Translational Psychiatry,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Dec. 18, 2024
The
relationships
of
the
gut
microbiota-inflammation-brain
axis
in
depressive
bipolar
disorder
(BD)
remains
under-elaborated.
Sixty-five
unmedicated
patients
with
BD
II
and
58
controls
(HCs)
were
prospectively
enrolled.
Resting-state
functional
MRI
data
static
dynamic
amplitude
low-frequency
fluctuation
(ALFF)
was
measured,
abnormal
ALFF
masks
subsequently
set
as
regions
interest
to
calculate
whole-brain
connectivity
(sFC)
(dFC).
Fecal
samples
collected
assess
diversity
enterotypes
using
16S
amplicon
sequencing.
Blood
also
collected,
serum
assayed
for
levels
cytokines
(interleukin
[IL]-2,
IL-4,
IL-6,
IL-8,
IL-10,
tumor
necrosis
factor
[TNF]-α).
Patients
exhibited
decreased
values
left
cerebellum
Crus
II,
cerebellar
sFC
dFC
right
inferior
parietal
lobule
superior
frontal
gyrus,
respectively.
Moreover,
higher
pro-inflammatory
anti-inflammatory
levels,
increased
proinflammatory
bacteria
glutamate
gamma-aminobutyric
acid
metabolism
related
identified
II.
interaction
Parabacteroides
×
IL-8
an
independent
contributor
findings
bridged
a
gap
underlying
pathophysiological
mechanism
depression.
Molecular Autism,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: April 4, 2024
Abstract
Background
This
meta-analysis
aimed
to
explore
the
most
robust
findings
across
numerous
existing
resting-state
functional
imaging
and
voxel-based
morphometry
(VBM)
studies
on
structural
brain
alterations
in
individuals
with
autism
spectrum
disorder
(ASD).
Methods
A
whole-brain
voxel-wise
was
conducted
compare
differences
intrinsic
activity
gray
matter
volume
(GMV)
between
ASD
typically
developing
(TDs)
using
Seed-based
d
Mapping
software.
Results
total
of
23
(786
ASD,
710
TDs)
52
VBM
(1728
1747
were
included.
Compared
TDs,
displayed
decreases
left
insula
(extending
superior
temporal
gyrus
[STG]),
bilateral
anterior
cingulate
cortex/medial
prefrontal
cortex
(ACC/mPFC),
angular
right
inferior
gyrus,
as
well
increases
supplementary
motor
area
precuneus.
For
meta-analysis,
decreased
GMV
ACC/mPFC
cerebellum,
increased
middle
STG),
olfactory
cortex,
precentral
gyrus.
Further,
after
overlapping
differences.
Conclusions
The
present
multimodal
demonstrated
that
exhibited
similar
both
function
structure
ACC/mPFC,
or
default
mode
network
(DMN),
primary
sensory
regions.
These
contribute
further
understanding
pathophysiology
ASD.
ABSTRACT
Background
The
resting‐state
functional
connectivity
(FC)
patterns
of
the
fronto‐parietal
network
(FPN)
and
language
(LN)
underlying
bipolar
disorder
(BD)
are
obscure.
This
study
aimed
to
uncover
abnormal
FC
FPN
LN
BD
their
evolution
following
treatment.
Methods
Imaging
data
at
rest
state
clinical
variables
were
acquired
from
82
patients
with
(with
43
finishing
follow‐up)
88
healthy
controls
(HCs).
Seed‐based
analysis
was
performed,
correlations
between
FCs
investigated
whole‐brain
multiple
regression
analyses.
Furthermore,
a
neuroimaging–transcription
spatial
association
conducted.
Results
At
baseline,
presented
elevated
FPN‐LN
FPN–prefrontal
gyrus
FCs,
hyperconnectivity
bilateral
thalamus,
right
angular
(AG),
cerebellum.
Following
3
months
treatment
intervention,
there
decreased
left
superior
temporal
(STG),
frontal
(SFG),
insula,
middle
(MTG)
(part
LN).
Neuroimaging
transcription
discovered
genes
correlated
alterations
in
BD.
Conclusions
Aberrant
might
be
involved
neural
pathogenetic
therapeutic
mechanisms
We
also
provided
potential
genetic
pathways
these
impairments
BMC Psychiatry,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Feb. 27, 2025
Recent
genome-wide
association
studies
have
linked
voltage-gated
calcium
channel
genes
to
bipolar
disorder
(BD),
in
which
CACNB2
gene
rs11013860
is
respectively
reported.
Less
known,
though,
about
how
precisely
its
polymorphism
affects
both
the
structure
and
function
of
brain.
173
BD
patients
207
healthy
controls
(HCs)
were
underwent
structural
functional
magnetic
resonance
imaging
scan
genotyped
for
rs11013860.
Grey
matter
volume
(GMV),
regional
homogeneity
(ReHo)
degree
centrality
(DC)
used
examine
brain
structure,
activity
connectivity
these
participants.
The
emotional
circuits
patients,
such
as
cerebellum,
insula,
cingulate
gyrus,
fusiform
superior
frontal
/
middle
temporal
occipital
lingual
precuneus,
putamen,
hippocampus
parahippocampal
main
areas
where
GMV,
ReHo,
DC
differed
from
HCs.
And
right
anterior
posterior
cerebellar
lobes,
gyrus
well
showed
an
interaction
between
genotypes
diagnoses
GMV.
In
addition,
there
was
a
significant
step-wise
increase
GMV
with
decreased
dosage
A
risk
allele
HCs,
but
this
pattern
relationship
absent
patients.
No
found
ReHo
DC.
These
results
suggest
that
may
be
associated
abnormalities
cerebellar,
limbic
system
other
regions,
perhaps
contributing
disease.
Translational Psychiatry,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: April 4, 2025
There
are
significant
sex
differences
in
the
prevalence,
symptom
presentation,
treatment
response
and
brain
abnormalities
of
patients
with
late-life
depression
(LLD).
The
functional
connectivity
habenula
has
been
associated
depressive
symptoms
cognitive
impairments
LLD.
However,
habenular
patterns
among
LLD
remain
unclear.
One
hundred
fourteen
75
healthy
controls
(HCs)
were
included
present
study.
Resting-state
magnetic
resonance
imaging
was
used
to
analyse
static
dynamic
(sFC
dFC)
habenula.
interactions
between
diagnosis
(LLD
vs.
HCs)
for
dFC
left
insula,
precentral
gyrus,
angular
middle
frontal
gyrus
right
temporal
gyrus.
Pairwise
comparisons
revealed
a
trend
HC
males
>
females
<
connections
Conversely,
found
pole.
Furthermore,
there
interaction
sFC
fusiform
trends
females,
males,
females.
Regression
analysis
that
habenular-left
insular
long-delay
memory
working
males;
habenular-right
pole
information
processing
speed
Sex
moderated
relationships
function
(global
cognition,
delay-recalled
memory)
insula.
In
conclusions,
this
study
sex-specific
alterations
patients,
these
various
functions
manner.
These
findings
provide
neurobiological
basis
understanding
patients.
