Chemoresistance and the tumor microenvironment: the critical role of cell–cell communication DOI Creative Commons
Bartosz Wilczyński, Alicja Dąbrowska, Julita Kulbacka

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 10, 2024

Resistance of cancer cells to anticancer drugs remains a major challenge in modern medicine. Understanding the mechanisms behind development chemoresistance is key developing appropriate therapies counteract it. Nowadays, with advances technology, we are paying more and attention role tumor microenvironment (TME) intercellular interactions this process. We also know that important elements TME not only themselves but other cell types, such as mesenchymal stem cells, cancer-associated fibroblasts, stromal macrophages. can communicate each indirectly (via cytokines, chemokines, growth factors, extracellular vesicles [EVs]) directly gap junctions, ligand-receptor pairs, adhesion, tunnel nanotubes). This communication appears be critical for chemoresistance. EVs seem particularly interesting structures regard. Within these structures, lipids, proteins, nucleic acids transported, acting signaling molecules interact numerous biochemical pathways, thereby contributing Moreover, drug efflux pumps, which responsible removing from transported via EVs.

Language: Английский

M7G-related tumor immunity: novel insights of RNA modification and potential therapeutic targets DOI Creative Commons
Mengzhen Han,

Qibo Huang,

Xinxin Li

et al.

International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(4), P. 1238 - 1255

Published: Jan. 1, 2024

RNA modifications play a pivotal role in regulating cellular biology by exerting influence over distribution features and molecular functions at the post-transcriptional level.Among these modifications, N7-methylguanosine (m7G) stands out as one of most prevalent.Over recent years, significant attention has been directed towards understanding implications m7G modification.This modification is present diverse molecules, including transfer RNAs, messenger ribosomal other noncoding RNAs.Its regulation occurs through series specific methyltransferases m7G-binding proteins.Notably, implicated various diseases, prominently across multiple cancer types.Earlier studies have elucidated significance context immune within tumor microenvironment.This comprehensive review culminates synthesis findings related to modulation cells infiltration, encompassing T cells, B innate all orchestrated modification.Furthermore, interplay between its regulatory proteins can profoundly affect efficacy adjuvant therapeutics, thereby potentially serving biomarker therapeutic target for combinatory interventions types.

Language: Английский

Citations

9
Tumorigenic and tumoricidal properties of exosomes in cancers; a forward look DOI Creative Commons
Zahra Abbasi‐Malati,

Seyed Ghader Azizi,

Soheil Zamen Milani

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 15, 2024

Abstract In recent decades, emerging data have highlighted the critical role of extracellular vesicles (EVs), especially (exosomes) Exos, in progression and development several cancer types. These nano-sized are released by different cell lineages within niche maintain a suitable platform for interchange various signaling molecules paracrine manner. Based on studies, Exos can transfer oncogenic factors to other cells, alter activity immune tumor microenvironment, leading expansion cells metastasis remote sites. It has been indicated that cell-to-cell crosstalk is so complicated wide array involved this process. How which mechanisms regulate behavior non-cancer at center debate. Here, we scrutinize molecular parenchyma. Besides, tumoricidal properties from stem (SC) types discussed detail.

Language: Английский

Citations

9
Tumour‐derived exosome SNHG17 induced by oestrogen contributes to ovarian cancer progression via the CCL13–CCR2–M2 macrophage axis DOI Creative Commons
Haiyan Liang, Shuo Geng,

Yadong Wang

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(9)

Published: April 28, 2024

Abstract Oestrogen is known to be strongly associated with ovarian cancer. There was much work show the importance of lncRNA SNHG17 in However, no study has revealed molecular regulatory mechanism and functional effects between oestrogen development metastasis In this study, we found that expression significantly increased cancer positively correlated treatment. could promote M2 macrophage polarization as well cells SKOV3 ES2 cell exosomal expression. When exposure oestrogen, promoted proliferation, migration, invasion epithelial‐mesenchymal transition (EMT) vitro, tumour growth lung vivo by accelerating M2‐like phenotype macrophages. Mechanically, facilitate release CCL13 from via PI3K‐Akt signalling pathway. Moreover, CCL13‐CCR2 axis identified involved behaviours driven oestrogen. results demonstrate a novel exerts an oncogenic effect on CCL13–CCR2–M2 upon treatment, which may potential biomarker therapeutic target for responded

Language: Английский

Citations

9
Circular RNAs in tumor immunity and immunotherapy DOI Creative Commons
Wenjie Zhang, Xu Chen, Zhipeng Yang

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Aug. 21, 2024

Circular RNAs (circRNAs) are unique noncoding that have a closed and stable loop structure generated through backsplicing. Due to their conservation, stability tissue specificity, circRNAs can potentially be used as diagnostic indicators therapeutic targets for certain tumors. Many studies shown act microRNA (miRNA) sponges, engage in interactions with proteins translation templates regulate gene expression signal transduction, thereby participating the occurrence development of variety malignant Immunotherapy has revolutionized treatment cancer. Early researches indicated involved regulating tumor immune microenvironment antitumor immunity. CircRNAs may potential important increasing sensitivity immunotherapy expanding population patients who benefit from cancer immunotherapy. However, few investigated correlation between In this review, we summarize current on regulation different mechanisms value efficacy goal providing new

Language: Английский

Citations

9
Chemoresistance and the tumor microenvironment: the critical role of cell–cell communication DOI Creative Commons
Bartosz Wilczyński, Alicja Dąbrowska, Julita Kulbacka

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 10, 2024

Resistance of cancer cells to anticancer drugs remains a major challenge in modern medicine. Understanding the mechanisms behind development chemoresistance is key developing appropriate therapies counteract it. Nowadays, with advances technology, we are paying more and attention role tumor microenvironment (TME) intercellular interactions this process. We also know that important elements TME not only themselves but other cell types, such as mesenchymal stem cells, cancer-associated fibroblasts, stromal macrophages. can communicate each indirectly (via cytokines, chemokines, growth factors, extracellular vesicles [EVs]) directly gap junctions, ligand-receptor pairs, adhesion, tunnel nanotubes). This communication appears be critical for chemoresistance. EVs seem particularly interesting structures regard. Within these structures, lipids, proteins, nucleic acids transported, acting signaling molecules interact numerous biochemical pathways, thereby contributing Moreover, drug efflux pumps, which responsible removing from transported via EVs.

Language: Английский

Citations

9