Analytica Chimica Acta, Journal Year: 2023, Volume and Issue: 1280, P. 341875 - 341875
Published: Oct. 5, 2023
Language: Английский
Analytica Chimica Acta, Journal Year: 2023, Volume and Issue: 1280, P. 341875 - 341875
Published: Oct. 5, 2023
Language: Английский
TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 169, P. 117376 - 117376
Published: Oct. 18, 2023
Language: Английский
Citations
34Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(40), P. 15008 - 15016
Published: Sept. 26, 2023
Efficient tuning of the polarity photoactive nanomaterials is great importance in improving performance photoelectrochemical (PEC) sensing platforms. Herein, Ag2S/AgInS2 heterojunction converted by radical-induced positive feedback polydopamine (PDA) adhesion, which further employed to develop a signal-switchable PEC biosensor. In nanocomposites, Ag2S and AgInS2 achieve electron-hole separation, exhibiting strong anodic response. Under irradiation light, able produce superoxide radical hydroxyl intermediate species, leading polymerization dopamine (DA) subsequent adhesion PDA onto (Ag2S/AgInS2@PDA). By constructing new electron-transfer pathway with PDA, converted, response changes from cathodic photocurrents. addition, since photoreduction activity stronger than that heterojunction, more can be produced Ag2S/AgInS2@PDA once generated, thereby promoting generation PDA. Consequently, mechanism established enhance conversion amplify responding DA. As result, bioanalytical method capable sensitively quantifying DA 10 orders magnitude an ultralow limit detection. Moreover, applicability this biosensor real samples identified measuring fetal bovine serum compared commercial ELISA method. Overall, work offers alternative perspective for adjusting photogenerated carriers designing high-performance biosensors.
Language: Английский
Citations
26Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(11), P. 4589 - 4596
Published: March 5, 2024
Herein, novel europium metal–organic gels (Eu-MOGs) with excellent cathode electrochemiluminescence (ECL) emission are first used to construct biosensors for the ultrasensitive detection of miRNA-222. Impressively, N and O elements organic ligand 2,2′:6,2″-terpyridine 4,4′,4″-tricarboxylic acid (H3-tctpy) can perfectly coordinate Eu3+ form Eu-MOGs, which not only reduce nonradiative transition caused by intramolecular free rotation phenyl rings in other MOGs enhance ECL signal extraordinary efficiency as high 37.2% (vs [Ru(bpy)3]2+/S2O82– system) but also reinforce ligand-to-metal charge transfer (LMCT) strong affinity between greatly improve stability signals. Besides, an improved nucleic cascade amplification reaction is developed raise conversion from target miRNA-222 a DNAzyme-mediated dual-drive DNA walker output DNA, simultaneously shear specific recognition sites two directions. In that way, proposed biosensor further sensitivity linear range 10 aM–1 nM limit (LOD) 8.5 aM, achieve accurate response cancer cell lysates MHCC-97L HeLa. Additionally, be self-regenerated folding/unfolding related triplets pH changes simplify experimental operations cost. Hence, this work stable intense signals construction renewable biosensor, supplying reliable method biomarker analysis disease diagnosis.
Language: Английский
Citations
15ACS Sensors, Journal Year: 2023, Volume and Issue: 8(7), P. 2656 - 2663
Published: June 26, 2023
Currently, studies on electrochemiluminescence (ECL) mainly focused the single emission of luminophores while those multi-color ECL were rarely reported. Here, a bi-mesoporous composite metal-organic framework (MOF)/covalent-organic (COF) with strong and stable dual-color was prepared to construct novel sensor for sensitive detecting targets. A PTCA-COF excellent performance loaded great amount another emitter Cu3(HHTP)2. Remarkably, integrated had both properties at 520 nm Cu3(HHTP)2 600 wavelengths. Furthermore, good electron transfer ability can greatly enhance electrical conductivity promote electrochemical activation. Thus, simultaneous enhanced two-color intensity catalytic conductive MOF exerted dual enhancement effect signal composite. Significantly, diclazepam not only be adsorbed well multi-stage porous structure MOF/COF by π-π interactions but also selectively quench PTCA-COF, realizing detection. The showed wide detection range from 1.0 × 10-13 10-8 g/L, limit (LOD) as low 2.6 10-14 g/L (S/N = 3). proposed preparation method simple sensitive, providing new perspective potential application in sensing field.
Language: Английский
Citations
18Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(27), P. 10457 - 10463
Published: June 29, 2023
The lumiol-O2 electrochemiluminescence (ECL) system constantly emits bright light at positive potential. Notably, compared with the anodic ECL signal of luminol-O2 system, great virtues cathodic are that it is simple and causes minor damage to biological samples. Unfortunately, little emphasis has been paid ECL, owing low reaction efficacy between luminol reactive oxygen species. state-of-the-art work mainly focuses on improving catalytic activity reduction reaction, which remains a significant challenge. In this work, synergistic amplification pathway established for ECL. effect based decomposition H2O2 by catalase-like (CAT-like) CoO nanorods (CoO NRs) regeneration carbonate/bicarbonate buffer. Compared Fe2O3 nanorod (Fe2O3 NR)- NiO microsphere-modified glassy carbon electrodes (GCEs), intensity nearly 50 times stronger when potential ranged from 0 -0.4 V NR-modified GCE in carbonate buffer solution. CAT-like NRs decompose electroreduction product into OH· O2·-, further oxidize HCO3- CO32- HCO3· CO3·-. These radicals very effectively interact form radical. More importantly, can be regenerated dimerizes produce (CO2)2*, provides cyclic during dimerization HCO3·. This inspires developing new avenue improve deeply understand mechanism reaction.
Language: Английский
Citations
18Sensors and Actuators B Chemical, Journal Year: 2025, Volume and Issue: unknown, P. 137260 - 137260
Published: Jan. 1, 2025
Language: Английский
Citations
1Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(37), P. 14143 - 14149
Published: Sept. 7, 2023
High-performance electrochemiluminescence is a significant approach for the examination of disease biomarkers, and utilization innovative detection systems represents viable strategy to enhance efficacy ECL analysis. In this work, biomimetic engineering metal-organic framework (MOF-818) has realized ultrasensitive immunoassay markers based on guidance free radical scavenging provided by antioxidant cascade. Initially, we synthesized hydrogen-bonded organic (HOF) consisting luminol three active ligands simple room-temperature self-assembly. The luminol-HOF (L-HOF) showed more stable brighter luminescence activity than monomer due nano-confinement enhancement coordinated units. Subsequently, MOF-818 with superoxide dismutase (SOD) catalase (CAT) activities were recruited first time as quenching agents sandwich mode. enzyme leads reverse transformation anion radicals (O2-) further decomposition, decreasing in responsiveness signals. Using carcinoembryonic antigen (CEA) an analytical model, limit 0.457 pg/mL was obtained within range 0.001-50 ng/mL. We believe that novel sensing model provides meaningful potential tool precise detection, expanding broader application nanoenzymes
Language: Английский
Citations
14Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 422, P. 136452 - 136452
Published: Sept. 4, 2024
Language: Английский
Citations
6Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(34), P. 12754 - 12760
Published: Aug. 17, 2023
In this study, a pH-stimulated self-locked DNA nanostructure (SLDN) was developed to efficiently distinguish cancer cells from other for the simultaneous detection and imaging of endogenous dual-microRNAs (miRNAs). Impressively, SLDN specifically unlocked in acidic environment form unlocked-SLDN disengage i-motif sequence with labeled fluorophore recovery fluorescence signal, resulting differentiation normal cells. Meanwhile, could combine recognize targets miRNA-21 miRNA-155 simultaneously trigger hybridization chain reaction (HCR) amplification sensitive dual-miRNA detection, limits 1.46 pM 0.72 miRNA-155. Significantly, compared current miRNA strategy based on traditional nanostructure, proposed here remarkably eliminates interference achieve high-resolution colocation miRNAs tumor an ultralow background signal. This work provided specific method materialize biomarker distinguishable high-definition live-cell precise diagnosis multifactor research progression.
Language: Английский
Citations
13Talanta, Journal Year: 2024, Volume and Issue: 273, P. 125942 - 125942
Published: March 19, 2024
Language: Английский
Citations
5