Modular Design of Peptide- or DNA-Modified AIEgen Probes for Biosensing Applications DOI
Fan Xia, Jun Wu, Xia Wu

et al.

Accounts of Chemical Research, Journal Year: 2019, Volume and Issue: 52(11), P. 3064 - 3074

Published: Oct. 28, 2019

ConspectusFluorophore probes are widely used for bioimaging in cells, tissues, and animals as well monitoring of multiple biological processes complex environments. Such imaging properties allow scientists to make direct visualizations pathological events cellular targets. Conventional fluorescent molecules have been developed several decades achieved great successes, but their emissions often weakened or quenched at high concentrations that might suffer from the aggregation-caused quenching (ACQ) effect, which reduces efficiencies applications.In contrast ACQ aggregation-induced emission (AIE) luminogens (AIEgens) display much higher fluorescence aggregated states possess various advantages such low background, long-term tracking ability, strong resistance photobleaching. Therefore, AIEgens employed unique building blocks biosensing applications fields ions, amino acids, carbohydrates, DNAs/RNAs, peptides/proteins, organelles, cancer bacteria, so on.Quite a few above missions accomplished by modular peptide-modified AIEgen (MPAPs) DNA-modified (MDAPs) because capabilities peptide DNA modules, including solubility, biocompatibility, recognition. Meanwhile, both electrostatic interactions coupling reactions could provide efficient methods construct different MPAPs MDAPs, finally resulting large variety probes. Those exhibit leading features detecting nucleic acids proteins mass biomolecules. For example, under design, modules possessing versatile recognition abilities enable detect numerous targets, integrin αvβ3, aminopeptidase N, MMP-2, MPO, H2O2, forth; MDAP mRNA cells tissue chips, suggesting diagnostic functions clinical samples. Modular design offers novel strategy generate AIEgen-based expedites functional biomacromolecules research. In this vein, here we review progress on MDAPs most recent 10 years highlight advanced briefly two aspects: (1) detection (2) imaging. By use MPAPs/MDAPs, bioanalytes can be efficiently analyzed directly visualized through high-contrast luminous Compared with MPAPs, quantities limited difficult synthesis long-length strands. future work, multifunctional sequences needed explore varieties diverse purposes. At end Account, some deficiencies challenges mentioned briging more attention accelerate development

Language: Английский

Aggregation‐Induced Emission: Recent Advances in Materials and Biomedical Applications DOI
Xiaolei Cai, Bin Liu

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 59(25), P. 9868 - 9886

Published: March 4, 2020

Abstract The concept of aggregation‐induced emission (AIE) has opened new opportunities in many research fields. Motivated by the unique feature AIE fluorogens (AIEgens), during past decade, molecular probes and nanoparticle (NP) have been developed for sensing, imaging theranostic applications with excellent performance outperforming conventional fluorescent probes. This Review summarizes latest advancement NP their emerging biomedical applications. Special focus is to reveal how are evolved development multifunctional AIEgens, strategies overcome limitations traditional more translational via fluorescence imaging, photoacoustic image‐guided photodynamic/photothermal therapy. outlook discusses challenges future AIEgens advance field.

Language: Английский

Citations

636
Design of superior phototheranostic agents guided by Jablonski diagrams DOI
Guangxue Feng, Guoqiang Zhang, Dan Ding

et al.

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(22), P. 8179 - 8234

Published: Jan. 1, 2020

Phototheranostics represents a promising direction for modern precision medicine, which has recently attracted great research interest from multidisciplinary areas. Organic optical agents including small molecular fluorophores, semiconducting/conjugated polymers, aggregation-induced emission luminogens, etc. with tuneable photophysical properties, high biosafety and biocompatibility, facile processability ease of functionalization have delivered encouraging performance in disease phototheranostics. This review summarizes the recent progress organic phototheranostic an emphasis on main strategies to manipulate three excitation energy dissipation pathways, namely, radiative decay, thermal deactivation, intersystem crossing, assistance Jablonski diagram, particularly showcases how diagram been guiding design molecule aggregate levels promote outcomes. Molecular nanoengineering modulate processes convert absorbed photons into fluorescent/phosphorescent/photoacoustic signals and/or photodynamic/photothermal curing effects improved phototheranostics are elaborated. Noteworthily, adaptive activatable transformable functions demand, regulation such as chemiexcitation efficacies also included. A brief summary discussion current challenges future perspectives this field is further presented.

Language: Английский

Citations

584
Massively Evoking Immunogenic Cell Death by Focused Mitochondrial Oxidative Stress using an AIE Luminogen with a Twisted Molecular Structure DOI
Chao Chen, Xiang Ni,

Shaorui Jia

et al.

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(52)

Published: Nov. 7, 2019

Immunogenic cell death (ICD) provides momentous theoretical principle for modern cancer immunotherapy. However, the currently available ICD inducers are still very limited and photosensitizer-based ones can hardly induce sufficient to achieve satisfactory immunotherapy by themselves. Herein, an organic photosensitizer (named TPE-DPA-TCyP) with a twisted molecular structure, strong aggregation-induced emission activity, specific ability is reported effectively inducing focused mitochondrial oxidative stress of cells, which serve as much superior inducer popularly used ones, including chlorin e6 (Ce6), pheophorbide A, oxaliplatin. Furthermore, more effective in vivo immunogenicity TPE-DPA-TCyP than Ce6 also demonstrated using prophylactic tumor vaccination model. The underlying mechanism effectiveness robustness antitumor immunity immune-memory effect verified immune analyses. This study thus reveals that highly strategy evoke abundant large-scale ICD.

Language: Английский

Citations

462
Aggregation‐enhanced theranostics: AIE sparkles in biomedical field DOI Creative Commons

Miaomiao Kang,

Zhijun Zhang, Nan Song

et al.

Aggregate, Journal Year: 2020, Volume and Issue: 1(1), P. 80 - 106

Published: Dec. 1, 2020

Abstract Theranostics referring to the ingenious integration of diagnostics and therapeutics has garnered tremendous attention in these years as it provides a promising opportunity for modern personalized precision medicine. By virtue good biocompatibility, outstanding fluorescence property, easy processability functionalization, promoted photosensitizing efficiency, well facile construction multi‐modality theranostics, fluorophores with aggregation‐induced emission (AIE) characteristics exhibit inexhaustible vigorous vitality field theranostics. Numerous significant breakthroughs state‐of‐the‐art progression have been witnessed past few years. This review highlights aggregation‐enhanced superiorities AIE luminogens (AIEgens) disease theranostics mainly involving diagnostic imaging (fluorescence room temperature phosphorescence), therapeutic intervention (photodynamic therapy), feasibility based on experimental measurements theoretical simulations. Additionally, latest advanced developments AIEgens aspect corresponding strategies design highly effective AIE‐active through triggering aggregation formation are comprehensively summarized. Moreover, brief conclusion discussion current challenges future perspectives this area is further presented.

Language: Английский

Citations

433
Chemiluminescence for bioimaging and therapeutics: recent advances and challenges DOI

Mingwang Yang,

Jiaguo Huang, Jiangli Fan

et al.

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(19), P. 6800 - 6815

Published: Jan. 1, 2020

The current progress, design principles in bioimaging and therapeutic applications, future perspectives of various chemiluminescent platforms are reviewed.

Language: Английский

Citations

417
An All‐Round Athlete on the Track of Phototheranostics: Subtly Regulating the Balance between Radiative and Nonradiative Decays for Multimodal Imaging‐Guided Synergistic Therapy DOI
Zhijun Zhang, Wenhan Xu,

Miaomiao Kang

et al.

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(36)

Published: July 21, 2020

Abstract Aiming to achieve versatile phototheranostics with the integrated functionalities of multiple diagnostic imaging and synergistic therapy, optimum use dissipated energy through both radiative nonradiative pathways is definitely appealing, yet a significantly challenging task. To best knowledge, there have been no previous reports on single molecular species effective at affording all phototheranostic modalities including fluorescence (FLI), photoacoustic (PAI), photothermal (PTI), photodynamic therapy (PDT), (PTT). Herein, simple highly powerful one‐for‐all based aggregation‐induced emission (AIE)‐active fluorophores tactfully designed constructed. Thanks its strong electron donor–acceptor interaction finely modulated intramolecular motion, AIE fluorophore‐based nanoparticles simultaneously exhibit bright near‐infrared II (NIR‐II) emission, efficient reactive oxygen generation, high conversion efficiency upon NIR irradiation, indicating actualization balance between dissipations. Furthermore, unprecedented performance NIR‐II FLI‐PAI‐PTI trimodal‐imaging‐guided PDT–PTT demonstrated by precise tumor diagnosis complete elimination outcomes. This study thus brings new insight into development superior for practical cancer theranostics.

Language: Английский

Citations

368
Regulating the Photophysical Property of Organic/Polymer Optical Agents for Promoted Cancer Phototheranostics DOI
Chao Chen, Hanlin Ou, Ruihua Liu

et al.

Advanced Materials, Journal Year: 2019, Volume and Issue: 32(3)

Published: March 29, 2019

Abstract On the basis of Jablonski diagram, photophysical properties optical agents are highly associated with biomedical function and efficacy. Herein, focus is on organic/polymer recent progress in main strategies for regulating their to achieve superior cancer diagnosis/phototheranostics applications highlighted. Both approaches nanoengineering molecular design, which can lead optimized effectiveness required function, discussed.

Language: Английский

Citations

306
Recent advances of AIE light-up probes for photodynamic therapy DOI Creative Commons
Shanshan Liu, Guangxue Feng, Ben Zhong Tang

et al.

Chemical Science, Journal Year: 2021, Volume and Issue: 12(19), P. 6488 - 6506

Published: Jan. 1, 2021

AIE fluorogens provide new opportunities for the development of light-up probes photodynamic therapy.

Language: Английский

Citations

301
Semiconducting Polycomplex Nanoparticles for Photothermal Ferrotherapy of Cancer DOI
Shasha He, Yuyan Jiang, Jing Li

et al.

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 59(26), P. 10633 - 10638

Published: March 24, 2020

Abstract This study reports the development of iron‐chelated semiconducting polycomplex nanoparticles (SPFeN) for photoacoustic (PA) imaging‐guided photothermal ferrotherapy cancer. The hybrid polymeric nanoagent comprises a ferroptosis initiator (Fe 3+ ) and an amphiphilic (SP C serving as both nanotransducer iron ion chelator. By virtue poly(ethylene glycol) (PEG) grafting its small size, SPFeN accumulates in tumor living mice after systemic administration, which can be monitored by PA imaging. In acidic microenvironment, generates hydroxyl radicals, leading to ferroptosis; meanwhile, under NIR laser irradiation, it localized heat not only accelerate Fenton reaction but also implement therapy. Such combined ferrotherapeutic effect leads minimized dosage compared previous studies effectively inhibits growth mice, is possible controls.

Language: Английский

Citations

273
Gathering brings strength: How organic aggregates boost disease phototheranostics DOI
Ji Qi, Hanlin Ou, Qian Liu

et al.

Aggregate, Journal Year: 2021, Volume and Issue: 2(1), P. 95 - 113

Published: Jan. 22, 2021

Abstract Phototheranostics that concurrently and complementarily integrate real‐time diagnosis in situ therapeutic capabilities one platform has become the advancing edge of precision medicine. Organic agents possess merits facile preparation, high purity, tunable photophysical property, good biocompatibility, potential biodegradability, which have shown great promise for disease theranostics. This review summarizes recent achievements organic phototheranostic applications, especially rationally utilize energy dissipation pathways Jablonski diagram to modulate fluorescence emission, photoacoustic/photothermal production, photodynamic processes. Of particular interest are systems exhibiting huge differences aggregate state as compared with solution or single molecule form, during intramolecular motions play an important role regulating properties. The advances from such aspect biomedical applications including high‐resolution imaging, activatable imaging therapy, adaptive theranostics, image‐guided surgery, immunotherapy, afterglow discussed. A brief summary perspective this field also presented. We hope will be helpful researchers interested bioprobe design theranostic inspire new insights into linkage between science field.

Language: Английский

Citations

247