Life Stress, Depression, and Religious Coping Among Low-Income African American Women DOI

Ivonne Andrea Flórez,

Natalie N. Watson-Singleton, Jennifer Wootten

et al.

Journal of African American Studies, Journal Year: 2023, Volume and Issue: 27(2), P. 159 - 171

Published: May 18, 2023

Language: Английский

Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature DOI Creative Commons

Olivia Remes,

João Francisco Mendes,

Peter Templeton

et al.

Brain Sciences, Journal Year: 2021, Volume and Issue: 11(12), P. 1633 - 1633

Published: Dec. 10, 2021

Depression is one of the leading causes disability, and, if left unmanaged, it can increase risk for suicide. The evidence base on determinants depression fragmented, which makes interpretation results across studies difficult. objective this study to conduct a thorough synthesis literature assessing biological, psychological, and social in order piece together puzzle key factors that are related condition. Titles abstracts published between 2017 2020 were identified PubMed, as well Medline, Scopus, PsycInfo. Key words relating social, psychological applied databases, screening data charting documents took place. We included 470 review. findings showed there plethora protective (relating determinants) depression; these interlinked influence outcomes through web causation. In paper, we describe present vast, complex topic. This review may be used guide practice, public health efforts, policy, research mental specifically, depression.

Language: Английский

Citations

237
Effects of urban living environments on mental health in adults DOI Creative Commons
Jiayuan Xu, Nana Liu, Elli Polemiti

et al.

Nature Medicine, Journal Year: 2023, Volume and Issue: 29(6), P. 1456 - 1467

Published: June 1, 2023

Abstract Urban-living individuals are exposed to many environmental factors that may combine and interact influence mental health. While individual of an urban environment have been investigated in isolation, no attempt has made model how complex, real-life exposure living the city relates brain health, this is moderated by genetic factors. Using data 156,075 participants from UK Biobank, we carried out sparse canonical correlation analyses investigate relationships between environments psychiatric symptoms. We found profile social deprivation, air pollution, street network land-use density was positively correlated with affective symptom group ( r = 0.22, P perm < 0.001), mediated volume differences consistent reward processing, genes enriched for stress response, including CRHR1 , explaining 2.01% variance differences. Protective such as greenness generous destination accessibility were negatively anxiety 0.10, regions necessary emotion regulation EXD3 1.65% variance. The third emotional instability 0.03, 0.001). Our findings suggest different profiles specific groups through distinct neurobiological pathways.

Language: Английский

Citations

86
Single-cell mass cytometry of microglia in major depressive disorder reveals a non-inflammatory phenotype with increased homeostatic marker expression DOI Creative Commons
Chotima Böttcher, Camila Fernández‐Zapata, Gijsje J. L. Snijders

et al.

Translational Psychiatry, Journal Year: 2020, Volume and Issue: 10(1)

Published: Sept. 11, 2020

Stress-induced disturbances of brain homeostasis and neuroinflammation have been implicated in the pathophysiology mood disorders. In major depressive disorder (MDD), elevated levels proinflammatory cytokines chemokines can be found peripheral blood, but very little is known about changes that occur directly brain. Microglia are primary immune effector cells central nervous system exquisitely sensitive to microenvironment. Here, we performed first single-cell analysis microglia from four different post-mortem regions (frontal lobe, temporal thalamus, subventricular zone) medicated individuals with MDD compared controls. We no evidence for induction inflammation-associated molecules, such as CD11b, CD45, CCL2, IL-1β, IL-6, TNF, MIP-1β (CCL4), IL-10, even decreased expression HLA-DR CD68 cases. contrast, detected increased homeostatic proteins P2Y12 receptor, TMEM119 CCR5 (CD195) all MDD. also identified enrichment non-inflammatory CD206hi macrophages brains sum, our results suggest enhanced functions

Language: Английский

Citations

71
Brain–heart communication in health and diseases DOI
Wei Liu, Xinying Zhang, Zifeng Wu

et al.

Brain Research Bulletin, Journal Year: 2022, Volume and Issue: 183, P. 27 - 37

Published: Feb. 22, 2022

Language: Английский

Citations

23
The role of glucocorticoid and mineralocorticoid receptor DNA methylation in antenatal depression and infant stress regulation DOI
Megan Galbally, Stuart Watson, Marinus H. van IJzendoorn

et al.

Psychoneuroendocrinology, Journal Year: 2020, Volume and Issue: 115, P. 104611 - 104611

Published: Feb. 8, 2020

Language: Английский

Citations

34
Parsing inter- and intra-individual variability in key nervous system mechanisms of stress responsivity and across functional domains DOI

Sharona L. Rab,

Roee Admon

Neuroscience & Biobehavioral Reviews, Journal Year: 2020, Volume and Issue: 120, P. 550 - 564

Published: Sept. 14, 2020

Language: Английский

Citations

29
Psychosocial outcomes of human papillomavirus (HPV)‐ and non‐HPV‐related head and neck cancers: A longitudinal study DOI
Mélissa Henry,

Emily Arnovitz,

Saul Frenkiel

et al.

Psycho-Oncology, Journal Year: 2021, Volume and Issue: 31(2), P. 185 - 197

Published: Sept. 7, 2021

Abstract Objectives Human papillomavirus (HPV) has prompted a need to further investigate how this new biomarker changes the head and neck cancer (HNC) psychosocial landscape. This study aimed to: (a) characterize sociodemographic, psychological, social profiles of patients with HPV‐positive versus ‐negative squamous cell carcinoma neck; (b) identify HPV status contributes anxiety depression (primary outcome), quality life (QoL), sexuality needs. Methods We conducted prospective longitudinal 146 newly diagnosed oral, oropharyngeal, nasopharyngeal, hypopharyngeal cancer. Seventy‐nine were 67 HPV‐negative. Patients completed self‐administered psychometric measures upon HNC 3‐month follow‐up, Structured Clinical Interviews for DSM Diagnoses. Results HPV‐negative tumors generally presented higher lower QoL immediately post‐HNC diagnosis (<2 weeks) compared cancers. A Major Depressive Disorder (MDD) negatively affected patients' levels only when was HPV‐positive. Immediately posttreatment, not associated outcomes. previous history suicidal ideation, cigarette smoking, depression, feeling close one's partner instead explanatory. Conclusion While present initially psychological distress, their vulnerability posttreatment indicates an equal support. Head clinics may better address MDD, prior health behavior change, relationships.

Language: Английский

Citations

21
Early adversity as the prototype gene × environment interaction in mental disorders? DOI
Jade Martins,

Natan Yusupov,

Elisabeth B. Binder

et al.

Pharmacology Biochemistry and Behavior, Journal Year: 2022, Volume and Issue: 215, P. 173371 - 173371

Published: March 8, 2022

Language: Английский

Citations

15
The antidepressant-like effects of Danzhi Xiaoyao San and its active ingredients DOI
Zhiqiang Xie,

Hongxiao Xie,

Xi Peng

et al.

Phytomedicine, Journal Year: 2023, Volume and Issue: 119, P. 155015 - 155015

Published: Aug. 8, 2023

Language: Английский

Citations

8
Genetic Risk For Depression and Quality of Life in Patients With Head and Neck Cancer DOI
Mélissa Henry, Lawrence M. Chen,

Laurence Ducharme

et al.

JAMA Otolaryngology–Head & Neck Surgery, Journal Year: 2024, Volume and Issue: 150(7), P. 598 - 598

Published: May 30, 2024

Although patients with head and neck cancer (HNC) have been shown to experience high distress, few longitudinal studies include a comprehensive evaluation of biopsychosocial factors affecting quality life (QoL), including genetic risk for depression.

Language: Английский

Citations

2