Chemical Physics Reviews,
Journal Year:
2024,
Volume and Issue:
5(4)
Published: Dec. 1, 2024
Metal
nanoclusters
(NCs)
composed
of
metal
atoms
and
ligands
show
promise
as
electrochemiluminescent
(ECL)
materials
due
to
their
optical
electrochemical
properties.
This
review
provides
a
comprehensive
overview
the
ECL
mechanisms,
advantages,
roles
NCs
luminophores,
catalysts,
quenchers,
substrates,
carriers.
Insights
into
factors
that
influence
in
will
lay
foundation
for
future
research.
In
addition,
applications
metallic
NC-based
detection
platforms
are
summarized,
potential
research
directions
presented.
Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
96(6), P. 2369 - 2377
Published: Feb. 4, 2024
Ultrasensitive
and
accurate
monitoring
of
carboxylesterase
(CE)
activity
is
extremely
crucial
for
the
early
diagnosis
hepatocellular
carcinoma
(HCC),
which
still
a
considerable
challenge.
Herein,
using
co-reactive
ligand
engineering
strategy,
ultra-bright
near-infrared
(λmax
=
830
nm)
self-enhanced
electrochemiluminescence
(ECL)
Au
nanoclusters
(NCs)
were
in
situ
prepared
with
2-(diethylamino)
ethanethiol
(DEAET)
as
ligand.
Remarkably,
not
only
acts
stabilizer
like
traditional
ligands
but
also
plays
role
co-reactant
to
ensure
confinement
effect
shorten
charge
transfer
distance
increase
local
concentration,
significantly
improving
collision
efficiency
between
electrogenerated
free
radicals.
Consequently,
DEAET
NCs
exhibited
record
stable
anodal
ECL
without
addition
an
exogenous
co-reactant,
dramatically
superior
classical
Ru(bpy)32+
certain
amount
co-reactant.
As
proof
concept,
convenient
label-free
CE
biosensor
was
innovatively
constructed
1-naphthyl
acetate
selective
substrate,
achieving
ultrasensitive
detection
low
limit
9.1
×
10–7
U/L.
Therefore,
this
work
paves
strategy
preparation
high-efficiency
metal
provides
platform
HCC.
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Feb. 24, 2025
Electrochemiluminescence
(ECL)
is
a
light-emitting
process
in
which
the
stability
of
electrochemically
generated
radicals
has
crucial
impact
on
efficiency
and
durability
excited
state
generation.
Therefore,
deciphering
relationship
between
radical
ECL
performance
highly
appealing.
In
this
work,
three
sp2
carbon-conjugated
covalent
organic
framework
(COF)
reticular
nanoemitters
compositing
same
pyrene
luminophores
but
different
acrylonitrile
linkers
are
designed
with
progressive
electron
affinities,
named
as
CN-COF-1,
2,
3.
By
precisely
modulating
affinity
CN-COFs,
volcano
discovered
78
folds
enhancement
intensity.
Density
functional
theoretical
calculations
indicate
that
CN-COF-2
exhibits
moderate
stabilization
capacity
well
efficient
transport
cores,
facilitating
Significantly,
appropriate
not
only
achieves
self-enhanced
cathodic
also
promotes
The
rational
regulation
paves
way
for
developing
decoding
fundamentals.
Deciphering
electrochemiluminescence
important
since
an
Here,
authors
describe
shaped
via
acrylonitrile-linked
frameworks.
Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
96(4), P. 1700 - 1706
Published: Jan. 18, 2024
The
commercialized
electrochemiluminescence
(ECL)
immunoassay
is
carried
out
by
holding
luminophore
Ru(bpy)32+
at
a
given
potential.
Designing
an
electrochemiluminophore
with
narrow
triggering
potential
window
strongly
anticipated
to
decrease
the
electrochemical
cross-talk
and
improve
flux
of
ECL
in
potential-resolved
way.
Herein,
L-penicillamine-capped
silver
nanoclusters
(LPA-AgNCs)
are
facilely
synthesized
utilized
as
tags
perform
sole
0.24
V
employing
hydrazine
(N2H4)
coreactant.
maximum
emission
LPA-AgNCs/N2H4
system
located
ca.
+1.27
V.
Upon
immobilizing
LPA-AgNCs
onto
electrode
surface
via
forming
sandwich
immunocomplex,
can
be
sensitively
selectively
determine
human
carcinoembryonic
antigen
from
0.5
1000
pg/mL
low
limit
detection
0.1
(S/N
=
3).
This
work
might
open
way
screen
electrochemiluminophores
for
multiple
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(5), P. 1355 - 1360
Published: Jan. 1, 2024
Gold
nanoclusters
(Au
NCs)
with
excellent
optical
properties
and
biocompatibility
have
become
one
of
the
most
promising
electrochemiluminescence
(ECL)
emitters.
However,
low
efficiency
poor
stability
Au
NCs
restrict
their
applications
in
ECL.
Herein,
by
supramolecular
assembly
L-arginine
(Arg)
4-hydroxy-2-mercapto-6-methylpyrimidine
(MTU)
on
surface
NCs,
Arg/MTU-Au
enhanced
ECL
were
prepared.
Compared
MTU-stabilized
(MTU-Au
NCs),
increased
24.8
times.
As
a
proof-of-concept,
sensitive
biosensing
platform
was
constructed
for
detection
hemoglobin
(Hb)
urine
using
as
The
proposed
provides
feasible
strategy
biomarkers
has
broad
application
prospects
disease
screening
clinical
marker
detection.
Inorganic Chemistry Frontiers,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
We
summarize
the
design
strategies
for
improving
ECL
of
metal
nanoclusters,
including
1.
aggregation-induced
emission;
2.
anodic
pre-oxidation;
3.
self-loading;
4.
Anionic
substitution;
5.
ion
doping;
6.
valence
engineering.
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 19, 2025
The
wash-free
method
represents
a
promising
strategy
for
enhancing
the
detection
efficiency
of
automated
chemiluminescent
(CL)
immunoassay
analyzers.
Herein,
novel
separation-free
and
was
developed
first
time
based
on
distance-driven
CL
technique.
In
immunoassay,
well-designed
Au–Co
metal
nanoclusters
(NCs)
exhibited
excellent
peroxidase-like
activity
good
stability,
allowing
efficient
catalysis
luminol
or
its
analogue
(ABEI)-H2O2
system
even
at
low
concentrations.
Furthermore,
large
specific
surface
area
NCs
facilitated
accommodation
greater
number
antibodies,
thereby
capture
antigens
achieving
dual
amplification
signal.
technique
relied
formation
sandwich-type
immunocomplexes.
Upon
generation
hydroxyl
radicals
superoxide
anion
through
catalytic
decomposition
H2O2
by
NCs,
ABEI
within
immunocomplexes
could
efficiently
react
with
these
radicals,
leading
to
significant
enhancement
in
signals.
C-reactive
protein
(CRP)
chosen
as
model
analyte
evaluate
practicability
proposed
immunoassay.
Notably,
presented
high
sensitivity,
selectivity,
reproducibility,
successfully
determining
CRP
serum
samples
recoveries
96.55–106.29%.
Accordingly,
advantage
separation-free,
wash-free,
reliable
characteristics
drastically
simplify
operation
steps
enhance
efficiency,
which
would
make
advances
revolution
traditional
