Treatment of Posttraumatic Stress Disorder: A State-of-the-art Review

Current Neuropharmacology, Journal Year: 2023, Volume and Issue: 22(4), P. 557 - 635

Published: May 3, 2023

Abstract: This narrative state-of-the-art review paper describes the progress in understanding and treatment of Posttraumatic Stress Disorder (PTSD). Over last four decades, scientific landscape has matured, with many interdisciplinary contributions to its diagnosis, etiology, epidemiology. Advances genetics, neurobiology, stress pathophysiology, brain imaging have made it apparent that chronic PTSD is a systemic disorder high allostatic load. The current state includes wide variety pharmacological psychotherapeutic approaches, which are evidence-based. However, myriad challenges inherent disorder, such as individual barriers good outcome, comorbidity, emotional dysregulation, suicidality, dissociation, substance use, trauma-related guilt shame, often render response suboptimal. These discussed drivers for emerging novel including early interventions Golden Hours, interventions, medication augmentation use psychedelics, well targeting nervous system. All this aims improve symptom relief clinical outcomes. Finally, phase orientation recognized tool strategize position step progression pathophysiology. Revisions guidelines systems care will be needed incorporate innovative treatments evidence emerges they become mainstream. generation well-positioned address devastating disabling impact traumatic events through holistic, cutting-edge efforts research.

Language: Английский

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Terahertz Photons Improve Cognitive Functions in Posttraumatic Stress Disorder

Research, Journal Year: 2023, Volume and Issue: 6

Published: Jan. 1, 2023

Posttraumatic stress disorder (PTSD) is a serious psychosis leading to cognitive impairment. To restore functions for patients, the main treatments are based on medication or rehabilitation training but with limited effectiveness and strong side effects. Here, we demonstrate new treatment approach PTSD by using terahertz (THz) photons stimulating hippocampal CA3 subregion. We verified that this method can nonthermally function in rats vivo. After THz photon irradiation, rats’ recognitive index improved about 10% novel object recognition test, accuracy 100% shuttler box numbers identify target was 5 times lower Barnes maze rate of staying arm increased approximately 40% Y-maze test. Further experimental studies found (34.5 THz) irradiation could improve expression NR2B (increased nearly 40%) phosphorylated 50%). In addition, molecular dynamics simulations showed at frequency 34.5 mainly absorbed pocket glutamate receptors rather than molecules. Moreover, binding between molecules photons. This study offers nondrug, nonthermal regulate excitatory neurotransmitter (glutamate) NR2B. By increasing synaptic plasticity, it effectively improves animals PTSD, providing promising strategy NR2B-related disorders.

Language: Английский

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Treatment with psychedelics is psychotherapy: beyond reductionism

The Lancet Psychiatry, Journal Year: 2023, Volume and Issue: 11(3), P. 231 - 236

Published: Dec. 12, 2023

Language: Английский

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Mendelian randomization analyses reveal causal relationships between brain functional networks and risk of psychiatric disorders

Nature Human Behaviour, Journal Year: 2024, Volume and Issue: 8(7), P. 1417 - 1428

Published: May 9, 2024

Language: Английский

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Post-Traumatic Stress Disorder: Administration, Clinical and Pharmacological, Organizational and Legal, Pharmaceutical Management, Recent Case Studies

SSP Modern Pharmacy and Medicine, Journal Year: 2024, Volume and Issue: 4(1), P. 1 - 8

Published: Jan. 1, 2024

Administered post-traumatic stress disorder based on ICD-11. The organizational and legal management of disorder’s pharmacotherapy evidence-based medicine pharmacy was studied. use medications to reduce symptoms is indicated. Analgesics, anxiolytics, antidepressants, anticonvulsants, drugs from other clinical-pharmacological groups can be used for analgesia, mood improvement, anxiety reduction, control hypergaining. Areas professional reintegration (support in job search, skills training, education, employment, adaptation civilian life) have been determined. Legal support the system relations "doctor-patient-pharmacist-lawyer" indicated order achieve a comprehensive multidimensional approach medical pharmaceutical care patients with disorder. Clinical pharmacological further development composition new drug known active ingredients an analgesic antipsychotic substantiated. Mentioned about social patient-oriented pharmacotherapy, recent case studies conflict conditions.

Language: Английский

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Mental health challenges faced by autistic people

Nature Human Behaviour, Journal Year: 2023, Volume and Issue: 7(10), P. 1620 - 1637

Published: Oct. 20, 2023

Language: Английский

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Health-related experiences of family court and domestic abuse in England: A looming public health crisis

Journal of Family Trauma Child Custody & Child Development, Journal Year: 2024, Volume and Issue: 21(3), P. 277 - 305

Published: Feb. 1, 2024

Domestic abuse is known to be harmful victim-survivor mothers' well-being, and women are disadvantaged by gender-biased systems in England. Less known, however, about victims' experiences with family court specifically relation their mental physical health. Interviews 45 mothers were conducted explore these experiences. Two main themes presented here: (1) health associated proceedings (2) parental alienation allegations as a weapon trap, silence, pathologise mothers. From themes, conceptual framework was developed: Court Perpetrator Induced Trauma (CPIT). These findings may have global significance for services practitioners who work exposed court.

Language: Английский

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Proposition of a transdiagnostic processual approach of emotion dysregulation based on core triggers and interpersonal styles

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 7, 2024

Emotion dysregulation (ED) has primarily been described in patients suffering from borderline personality disorder (BPD) and is an integral part of this diagnosis, but it also a transdiagnostic construct that can be found several other psychiatric disorders. The strong relationships between ED BPD may lead clinicians to underestimate associated clinical contexts. This difficulties diagnostic treatment orientation, especially the context comorbidities. In article, after reviewing literature on development functioning emotion dysregulation, evidence for eight disorders (borderline disorder, pathological narcissism with/without narcissistic obsessive-compulsive antisocial bipolar autism spectrum complex post-traumatic stress adult attention deficit hyperactivity disorder), we present processual model based core triggers interpersonal styles try address issue provide simple technical tool help their assessment orientation. By focusing more typical patterns dynamics than only categories, believe contribute actual need improvement our current classifications, alongside well-studied under-used dimensional models psychopathology (e.g., HiTOP, AMPD), useful build specific frameworks ED.

Language: Английский

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Improvements of complex post-traumatic stress disorder symptoms during a multimodal psychodynamic inpatient rehabilitation treatment – results of an observational single-centre pilot study

European journal of psychotraumatology, Journal Year: 2024, Volume and Issue: 15(1)

Published: April 5, 2024

Background: Complex post-traumatic stress disorder (CPTSD) describes chronic disturbances in self-organization (i.e. affect dysregulation; negative self-concept; severe difficulties relationships) which are frequently observed survivors of prolonged, repeated or multiple traumatic stressors. So far, evidence psychodynamic treatment approaches for CPTSD is scarce.

Language: Английский

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PTSD and CPTSD in the new ICD-11 – a latent profile analysis

Psychiatry Research, Journal Year: 2025, Volume and Issue: 344, P. 116350 - 116350

Published: Jan. 5, 2025

Language: Английский

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