DOI Creative Commons
Yongfeng Chen, Jia Chen, Zhenyou Zou

et al.

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: Jan. 24, 2024

Abstract Acute myeloid leukemia (AML), a prevalent form of in adults, is often characterized by low response rates to chemotherapy, high recurrence rates, and unfavorable prognosis. A critical barrier managing refractory or recurrent AML the resistance chemotherapy. Increasing evidence indicates that tumor cell metabolism plays crucial role progression, survival, metastasis, treatment resistance. Autophagy, an essential regulator cellular energy metabolism, increasingly recognized for its metabolic reprogramming AML. Autophagy sustains cells during chemotherapy not only providing but also facilitating rapid proliferation through supply components such as amino acids nucleotides. Conversely, state can influence activity autophagy. Their mutual coordination helps maintain intrinsic homeostasis, which significant contributor cells. This review explores recent advancements understanding interaction between autophagy cells, emphasizing their roles survival drug comprehensive interplay shed light on strategies, particularly under adverse conditions insight may pave way innovative targeted strategies.

Language: Английский

Citations

7
Pancreatic cancer and fibrosis: Targeting metabolic reprogramming and crosstalk of cancer-associated fibroblasts in the tumor microenvironment DOI Creative Commons
Xin Li, Jianbo Zhou, Xue Wang

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: March 22, 2023

Pancreatic cancer is one of the most dangerous types today, notable for its low survival rate and fibrosis. Deciphering cellular composition intercellular interactions in tumor microenvironment (TME) a necessary prerequisite to combat pancreatic with precision. Cancer-associated fibroblasts (CAFs), as major producers extracellular matrix (ECM), play key role progression. CAFs display significant heterogeneity perform different roles Tumor cells turn into their slaves by inducing metabolic dysregulation, exacerbating fibrosis acquire drug resistance immune evasion. This article reviews impact reprogramming, effect obesity crosstalk on describes relevant therapies targeting reprogramming.

Language: Английский

Citations

14