Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond

Neuropsychopharmacology, Journal Year: 2016, Volume and Issue: 42(1), P. 254 - 270

Published: Aug. 11, 2016

Language: Английский

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International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

Nature Communications, Journal Year: 2019, Volume and Issue: 10(1)

Published: Oct. 8, 2019

The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls we conduct genome-wide association study PTSD. We demonstrate SNP-based heritability estimates 5-20%, varying by sex. Three significant loci are identified, 2 in European 1 African-ancestry analyses. Analyses stratified sex implicate 3 additional men. Along with other novel genes non-coding RNAs, Parkinson's disease gene involved dopamine regulation, PARK2, associated Finally, that polygenic for significantly predictive re-experiencing symptoms the Million Veteran Program dataset, although specific did not replicate. These results role genetic variation biology highlight necessity conducting sex-stratified analyses expanding GWAS beyond ancestry populations.

Language: Английский

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Depression and Anxiety in Heart Failure: A Review

Harvard Review of Psychiatry, Journal Year: 2018, Volume and Issue: 26(4), P. 175 - 184

Published: July 1, 2018

After participating in this activity, learners should be better able to:• Identify the relationships between depression, anxiety, and heart failure (HF).• Assess methods for accurately diagnosing depression anxiety disorders patients with HF.• Evaluate current evidence treatment of HF.In (HF), are common associated adverse outcomes such as reduced adherence to treatment, poor function, increased hospitalizations, elevated mortality. Despite impact these disorders, remain underdiagnosed undertreated HF patients.We performed a targeted literature review (1) identify associations HF, (2) examine mechanisms mediating conditions medical outcomes, (3) (4) treatments population.Both development progression including rates mortality, likely mediated through both physiologic behavioral mechanisms. Given overlap cardiac psychiatric symptoms, or can challenging. Adherence formal diagnostic criteria utilization clinical interview best courses action evaluation process. There is limited efficacy pharmacologic psychotherapy HF. However, cognitive-behavioral therapy has been shown improve mental health selective serotonin reuptake inhibitors appear safe cohort.Depression common, underrecognized, linked outcomes. Further research detection develop effective badly needed.

Language: Английский

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Psychological Stress, Inflammation, and Coronary Heart Disease

Current Cardiology Reports, Journal Year: 2017, Volume and Issue: 19(11)

Published: Sept. 20, 2017

Language: Английский

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Immunoneuropsychiatry — novel perspectives on brain disorders

Nature Reviews Neurology, Journal Year: 2019, Volume and Issue: 15(6), P. 317 - 328

Published: April 15, 2019

Language: Английский

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Psychiatric and neuropsychiatric sequelae of COVID-19 – A systematic review

Brain Behavior and Immunity, Journal Year: 2021, Volume and Issue: 97, P. 328 - 348

Published: July 30, 2021

It has become evident that coronavirus disease 2019 (COVID-19) a multi-organ pathology includes the brain and nervous system. Several studies have also reported acute psychiatric symptoms in COVID-19 patients. An increasing number of are suggesting deficits may persist after recovery from primary infection. In current systematic review, we provide an overview available evidence supply information on potential risk factors underlying biological mechanisms behind such sequelae. We performed search for sequelae patients using databases PubMed Embase. Included all contained follow-up period provided quantitative measures mental health. The was June 4th 2021. 1725 unique were identified. Of these, 66 met inclusion criteria included. Time to ranged immediately hospital discharge up 7 months discharge, participants spanned 3 266,586 participants. Forty anxiety and/or depression, 20 symptoms- or diagnoses post-traumatic stress disorder (PTSD), 27 cognitive deficits, 32 articles found fatigue at follow-up, sleep disturbances 23 studies. Highlighted severity, duration symptoms, female sex. One study showed abnormalities correlating with several inflammatory markers correlate symptoms. Overall, results this review suggest survivors but generally improve over time.

Language: Английский

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Imaging the Role of Inflammation in Mood and Anxiety-related Disorders

Current Neuropharmacology, Journal Year: 2017, Volume and Issue: 16(5), P. 533 - 558

Published: Nov. 25, 2017

Background: Studies investigating the impact of a variety inflammatory stimuli on brain and behavior have reported evidence that inflammation release cytokines affect circuitry relevant to both reward threat sensitivity contribute behavioral change. Of relevance mood anxiety-related disorders, biomarkers such as acute-phase proteins are reliably elevated in significant proportion patients with major depressive disorder (MDD), bipolar disorder, anxiety disorders post-traumatic stress (PTSD). Methods: This review summarized clinical translational work demonstrating peripheral regions neurotransmitter systems sensitivity, focus neuroimaging studies involving administration stimuli. Recent translation these findings further understand role is also discussed. Results: Inflammation was consistently found basal ganglia cortical motor circuits drive reduced motivation activity, well including amygdala, insula anterior cingulate cortex, which may result from cytokine effects monoamines glutamate. Similar relationships between altered neurocircuitry been observed MDD increased markers, horizon for PTSD. Conclusion: Neuroimaging be used future development novel therapeutic strategies better treat high inflammation. Keywords: Neuroimaging, inflammation, cytokines, microglia, depression, anxiety, PTSD, motivation, slowing.

Language: Английский

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Immune and Neuroendocrine Mechanisms of Stress Vulnerability and Resilience

Neuropsychopharmacology, Journal Year: 2016, Volume and Issue: 42(1), P. 62 - 80

Published: June 13, 2016

Language: Английский

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Psychoneuroimmunology of Early-Life Stress: The Hidden Wounds of Childhood Trauma?

Neuropsychopharmacology, Journal Year: 2016, Volume and Issue: 42(1), P. 99 - 114

Published: Sept. 15, 2016

Language: Английский

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Inflammation and post‐traumatic stress disorder

Psychiatry and Clinical Neurosciences, Journal Year: 2019, Volume and Issue: 73(4), P. 143 - 153

Published: Jan. 17, 2019

While post-traumatic stress disorder (PTSD) is currently diagnosed based solely on classic psychological and behavioral symptoms, a growing body of evidence has highlighted link between this alterations in the immune inflammatory systems. Epidemiological studies have demonstrated that PTSD associated with significantly increased rates physical comorbidities which dysregulation involved, such as metabolic syndrome, atherosclerotic cardiovascular disease, autoimmune diseases. In line this, number blood biomarker reported compared to healthy controls, individuals exhibit elevated levels proinflammatory markers, interleukin-1β, interleukin-6, tumor necrosis factor-α, C-reactive protein. Moreover, various lines animal human research suggested inflammation not only but also can play an important role its pathogenesis pathophysiology. review, we first summarize suggestive PTSD. We then examine findings suggest possible mechanisms terms two different interrelated perspectives: putative causes activities potential consequences generates. Given there dearth treatment options for PTSD, possibilities new therapeutic approaches using pharmacological non-pharmacological treatments/interventions anti-inflammatory effects are discussed. Despite increasing attention given pathology remains much be elucidated, including more detailed inflammation, usefulness biomarkers diagnostic prognostic efficacy novel strategies targeting inflammation.

Language: Английский

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