Proceedings of the National Academy of Sciences,
Journal Year:
2024,
Volume and Issue:
121(9)
Published: Feb. 21, 2024
Photon-controlled
pyroptosis
activation
(PhotoPyro)
is
a
promising
technique
for
cancer
immunotherapy
due
to
its
noninvasive
nature,
precise
control,
and
ease
of
operation.
Here,
we
report
that
biomolecular
photoredox
catalysis
in
cells
might
be
an
important
mechanism
underlying
PhotoPyro.
Our
findings
reveal
the
photocatalyst
lutetium
texaphyrin
(
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(7), P. 4081 - 4087
Published: Feb. 13, 2023
The
highly
oxygen-dependent
nature
of
photodynamic
therapy
(PDT)
limits
its
therapeutic
efficacy
against
hypoxic
solid
tumors
in
clinics,
which
is
an
urgent
problem
to
be
solved.
Herein,
we
develop
oxygen-independent
supramolecular
agent
that
produces
hydroxyl
radical
(•OH)
by
oxidizing
water
the
presence
intracellularly
abundant
pyruvic
acid
under
oxygen-free
conditions.
A
fluorene-substituted
BODIPY
was
designed
as
electron
donor
and
coassembled
with
perylene
diimide
acceptor
form
quadruple
hydrogen-bonded
agent.
Detailed
mechanism
studies
reveal
intermolecular
transfer
charge
separation
upon
light
irradiation
result
efficient
generation
ion
pairs.
Under
conditions,
cationic
radicals
directly
oxidize
generate
cytotoxic
•OH,
anionic
electrons
acid,
realizing
catalytic
cycle.
Thus,
this
exhibited
superb
photocytotoxicity
even
severe
environments
excellent
vivo
antitumor
on
HeLa-bearing
mouse
models.
This
work
provides
a
strategy
for
constructing
agents,
opens
up
avenue
effective
PDT
tumors.
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(11), P. 6007 - 6023
Published: March 7, 2023
Pyroptosis
refers
to
the
process
of
gasdermin-mediated
lytic
programmed
cell
death
(PCD)
characterized
by
release
pro-inflammatory
cytokines.
Our
knowledge
pyroptosis
has
expanded
beyond
cellular
level
and
now
includes
extracellular
responses.
In
recent
years,
attracted
considerable
attention
due
its
potential
induce
host
immunity.
For
instance,
at
2022
International
Medicinal
Chemistry
Natural
Active
Ligand
Metal-Based
Drugs
(MCNALMD)
conference,
numerous
researchers
demonstrated
an
interest
in
photon-controlled
activation
("PhotoPyro"),
emerging
pyroptosis-engineered
approach
for
activating
systemic
immunity
via
photoirradiation.
Given
this
enthusiasm,
we
share
Perspective
our
views
on
area
expound
how
why
"PhotoPyro"
could
trigger
antitumor
(i.e.,
turning
so-called
"cold"
tumors
"hot").
doing
so,
have
tried
highlight
cutting-edge
breakthroughs
PhotoPyro
while
suggesting
areas
future
contributions.
By
providing
insights
into
current
state
art
serving
as
a
resource
individuals
interested
working
area,
it
is
hoped
that
will
set
stage
evolve
broadly
applicable
cancer
treatment
strategy.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Aug. 10, 2023
Rapid
advancements
in
materials
science
and
nanotechnology,
intertwined
with
oncology,
have
positioned
photothermal
therapy
(PTT)
as
a
promising
noninvasive
treatment
strategy
for
cancer.
The
breast's
superficial
anatomical
location
aesthetic
significance
render
breast
cancer
particularly
pertinent
candidate
the
clinical
application
of
PTT
following
melanoma.
This
review
comprehensively
explores
research
conducted
on
various
types
nanoparticles
employed
elaborates
their
specific
roles
mechanisms
action.
integration
existing
therapies
is
scrutinized,
underscoring
its
potential
synergistic
outcomes.
Additionally,
underlying
consequential
modifications
to
tumor
microenvironment
after
are
elaborated
from
medical
perspective.
Future
directions
suggested,
an
emphasis
development
integrative
platforms
that
combine
multiple
therapeutic
approaches
optimization
nanoparticle
synthesis
enhanced
efficacy.
goal
push
boundaries
toward
comprehensive,
clinically
applicable
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(13), P. 7361 - 7375
Published: March 24, 2023
An
advanced
photodynamic
molecular
beacon
(PMB)
was
designed
and
synthesized,
in
which
a
distyryl
boron
dipyrromethene
(DSBDP)-based
photosensitizer
Black
Hole
Quencher
3
moiety
were
connected
via
two
peptide
segments
containing
the
sequences
PLGVR
GFLG,
respectively,
of
cyclic
peptide.
These
short
are
well-known
substrates
matrix
metalloproteinase-2
(MMP-2)
cathepsin
B,
both
overexpressed
wide
range
cancer
cells
either
extracellularly
(for
MMP-2)
or
intracellularly
B).
Owing
to
efficient
Förster
resonance
energy
transfer
between
components,
this
PMB
fully
quenched
native
form.
Only
upon
interaction
with
MMP-2
buffer
solution
cells,
cleaved
specifically,
components
could
be
completely
separated,
thereby
restoring
activities
DSBDP
moiety.
This
also
activated
tumors,
it
effectively
suppressed
tumor
growth
A549
tumor-bearing
nude
mice
laser
irradiation
without
causing
notable
side
effects.
In
particular,
did
not
cause
skin
photosensitivity,
is
very
common
effect
therapy
(PDT)
using
conventional
"always-on"
photosensitizers.
The
overall
results
showed
that
"double-locked"
functioned
as
biological
AND
logic
gate
only
unlocked
by
coexistence
tumor-associated
enzymes,
greatly
enhance
specificity
PDT.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: March 21, 2024
Abstract
Photodynamic
therapy
(PDT)
is
a
promising
cancer
treatment
but
has
limitations
due
to
its
dependence
on
oxygen
and
high-power-density
photoexcitation.
Here,
we
report
polymer-based
organic
photosensitizers
(PSs)
through
rational
PS
skeleton
design
precise
side-chain
engineering
generate
•O
2
−
•OH
under
oxygen-free
conditions
using
ultralow-power
808
nm
photoexcitation
for
tumor-specific
photodynamic
ablation.
The
designed
skeletons
can
electron-hole
pairs
sensitize
H
O
into
with
photoexcitation,
achieving
NIR-photoexcited
oxygen-independent
production.
Further,
compared
commonly
used
alkyl
side
chains,
glycol
oligomer
as
the
chain
mitigates
recombination
offers
more
molecules
around
generated
from
hydrophobic
skeletons,
which
yield
4-fold
stronger
production,
thus
allowing
an
high
PDT
effect.
Finally,
feasibility
of
developing
activatable
PSs
in
female
mice
further
demonstrated
irradiation
15
mW
cm
−2
.
study
not
only
provides
insights
mechanism
also
general
guideline
develop
NIR
PDT.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(4)
Published: Aug. 29, 2023
Photodynamic
therapy
(PDT),
which
utilizes
type
I
photoreactions,
has
great
potential
as
an
effective
cancer
treatment
because
of
its
hypoxia-tolerant
superiority
over
the
commonly
used
II
pathway.
A
few
photosensitizers
are
exploited;
however,
they
majorly
induce
cytotoxicity
and
possess
poor
tumor
specificity
low-efficient
theranostics.
To
resolve
this
issue,
herein
aminopeptidase
N
(APN)-activated
phototheranostic
probe
(CyA)
is
reported
for
anti-hypoxic
PDT
in
conjunction
with
immunotherapy
treatment.
CyA
can
specifically
activate
near-infrared
fluorescence,
photoacoustic
signals,
phototoxicity
following
APN-induced
substrate
cleavage
subsequent
generation
active
molecules
(such
CyBr).
endows
specific
imaging
capabilities
toward
cells
overexpressing
APN
under
both
normoxia
hypoxia.
In
addition,
locally
activatable
induces
systemic
antitumor
immune
responses.
More
importantly,
integration
localized
activated
evokes
enhanced
therapeutic
effects
improved
inhibition
efficiency
live
mice
compared
individual
treatments.
This
study
aims
to
present
combination
therapy.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(24), P. 13966 - 14037
Published: Nov. 22, 2023
Phosphorescence,
characterized
by
luminescent
lifetimes
significantly
longer
than
that
of
biological
autofluorescence
under
ambient
environment,
is
great
value
for
biomedical
applications.
Academic
evidence
fluorescence
imaging
indicates
virtually
all
metrics
(sensitivity,
resolution,
and
penetration
depths)
are
improved
when
progressing
into
wavelength
regions,
especially
the
recently
reported
second
near-infrared
(NIR-II,
1000–1700
nm)
window.
Although
emission
probes
does
matter,
it
not
clear
whether
guideline
"the
wavelength,
better
effect"
still
suitable
developing
phosphorescent
probes.
For
tissue-specific
bioimaging,
long-lived
probes,
even
if
they
emit
visible
phosphorescence,
enable
accurate
visualization
large
deep
tissues.
studies
dealing
with
bioimaging
tiny
architectures
or
dynamic
physiopathological
activities,
prerequisite
rigorous
planning
long-wavelength
being
aware
cooperative
contribution
long
wavelengths
improving
spatiotemporal
depth,
sensitivity
bioimaging.
In
this
Review,
emerging
molecular
engineering
methods
room-temperature
phosphorescence
discussed
through
lens
photophysical
mechanisms.
We
highlight
roles
from
to
NIR-II
windows
toward
bioapplications.
To
appreciate
such
advances,
challenges
prospects
in
rapidly
growing
described.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(12)
Published: Jan. 23, 2024
We
herein
present
an
approach
of
photo-induced
disproportionation
for
preparation
Type-I
photodynamic
agents.
As
a
proof
concept,
BODIPY-based
photosensitizers
were
rationally
designed
and
prepared.
The
intermolecular
electron
transfer
between
homotypic
chromophores
leads
to
the
reaction,
resulting
in
formation
charged
intermediates,
cationic
anionic
radicals.
radicals
efficiently
oxidize
cellularimportant
coenzyme,
tetrahydrobiopterin
(BH
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(13), P. 9413 - 9421
Published: March 20, 2024
Precise
control
of
cellular
signaling
events
during
programmed
cell
death
is
crucial
yet
challenging
for
cancer
therapy.
The
modulation
signal
transduction
in
cells
holds
promise
but
limited
by
the
lack
efficient,
biocompatible,
and
spatiotemporally
controllable
approaches.
Here
we
report
a
photodynamic
strategy
that
modulates
both
apoptotic
pyroptotic
altering
caspase-3
protein
activity
associated
crosstalk.
This
employs
mitochondria-targeting,
near-infrared
activatable
probe
(termed
M-TOP)
functions
via
type-I
photochemical
mechanism.
M-TOP
less
dependent
on
oxygen
more
effective
treating
drug-resistant
cells,
even
under
hypoxic
conditions.
Our
study
shows
higher
doses
induce
caspase-3/gasdermin-E
pathway,
whereas
lower
lead
to
apoptosis.
method
across
diverse
gasdermin-E-expressing
cells.
Moreover,
mediated
shift
from
can
evoke
controlled
inflammatory
response,
leading
robust
balanced
immune
reaction.
effectively
inhibits
distal
tumor
growth
postsurgical
recurrence.
work
demonstrates
feasibility
modulating
intracellular
through
rational
design
anticancer
drugs.